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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CD55 |
 Gene summary |
| Gene information | Gene symbol | CD55 | Gene ID | 1604 |
| Gene name | CD55 molecule (Cromer blood group) | |
| Synonyms | CHAPLE|CR|CROM|DAF|TC | |
| Cytomap | 1q32.2 | |
| Type of gene | protein-coding | |
| Description | complement decay-accelerating factorCD55 antigenCD55 molecule, decay accelerating factor for complement (Cromer blood group)Cromer blood group antigen | |
| Modification date | 20180519 | |
| UniProtAcc | P08174 | |
| Context | PubMed: CD55 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CD55 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 8223854 |
| CD55 | GO:0031664 | regulation of lipopolysaccharide-mediated signaling pathway | 12731067 |
| CD55 | GO:0035743 | CD4-positive, alpha-beta T cell cytokine production | 16818763 |
| CD55 | GO:0045916 | negative regulation of complement activation | 6211481 |
| CD55 | GO:2000516 | positive regulation of CD4-positive, alpha-beta T cell activation | 16818763 |
| CD55 | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation | 16818763 |
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Exon skipping events across known transcript of Ensembl for CD55 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CD55 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CD55 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_17352 | 1 | 207495135:207495210:207495580:207495634:207495726:207495912 | 207495580:207495634 | ENSG00000196352.9 | ENST00000343420.6 |
| exon_skip_17355 | 1 | 207495726:207495912:207497903:207498095:207498966:207499020 | 207497903:207498095 | ENSG00000196352.9 | ENST00000482390.2,ENST00000391920.4,ENST00000343420.6,ENST00000367063.2,ENST00000367062.4,ENST00000314754.8,ENST00000488171.1,ENST00000367064.3,ENST00000367065.5 |
| exon_skip_17362 | 1 | 207500144:207500182:207504452:207504641:207510037:207510133 | 207504452:207504641 | ENSG00000196352.9 | ENST00000482390.2,ENST00000391920.4,ENST00000465534.1,ENST00000343420.6,ENST00000367067.4,ENST00000367063.2,ENST00000476590.1,ENST00000391921.4,ENST00000367062.4,ENST00000314754.8,ENST00000488171.1,ENST00000367064.3,ENST00000367065.5 |
| exon_skip_17370 | 1 | 207504452:207504641:207510037:207510163:207510673:207510754 | 207510037:207510163 | ENSG00000196352.9 | ENST00000482390.2,ENST00000391920.4,ENST00000367067.4,ENST00000367063.2,ENST00000391921.4,ENST00000367062.4,ENST00000314754.8,ENST00000488171.1,ENST00000367064.3,ENST00000367065.5 |
| exon_skip_17379 | 1 | 207510673:207510754:207512741:207512762:207513735:207513853 | 207512741:207512762 | ENSG00000196352.9 | ENST00000367063.2,ENST00000314754.8 |
| exon_skip_17380 | 1 | 207510673:207510754:207512741:207512762:207532890:207532987 | 207512741:207512762 | ENSG00000196352.9 | ENST00000367067.4,ENST00000476590.1,ENST00000391921.4,ENST00000367064.3 |
| exon_skip_17393 | 1 | 207512741:207512762:207513735:207513853:207532890:207532980 | 207513735:207513853 | ENSG00000196352.9 | ENST00000314754.8 |
| exon_skip_17397 | 1 | 207512741:207512762:207520476:207520601:207520788:207520906 | 207520476:207520601 | ENSG00000196352.9 | ENST00000482390.2 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENSG00000196352.9 | ENST00000367065.5 |
| exon_skip_17405 | 1 | 207512741:207512762:207523482:207523567:207532890:207532987 | 207523482:207523567 | ENSG00000196352.9 | ENST00000367062.4 |
| exon_skip_17407 | 1 | 207512741:207512762:207527351:207527444:207532890:207532987 | 207527351:207527444 | ENSG00000196352.9 | ENST00000391920.4 |
| exon_skip_17408 | 1 | 207512741:207512762:207531860:207531966:207532890:207532987 | 207531860:207531966 | ENSG00000196352.9 | ENST00000465534.1 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENSG00000196352.9 | ENST00000482390.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CD55 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_17352 | 1 | 207495135:207495210:207495580:207495634:207495726:207495912 | 207495580:207495634 | ENSG00000196352.9 | ENST00000343420.6 |
| exon_skip_17355 | 1 | 207495726:207495912:207497903:207498095:207498966:207499020 | 207497903:207498095 | ENSG00000196352.9 | ENST00000367064.3,ENST00000367063.2,ENST00000488171.1,ENST00000314754.8,ENST00000367065.5,ENST00000391920.4,ENST00000367062.4,ENST00000482390.2,ENST00000343420.6 |
| exon_skip_17362 | 1 | 207500144:207500182:207504452:207504641:207510037:207510133 | 207504452:207504641 | ENSG00000196352.9 | ENST00000367064.3,ENST00000367063.2,ENST00000391921.4,ENST00000367067.4,ENST00000488171.1,ENST00000314754.8,ENST00000367065.5,ENST00000391920.4,ENST00000367062.4,ENST00000482390.2,ENST00000343420.6,ENST00000465534.1,ENST00000476590.1 |
| exon_skip_17370 | 1 | 207504452:207504641:207510037:207510163:207510673:207510754 | 207510037:207510163 | ENSG00000196352.9 | ENST00000367064.3,ENST00000367063.2,ENST00000391921.4,ENST00000367067.4,ENST00000488171.1,ENST00000314754.8,ENST00000367065.5,ENST00000391920.4,ENST00000367062.4,ENST00000482390.2 |
| exon_skip_17379 | 1 | 207510673:207510754:207512741:207512762:207513735:207513853 | 207512741:207512762 | ENSG00000196352.9 | ENST00000367063.2,ENST00000314754.8 |
| exon_skip_17380 | 1 | 207510673:207510754:207512741:207512762:207532890:207532987 | 207512741:207512762 | ENSG00000196352.9 | ENST00000367064.3,ENST00000391921.4,ENST00000367067.4,ENST00000476590.1 |
| exon_skip_17393 | 1 | 207512741:207512762:207513735:207513853:207532890:207532980 | 207513735:207513853 | ENSG00000196352.9 | ENST00000314754.8 |
| exon_skip_17397 | 1 | 207512741:207512762:207520476:207520601:207520788:207520906 | 207520476:207520601 | ENSG00000196352.9 | ENST00000482390.2 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENSG00000196352.9 | ENST00000367065.5 |
| exon_skip_17405 | 1 | 207512741:207512762:207523482:207523567:207532890:207532987 | 207523482:207523567 | ENSG00000196352.9 | ENST00000367062.4 |
| exon_skip_17407 | 1 | 207512741:207512762:207527351:207527444:207532890:207532987 | 207527351:207527444 | ENSG00000196352.9 | ENST00000391920.4 |
| exon_skip_17408 | 1 | 207512741:207512762:207531860:207531966:207532890:207532987 | 207531860:207531966 | ENSG00000196352.9 | ENST00000465534.1 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENSG00000196352.9 | ENST00000482390.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CD55 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367064 | 207497903 | 207498095 | In-frame |
| ENST00000367064 | 207504452 | 207504641 | In-frame |
| ENST00000367064 | 207510037 | 207510163 | In-frame |
| ENST00000367064 | 207512741 | 207512762 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367064 | 207497903 | 207498095 | In-frame |
| ENST00000367064 | 207504452 | 207504641 | In-frame |
| ENST00000367064 | 207510037 | 207510163 | In-frame |
| ENST00000367064 | 207512741 | 207512762 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CD55 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000367064 | 2777 | 381 | 207497903 | 207498095 | 545 | 736 | 95 | 159 |
| ENST00000367064 | 2777 | 381 | 207504452 | 207504641 | 923 | 1111 | 221 | 284 |
| ENST00000367064 | 2777 | 381 | 207510037 | 207510163 | 1112 | 1237 | 284 | 326 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000367064 | 2777 | 381 | 207497903 | 207498095 | 545 | 736 | 95 | 159 |
| ENST00000367064 | 2777 | 381 | 207504452 | 207504641 | 923 | 1111 | 221 | 284 |
| ENST00000367064 | 2777 | 381 | 207510037 | 207510163 | 1112 | 1237 | 284 | 326 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CD55 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BRCA | TCGA-A2-A04N-01 | exon_skip_17355 | 207497904 | 207498095 | 207498015 | 207498015 | Frame_Shift_Del | A | - | p.Y133fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_17362 | 207504453 | 207504641 | 207504477 | 207504477 | Frame_Shift_Del | A | - | p.Q230fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_17370 | 207510038 | 207510163 | 207510060 | 207510060 | Frame_Shift_Del | C | - | p.V292fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_17370 | 207510038 | 207510163 | 207510127 | 207510127 | Frame_Shift_Del | A | - | p.K315fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_17370 | 207510038 | 207510163 | 207510138 | 207510138 | Frame_Shift_Del | A | - | p.T318fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HCC2108_LUNG | 207497904 | 207498095 | 207498012 | 207498012 | Missense_Mutation | G | T | p.G132V |
| MORCPR_LUNG | 207497904 | 207498095 | 207498012 | 207498012 | Missense_Mutation | G | T | p.G132V |
| G361_SKIN | 207497904 | 207498095 | 207498083 | 207498083 | Missense_Mutation | G | A | p.E156K |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 207497904 | 207498095 | 207498083 | 207498083 | Missense_Mutation | G | A | p.E156K |
| CORL88_LUNG | 207510038 | 207510163 | 207510094 | 207510094 | Missense_Mutation | G | A | p.V304I |
| JHH1_LIVER | 207510038 | 207510163 | 207510142 | 207510142 | Missense_Mutation | A | G | p.T320A |
| HGC27_STOMACH | 207512742 | 207512762 | 207512757 | 207512757 | Missense_Mutation | T | C | p.L359P |
| NCIH1155_LUNG | 207497904 | 207498095 | 207498016 | 207498016 | Nonsense_Mutation | C | G | p.Y133* |
| HCC2157_BREAST | 207504453 | 207504641 | 207504527 | 207504527 | Nonsense_Mutation | C | T | p.Q247* |
| HCC2157_MATCHED_NORMAL_TISSUE | 207504453 | 207504641 | 207504527 | 207504527 | Nonsense_Mutation | C | T | p.Q247* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CD55 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | ESCA | rs1257729 | chr1:207520788 | G/A | 3.14e-04 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | HNSC | rs1257729 | chr1:207520788 | G/A | 2.47e-03 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | LUAD | rs1257729 | chr1:207520788 | G/A | 1.31e-03 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | LUSC | rs1257729 | chr1:207520788 | G/A | 5.73e-04 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | LUSC | rs1257729 | chr1:207520788 | G/A | 3.10e-03 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | THYM | rs1257729 | chr1:207520788 | G/A | 8.05e-04 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | THYM | rs1257729 | chr1:207520788 | G/A | 8.05e-04 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | STAD | rs1257729 | chr1:207520788 | G/A | 1.72e-04 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | THCA | rs1257729 | chr1:207520788 | G/A | 9.13e-05 |
| exon_skip_17404 | 1 | 207512741:207512762:207520791:207520906:207532890:207532987 | 207520791:207520906 | ENST00000367065.5 | UCEC | rs1257729 | chr1:207520788 | G/A | 2.12e-04 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | ESCA | rs1257729 | chr1:207520788 | G/A | 3.14e-04 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | HNSC | rs1257729 | chr1:207520788 | G/A | 2.47e-03 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | LUAD | rs1257729 | chr1:207520788 | G/A | 1.31e-03 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | LUSC | rs1257729 | chr1:207520788 | G/A | 5.73e-04 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | LUSC | rs1257729 | chr1:207520788 | G/A | 3.10e-03 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | THYM | rs1257729 | chr1:207520788 | G/A | 8.05e-04 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | THYM | rs1257729 | chr1:207520788 | G/A | 8.05e-04 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | STAD | rs1257729 | chr1:207520788 | G/A | 1.72e-04 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | THCA | rs1257729 | chr1:207520788 | G/A | 9.13e-05 |
| exon_skip_17413 | 1 | 207520476:207520601:207520788:207520906:207532890:207532987 | 207520788:207520906 | ENST00000482390.2 | UCEC | rs1257729 | chr1:207520788 | G/A | 2.12e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CD55 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CD55 |
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RelatedDrugs for CD55 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P08174 | DB00446 | Chloramphenicol | Complement decay-accelerating factor | small molecule | approved|vet_approved |
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RelatedDiseases for CD55 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CD55 | C0014175 | Endometriosis | 1 | CTD_human |
| CD55 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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