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Open reading frame (ORF) annotation in the exon skipping event | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon | |
Gene summary for MAPK14 |
Gene summary |
Gene information | Gene symbol | MAPK14 | Gene ID | 1432 |
Gene name | mitogen-activated protein kinase 14 | |
Synonyms | CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA | |
Cytomap | 6p21.31 | |
Type of gene | protein-coding | |
Description | mitogen-activated protein kinase 14CSAID-binding proteinCsaids binding proteinMAP kinase 14MAP kinase Mxi2MAP kinase p38 alphaMAX-interacting protein 2cytokine suppressive anti-inflammatory drug binding proteinmitogen-activated protein kinase p38 | |
Modification date | 20180523 | |
UniProtAcc | Q16539 | |
Context | PubMed: MAPK14 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
MAPK14 | GO:0035556 | intracellular signal transduction | 10838079 |
MAPK14 | GO:0071222 | cellular response to lipopolysaccharide | 23776175 |
MAPK14 | GO:1900015 | regulation of cytokine production involved in inflammatory response | 15251176 |
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Exon skipping events across known transcript of Ensembl for MAPK14 from UCSC genome browser |
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAPK14 |
Expression levels of gene isoforms across TCGA. |
Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAPK14 |
Information of exkip skipping event in TCGA. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_451074 | 6 | 36027065:36027124:36040649:36040761:36041467:36041497 | 36040649:36040761 | ENSG00000112062.6 | ENST00000229794.4,ENST00000310795.4,ENST00000229795.3,ENST00000468133.1,ENST00000491957.1,ENST00000496250.1,ENST00000472333.1 |
exon_skip_451089 | 6 | 36063763:36063843:36070347:36070426:36075231:36075306 | 36070347:36070426 | ENSG00000112062.6 | ENST00000229794.4,ENST00000468133.1,ENST00000474429.1 |
exon_skip_451090 | 6 | 36067964:36068044:36070347:36070426:36075231:36075306 | 36070347:36070426 | ENSG00000112062.6 | ENST00000229795.3 |
exon_skip_451092 | 6 | 36070347:36070426:36075231:36075405:36076156:36076286 | 36075231:36075405 | ENSG00000112062.6 | ENST00000229794.4,ENST00000229795.3,ENST00000468133.1 |
PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAPK14 |
Information of exkip skipping event in GTEx |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_451074 | 6 | 36027065:36027124:36040649:36040761:36041467:36041497 | 36040649:36040761 | ENSG00000112062.6 | ENST00000229795.3,ENST00000229794.4,ENST00000468133.1,ENST00000496250.1,ENST00000491957.1,ENST00000310795.4,ENST00000472333.1 |
exon_skip_451076 | 6 | 36027065:36027124:36040822:36040882:36041467:36041497 | 36040822:36040882 | ENSG00000112062.6 | ENST00000474429.1 |
exon_skip_451089 | 6 | 36063763:36063843:36070347:36070426:36075231:36075306 | 36070347:36070426 | ENSG00000112062.6 | ENST00000229794.4,ENST00000468133.1,ENST00000474429.1 |
exon_skip_451090 | 6 | 36067964:36068044:36070347:36070426:36075231:36075306 | 36070347:36070426 | ENSG00000112062.6 | ENST00000229795.3 |
exon_skip_451092 | 6 | 36070347:36070426:36075231:36075405:36076156:36076286 | 36075231:36075405 | ENSG00000112062.6 | ENST00000229795.3,ENST00000229794.4,ENST00000468133.1 |
PSI values of skipped exons in GTEx. |
* Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAPK14 |
Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000229794 | 36040649 | 36040761 | Frame-shift |
ENST00000229794 | 36070347 | 36070426 | Frame-shift |
ENST00000229794 | 36075231 | 36075405 | In-frame |
Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000229794 | 36040649 | 36040761 | Frame-shift |
ENST00000229794 | 36070347 | 36070426 | Frame-shift |
ENST00000229794 | 36075231 | 36075405 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAPK14 |
Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000229794 | 3796 | 360 | 36075231 | 36075405 | 1230 | 1403 | 280 | 338 |
Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000229794 | 3796 | 360 | 36075231 | 36075405 | 1230 | 1403 | 280 | 338 |
Lost protein functional features of individual exon skipping events in TCGA. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in GTEx. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MAPK14 |
- Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
- Differential PSIs between mutated versus non-mutated samples. |
- Non-synonymous mutations located in the skipped exons in TCGA. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
LIHC | TCGA-DD-A39Y-01 | exon_skip_451092 | 36075232 | 36075405 | 36075369 | 36075369 | Frame_Shift_Del | T | - | p.F327fs |
LUAD | TCGA-44-6777-01 | exon_skip_451092 | 36075232 | 36075405 | 36075268 | 36075268 | Nonsense_Mutation | C | G | p.S293* |
- Depth of coverage in the three exons composing exon skipping event |
Depth of coverage in three exons | Mutation description |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
HT115_LARGE_INTESTINE | 36040650 | 36040761 | 36040706 | 36040706 | Missense_Mutation | A | C | p.K121T |
SNU1197_LARGE_INTESTINE | 36070348 | 36070426 | 36070378 | 36070378 | Missense_Mutation | A | C | p.M265L |
T3M10_LUNG | 36070348 | 36070426 | 36070378 | 36070378 | Missense_Mutation | A | C | p.M265L |
SNU1_STOMACH | 36075232 | 36075405 | 36075255 | 36075255 | Missense_Mutation | C | T | p.L289F |
HT115_LARGE_INTESTINE | 36075232 | 36075405 | 36075277 | 36075277 | Missense_Mutation | G | T | p.R296I |
NCIH2126_LUNG | 36075232 | 36075405 | 36075355 | 36075355 | Missense_Mutation | C | G | p.P322R |
MC116_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36040650 | 36040761 | 36040650 | 36040650 | Splice_Site | G | C | p.V102V |
BICR18_UPPER_AERODIGESTIVE_TRACT | 36075232 | 36075405 | 36075404 | 36075404 | Splice_Site | A | G | p.K338K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK14 |
sQTL information located at the skipped exons. |
Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK14 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK14 |
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RelatedDrugs for MAPK14 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Q16539 | DB01254 | Dasatinib | Mitogen-activated protein kinase 14 | small molecule | approved|investigational | |
Q16539 | DB12010 | Fostamatinib | Mitogen-activated protein kinase 14 | small molecule | approved|investigational |
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RelatedDiseases for MAPK14 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
MAPK14 | C0008370 | Cholestasis | 1 | CTD_human |
MAPK14 | C0023473 | Myeloid Leukemia, Chronic | 1 | CTD_human |
MAPK14 | C0023903 | Liver neoplasms | 1 | CTD_human |
MAPK14 | C0024121 | Lung Neoplasms | 1 | CTD_human |
MAPK14 | C0024809 | Marijuana Abuse | 1 | PSYGENET |
MAPK14 | C0036341 | Schizophrenia | 1 | PSYGENET |
MAPK14 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
MAPK14 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
MAPK14 | C0233477 | Dysphoric mood | 1 | PSYGENET |
MAPK14 | C0338715 | Drug-induced depressive state | 1 | PSYGENET |
MAPK14 | C0878544 | Cardiomyopathies | 1 | CTD_human |