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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PARP15 |
 Gene summary |
| Gene information | Gene symbol | PARP15 | Gene ID | 165631 |
| Gene name | poly(ADP-ribose) polymerase family member 15 | |
| Synonyms | ARTD7|BAL3|pART7 | |
| Cytomap | 3q21.1 | |
| Type of gene | protein-coding | |
| Description | poly [ADP-ribose] polymerase 15ADP-ribosyltransferase diphtheria toxin-like 7B-aggressive lymphoma 3B-aggressive lymphoma protein 3PARP-15 | |
| Modification date | 20180519 | |
| UniProtAcc | Q460N3 | |
| Context | PubMed: PARP15 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for PARP15 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PARP15 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PARP15 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_377124 | 3 | 122296474:122296700:122324782:122324902:122329340:122329577 | 122324782:122324902 | ENSG00000173200.8 | ENST00000483793.1 |
| exon_skip_377127 | 3 | 122329340:122329577:122331887:122332115:122334132:122334167 | 122331887:122332115 | ENSG00000173200.8 | ENST00000465304.1 |
| exon_skip_377128 | 3 | 122329340:122329577:122331887:122332115:122334625:122334704 | 122331887:122332115 | ENSG00000173200.8 | ENST00000464300.2 |
| exon_skip_377132 | 3 | 122331887:122332115:122334132:122334167:122334625:122334704 | 122334132:122334167 | ENSG00000173200.8 | ENST00000465304.1 |
| exon_skip_377134 | 3 | 122331887:122332115:122334625:122334704:122335861:122336011 | 122334625:122334704 | ENSG00000173200.8 | ENST00000464300.2 |
| exon_skip_377137 | 3 | 122340290:122340458:122345673:122345880:122350932:122351020 | 122345673:122345880 | ENSG00000173200.8 | ENST00000473627.1,ENST00000464300.2,ENST00000465304.1,ENST00000310366.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PARP15 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_377124 | 3 | 122296474:122296700:122324782:122324902:122329340:122329577 | 122324782:122324902 | ENSG00000173200.8 | ENST00000483793.1 |
| exon_skip_377127 | 3 | 122329340:122329577:122331887:122332115:122334132:122334167 | 122331887:122332115 | ENSG00000173200.8 | ENST00000465304.1 |
| exon_skip_377128 | 3 | 122329340:122329577:122331887:122332115:122334625:122334704 | 122331887:122332115 | ENSG00000173200.8 | ENST00000464300.2 |
| exon_skip_377132 | 3 | 122331887:122332115:122334132:122334167:122334625:122334704 | 122334132:122334167 | ENSG00000173200.8 | ENST00000465304.1 |
| exon_skip_377134 | 3 | 122331887:122332115:122334625:122334704:122335861:122336011 | 122334625:122334704 | ENSG00000173200.8 | ENST00000464300.2 |
| exon_skip_377137 | 3 | 122340290:122340458:122345673:122345880:122350932:122351020 | 122345673:122345880 | ENSG00000173200.8 | ENST00000464300.2,ENST00000465304.1,ENST00000310366.4,ENST00000473627.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PARP15 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000464300 | 122334625 | 122334704 | Frame-shift |
| ENST00000464300 | 122331887 | 122332115 | In-frame |
| ENST00000464300 | 122345673 | 122345880 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000464300 | 122334625 | 122334704 | Frame-shift |
| ENST00000464300 | 122331887 | 122332115 | In-frame |
| ENST00000464300 | 122345673 | 122345880 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PARP15 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000464300 | 2173 | 678 | 122331887 | 122332115 | 610 | 837 | 181 | 257 |
| ENST00000464300 | 2173 | 678 | 122345673 | 122345880 | 1298 | 1504 | 410 | 479 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000464300 | 2173 | 678 | 122331887 | 122332115 | 610 | 837 | 181 | 257 |
| ENST00000464300 | 2173 | 678 | 122345673 | 122345880 | 1298 | 1504 | 410 | 479 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q460N3 | 181 | 257 | 1 | 234 | Alternative sequence | ID=VSP_020971;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q460N3 | 181 | 257 | 235 | 256 | Alternative sequence | ID=VSP_020972;Note=In isoform 2. RPITSPLQEVHFLVYTNDDEGC->MLQRIGLIFLHNIVVVSNCFYF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q460N3 | 181 | 257 | 1 | 678 | Chain | ID=PRO_0000252436;Note=Poly [ADP-ribose] polymerase 15 |
| Q460N3 | 181 | 257 | 78 | 267 | Domain | Note=Macro 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 |
| Q460N3 | 410 | 479 | 442 | 449 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2B |
| Q460N3 | 410 | 479 | 449 | 449 | Binding site | Note=Substrate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3V2B,ECO:0000269|PubMed:23473667;Dbxref=PMID:23473667 |
| Q460N3 | 410 | 479 | 1 | 678 | Chain | ID=PRO_0000252436;Note=Poly [ADP-ribose] polymerase 15 |
| Q460N3 | 410 | 479 | 293 | 464 | Domain | Note=Macro 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 |
| Q460N3 | 410 | 479 | 417 | 434 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2B |
| Q460N3 | 410 | 479 | 451 | 461 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2B |
| Q460N3 | 410 | 479 | 409 | 413 | Region | Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3V2B,ECO:0000269|PubMed:23473667;Dbxref=PMID:23473667 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q460N3 | 181 | 257 | 1 | 234 | Alternative sequence | ID=VSP_020971;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q460N3 | 181 | 257 | 235 | 256 | Alternative sequence | ID=VSP_020972;Note=In isoform 2. RPITSPLQEVHFLVYTNDDEGC->MLQRIGLIFLHNIVVVSNCFYF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q460N3 | 181 | 257 | 1 | 678 | Chain | ID=PRO_0000252436;Note=Poly [ADP-ribose] polymerase 15 |
| Q460N3 | 181 | 257 | 78 | 267 | Domain | Note=Macro 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 |
| Q460N3 | 410 | 479 | 442 | 449 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2B |
| Q460N3 | 410 | 479 | 449 | 449 | Binding site | Note=Substrate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3V2B,ECO:0000269|PubMed:23473667;Dbxref=PMID:23473667 |
| Q460N3 | 410 | 479 | 1 | 678 | Chain | ID=PRO_0000252436;Note=Poly [ADP-ribose] polymerase 15 |
| Q460N3 | 410 | 479 | 293 | 464 | Domain | Note=Macro 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 |
| Q460N3 | 410 | 479 | 417 | 434 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2B |
| Q460N3 | 410 | 479 | 451 | 461 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2B |
| Q460N3 | 410 | 479 | 409 | 413 | Region | Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3V2B,ECO:0000269|PubMed:23473667;Dbxref=PMID:23473667 |
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SNVs in the skipped exons for PARP15 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_377128 exon_skip_377127 | 122331888 | 122332115 | 122331997 | 122331997 | Frame_Shift_Del | T | - | p.V218fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_377137 | 122345674 | 122345880 | 122345762 | 122345762 | Frame_Shift_Del | A | - | p.L440fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_377137 | 122345674 | 122345880 | 122345823 | 122345823 | Frame_Shift_Del | A | - | p.K462fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_377137 | 122345674 | 122345880 | 122345823 | 122345823 | Frame_Shift_Del | A | - | p.K462fs |
| STAD | TCGA-BR-6852-01 | exon_skip_377137 | 122345674 | 122345880 | 122345823 | 122345823 | Frame_Shift_Del | A | - | p.M460fs |
| STAD | TCGA-CG-5721-01 | exon_skip_377137 | 122345674 | 122345880 | 122345823 | 122345823 | Frame_Shift_Del | A | - | p.M460fs |
| STAD | TCGA-CG-5728-01 | exon_skip_377137 | 122345674 | 122345880 | 122345823 | 122345823 | Frame_Shift_Del | A | - | p.M460fs |
| COAD | TCGA-AA-A01Q-01 | exon_skip_377137 | 122345674 | 122345880 | 122345683 | 122345684 | Frame_Shift_Ins | - | A | p.G180fs |
| SKCM | TCGA-BF-A3DL-01 | exon_skip_377137 | 122345674 | 122345880 | 122345787 | 122345787 | Nonsense_Mutation | C | T | p.Q215X |
| SKCM | TCGA-BF-A3DL-01 | exon_skip_377137 | 122345674 | 122345880 | 122345787 | 122345787 | Nonsense_Mutation | C | T | p.Q449* |
| PAAD | TCGA-IB-A6UF-01 | exon_skip_377137 | 122345674 | 122345880 | 122345673 | 122345673 | Splice_Site | G | - | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| IM95_STOMACH | 122345674 | 122345880 | 122345684 | 122345684 | Frame_Shift_Del | A | - | p.G414fs |
| KGN_OVARY | 122324783 | 122324902 | 122324811 | 122324811 | Missense_Mutation | A | T | p.D72V |
| HT115_LARGE_INTESTINE | 122324783 | 122324902 | 122324816 | 122324816 | Missense_Mutation | C | A | p.L74I |
| BC3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 122324783 | 122324902 | 122324861 | 122324861 | Missense_Mutation | C | G | p.L89V |
| LN229_CENTRAL_NERVOUS_SYSTEM | 122324783 | 122324902 | 122324875 | 122324875 | Missense_Mutation | G | C | p.L93F |
| HCC2998_LARGE_INTESTINE | 122331888 | 122332115 | 122331910 | 122331910 | Missense_Mutation | A | C | p.K189T |
| MDAMB361_BREAST | 122331888 | 122332115 | 122331927 | 122331927 | Missense_Mutation | G | C | p.E195Q |
| COLO783_SKIN | 122331888 | 122332115 | 122332029 | 122332029 | Missense_Mutation | G | A | p.E229K |
| RKO_LARGE_INTESTINE | 122331888 | 122332115 | 122332033 | 122332033 | Missense_Mutation | A | G | p.Y230C |
| NCIH847_LUNG | 122334626 | 122334704 | 122334699 | 122334699 | Missense_Mutation | C | T | p.T282I |
| HT115_LARGE_INTESTINE | 122345674 | 122345880 | 122345784 | 122345784 | Missense_Mutation | T | G | p.F448V |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 122345674 | 122345880 | 122345814 | 122345814 | Missense_Mutation | G | A | p.D458N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PARP15 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_377137 | 3 | 122340290:122340458:122345673:122345880:122350932:122351020 | 122345673:122345880 | ENST00000473627.1,ENST00000464300.2,ENST00000465304.1,ENST00000310366.4 | LAML | rs17208928 | chr3:122345870 | C/T | 8.91e-16 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PARP15 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PARP15 |
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RelatedDrugs for PARP15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PARP15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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