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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FCER1G |
 Gene summary |
| Gene information | Gene symbol | FCER1G | Gene ID | 2207 |
| Gene name | Fc fragment of IgE receptor Ig | |
| Synonyms | FCRG | |
| Cytomap | 1q23.3 | |
| Type of gene | protein-coding | |
| Description | high affinity immunoglobulin epsilon receptor subunit gammaFc epsilon receptor IgFc fragment of IgE, high affinity I, receptor for; gamma polypeptideFc receptor gamma-chainfc-epsilon RI-gammafcRgammafceRI gammaimmunoglobulin E receptor, high affini | |
| Modification date | 20180523 | |
| UniProtAcc | P30273 | |
| Context | PubMed: FCER1G [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for FCER1G from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FCER1G |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FCER1G |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_13269 | 1 | 161185086:161185160:161187775:161187867:161188030:161188066 | 161187775:161187867 | ENSG00000158869.6 | ENST00000289902.1,ENST00000367992.3 |
| exon_skip_13274 | 1 | 161187775:161187867:161188030:161188066:161188492:161188513 | 161188030:161188066 | ENSG00000158869.6 | ENST00000289902.1,ENST00000367992.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FCER1G |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_13269 | 1 | 161185086:161185160:161187775:161187867:161188030:161188066 | 161187775:161187867 | ENSG00000158869.6 | ENST00000367992.3,ENST00000289902.1 |
| exon_skip_13274 | 1 | 161187775:161187867:161188030:161188066:161188492:161188513 | 161188030:161188066 | ENSG00000158869.6 | ENST00000367992.3,ENST00000289902.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FCER1G |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000289902 | 161187775 | 161187867 | Frame-shift |
| ENST00000289902 | 161188030 | 161188066 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000289902 | 161187775 | 161187867 | Frame-shift |
| ENST00000289902 | 161188030 | 161188066 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FCER1G |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000289902 | 608 | 86 | 161188030 | 161188066 | 167 | 202 | 47 | 59 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000289902 | 608 | 86 | 161188030 | 161188066 | 167 | 202 | 47 | 59 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P30273 | 47 | 59 | 19 | 86 | Chain | ID=PRO_0000016501;Note=High affinity immunoglobulin epsilon receptor subunit gamma |
| P30273 | 47 | 59 | 54 | 82 | Domain | Note=ITAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00379 |
| P30273 | 47 | 59 | 45 | 86 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P30273 | 47 | 59 | 19 | 86 | Chain | ID=PRO_0000016501;Note=High affinity immunoglobulin epsilon receptor subunit gamma |
| P30273 | 47 | 59 | 54 | 82 | Domain | Note=ITAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00379 |
| P30273 | 47 | 59 | 45 | 86 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for FCER1G |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| PAAD | TCGA-FB-AAPQ-01 | exon_skip_13269 | 161187776 | 161187867 | 161187859 | 161187859 | Nonsense_Mutation | C | T | p.R45* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| OUMS23_LARGE_INTESTINE | 161187776 | 161187867 | 161187800 | 161187800 | Missense_Mutation | G | T | p.C25F |
| TGBC11TKB_STOMACH | 161187776 | 161187867 | 161187811 | 161187811 | Missense_Mutation | G | A | p.D29N |
| NB12_AUTONOMIC_GANGLIA | 161187776 | 161187867 | 161187850 | 161187850 | Missense_Mutation | C | T | p.L42F |
| SNU81_LARGE_INTESTINE | 161187776 | 161187867 | 161187859 | 161187859 | Nonsense_Mutation | C | T | p.R45* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FCER1G |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCER1G |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCER1G |
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RelatedDrugs for FCER1G |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P30273 | DB00895 | Benzylpenicilloyl Polylysine | High affinity immunoglobulin epsilon receptor subunit gamma | small molecule | approved |
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RelatedDiseases for FCER1G |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FCER1G | C0013182 | Drug Allergy | 2 | CTD_human |
| FCER1G | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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