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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SOGA1 |
 Gene summary |
| Gene information | Gene symbol | SOGA1 | Gene ID | 140710 |
| Gene name | suppressor of glucose, autophagy associated 1 | |
| Synonyms | C20orf117|KIAA0889|SOGA | |
| Cytomap | 20q11.23 | |
| Type of gene | protein-coding | |
| Description | protein SOGA1SOGA family member 1suppressor of glucose by autophagysuppressor of glucose from autophagysuppressor of glucose, autophagy-associated protein 1 | |
| Modification date | 20180523 | |
| UniProtAcc | O94964 | |
| Context | PubMed: SOGA1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SOGA1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SOGA1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SOGA1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_356832 | 20 | 35412184:35412761:35414812:35415040:35421651:35423002 | 35414812:35415040 | ENSG00000149639.10 | ENST00000456801.2,ENST00000465671.1 |
| exon_skip_356833 | 20 | 35425904:35425976:35431258:35431510:35433137:35433305 | 35431258:35431510 | ENSG00000149639.10 | ENST00000357779.3,ENST00000456801.2,ENST00000237536.4,ENST00000279034.6,ENST00000465671.1 |
| exon_skip_356834 | 20 | 35433137:35433305:35434255:35434360:35436915:35437146 | 35434255:35434360 | ENSG00000149639.10 | ENST00000357779.3,ENST00000456801.2,ENST00000237536.4,ENST00000279034.6,ENST00000465671.1 |
| exon_skip_356835 | 20 | 35434255:35434360:35436915:35437146:35438384:35438510 | 35436915:35437146 | ENSG00000149639.10 | ENST00000357779.3,ENST00000456801.2,ENST00000237536.4,ENST00000279034.6,ENST00000465671.1 |
| exon_skip_356836 | 20 | 35438384:35438510:35441106:35441247:35443528:35444684 | 35441106:35441247 | ENSG00000149639.10 | ENST00000357779.3,ENST00000456801.2,ENST00000237536.4,ENST00000279034.6,ENST00000465671.1 |
| exon_skip_356837 | 20 | 35443528:35444710:35445809:35445872:35457456:35457615 | 35445809:35445872 | ENSG00000149639.10 | ENST00000357779.3,ENST00000237536.4,ENST00000279034.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SOGA1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_356832 | 20 | 35412184:35412761:35414812:35415040:35421651:35423002 | 35414812:35415040 | ENSG00000149639.10 | ENST00000465671.1,ENST00000456801.2 |
| exon_skip_356834 | 20 | 35433137:35433305:35434255:35434360:35436915:35437146 | 35434255:35434360 | ENSG00000149639.10 | ENST00000237536.4,ENST00000279034.6,ENST00000465671.1,ENST00000456801.2,ENST00000357779.3 |
| exon_skip_356835 | 20 | 35434255:35434360:35436915:35437146:35438384:35438510 | 35436915:35437146 | ENSG00000149639.10 | ENST00000237536.4,ENST00000279034.6,ENST00000465671.1,ENST00000456801.2,ENST00000357779.3 |
| exon_skip_356836 | 20 | 35438384:35438510:35441106:35441247:35443528:35444684 | 35441106:35441247 | ENSG00000149639.10 | ENST00000237536.4,ENST00000279034.6,ENST00000465671.1,ENST00000456801.2,ENST00000357779.3 |
| exon_skip_356837 | 20 | 35443528:35444710:35445809:35445872:35457456:35457615 | 35445809:35445872 | ENSG00000149639.10 | ENST00000237536.4,ENST00000279034.6,ENST00000357779.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SOGA1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for SOGA1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SOGA1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-AU-6004-01 | exon_skip_356832 | 35414813 | 35415040 | 35414897 | 35414897 | Frame_Shift_Del | G | - | p.S1660fs |
| ESCA | TCGA-L5-A8NM-01 | exon_skip_356832 | 35414813 | 35415040 | 35414897 | 35414897 | Frame_Shift_Del | G | - | p.P1659fs |
| ESCA | TCGA-L5-A8NM-01 | exon_skip_356832 | 35414813 | 35415040 | 35414897 | 35414897 | Frame_Shift_Del | G | - | p.S1660fs |
| LIHC | TCGA-DD-A3A1-01 | exon_skip_356833 | 35431259 | 35431510 | 35431314 | 35431314 | Frame_Shift_Del | C | - | p.G1095fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_356833 | 35431259 | 35431510 | 35431314 | 35431314 | Frame_Shift_Del | C | - | p.G1095fs |
| CHOL | TCGA-W5-AA2Q-01 | exon_skip_356837 | 35445810 | 35445872 | 35445812 | 35445812 | Nonsense_Mutation | G | A | p.Q378X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC265_ENDOMETRIUM | 35414813 | 35415040 | 35414897 | 35414897 | Frame_Shift_Del | G | - | p.P1421fs |
| TOV21G_OVARY | 35414813 | 35415040 | 35414897 | 35414897 | Frame_Shift_Del | G | - | p.P1421fs |
| COLO679_SKIN | 35431259 | 35431510 | 35431286 | 35431297 | In_Frame_Del | CACCTGCTGCTC | - | p.EQQV863del |
| SKMEL28_SKIN | 35414813 | 35415040 | 35414908 | 35414908 | Missense_Mutation | C | A | p.A1418S |
| KM12_LARGE_INTESTINE | 35414813 | 35415040 | 35414941 | 35414941 | Missense_Mutation | G | A | p.P1407S |
| OV17R_OVARY | 35414813 | 35415040 | 35414991 | 35414991 | Missense_Mutation | C | T | p.R1390Q |
| SNU61_LARGE_INTESTINE | 35414813 | 35415040 | 35415037 | 35415037 | Missense_Mutation | C | G | p.A1375P |
| NCIH1155_LUNG | 35431259 | 35431510 | 35431263 | 35431263 | Missense_Mutation | C | T | p.S874N |
| SNU1040_LARGE_INTESTINE | 35431259 | 35431510 | 35431323 | 35431323 | Missense_Mutation | C | T | p.R854Q |
| SCABER_URINARY_TRACT | 35431259 | 35431510 | 35431477 | 35431477 | Missense_Mutation | G | A | p.R803W |
| JSC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 35434256 | 35434360 | 35434324 | 35434324 | Missense_Mutation | C | T | p.E713K |
| OVTOKO_OVARY | 35434256 | 35434360 | 35434351 | 35434351 | Missense_Mutation | T | C | p.M704V |
| NUGC3_STOMACH | 35436916 | 35437146 | 35436934 | 35436934 | Missense_Mutation | T | A | p.E694D |
| LN18_CENTRAL_NERVOUS_SYSTEM | 35436916 | 35437146 | 35436988 | 35436988 | Missense_Mutation | C | T | p.M676I |
| NCIH2347_LUNG | 35436916 | 35437146 | 35437104 | 35437104 | Missense_Mutation | C | G | p.E638Q |
| OC316_OVARY | 35445810 | 35445872 | 35445842 | 35445842 | Missense_Mutation | G | T | p.L130M |
| OC314_OVARY | 35445810 | 35445872 | 35445842 | 35445842 | Missense_Mutation | G | T | p.L130M |
| HEC108_ENDOMETRIUM | 35445810 | 35445872 | 35445851 | 35445851 | Missense_Mutation | T | A | p.T127S |
| HCC515_LUNG | 35431259 | 35431510 | 35431372 | 35431373 | Nonsense_Mutation | GC | AT | p.Q838* |
| NCIH650_LUNG | 35431259 | 35431510 | 35431507 | 35431507 | Nonsense_Mutation | C | A | p.E793* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SOGA1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SOGA1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SOGA1 |
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RelatedDrugs for SOGA1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SOGA1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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