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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CDC20B |
 Gene summary |
| Gene information | Gene symbol | CDC20B | Gene ID | 166979 |
| Gene name | cell division cycle 20B | |
| Synonyms | G6VTS76519 | |
| Cytomap | 5q11.2 | |
| Type of gene | protein-coding | |
| Description | cell division cycle protein 20 homolog BCDC20 cell division cycle 20 homolog BCDC20-like proteincell division cycle 20 homolog B | |
| Modification date | 20180519 | |
| UniProtAcc | Q86Y33 | |
| Context | PubMed: CDC20B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for CDC20B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CDC20B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CDC20B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_442119 | 5 | 54415645:54415746:54416252:54416378:54420630:54420856 | 54416252:54416378 | ENSG00000164287.8 | ENST00000513180.1,ENST00000381375.2,ENST00000296733.1,ENST00000334206.5 |
| exon_skip_442120 | 5 | 54420630:54420856:54422181:54422267:54423084:54423179 | 54422181:54422267 | ENSG00000164287.8 | ENST00000513180.1,ENST00000334206.5 |
| exon_skip_442121 | 5 | 54424248:54424445:54429239:54429356:54436141:54436235 | 54429239:54429356 | ENSG00000164287.8 | ENST00000513180.1,ENST00000381375.2,ENST00000296733.1,ENST00000334206.5,ENST00000322374.6 |
| exon_skip_442123 | 5 | 54442455:54442684:54468415:54468478:54468765:54468843 | 54468415:54468478 | ENSG00000164287.8 | ENST00000513180.1,ENST00000381375.2,ENST00000296733.1,ENST00000322374.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CDC20B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_442119 | 5 | 54415645:54415746:54416252:54416378:54420630:54420856 | 54416252:54416378 | ENSG00000164287.8 | ENST00000334206.5,ENST00000296733.1,ENST00000381375.2,ENST00000513180.1 |
| exon_skip_442120 | 5 | 54420630:54420856:54422181:54422267:54423084:54423179 | 54422181:54422267 | ENSG00000164287.8 | ENST00000334206.5,ENST00000513180.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CDC20B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381375 | 54416252 | 54416378 | In-frame |
| ENST00000381375 | 54429239 | 54429356 | In-frame |
| ENST00000381375 | 54468415 | 54468478 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381375 | 54416252 | 54416378 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CDC20B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000381375 | 2608 | 519 | 54468415 | 54468478 | 210 | 272 | 21 | 42 |
| ENST00000381375 | 2608 | 519 | 54429239 | 54429356 | 727 | 843 | 193 | 232 |
| ENST00000381375 | 2608 | 519 | 54416252 | 54416378 | 1362 | 1487 | 405 | 447 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000381375 | 2608 | 519 | 54416252 | 54416378 | 1362 | 1487 | 405 | 447 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CDC20B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_442119 | 54416253 | 54416378 | 54416269 | 54416269 | Frame_Shift_Del | G | - | p.P442fs |
| PAAD | TCGA-IB-7651-01 | exon_skip_442119 | 54416253 | 54416378 | 54416252 | 54416252 | Splice_Site | C | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNU1040_LARGE_INTESTINE | 54416253 | 54416378 | 54416373 | 54416373 | Missense_Mutation | C | T | p.M407I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDC20B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDC20B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDC20B |
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RelatedDrugs for CDC20B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC20B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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