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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for CLU

check button Gene summary
Gene informationGene symbol

CLU

Gene ID

1191

Gene nameclusterin
SynonymsAAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2
Cytomap

8p21.1

Type of geneprotein-coding
Descriptionclusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40ku70-binding protein 1sulfated glycoprotein 2testosterone-repressed prostate message 2
Modification date20180527
UniProtAcc

P10909

ContextPubMed: CLU [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
CLU

GO:0000902

cell morphogenesis

15857407

CLU

GO:0001774

microglial cell activation

15857407

CLU

GO:0017038

protein import

24446231

CLU

GO:0032463

negative regulation of protein homooligomerization

22179788|23106396

CLU

GO:0032464

positive regulation of protein homooligomerization

22179788

CLU

GO:0032760

positive regulation of tumor necrosis factor production

15857407

CLU

GO:0045429

positive regulation of nitric oxide biosynthetic process

15857407

CLU

GO:0050821

protein stabilization

11123922

CLU

GO:0051131

chaperone-mediated protein complex assembly

17412999

CLU

GO:0051788

response to misfolded protein

19996109

CLU

GO:0061077

chaperone-mediated protein folding

11123922

CLU

GO:0061518

microglial cell proliferation

15857407

CLU

GO:1900221

regulation of amyloid-beta clearance

24446231

CLU

GO:1901214

regulation of neuron death

17412999

CLU

GO:1901216

positive regulation of neuron death

15857407

CLU

GO:1902430

negative regulation of amyloid-beta formation

12047389|17412999

CLU

GO:1905907

negative regulation of amyloid fibril formation

22179788


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Exon skipping events across known transcript of Ensembl for CLU from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for CLU

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for CLU

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_488892827456053:27456152:27457296:27457526:27461807:2746191227457296:27457526ENSG00000120885.15ENST00000405140.3,ENST00000316403.10,ENST00000523500.1,ENST00000560366.1,ENST00000522098.1,ENST00000546343.1
exon_skip_488896827457296:27457526:27461807:27461912:27462440:2746253427461807:27461912ENSG00000120885.15ENST00000405140.3,ENST00000522299.1,ENST00000316403.10,ENST00000523500.1,ENST00000560366.1,ENST00000522098.1,ENST00000546343.1
exon_skip_488899827461882:27461912:27462440:27462852:27463870:2746404127462440:27462852ENSG00000120885.15ENST00000405140.3,ENST00000522299.1,ENST00000316403.10,ENST00000523500.1,ENST00000560366.1,ENST00000560566.1,ENST00000546343.1
exon_skip_488903827462688:27462852:27463870:27464041:27466454:2746660327463870:27464041ENSG00000120885.15ENST00000405140.3,ENST00000522299.1,ENST00000316403.10,ENST00000523500.1,ENST00000560366.1,ENST00000560566.1,ENST00000520796.1,ENST00000546343.1,ENST00000523589.1
exon_skip_488907827463898:27464041:27466454:27466603:27467991:2746811727466454:27466603ENSG00000120885.15ENST00000519742.1,ENST00000405140.3,ENST00000522299.1,ENST00000316403.10,ENST00000522413.1,ENST00000523500.1,ENST00000560366.1,ENST00000560566.1,ENST00000520796.1,ENST00000546343.1,ENST00000520491.1,ENST00000523589.1
exon_skip_488921827466585:27466603:27467991:27468117:27472171:2747219827467991:27468117ENSG00000120885.15ENST00000522299.1,ENST00000560366.1,ENST00000519472.1,ENST00000523589.1,ENST00000518050.1
exon_skip_488942827467992:27468117:27471094:27471200:27472171:2747219827471094:27471200ENSG00000120885.15ENST00000523396.1
exon_skip_488946827467992:27468117:27471689:27471887:27472171:2747219827471689:27471887ENSG00000120885.15ENST00000522413.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for CLU

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_488892827456053:27456152:27457296:27457526:27461807:2746191227457296:27457526ENSG00000120885.15ENST00000316403.10,ENST00000560366.1,ENST00000546343.1,ENST00000405140.3,ENST00000523500.1,ENST00000522098.1
exon_skip_488896827457296:27457526:27461807:27461912:27462440:2746253427461807:27461912ENSG00000120885.15ENST00000316403.10,ENST00000560366.1,ENST00000546343.1,ENST00000405140.3,ENST00000523500.1,ENST00000522299.1,ENST00000522098.1
exon_skip_488899827461882:27461912:27462440:27462852:27463870:2746404127462440:27462852ENSG00000120885.15ENST00000316403.10,ENST00000560366.1,ENST00000546343.1,ENST00000405140.3,ENST00000523500.1,ENST00000522299.1,ENST00000560566.1
exon_skip_488903827462688:27462852:27463870:27464041:27466454:2746660327463870:27464041ENSG00000120885.15ENST00000316403.10,ENST00000560366.1,ENST00000546343.1,ENST00000405140.3,ENST00000523500.1,ENST00000522299.1,ENST00000523589.1,ENST00000560566.1,ENST00000520796.1
exon_skip_488907827463898:27464041:27466454:27466603:27467991:2746811727466454:27466603ENSG00000120885.15ENST00000316403.10,ENST00000560366.1,ENST00000546343.1,ENST00000405140.3,ENST00000523500.1,ENST00000522299.1,ENST00000523589.1,ENST00000560566.1,ENST00000520796.1,ENST00000519742.1,ENST00000520491.1,ENST00000522413.1
exon_skip_488921827466585:27466603:27467991:27468117:27472171:2747219827467991:27468117ENSG00000120885.15ENST00000560366.1,ENST00000522299.1,ENST00000523589.1,ENST00000518050.1,ENST00000519472.1
exon_skip_488942827467992:27468117:27471094:27471200:27472171:2747219827471094:27471200ENSG00000120885.15ENST00000523396.1
exon_skip_488946827467992:27468117:27471689:27471887:27472171:2747219827471689:27471887ENSG00000120885.15ENST00000522413.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for CLU

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003164032745729627457526Frame-shift
ENST000004051402745729627457526Frame-shift
ENST000005235002745729627457526Frame-shift
ENST000003164032746244027462852Frame-shift
ENST000004051402746244027462852Frame-shift
ENST000005235002746244027462852Frame-shift
ENST000003164032746645427466603Frame-shift
ENST000004051402746645427466603Frame-shift
ENST000005235002746645427466603Frame-shift
ENST000003164032746180727461912In-frame
ENST000004051402746180727461912In-frame
ENST000005235002746180727461912In-frame
ENST000003164032746387027464041In-frame
ENST000004051402746387027464041In-frame
ENST000005235002746387027464041In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003164032745729627457526Frame-shift
ENST000004051402745729627457526Frame-shift
ENST000005235002745729627457526Frame-shift
ENST000003164032746244027462852Frame-shift
ENST000004051402746244027462852Frame-shift
ENST000005235002746244027462852Frame-shift
ENST000003164032746645427466603Frame-shift
ENST000004051402746645427466603Frame-shift
ENST000005235002746645427466603Frame-shift
ENST000003164032746180727461912In-frame
ENST000004051402746180727461912In-frame
ENST000005235002746180727461912In-frame
ENST000003164032746387027464041In-frame
ENST000004051402746387027464041In-frame
ENST000005235002746387027464041In-frame

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Infer the effects of exon skipping event on protein functional features for CLU

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003164033097449274638702746404165382382139
ENST000004051402115449274638702746404156273282139
ENST00000523500239844927463870274640411033120382139
ENST000003164033097449274618072746191212361340276311
ENST000004051402115449274618072746191211451249276311
ENST000005235002398449274618072746191216161720276311

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003164033097449274638702746404165382382139
ENST000004051402115449274638702746404156273282139
ENST00000523500239844927463870274640411033120382139
ENST000003164033097449274618072746191212361340276311
ENST000004051402115449274618072746191211451249276311
ENST000005235002398449274618072746191216161720276311

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P10909821391175Alternative sequenceID=VSP_041475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P10909821391175Alternative sequenceID=VSP_041475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P10909821391175Alternative sequenceID=VSP_041475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P109098213923449ChainID=PRO_0000005529;Note=Clusterin
P109098213923449ChainID=PRO_0000005529;Note=Clusterin
P109098213923449ChainID=PRO_0000005529;Note=Clusterin
P109098213923227ChainID=PRO_0000005530;Note=Clusterin beta chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P109098213923227ChainID=PRO_0000005530;Note=Clusterin beta chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P109098213923227ChainID=PRO_0000005530;Note=Clusterin beta chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P1090982139102313Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139102313Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139102313Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139113305Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139113305Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139113305Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139116302Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139116302Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139116302Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139121295Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139121295Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139121295Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139129285Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139129285Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139129285Disulfide bondNote=Interchain (between beta and alpha chains)
P10909821398686GlycosylationNote=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|Pu
P10909821398686GlycosylationNote=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|Pu
P10909821398686GlycosylationNote=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|Pu
P1090982139103103GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P1090982139103103GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P1090982139103103GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P1090982139133133Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
P1090982139133133Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
P1090982139133133Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
P1090927631123449ChainID=PRO_0000005529;Note=Clusterin
P1090927631123449ChainID=PRO_0000005529;Note=Clusterin
P1090927631123449ChainID=PRO_0000005529;Note=Clusterin
P10909276311228449ChainID=PRO_0000005531;Note=Clusterin alpha chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P10909276311228449ChainID=PRO_0000005531;Note=Clusterin alpha chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P10909276311228449ChainID=PRO_0000005531;Note=Clusterin alpha chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P10909276311102313Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311102313Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311102313Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311113305Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311113305Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311113305Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311116302Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311116302Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311116302Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311121295Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311121295Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311121295Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311129285Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311129285Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311129285Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311291291GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P10909276311291291GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P10909276311291291GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P10909276311305305Sequence conflictNote=C->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
P10909276311305305Sequence conflictNote=C->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
P10909276311305305Sequence conflictNote=C->M;Ontology_term=ECO:0000305;evidence=ECO:0000305


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P10909821391175Alternative sequenceID=VSP_041475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P10909821391175Alternative sequenceID=VSP_041475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P10909821391175Alternative sequenceID=VSP_041475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P109098213923449ChainID=PRO_0000005529;Note=Clusterin
P109098213923449ChainID=PRO_0000005529;Note=Clusterin
P109098213923449ChainID=PRO_0000005529;Note=Clusterin
P109098213923227ChainID=PRO_0000005530;Note=Clusterin beta chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P109098213923227ChainID=PRO_0000005530;Note=Clusterin beta chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P109098213923227ChainID=PRO_0000005530;Note=Clusterin beta chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P1090982139102313Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139102313Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139102313Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139113305Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139113305Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139113305Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139116302Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139116302Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139116302Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139121295Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139121295Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139121295Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139129285Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139129285Disulfide bondNote=Interchain (between beta and alpha chains)
P1090982139129285Disulfide bondNote=Interchain (between beta and alpha chains)
P10909821398686GlycosylationNote=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|Pu
P10909821398686GlycosylationNote=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|Pu
P10909821398686GlycosylationNote=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|Pu
P1090982139103103GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P1090982139103103GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P1090982139103103GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P1090982139133133Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
P1090982139133133Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
P1090982139133133Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
P1090927631123449ChainID=PRO_0000005529;Note=Clusterin
P1090927631123449ChainID=PRO_0000005529;Note=Clusterin
P1090927631123449ChainID=PRO_0000005529;Note=Clusterin
P10909276311228449ChainID=PRO_0000005531;Note=Clusterin alpha chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P10909276311228449ChainID=PRO_0000005531;Note=Clusterin alpha chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P10909276311228449ChainID=PRO_0000005531;Note=Clusterin alpha chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
P10909276311102313Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311102313Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311102313Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311113305Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311113305Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311113305Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311116302Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311116302Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311116302Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311121295Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311121295Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311121295Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311129285Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311129285Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311129285Disulfide bondNote=Interchain (between beta and alpha chains)
P10909276311291291GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P10909276311291291GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P10909276311291291GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:933683
P10909276311305305Sequence conflictNote=C->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
P10909276311305305Sequence conflictNote=C->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
P10909276311305305Sequence conflictNote=C->M;Ontology_term=ECO:0000305;evidence=ECO:0000305


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SNVs in the skipped exons for CLU

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
CLU_LGG_exon_skip_488921_psi_boxplot.png
boxplot
CLU_LIHC_exon_skip_488921_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A1EG-01exon_skip_488899
27462441274628522746264427462644Frame_Shift_DelA-p.F209fs
LGGTCGA-HT-8564-01exon_skip_488921
27467992274681172746807527468076Frame_Shift_DelAG-p.5_5del
LGGTCGA-HT-8564-01exon_skip_488921
27467992274681172746807527468076Frame_Shift_DelAG-p.L7fs
LIHCTCGA-DD-A3A1-01exon_skip_488921
27467992274681172746811527468115Frame_Shift_DelC-p.A44fs
STADTCGA-BR-4362-01exon_skip_488907
27466455274666032746651427466515Frame_Shift_Ins-Tp.T74fs
BRCATCGA-EW-A1J5-01exon_skip_488892
27457297274575262745750327457503Nonsense_MutationGAp.Q372*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
CLU_27466585_27466603_27467991_27468117_27472171_27472198_TCGA-HT-8564-01Sample: TCGA-HT-8564-01
Cancer type: LGG
ESID: exon_skip_488921
Skipped exon start: 27467992
Skipped exon end: 27468117
Mutation start: 27468075
Mutation end: 27468076
Mutation type: Frame_Shift_Del
Reference seq: AG
Mutation seq: -
AAchange: p.5_5del
CLU_27466585_27466603_27467991_27468117_27472171_27472198_TCGA-HT-8564-01Sample: TCGA-HT-8564-01
Cancer type: LGG
ESID: exon_skip_488921
Skipped exon start: 27467992
Skipped exon end: 27468117
Mutation start: 27468075
Mutation end: 27468076
Mutation type: Frame_Shift_Del
Reference seq: AG
Mutation seq: -
AAchange: p.L7fs
exon_skip_361152_LGG_TCGA-HT-8564-01.png
boxplot
exon_skip_488921_LGG_TCGA-HT-8564-01.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
HEC108_ENDOMETRIUM27466455274666032746651327466514Frame_Shift_Ins-Tp.T63fs
EN_ENDOMETRIUM27466455274666032746651327466514Frame_Shift_Ins-Tp.T63fs
LN340_CENTRAL_NERVOUS_SYSTEM27457297274575262745731427457314Missense_MutationATp.Y383N
SNU1040_LARGE_INTESTINE27457297274575262745734427457344Missense_MutationCTp.A373T
SNU1040_LARGE_INTESTINE27457297274575262745741827457418Missense_MutationTCp.Y348C
MET2B27457297274575262745747627457476Missense_MutationCTp.E329K
MERO41_LUNG27457297274575262745750527457505Missense_MutationGAp.S319F
MCC13_SKIN27457297274575262745750827457508Missense_MutationGAp.P318L
NCIH1755_LUNG27457297274575262745750827457508Missense_MutationGTp.P318H
CS1_BONE27461808274619122746183527461835Missense_MutationCTp.D303N
BICR31_UPPER_AERODIGESTIVE_TRACT27462441274628522746247627462476Missense_MutationGAp.P265L
SNU407_LARGE_INTESTINE27462441274628522746259427462594Missense_MutationCTp.V226I
HMVII_SKIN27462441274628522746259427462594Missense_MutationCAp.V226F
CORL32_LUNG27462441274628522746268827462688Missense_MutationCGp.R194S
NCIH1373_LUNG27462441274628522746276127462761Missense_MutationGCp.T170R
P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27462441274628522746277327462773Missense_MutationTCp.D166G
S117_SOFT_TISSUE27462441274628522746279727462797Missense_MutationCTp.R158H
HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27463871274640412746387627463876Missense_MutationGAp.R138C
RCK8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27463871274640412746390827463908Missense_MutationCTp.R127H
KYSE220_OESOPHAGUS27463871274640412746394227463942Missense_MutationAGp.C116R
CJM_SKIN27463871274640412746395427463954Missense_MutationCTp.E112K
SARC9371_BONE27463871274640412746396627463966Missense_MutationCTp.A108T
MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27466455274666032746650127466501Missense_MutationCTp.R67H
SNU503_LARGE_INTESTINE27466455274666032746653027466530Missense_MutationCAp.K57N
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27466455274666032746654727466547Missense_MutationCTp.G52R
JHU029_UPPER_AERODIGESTIVE_TRACT27466455274666032746656227466562Missense_MutationGCp.Q47E
GP5D_LARGE_INTESTINE27466455274666032746657627466576Missense_MutationAGp.V42A
BT474_BREAST27467992274681172746800927468009Missense_MutationGAp.S27L
JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27467992274681172746804627468046Missense_MutationAGp.W15R
HEC59_ENDOMETRIUM27467992274681172746806427468064Missense_MutationCTp.V9M
NCIH1838_LUNG27461808274619122746191227461913Splice_SiteTCAAp.G277V

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CLU

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_488899827461882:27461912:27462440:27462852:27463870:2746404127462440:27462852ENST00000405140.3,ENST00000522299.1,ENST00000316403.10,ENST00000523500.1,ENST00000560366.1,ENST00000560566.1,ENST00000546343.1LGGrs7982chr8:27462481A/G2.04e-06
exon_skip_488899827461882:27461912:27462440:27462852:27463870:2746404127462440:27462852ENST00000405140.3,ENST00000522299.1,ENST00000316403.10,ENST00000523500.1,ENST00000560366.1,ENST00000560566.1,ENST00000546343.1LGGrs7982chr8:27462481A/G3.37e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLU


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLU


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RelatedDrugs for CLU

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
P10909DB01593ZincClusterinsmall moleculeapproved|investigational
P10909DB14487Zinc acetateClusterinsmall moleculeapproved|investigational
P10909DB14533Zinc chlorideClusterinsmall moleculeapproved|investigational

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RelatedDiseases for CLU

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
CLUC2609414Acute kidney injury5CTD_human
CLUC0002395Alzheimer's Disease3CTD_human
CLUC0022658Kidney Diseases3CTD_human
CLUC0029408Degenerative polyarthritis2CTD_human
CLUC0024141Lupus Erythematosus, Systemic1CTD_human
CLUC0025202melanoma1CTD_human
CLUC0027686Pathologic Neovascularization1CTD_human
CLUC0033578Prostatic Neoplasms1CTD_human
CLUC0036341Schizophrenia1PSYGENET
CLUC0036572Seizures1CTD_human
CLUC0041755Adverse reaction to drug1CTD_human
CLUC0333641Atrophic1CTD_human
CLUC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
CLUC3495559Juvenile arthritis1CTD_human
CLUC4277682Chemical and Drug Induced Liver Injury1CTD_human