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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for METTL6 |
 Gene summary |
| Gene information | Gene symbol | METTL6 | Gene ID | 131965 |
| Gene name | methyltransferase like 6 | |
| Synonyms | - | |
| Cytomap | 3p25.1 | |
| Type of gene | protein-coding | |
| Description | methyltransferase-like protein 6 | |
| Modification date | 20180523 | |
| UniProtAcc | Q8TCB7 | |
| Context | PubMed: METTL6 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for METTL6 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for METTL6 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for METTL6 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_381624 | 3 | 15425408:15425694:15452751:15452944:15455527:15455604 | 15452751:15452944 | ENSG00000206562.7 | ENST00000443029.1 |
| exon_skip_381646 | 3 | 15452842:15452944:15455527:15455669:15456236:15456421 | 15455527:15455669 | ENSG00000206562.7 | ENST00000485131.1 |
| exon_skip_381647 | 3 | 15452842:15452944:15455527:15455669:15457004:15457090 | 15455527:15455669 | ENSG00000206562.7 | ENST00000489881.1 |
| exon_skip_381648 | 3 | 15452842:15452944:15455527:15455669:15457278:15457367 | 15455527:15455669 | ENSG00000206562.7 | ENST00000383790.3,ENST00000443029.1,ENST00000450816.2 |
| exon_skip_381663 | 3 | 15455177:15455452:15457004:15457090:15457278:15457367 | 15457004:15457090 | ENSG00000206562.7 | ENST00000453819.1 |
| exon_skip_381669 | 3 | 15455527:15455669:15456236:15456421:15457004:15457090 | 15456236:15456421 | ENSG00000206562.7 | ENST00000485131.1 |
| exon_skip_381672 | 3 | 15455527:15455669:15457004:15457090:15457278:15457367 | 15457004:15457090 | ENSG00000206562.7 | ENST00000489881.1 |
| exon_skip_381674 | 3 | 15455527:15455669:15457278:15457449:15466461:15466542 | 15457278:15457449 | ENSG00000206562.7 | ENST00000383790.3,ENST00000443029.1 |
| exon_skip_381675 | 3 | 15455527:15455669:15457278:15457449:15467793:15468142 | 15457278:15457449 | ENSG00000206562.7 | ENST00000450816.2 |
| exon_skip_381680 | 3 | 15456236:15456421:15457004:15457090:15457278:15457367 | 15457004:15457090 | ENSG00000206562.7 | ENST00000485131.1,ENST00000383789.5 |
| exon_skip_381683 | 3 | 15457278:15457449:15466461:15466596:15467793:15468142 | 15466461:15466596 | ENSG00000206562.7 | ENST00000383790.3,ENST00000443029.1,ENST00000383789.5 |
| exon_skip_381684 | 3 | 15466461:15466596:15467793:15468142:15468908:15469025 | 15467793:15468142 | ENSG00000206562.7 | ENST00000383790.3,ENST00000383789.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for METTL6 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_381624 | 3 | 15425408:15425694:15452751:15452944:15455527:15455604 | 15452751:15452944 | ENSG00000206562.7 | ENST00000443029.1 |
| exon_skip_381632 | 3 | 15425408:15425694:15455527:15455669:15457278:15457367 | 15455527:15455669 | ENSG00000206562.7 | ENST00000458728.1 |
| exon_skip_381646 | 3 | 15452842:15452944:15455527:15455669:15456236:15456421 | 15455527:15455669 | ENSG00000206562.7 | ENST00000485131.1 |
| exon_skip_381647 | 3 | 15452842:15452944:15455527:15455669:15457004:15457090 | 15455527:15455669 | ENSG00000206562.7 | ENST00000489881.1 |
| exon_skip_381648 | 3 | 15452842:15452944:15455527:15455669:15457278:15457367 | 15455527:15455669 | ENSG00000206562.7 | ENST00000443029.1,ENST00000383790.3,ENST00000450816.2 |
| exon_skip_381663 | 3 | 15455177:15455452:15457004:15457090:15457278:15457367 | 15457004:15457090 | ENSG00000206562.7 | ENST00000453819.1 |
| exon_skip_381669 | 3 | 15455527:15455669:15456236:15456421:15457004:15457090 | 15456236:15456421 | ENSG00000206562.7 | ENST00000485131.1 |
| exon_skip_381672 | 3 | 15455527:15455669:15457004:15457090:15457278:15457367 | 15457004:15457090 | ENSG00000206562.7 | ENST00000489881.1 |
| exon_skip_381674 | 3 | 15455527:15455669:15457278:15457449:15466461:15466542 | 15457278:15457449 | ENSG00000206562.7 | ENST00000443029.1,ENST00000383790.3 |
| exon_skip_381675 | 3 | 15455527:15455669:15457278:15457449:15467793:15468142 | 15457278:15457449 | ENSG00000206562.7 | ENST00000450816.2 |
| exon_skip_381680 | 3 | 15456236:15456421:15457004:15457090:15457278:15457367 | 15457004:15457090 | ENSG00000206562.7 | ENST00000485131.1,ENST00000383789.5 |
| exon_skip_381683 | 3 | 15457278:15457449:15466461:15466596:15467793:15468142 | 15466461:15466596 | ENSG00000206562.7 | ENST00000443029.1,ENST00000383790.3,ENST00000383789.5 |
| exon_skip_381684 | 3 | 15466461:15466596:15467793:15468142:15468908:15469025 | 15467793:15468142 | ENSG00000206562.7 | ENST00000383790.3,ENST00000383789.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for METTL6 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000383790 | 15467793 | 15468142 | 3UTR-3CDS |
| ENST00000443029 | 15452751 | 15452944 | 5CDS-5UTR |
| ENST00000383790 | 15455527 | 15455669 | Frame-shift |
| ENST00000443029 | 15455527 | 15455669 | Frame-shift |
| ENST00000383790 | 15457278 | 15457449 | In-frame |
| ENST00000443029 | 15457278 | 15457449 | In-frame |
| ENST00000383790 | 15466461 | 15466596 | In-frame |
| ENST00000443029 | 15466461 | 15466596 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000383790 | 15467793 | 15468142 | 3UTR-3CDS |
| ENST00000443029 | 15452751 | 15452944 | 5CDS-5UTR |
| ENST00000383790 | 15455527 | 15455669 | Frame-shift |
| ENST00000443029 | 15455527 | 15455669 | Frame-shift |
| ENST00000383790 | 15457278 | 15457449 | In-frame |
| ENST00000443029 | 15457278 | 15457449 | In-frame |
| ENST00000383790 | 15466461 | 15466596 | In-frame |
| ENST00000443029 | 15466461 | 15466596 | In-frame |
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Infer the effects of exon skipping event on protein functional features for METTL6 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000383790 | 1352 | 284 | 15466461 | 15466596 | 467 | 601 | 75 | 120 |
| ENST00000443029 | 4037 | 284 | 15466461 | 15466596 | 467 | 601 | 75 | 120 |
| ENST00000383790 | 1352 | 284 | 15457278 | 15457449 | 602 | 772 | 120 | 177 |
| ENST00000443029 | 4037 | 284 | 15457278 | 15457449 | 602 | 772 | 120 | 177 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000383790 | 1352 | 284 | 15466461 | 15466596 | 467 | 601 | 75 | 120 |
| ENST00000443029 | 4037 | 284 | 15466461 | 15466596 | 467 | 601 | 75 | 120 |
| ENST00000383790 | 1352 | 284 | 15457278 | 15457449 | 602 | 772 | 120 | 177 |
| ENST00000443029 | 4037 | 284 | 15457278 | 15457449 | 602 | 772 | 120 | 177 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TCB7 | 75 | 120 | 1 | 284 | Chain | ID=PRO_0000204454;Note=Methyltransferase-like protein 6 |
| Q8TCB7 | 75 | 120 | 1 | 284 | Chain | ID=PRO_0000204454;Note=Methyltransferase-like protein 6 |
| Q8TCB7 | 120 | 177 | 1 | 284 | Chain | ID=PRO_0000204454;Note=Methyltransferase-like protein 6 |
| Q8TCB7 | 120 | 177 | 1 | 284 | Chain | ID=PRO_0000204454;Note=Methyltransferase-like protein 6 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TCB7 | 75 | 120 | 1 | 284 | Chain | ID=PRO_0000204454;Note=Methyltransferase-like protein 6 |
| Q8TCB7 | 75 | 120 | 1 | 284 | Chain | ID=PRO_0000204454;Note=Methyltransferase-like protein 6 |
| Q8TCB7 | 120 | 177 | 1 | 284 | Chain | ID=PRO_0000204454;Note=Methyltransferase-like protein 6 |
| Q8TCB7 | 120 | 177 | 1 | 284 | Chain | ID=PRO_0000204454;Note=Methyltransferase-like protein 6 |
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SNVs in the skipped exons for METTL6 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_381624 | 15452752 | 15452944 | 15452777 | 15452777 | Frame_Shift_Del | C | - | p.D281fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_381624 | 15452752 | 15452944 | 15452862 | 15452862 | Frame_Shift_Del | T | - | p.K252fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_381624 | 15452752 | 15452944 | 15452862 | 15452862 | Frame_Shift_Del | T | - | p.K252fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_381647 exon_skip_381646 exon_skip_381648 | 15455528 | 15455669 | 15455535 | 15455535 | Frame_Shift_Del | A | - | p.F222fs |
| STAD | TCGA-BR-4201-01 | exon_skip_381647 exon_skip_381646 exon_skip_381648 | 15455528 | 15455669 | 15455535 | 15455535 | Frame_Shift_Del | A | - | p.T223fs |
| STAD | TCGA-CG-4306-01 | exon_skip_381647 exon_skip_381646 exon_skip_381648 | 15455528 | 15455669 | 15455535 | 15455535 | Frame_Shift_Del | A | - | p.T223fs |
| STAD | TCGA-F1-6177-01 | exon_skip_381647 exon_skip_381646 exon_skip_381648 | 15455528 | 15455669 | 15455535 | 15455535 | Frame_Shift_Del | A | - | p.F222fs |
| STAD | TCGA-F1-6177-01 | exon_skip_381647 exon_skip_381646 exon_skip_381648 | 15455528 | 15455669 | 15455535 | 15455535 | Frame_Shift_Del | A | - | p.T223fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_381674 exon_skip_381675 | 15457279 | 15457449 | 15457445 | 15457445 | Frame_Shift_Del | T | - | p.N122fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_381683 | 15466462 | 15466596 | 15466554 | 15466554 | Frame_Shift_Del | C | - | p.V90fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_381684 | 15467794 | 15468142 | 15467998 | 15467998 | Frame_Shift_Del | T | - | p.K7fs |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_381684 | 15467794 | 15468142 | 15467873 | 15467874 | Frame_Shift_Ins | - | A | p.Q49fs |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_381684 | 15467794 | 15468142 | 15467873 | 15467874 | Frame_Shift_Ins | - | A | p.Y49fs |
| BLCA | TCGA-DK-A6AW-01 | exon_skip_381624 | 15452752 | 15452944 | 15452882 | 15452882 | Nonsense_Mutation | G | A | p.R246* |
| LUSC | TCGA-18-3408-01 | exon_skip_381683 | 15466462 | 15466596 | 15466468 | 15466468 | Nonsense_Mutation | A | T | p.Y118* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC265_ENDOMETRIUM | 15455528 | 15455669 | 15455535 | 15455535 | Frame_Shift_Del | A | - | p.F222fs |
| SNU1_STOMACH | 15455528 | 15455669 | 15455535 | 15455535 | Frame_Shift_Del | A | - | p.F222fs |
| LOVO_LARGE_INTESTINE | 15455528 | 15455669 | 15455535 | 15455535 | Frame_Shift_Del | A | - | p.F222fs |
| SW48_LARGE_INTESTINE | 15455528 | 15455669 | 15455535 | 15455535 | Frame_Shift_Del | A | - | p.F222fs |
| SNGM_ENDOMETRIUM | 15455528 | 15455669 | 15455651 | 15455651 | Frame_Shift_Del | T | - | p.S184fs |
| SNU407_LARGE_INTESTINE | 15452752 | 15452944 | 15452861 | 15452862 | Frame_Shift_Ins | - | T | p.E253fs |
| RKO_LARGE_INTESTINE | 15455528 | 15455669 | 15455534 | 15455535 | Frame_Shift_Ins | - | A | p.T223fs |
| SW48_LARGE_INTESTINE | 15452752 | 15452944 | 15452783 | 15452783 | Missense_Mutation | C | A | p.G279C |
| MZ7MEL_SKIN | 15452752 | 15452944 | 15452861 | 15452861 | Missense_Mutation | C | T | p.E253K |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15452752 | 15452944 | 15452875 | 15452875 | Missense_Mutation | G | A | p.T248M |
| GMS10_CENTRAL_NERVOUS_SYSTEM | 15455528 | 15455669 | 15455639 | 15455639 | Missense_Mutation | G | A | p.R188C |
| HS944T_SKIN | 15466462 | 15466596 | 15466484 | 15466484 | Missense_Mutation | G | A | p.P113L |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15466462 | 15466596 | 15466503 | 15466503 | Missense_Mutation | A | G | p.Y107H |
| KYSE70_OESOPHAGUS | 15466462 | 15466596 | 15466524 | 15466524 | Missense_Mutation | C | T | p.E100K |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15466462 | 15466596 | 15466550 | 15466550 | Missense_Mutation | C | A | p.G91V |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15467794 | 15468142 | 15467843 | 15467843 | Missense_Mutation | T | C | p.D59G |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15467794 | 15468142 | 15467843 | 15467843 | Missense_Mutation | T | C | p.D59G |
| HEC6_ENDOMETRIUM | 15467794 | 15468142 | 15467881 | 15467881 | Missense_Mutation | A | T | p.D46E |
| CW2_LARGE_INTESTINE | 15467794 | 15468142 | 15467887 | 15467887 | Missense_Mutation | A | T | p.N44K |
| CP50EBV_MATCHED_NORMAL_TISSUE | 15467794 | 15468142 | 15467976 | 15467976 | Missense_Mutation | T | C | p.T15A |
| HCC2998_LARGE_INTESTINE | 15467794 | 15468142 | 15467981 | 15467981 | Missense_Mutation | A | G | p.I13T |
| TE9_OESOPHAGUS | 15452752 | 15452944 | 15452764 | 15452764 | Nonstop_Mutation | C | A | p.*285L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for METTL6 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_381669 | 3 | 15455527:15455669:15456236:15456421:15457004:15457090 | 15456236:15456421 | ENST00000485131.1 | PAAD | rs7652289 | chr3:15456291 | C/G | 2.42e-04 |
| exon_skip_381669 | 3 | 15455527:15455669:15456236:15456421:15457004:15457090 | 15456236:15456421 | ENST00000485131.1 | PAAD | rs7652289 | chr3:15456291 | C/G | 6.08e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for METTL6 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for METTL6 |
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RelatedDrugs for METTL6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for METTL6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| METTL6 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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