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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for MAPK14

check button Gene summary
Gene informationGene symbol

MAPK14

Gene ID

1432

Gene namemitogen-activated protein kinase 14
SynonymsCSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA
Cytomap

6p21.31

Type of geneprotein-coding
Descriptionmitogen-activated protein kinase 14CSAID-binding proteinCsaids binding proteinMAP kinase 14MAP kinase Mxi2MAP kinase p38 alphaMAX-interacting protein 2cytokine suppressive anti-inflammatory drug binding proteinmitogen-activated protein kinase p38
Modification date20180523
UniProtAcc

Q16539

ContextPubMed: MAPK14 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
MAPK14

GO:0035556

intracellular signal transduction

10838079

MAPK14

GO:0071222

cellular response to lipopolysaccharide

23776175

MAPK14

GO:1900015

regulation of cytokine production involved in inflammatory response

15251176


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Exon skipping events across known transcript of Ensembl for MAPK14 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for MAPK14

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for MAPK14

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_451074636027065:36027124:36040649:36040761:36041467:3604149736040649:36040761ENSG00000112062.6ENST00000229794.4,ENST00000310795.4,ENST00000229795.3,ENST00000468133.1,ENST00000491957.1,ENST00000496250.1,ENST00000472333.1
exon_skip_451089636063763:36063843:36070347:36070426:36075231:3607530636070347:36070426ENSG00000112062.6ENST00000229794.4,ENST00000468133.1,ENST00000474429.1
exon_skip_451090636067964:36068044:36070347:36070426:36075231:3607530636070347:36070426ENSG00000112062.6ENST00000229795.3
exon_skip_451092636070347:36070426:36075231:36075405:36076156:3607628636075231:36075405ENSG00000112062.6ENST00000229794.4,ENST00000229795.3,ENST00000468133.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for MAPK14

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_451074636027065:36027124:36040649:36040761:36041467:3604149736040649:36040761ENSG00000112062.6ENST00000229795.3,ENST00000229794.4,ENST00000468133.1,ENST00000496250.1,ENST00000491957.1,ENST00000310795.4,ENST00000472333.1
exon_skip_451076636027065:36027124:36040822:36040882:36041467:3604149736040822:36040882ENSG00000112062.6ENST00000474429.1
exon_skip_451089636063763:36063843:36070347:36070426:36075231:3607530636070347:36070426ENSG00000112062.6ENST00000229794.4,ENST00000468133.1,ENST00000474429.1
exon_skip_451090636067964:36068044:36070347:36070426:36075231:3607530636070347:36070426ENSG00000112062.6ENST00000229795.3
exon_skip_451092636070347:36070426:36075231:36075405:36076156:3607628636075231:36075405ENSG00000112062.6ENST00000229795.3,ENST00000229794.4,ENST00000468133.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for MAPK14

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002297943604064936040761Frame-shift
ENST000002297943607034736070426Frame-shift
ENST000002297943607523136075405In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002297943604064936040761Frame-shift
ENST000002297943607034736070426Frame-shift
ENST000002297943607523136075405In-frame

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Infer the effects of exon skipping event on protein functional features for MAPK14

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000002297943796360360752313607540512301403280338

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000002297943796360360752313607540512301403280338

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for MAPK14

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A39Y-01exon_skip_451092
36075232360754053607536936075369Frame_Shift_DelT-p.F327fs
LUADTCGA-44-6777-01exon_skip_451092
36075232360754053607526836075268Nonsense_MutationCGp.S293*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
HT115_LARGE_INTESTINE36040650360407613604070636040706Missense_MutationACp.K121T
SNU1197_LARGE_INTESTINE36070348360704263607037836070378Missense_MutationACp.M265L
T3M10_LUNG36070348360704263607037836070378Missense_MutationACp.M265L
SNU1_STOMACH36075232360754053607525536075255Missense_MutationCTp.L289F
HT115_LARGE_INTESTINE36075232360754053607527736075277Missense_MutationGTp.R296I
NCIH2126_LUNG36075232360754053607535536075355Missense_MutationCGp.P322R
MC116_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE36040650360407613604065036040650Splice_SiteGCp.V102V
BICR18_UPPER_AERODIGESTIVE_TRACT36075232360754053607540436075404Splice_SiteAGp.K338K

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK14

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK14


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK14


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RelatedDrugs for MAPK14

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
Q16539DB01254DasatinibMitogen-activated protein kinase 14small moleculeapproved|investigational
Q16539DB12010FostamatinibMitogen-activated protein kinase 14small moleculeapproved|investigational

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RelatedDiseases for MAPK14

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
MAPK14C0008370Cholestasis1CTD_human
MAPK14C0023473Myeloid Leukemia, Chronic1CTD_human
MAPK14C0023903Liver neoplasms1CTD_human
MAPK14C0024121Lung Neoplasms1CTD_human
MAPK14C0024809Marijuana Abuse1PSYGENET
MAPK14C0036341Schizophrenia1PSYGENET
MAPK14C0086132Depressive Symptoms1PSYGENET
MAPK14C0151744Myocardial Ischemia1CTD_human
MAPK14C0233477Dysphoric mood1PSYGENET
MAPK14C0338715Drug-induced depressive state1PSYGENET
MAPK14C0878544Cardiomyopathies1CTD_human