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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MARK2 |
 Gene summary |
| Gene information | Gene symbol | MARK2 | Gene ID | 2011 |
| Gene name | microtubule affinity regulating kinase 2 | |
| Synonyms | EMK-1|EMK1|PAR-1|Par-1b|Par1b | |
| Cytomap | 11q13.1 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117 | |
| Modification date | 20180523 | |
| UniProtAcc | Q7KZI7 | |
| Context | PubMed: MARK2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MARK2 | GO:0006468 | protein phosphorylation | 14976552 |
| MARK2 | GO:0010976 | positive regulation of neuron projection development | 12429843 |
| MARK2 | GO:0018105 | peptidyl-serine phosphorylation | 10542369 |
| MARK2 | GO:0030010 | establishment of cell polarity | 12429843 |
| MARK2 | GO:0035556 | intracellular signal transduction | 14976552 |
| MARK2 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 15324659 |
| MARK2 | GO:0070507 | regulation of microtubule cytoskeleton organization | 10542369 |
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Exon skipping events across known transcript of Ensembl for MARK2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MARK2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MARK2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_60333 | 11 | 63636747:63636844:63647619:63647700:63662630:63662698 | 63647619:63647700 | ENSG00000072518.16 | ENST00000540169.1 |
| exon_skip_60334 | 11 | 63656167:63656436:63657693:63657767:63662630:63662698 | 63657693:63657767 | ENSG00000072518.16 | ENST00000512060.1 |
| exon_skip_60335 | 11 | 63665703:63665752:63666079:63666145:63666234:63666265 | 63666079:63666145 | ENSG00000072518.16 | ENST00000361128.5,ENST00000543220.1,ENST00000413835.2,ENST00000377810.3,ENST00000408948.3,ENST00000513765.2,ENST00000350490.7,ENST00000502399.3,ENST00000377809.4,ENST00000425897.2,ENST00000508192.1,ENST00000509502.2,ENST00000540169.1,ENST00000402010.2,ENS |
| exon_skip_60336 | 11 | 63668251:63668351:63668428:63668541:63669669:63669802 | 63668428:63668541 | ENSG00000072518.16 | ENST00000361128.5,ENST00000413835.2,ENST00000377810.3,ENST00000408948.3,ENST00000513765.2,ENST00000350490.7,ENST00000502399.3,ENST00000377809.4,ENST00000425897.2,ENST00000508192.1,ENST00000509502.2,ENST00000402010.2,ENST00000315032.8 |
| exon_skip_60338 | 11 | 63669669:63669802:63670072:63670254:63670532:63670604 | 63670072:63670254 | ENSG00000072518.16 | ENST00000361128.5,ENST00000413835.2,ENST00000513765.2,ENST00000377809.4,ENST00000402010.2,ENST00000315032.8 |
| exon_skip_60340 | 11 | 63669669:63669802:63670075:63670254:63670532:63670604 | 63670075:63670254 | ENSG00000072518.16 | ENST00000377810.3,ENST00000408948.3,ENST00000350490.7,ENST00000502399.3,ENST00000425897.2,ENST00000508192.1,ENST00000509502.2 |
| exon_skip_60341 | 11 | 63670158:63670254:63670532:63670630:63671457:63671619 | 63670532:63670630 | ENSG00000072518.16 | ENST00000513765.2,ENST00000502399.3,ENST00000377809.4,ENST00000509502.2,ENST00000402010.2,ENST00000315032.8 |
| exon_skip_60342 | 11 | 63670158:63670254:63670532:63670630:63672257:63672515 | 63670532:63670630 | ENSG00000072518.16 | ENST00000361128.5,ENST00000413835.2,ENST00000377810.3,ENST00000408948.3,ENST00000350490.7,ENST00000508192.1 |
| exon_skip_60345 | 11 | 63670532:63670630:63671457:63671619:63672257:63672393 | 63671457:63671619 | ENSG00000072518.16 | ENST00000513765.2,ENST00000502399.3,ENST00000377809.4,ENST00000509502.2,ENST00000402010.2,ENST00000315032.8 |
| exon_skip_60352 | 11 | 63672262:63672515:63673559:63673586:63675731:63675776 | 63673559:63673586 | ENSG00000072518.16 | ENST00000413835.2,ENST00000513765.2,ENST00000402010.2 |
| exon_skip_60353 | 11 | 63672257:63672515:63673559:63673586:63676348:63676403 | 63673559:63673586 | ENSG00000072518.16 | ENST00000361128.5,ENST00000377809.4 |
| exon_skip_60356 | 11 | 63672257:63672515:63675731:63675776:63676348:63676403 | 63675731:63675776 | ENSG00000072518.16 | ENST00000377810.3,ENST00000408948.3,ENST00000502399.3,ENST00000425897.2,ENST00000508192.1,ENST00000509502.2,ENST00000315032.8 |
| exon_skip_60359 | 11 | 63673559:63673586:63675731:63675776:63676348:63676403 | 63675731:63675776 | ENSG00000072518.16 | ENST00000413835.2,ENST00000513765.2,ENST00000402010.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MARK2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_60334 | 11 | 63656167:63656436:63657693:63657767:63662630:63662698 | 63657693:63657767 | ENSG00000072518.16 | ENST00000512060.1 |
| exon_skip_60335 | 11 | 63665703:63665752:63666079:63666145:63666234:63666265 | 63666079:63666145 | ENSG00000072518.16 | ENST00000402010.2,ENST00000315032.8,ENST00000377809.4,ENST00000413835.2,ENST00000377810.3,ENST00000508192.1,ENST00000361128.5,ENST00000350490.7,ENST00000502399.3,ENST00000543220.1,ENST00000540169.1,ENST00000509502.2,ENST00000513765.2,ENST00000408948.3,ENS |
| exon_skip_60336 | 11 | 63668251:63668351:63668428:63668541:63669669:63669802 | 63668428:63668541 | ENSG00000072518.16 | ENST00000402010.2,ENST00000315032.8,ENST00000377809.4,ENST00000413835.2,ENST00000377810.3,ENST00000508192.1,ENST00000361128.5,ENST00000350490.7,ENST00000502399.3,ENST00000509502.2,ENST00000513765.2,ENST00000408948.3,ENST00000425897.2 |
| exon_skip_60338 | 11 | 63669669:63669802:63670072:63670254:63670532:63670604 | 63670072:63670254 | ENSG00000072518.16 | ENST00000402010.2,ENST00000315032.8,ENST00000377809.4,ENST00000413835.2,ENST00000361128.5,ENST00000513765.2 |
| exon_skip_60340 | 11 | 63669669:63669802:63670075:63670254:63670532:63670604 | 63670075:63670254 | ENSG00000072518.16 | ENST00000377810.3,ENST00000508192.1,ENST00000350490.7,ENST00000502399.3,ENST00000509502.2,ENST00000408948.3,ENST00000425897.2 |
| exon_skip_60341 | 11 | 63670158:63670254:63670532:63670630:63671457:63671619 | 63670532:63670630 | ENSG00000072518.16 | ENST00000402010.2,ENST00000315032.8,ENST00000377809.4,ENST00000502399.3,ENST00000509502.2,ENST00000513765.2 |
| exon_skip_60342 | 11 | 63670158:63670254:63670532:63670630:63672257:63672515 | 63670532:63670630 | ENSG00000072518.16 | ENST00000413835.2,ENST00000377810.3,ENST00000508192.1,ENST00000361128.5,ENST00000350490.7,ENST00000408948.3 |
| exon_skip_60345 | 11 | 63670532:63670630:63671457:63671619:63672257:63672393 | 63671457:63671619 | ENSG00000072518.16 | ENST00000402010.2,ENST00000315032.8,ENST00000377809.4,ENST00000502399.3,ENST00000509502.2,ENST00000513765.2 |
| exon_skip_60352 | 11 | 63672262:63672515:63673559:63673586:63675731:63675776 | 63673559:63673586 | ENSG00000072518.16 | ENST00000402010.2,ENST00000413835.2,ENST00000513765.2 |
| exon_skip_60353 | 11 | 63672257:63672515:63673559:63673586:63676348:63676403 | 63673559:63673586 | ENSG00000072518.16 | ENST00000377809.4,ENST00000361128.5 |
| exon_skip_60356 | 11 | 63672257:63672515:63675731:63675776:63676348:63676403 | 63675731:63675776 | ENSG00000072518.16 | ENST00000315032.8,ENST00000377810.3,ENST00000508192.1,ENST00000502399.3,ENST00000509502.2,ENST00000408948.3,ENST00000425897.2 |
| exon_skip_60359 | 11 | 63673559:63673586:63675731:63675776:63676348:63676403 | 63675731:63675776 | ENSG00000072518.16 | ENST00000402010.2,ENST00000413835.2,ENST00000513765.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MARK2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402010 | 63668428 | 63668541 | Frame-shift |
| ENST00000402010 | 63670072 | 63670254 | Frame-shift |
| ENST00000402010 | 63670532 | 63670630 | Frame-shift |
| ENST00000402010 | 63666079 | 63666145 | In-frame |
| ENST00000402010 | 63671457 | 63671619 | In-frame |
| ENST00000402010 | 63673559 | 63673586 | In-frame |
| ENST00000402010 | 63675731 | 63675776 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402010 | 63668428 | 63668541 | Frame-shift |
| ENST00000402010 | 63670072 | 63670254 | Frame-shift |
| ENST00000402010 | 63670532 | 63670630 | Frame-shift |
| ENST00000402010 | 63666079 | 63666145 | In-frame |
| ENST00000402010 | 63671457 | 63671619 | In-frame |
| ENST00000402010 | 63673559 | 63673586 | In-frame |
| ENST00000402010 | 63675731 | 63675776 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MARK2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402010 | 4745 | 788 | 63666079 | 63666145 | 917 | 982 | 112 | 134 |
| ENST00000402010 | 4745 | 788 | 63671457 | 63671619 | 2094 | 2255 | 505 | 558 |
| ENST00000402010 | 4745 | 788 | 63675731 | 63675776 | 2541 | 2585 | 654 | 668 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402010 | 4745 | 788 | 63666079 | 63666145 | 917 | 982 | 112 | 134 |
| ENST00000402010 | 4745 | 788 | 63671457 | 63671619 | 2094 | 2255 | 505 | 558 |
| ENST00000402010 | 4745 | 788 | 63675731 | 63675776 | 2541 | 2585 | 654 | 668 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7KZI7 | 112 | 134 | 115 | 120 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEC |
| Q7KZI7 | 112 | 134 | 122 | 129 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEC |
| Q7KZI7 | 112 | 134 | 1 | 788 | Chain | ID=PRO_0000086301;Note=Serine/threonine-protein kinase MARK2 |
| Q7KZI7 | 112 | 134 | 53 | 304 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q7KZI7 | 505 | 558 | 505 | 558 | Alternative sequence | ID=VSP_051706;Note=In isoform 2%2C isoform 4%2C isoform 5%2C isoform 7%2C isoform 9%2C isoform 10%2C isoform 13%2C isoform 15 and isoform 16. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11433294,ECO:00 |
| Q7KZI7 | 505 | 558 | 1 | 788 | Chain | ID=PRO_0000086301;Note=Serine/threonine-protein kinase MARK2 |
| Q7KZI7 | 654 | 668 | 645 | 668 | Alternative sequence | ID=VSP_041853;Note=In isoform 15. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q7KZI7 | 654 | 668 | 654 | 668 | Alternative sequence | ID=VSP_051708;Note=In isoform 5%2C isoform 11%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11433294,ECO:0000303|PubMed:9730619,ECO:0000303|Ref.2;Dbxref=PMID:11433294,PMID:9730619 |
| Q7KZI7 | 654 | 668 | 1 | 788 | Chain | ID=PRO_0000086301;Note=Serine/threonine-protein kinase MARK2 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7KZI7 | 112 | 134 | 115 | 120 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEC |
| Q7KZI7 | 112 | 134 | 122 | 129 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEC |
| Q7KZI7 | 112 | 134 | 1 | 788 | Chain | ID=PRO_0000086301;Note=Serine/threonine-protein kinase MARK2 |
| Q7KZI7 | 112 | 134 | 53 | 304 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q7KZI7 | 505 | 558 | 505 | 558 | Alternative sequence | ID=VSP_051706;Note=In isoform 2%2C isoform 4%2C isoform 5%2C isoform 7%2C isoform 9%2C isoform 10%2C isoform 13%2C isoform 15 and isoform 16. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11433294,ECO:00 |
| Q7KZI7 | 505 | 558 | 1 | 788 | Chain | ID=PRO_0000086301;Note=Serine/threonine-protein kinase MARK2 |
| Q7KZI7 | 654 | 668 | 645 | 668 | Alternative sequence | ID=VSP_041853;Note=In isoform 15. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q7KZI7 | 654 | 668 | 654 | 668 | Alternative sequence | ID=VSP_051708;Note=In isoform 5%2C isoform 11%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11433294,ECO:0000303|PubMed:9730619,ECO:0000303|Ref.2;Dbxref=PMID:11433294,PMID:9730619 |
| Q7KZI7 | 654 | 668 | 1 | 788 | Chain | ID=PRO_0000086301;Note=Serine/threonine-protein kinase MARK2 |
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SNVs in the skipped exons for MARK2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BRCA | TCGA-D8-A1JK-01 | exon_skip_60338 exon_skip_60340 | 63670073 | 63670254 | 63670121 | 63670122 | Frame_Shift_Del | AG | - | p.S396fs |
| BRCA | TCGA-D8-A1JK-01 | exon_skip_60338 exon_skip_60340 | 63670076 | 63670254 | 63670121 | 63670122 | Frame_Shift_Del | AG | - | p.S396fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_60338 exon_skip_60340 | 63670073 | 63670254 | 63670238 | 63670238 | Frame_Shift_Del | C | - | p.T467fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_60338 exon_skip_60340 | 63670076 | 63670254 | 63670238 | 63670238 | Frame_Shift_Del | C | - | p.T467fs |
| STAD | TCGA-CG-4306-01 | exon_skip_60338 exon_skip_60340 | 63670073 | 63670254 | 63670244 | 63670244 | Frame_Shift_Del | C | - | p.T469fs |
| STAD | TCGA-CG-4306-01 | exon_skip_60338 exon_skip_60340 | 63670076 | 63670254 | 63670244 | 63670244 | Frame_Shift_Del | C | - | p.T469fs |
| BLCA | TCGA-E7-A519-01 | exon_skip_60341 exon_skip_60342 | 63670533 | 63670630 | 63670556 | 63670556 | Frame_Shift_Del | A | - | p.T480fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_60341 exon_skip_60342 | 63670533 | 63670630 | 63670573 | 63670573 | Frame_Shift_Del | C | - | p.S486fs |
| BLCA | TCGA-DK-A6B2-01 | exon_skip_60345 | 63671458 | 63671619 | 63671582 | 63671582 | Frame_Shift_Del | C | - | p.P548fs |
| LUAD | TCGA-38-4631-01 | exon_skip_60335 | 63666080 | 63666145 | 63666130 | 63666130 | Nonsense_Mutation | G | T | p.E130* |
| BLCA | TCGA-FD-A3B6-01 | exon_skip_60336 | 63668429 | 63668541 | 63668461 | 63668461 | Nonsense_Mutation | G | T | p.E341* |
| LUAD | TCGA-78-7167-01 | exon_skip_60336 | 63668429 | 63668541 | 63668529 | 63668529 | Nonsense_Mutation | C | G | p.Y363* |
| BLCA | TCGA-DK-A1AC-01 | exon_skip_60336 | 63668429 | 63668541 | 63668428 | 63668428 | Splice_Site | G | A | p.E330_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 63670073 | 63670254 | 63670155 | 63670156 | Frame_Shift_Del | GG | - | p.D406fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 63670076 | 63670254 | 63670155 | 63670156 | Frame_Shift_Del | GG | - | p.D406fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 63670073 | 63670254 | 63670158 | 63670161 | Frame_Shift_Del | CCGG | - | p.DR406fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 63670076 | 63670254 | 63670158 | 63670161 | Frame_Shift_Del | CCGG | - | p.DR406fs |
| JHUEM1_ENDOMETRIUM | 63671458 | 63671619 | 63671582 | 63671582 | Frame_Shift_Del | C | - | p.P514fs |
| KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 63670073 | 63670254 | 63670237 | 63670238 | Frame_Shift_Ins | - | C | p.T433fs |
| KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 63670076 | 63670254 | 63670237 | 63670238 | Frame_Shift_Ins | - | C | p.T433fs |
| SNUC5_LARGE_INTESTINE | 63671458 | 63671619 | 63671581 | 63671582 | Frame_Shift_Ins | - | C | p.P513fs |
| LU134A_LUNG | 63668429 | 63668541 | 63668456 | 63668456 | Missense_Mutation | G | C | p.R306P |
| MELHO_SKIN | 63670073 | 63670254 | 63670172 | 63670172 | Missense_Mutation | G | A | p.R411Q |
| MELHO_SKIN | 63670076 | 63670254 | 63670172 | 63670172 | Missense_Mutation | G | A | p.R411Q |
| MELHO_SKIN | 63670073 | 63670254 | 63670172 | 63670173 | Missense_Mutation | GG | AA | p.R411Q |
| MELHO_SKIN | 63670076 | 63670254 | 63670172 | 63670173 | Missense_Mutation | GG | AA | p.R411Q |
| EBC1_LUNG | 63670073 | 63670254 | 63670190 | 63670190 | Missense_Mutation | C | T | p.A417V |
| EBC1_LUNG | 63670076 | 63670254 | 63670190 | 63670190 | Missense_Mutation | C | T | p.A417V |
| HDMYZ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 63670073 | 63670254 | 63670229 | 63670229 | Missense_Mutation | A | G | p.K430R |
| HDMYZ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 63670076 | 63670254 | 63670229 | 63670229 | Missense_Mutation | A | G | p.K430R |
| PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 63670533 | 63670630 | 63670603 | 63670603 | Missense_Mutation | A | G | p.Q462R |
| HEC59_ENDOMETRIUM | 63671458 | 63671619 | 63671496 | 63671496 | Missense_Mutation | C | T | p.A484V |
| TC138_BONE | 63671458 | 63671619 | 63671514 | 63671514 | Missense_Mutation | C | T | p.A490V |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 63671458 | 63671619 | 63671514 | 63671514 | Missense_Mutation | C | T | p.A490V |
| MESSA_SOFT_TISSUE | 63671458 | 63671619 | 63671612 | 63671612 | Missense_Mutation | C | T | p.R523W |
| NCIH2110_LUNG | 63673560 | 63673586 | 63673570 | 63673570 | Missense_Mutation | T | G | p.F595V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MARK2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MARK2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MARK2 |
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RelatedDrugs for MARK2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q7KZI7 | DB12010 | Fostamatinib | Serine/threonine-protein kinase MARK2 | small molecule | approved|investigational |
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RelatedDiseases for MARK2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MARK2 | C0036341 | Schizophrenia | 2 | PSYGENET |
| MARK2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| MARK2 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
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