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Open reading frame (ORF) annotation in the exon skipping event | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon | |
Gene summary for ZNF467 |
Gene summary |
Gene information | Gene symbol | ZNF467 | Gene ID | 168544 |
Gene name | zinc finger protein 467 | |
Synonyms | EZI|Zfp467 | |
Cytomap | 7q36.1 | |
Type of gene | protein-coding | |
Description | zinc finger protein 467zinc finger protein EZI | |
Modification date | 20180522 | |
UniProtAcc | Q7Z7K2 | |
Context | PubMed: ZNF467 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF467 from UCSC genome browser |
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF467 |
Expression levels of gene isoforms across TCGA. |
Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF467 |
Information of exkip skipping event in TCGA. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_480189 | 7 | 149461270:149461767:149466178:149466289:149467528:149467645 | 149466178:149466289 | ENSG00000181444.8 | ENST00000484747.1 |
exon_skip_480196 | 7 | 149463266:149463328:149466178:149466289:149467528:149467645 | 149466178:149466289 | ENSG00000181444.8 | ENST00000302017.3 |
exon_skip_480205 | 7 | 149466178:149466289:149467528:149467645:149468087:149468163 | 149467528:149467645 | ENSG00000181444.8 | ENST00000484747.1,ENST00000302017.3 |
exon_skip_480209 | 7 | 149467528:149467645:149468087:149468163:149470196:149470308 | 149468087:149468163 | ENSG00000181444.8 | ENST00000302017.3 |
PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF467 |
Information of exkip skipping event in GTEx |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_480189 | 7 | 149461270:149461767:149466178:149466289:149467528:149467645 | 149466178:149466289 | ENSG00000181444.8 | ENST00000484747.1 |
exon_skip_480196 | 7 | 149463266:149463328:149466178:149466289:149467528:149467645 | 149466178:149466289 | ENSG00000181444.8 | ENST00000302017.3 |
exon_skip_480205 | 7 | 149466178:149466289:149467528:149467645:149468087:149468163 | 149467528:149467645 | ENSG00000181444.8 | ENST00000484747.1,ENST00000302017.3 |
exon_skip_480209 | 7 | 149467528:149467645:149468087:149468163:149470196:149470308 | 149468087:149468163 | ENSG00000181444.8 | ENST00000302017.3 |
PSI values of skipped exons in GTEx. |
* Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF467 |
Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000302017 | 149468087 | 149468163 | 3UTR-3CDS |
ENST00000302017 | 149466178 | 149466289 | In-frame |
ENST00000302017 | 149467528 | 149467645 | In-frame |
Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000302017 | 149468087 | 149468163 | 3UTR-3CDS |
ENST00000302017 | 149466178 | 149466289 | In-frame |
ENST00000302017 | 149467528 | 149467645 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF467 |
Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000302017 | 2570 | 595 | 149467528 | 149467645 | 449 | 565 | 11 | 50 |
ENST00000302017 | 2570 | 595 | 149466178 | 149466289 | 566 | 676 | 50 | 87 |
Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000302017 | 2570 | 595 | 149467528 | 149467645 | 449 | 565 | 11 | 50 |
ENST00000302017 | 2570 | 595 | 149466178 | 149466289 | 566 | 676 | 50 | 87 |
Lost protein functional features of individual exon skipping events in TCGA. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q7Z7K2 | 11 | 50 | 1 | 595 | Chain | ID=PRO_0000247517;Note=Zinc finger protein 467 |
Q7Z7K2 | 50 | 87 | 1 | 595 | Chain | ID=PRO_0000247517;Note=Zinc finger protein 467 |
Lost protein functional features of individual exon skipping events in GTEx. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q7Z7K2 | 11 | 50 | 1 | 595 | Chain | ID=PRO_0000247517;Note=Zinc finger protein 467 |
Q7Z7K2 | 50 | 87 | 1 | 595 | Chain | ID=PRO_0000247517;Note=Zinc finger protein 467 |
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SNVs in the skipped exons for ZNF467 |
- Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
- Differential PSIs between mutated versus non-mutated samples. |
- Non-synonymous mutations located in the skipped exons in TCGA. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
UCEC | TCGA-B5-A0K9-01 | exon_skip_480205 | 149467529 | 149467645 | 149467612 | 149467613 | Frame_Shift_Ins | - | G | p.Q23fs |
ACC | TCGA-OR-A5KB-01 | exon_skip_480189 exon_skip_480196 | 149466179 | 149466289 | 149466284 | 149466284 | Nonsense_Mutation | C | A | p.E53* |
ACC | TCGA-OR-A5KB-01 | exon_skip_480189 exon_skip_480196 | 149466179 | 149466289 | 149466284 | 149466284 | Nonsense_Mutation | C | A | p.E53X |
UCEC | TCGA-B5-A0JY-01 | exon_skip_480205 | 149467529 | 149467645 | 149467625 | 149467625 | Nonsense_Mutation | C | A | p.E19* |
PAAD | TCGA-IB-7651-01 | exon_skip_480205 | 149467529 | 149467645 | 149467528 | 149467528 | Splice_Site | C | T | . |
- Depth of coverage in the three exons composing exon skipping event |
Depth of coverage in three exons | Mutation description |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 149466179 | 149466289 | 149466183 | 149466183 | Missense_Mutation | G | C | p.C86W |
MCC13_SKIN | 149466179 | 149466289 | 149466271 | 149466271 | Missense_Mutation | G | A | p.P57L |
MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 149467529 | 149467645 | 149467606 | 149467606 | Missense_Mutation | T | C | p.E25G |
NCIH460_LUNG | 149467529 | 149467645 | 149467634 | 149467634 | Missense_Mutation | C | T | p.G16R |
SNUC5_LARGE_INTESTINE | 149467529 | 149467645 | 149467636 | 149467636 | Missense_Mutation | A | G | p.V15A |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF467 |
sQTL information located at the skipped exons. |
Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF467 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF467 |
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RelatedDrugs for ZNF467 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF467 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |