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Open reading frame (ORF) annotation in the exon skipping event | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon | |
Gene summary for CSNK1E |
Gene summary |
Gene information | Gene symbol | CSNK1E | Gene ID | 1454 |
Gene name | casein kinase 1 epsilon | |
Synonyms | CKIe|CKIepsilon|HCKIE | |
Cytomap | 22q13.1 | |
Type of gene | protein-coding | |
Description | casein kinase I isoform epsilon | |
Modification date | 20180523 | |
UniProtAcc | P49674 | |
Context | PubMed: CSNK1E [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
CSNK1E | GO:0006468 | protein phosphorylation | 15917222|17244647 |
CSNK1E | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
CSNK1E | GO:0032091 | negative regulation of protein binding | 23109420 |
CSNK1E | GO:0060070 | canonical Wnt signaling pathway | 14722104 |
CSNK1E | GO:1903827 | regulation of cellular protein localization | 17244647 |
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Exon skipping events across known transcript of Ensembl for CSNK1E from UCSC genome browser |
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CSNK1E |
Expression levels of gene isoforms across TCGA. |
Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CSNK1E |
Information of exkip skipping event in TCGA. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_369449 | 22 | 38690347:38690540:38691392:38691453:38694790:38694857 | 38691392:38691453 | ENSG00000213923.6 | ENST00000431611.1 |
exon_skip_369450 | 22 | 38690347:38690540:38694790:38694939:38695899:38696030 | 38694790:38694939 | ENSG00000213923.6 | ENST00000359867.3,ENST00000400206.2,ENST00000396832.1,ENST00000403904.1 |
exon_skip_369457 | 22 | 38693607:38694004:38694099:38694209:38694790:38694857 | 38694099:38694209 | ENSG00000213923.6 | ENST00000442216.1 |
exon_skip_369459 | 22 | 38695960:38696070:38696728:38696957:38698865:38698995 | 38696728:38696957 | ENSG00000213923.6 | ENST00000430335.1,ENST00000359867.3,ENST00000400206.2,ENST00000467976.1,ENST00000396832.1,ENST00000405675.3,ENST00000451964.1,ENST00000413574.2,ENST00000403904.1 |
exon_skip_369469 | 22 | 38732612:38732711:38757403:38757565:38776374:38776428 | 38757403:38757565 | ENSG00000213923.6 | ENST00000400206.2 |
PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CSNK1E |
Information of exkip skipping event in GTEx |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_369449 | 22 | 38690347:38690540:38691392:38691453:38694790:38694857 | 38691392:38691453 | ENSG00000213923.6 | ENST00000431611.1 |
exon_skip_369450 | 22 | 38690347:38690540:38694790:38694939:38695899:38696030 | 38694790:38694939 | ENSG00000213923.6 | ENST00000359867.3,ENST00000396832.1,ENST00000400206.2,ENST00000403904.1 |
exon_skip_369457 | 22 | 38693607:38694004:38694099:38694209:38694790:38694857 | 38694099:38694209 | ENSG00000213923.6 | ENST00000442216.1 |
exon_skip_369459 | 22 | 38695960:38696070:38696728:38696957:38698865:38698995 | 38696728:38696957 | ENSG00000213923.6 | ENST00000359867.3,ENST00000396832.1,ENST00000400206.2,ENST00000403904.1,ENST00000413574.2,ENST00000405675.3,ENST00000451964.1,ENST00000467976.1,ENST00000430335.1 |
exon_skip_369469 | 22 | 38732612:38732711:38757403:38757565:38776374:38776428 | 38757403:38757565 | ENSG00000213923.6 | ENST00000400206.2 |
PSI values of skipped exons in GTEx. |
* Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CSNK1E |
Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000359867 | 38694790 | 38694939 | Frame-shift |
ENST00000396832 | 38694790 | 38694939 | Frame-shift |
ENST00000403904 | 38694790 | 38694939 | Frame-shift |
ENST00000359867 | 38696728 | 38696957 | Frame-shift |
ENST00000396832 | 38696728 | 38696957 | Frame-shift |
ENST00000403904 | 38696728 | 38696957 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000359867 | 38694790 | 38694939 | Frame-shift |
ENST00000396832 | 38694790 | 38694939 | Frame-shift |
ENST00000403904 | 38694790 | 38694939 | Frame-shift |
ENST00000359867 | 38696728 | 38696957 | Frame-shift |
ENST00000396832 | 38696728 | 38696957 | Frame-shift |
ENST00000403904 | 38696728 | 38696957 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CSNK1E |
Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in TCGA. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in GTEx. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CSNK1E |
- Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
- Differential PSIs between mutated versus non-mutated samples. |
- Non-synonymous mutations located in the skipped exons in TCGA. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
BLCA | TCGA-C4-A0F0-01 | exon_skip_369459 | 38696729 | 38696957 | 38696882 | 38696883 | Frame_Shift_Del | GC | - | p.G137fs |
BLCA | TCGA-C4-A0F0-01 | exon_skip_369459 | 38696729 | 38696957 | 38696882 | 38696883 | Frame_Shift_Del | GC | - | p.L138fs |
- Depth of coverage in the three exons composing exon skipping event |
Depth of coverage in three exons | Mutation description |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
SKUT1_SOFT_TISSUE | 38694791 | 38694939 | 38694819 | 38694819 | Missense_Mutation | T | C | p.Y286C |
NCIH2122_LUNG | 38694791 | 38694939 | 38694909 | 38694909 | Missense_Mutation | C | A | p.R256L |
OC316_OVARY | 38696729 | 38696957 | 38696792 | 38696792 | Missense_Mutation | G | A | p.R168W |
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 38696729 | 38696957 | 38696792 | 38696792 | Missense_Mutation | G | A | p.R168W |
OC314_OVARY | 38696729 | 38696957 | 38696792 | 38696792 | Missense_Mutation | G | A | p.R168W |
HCC202_BREAST | 38696729 | 38696957 | 38696834 | 38696834 | Missense_Mutation | T | C | p.K154E |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CSNK1E |
sQTL information located at the skipped exons. |
Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CSNK1E |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CSNK1E |
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RelatedDrugs for CSNK1E |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CSNK1E |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
CSNK1E | C0005586 | Bipolar Disorder | 5 | PSYGENET |
CSNK1E | C0036341 | Schizophrenia | 2 | PSYGENET |
CSNK1E | C0033975 | Psychotic Disorders | 1 | PSYGENET |
CSNK1E | C0349204 | Nonorganic psychosis | 1 | PSYGENET |