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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DUSP18 |
 Gene summary |
| Gene information | Gene symbol | DUSP18 | Gene ID | 150290 |
| Gene name | dual specificity phosphatase 18 | |
| Synonyms | DSP18|DUSP20|LMWDSP20 | |
| Cytomap | 22q12.2 | |
| Type of gene | protein-coding | |
| Description | dual specificity protein phosphatase 18low molecular weight dual specificity phosphatase 20 | |
| Modification date | 20180522 | |
| UniProtAcc | Q8NEJ0 | |
| Context | PubMed: DUSP18 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DUSP18 | GO:0016311 | dephosphorylation | 24531476 |
| DUSP18 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 12408986|12591617 |
| DUSP18 | GO:0035970 | peptidyl-threonine dephosphorylation | 12591617 |
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Exon skipping events across known transcript of Ensembl for DUSP18 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DUSP18 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DUSP18 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_368683 | 22 | 31048082:31048284:31059390:31060067:31062793:31062925 | 31059390:31060067 | ENSG00000167065.9 | ENST00000407308.1 |
| exon_skip_368684 | 22 | 31048082:31048284:31059390:31060067:31063448:31063796 | 31059390:31060067 | ENSG00000167065.9 | ENST00000404885.1 |
| exon_skip_368687 | 22 | 31048082:31048284:31062793:31062925:31063448:31063796 | 31062793:31062925 | ENSG00000167065.9 | ENST00000461301.1 |
| exon_skip_368691 | 22 | 31059957:31060067:31060941:31061108:31063448:31063796 | 31060941:31061108 | ENSG00000167065.9 | ENST00000342474.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DUSP18 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_368683 | 22 | 31048082:31048284:31059390:31060067:31062793:31062925 | 31059390:31060067 | ENSG00000167065.9 | ENST00000407308.1 |
| exon_skip_368684 | 22 | 31048082:31048284:31059390:31060067:31063448:31063796 | 31059390:31060067 | ENSG00000167065.9 | ENST00000404885.1 |
| exon_skip_368687 | 22 | 31048082:31048284:31062793:31062925:31063448:31063796 | 31062793:31062925 | ENSG00000167065.9 | ENST00000461301.1 |
| exon_skip_368691 | 22 | 31059957:31060067:31060941:31061108:31063448:31063796 | 31060941:31061108 | ENSG00000167065.9 | ENST00000342474.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DUSP18 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000404885 | 31059390 | 31060067 | 3UTR-5UTR |
| ENST00000407308 | 31059390 | 31060067 | 3UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000404885 | 31059390 | 31060067 | 3UTR-5UTR |
| ENST00000407308 | 31059390 | 31060067 | 3UTR-5UTR |
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Infer the effects of exon skipping event on protein functional features for DUSP18 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for DUSP18 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DLBC | TCGA-G8-6909-01 | exon_skip_368684 exon_skip_368683 | 31059391 | 31060067 | 31059499 | 31059500 | Frame_Shift_Del | CA | - | p.164_165del |
| LIHC | TCGA-DD-A3A1-01 | exon_skip_368684 exon_skip_368683 | 31059391 | 31060067 | 31059514 | 31059514 | Frame_Shift_Del | A | - | p.F159fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_368684 exon_skip_368683 | 31059391 | 31060067 | 31059698 | 31059698 | Frame_Shift_Del | C | - | p.G61fs |
| SKCM | TCGA-D3-A51F-06 | exon_skip_368684 exon_skip_368683 | 31059391 | 31060067 | 31059547 | 31059547 | Nonsense_Mutation | C | T | p.W148* |
| SKCM | TCGA-D3-A51F-06 | exon_skip_368684 exon_skip_368683 | 31059391 | 31060067 | 31059547 | 31059547 | Nonsense_Mutation | C | T | p.W148X |
| SARC | TCGA-QQ-A8VF-01 | exon_skip_368684 exon_skip_368683 | 31059391 | 31060067 | 31059789 | 31059789 | Nonsense_Mutation | G | A | p.Q68* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNU119_OVARY | 31059391 | 31060067 | 31059456 | 31059456 | Missense_Mutation | C | G | p.E179Q |
| CW2_LARGE_INTESTINE | 31059391 | 31060067 | 31059498 | 31059498 | Missense_Mutation | G | A | p.H165Y |
| SISO_CERVIX | 31059391 | 31060067 | 31059603 | 31059603 | Missense_Mutation | C | T | p.A130T |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 31059391 | 31060067 | 31059603 | 31059603 | Missense_Mutation | C | T | p.A130T |
| SNU175_LARGE_INTESTINE | 31059391 | 31060067 | 31059621 | 31059621 | Missense_Mutation | C | T | p.A124T |
| LN340_CENTRAL_NERVOUS_SYSTEM | 31059391 | 31060067 | 31059621 | 31059621 | Missense_Mutation | C | T | p.A124T |
| FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 31059391 | 31060067 | 31059632 | 31059632 | Missense_Mutation | A | G | p.M120T |
| AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 31059391 | 31060067 | 31059672 | 31059672 | Missense_Mutation | C | A | p.G107C |
| CW2_LARGE_INTESTINE | 31059391 | 31060067 | 31059744 | 31059744 | Missense_Mutation | A | G | p.F83L |
| HCC2108_LUNG | 31059391 | 31060067 | 31059847 | 31059847 | Missense_Mutation | C | T | p.M48I |
| MORCPR_LUNG | 31059391 | 31060067 | 31059847 | 31059847 | Missense_Mutation | C | T | p.M48I |
| SNUC5_LARGE_INTESTINE | 31059391 | 31060067 | 31059873 | 31059873 | Missense_Mutation | T | C | p.M40V |
| SW48_LARGE_INTESTINE | 31059391 | 31060067 | 31059929 | 31059929 | Missense_Mutation | G | A | p.S21L |
| KU1919_URINARY_TRACT | 31059391 | 31060067 | 31059936 | 31059936 | Missense_Mutation | C | T | p.G19S |
| IHH4_THYROID | 31059391 | 31060067 | 31059936 | 31059936 | Missense_Mutation | C | T | p.G19S |
| RERFLCKJ_LUNG | 31059391 | 31060067 | 31059949 | 31059949 | Missense_Mutation | C | A | p.Q14H |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DUSP18 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_368684 | 22 | 31048082:31048284:31059390:31060067:31063448:31063796 | 31059390:31060067 | ENST00000404885.1 | LGG | rs1005887 | chr22:31060029 | C/G | 1.21e-03 |
| exon_skip_368684 | 22 | 31048082:31048284:31059390:31060067:31063448:31063796 | 31059390:31060067 | ENST00000404885.1 | LGG | rs1005887 | chr22:31060029 | C/G | 2.41e-03 |
| exon_skip_368684 | 22 | 31048082:31048284:31059390:31060067:31063448:31063796 | 31059390:31060067 | ENST00000404885.1 | KIRC | rs1005887 | chr22:31060029 | C/G | 1.46e-03 |
| exon_skip_368684 | 22 | 31048082:31048284:31059390:31060067:31063448:31063796 | 31059390:31060067 | ENST00000404885.1 | LUAD | rs1005887 | chr22:31060029 | C/G | 1.31e-03 |
| exon_skip_368684 | 22 | 31048082:31048284:31059390:31060067:31063448:31063796 | 31059390:31060067 | ENST00000404885.1 | STAD | rs1005887 | chr22:31060029 | C/G | 7.12e-04 |
| exon_skip_368684 | 22 | 31048082:31048284:31059390:31060067:31063448:31063796 | 31059390:31060067 | ENST00000404885.1 | STAD | rs1005887 | chr22:31060029 | C/G | 1.84e-03 |
| exon_skip_368683 | 22 | 31048082:31048284:31059390:31060067:31062793:31062925 | 31059390:31060067 | ENST00000407308.1 | LGG | rs1005887 | chr22:31060029 | C/G | 1.21e-03 |
| exon_skip_368683 | 22 | 31048082:31048284:31059390:31060067:31062793:31062925 | 31059390:31060067 | ENST00000407308.1 | LGG | rs1005887 | chr22:31060029 | C/G | 2.41e-03 |
| exon_skip_368683 | 22 | 31048082:31048284:31059390:31060067:31062793:31062925 | 31059390:31060067 | ENST00000407308.1 | KIRC | rs1005887 | chr22:31060029 | C/G | 1.46e-03 |
| exon_skip_368683 | 22 | 31048082:31048284:31059390:31060067:31062793:31062925 | 31059390:31060067 | ENST00000407308.1 | LUAD | rs1005887 | chr22:31060029 | C/G | 1.31e-03 |
| exon_skip_368683 | 22 | 31048082:31048284:31059390:31060067:31062793:31062925 | 31059390:31060067 | ENST00000407308.1 | STAD | rs1005887 | chr22:31060029 | C/G | 7.12e-04 |
| exon_skip_368683 | 22 | 31048082:31048284:31059390:31060067:31062793:31062925 | 31059390:31060067 | ENST00000407308.1 | STAD | rs1005887 | chr22:31060029 | C/G | 1.84e-03 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DUSP18 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DUSP18 |
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RelatedDrugs for DUSP18 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DUSP18 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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