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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ART5 |
 Gene summary |
| Gene information | Gene symbol | ART5 | Gene ID | 116969 |
| Gene name | ADP-ribosyltransferase 5 | |
| Synonyms | ARTC5 | |
| Cytomap | 11p15.4 | |
| Type of gene | protein-coding | |
| Description | ecto-ADP-ribosyltransferase 5ADP-ribosyltransferase C2 and C3 toxin-like 5NAD(P)(+)--arginine ADP-ribosyltransferase 5mono(ADP-ribosyl)transferase 5 | |
| Modification date | 20180523 | |
| UniProtAcc | Q96L15 | |
| Context | PubMed: ART5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ART5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ART5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ART5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_68180 | 11 | 3659994:3660149:3660232:3660265:3661075:3661601 | 3660232:3660265 | ENSG00000167311.9 | ENST00000397067.3 |
| exon_skip_68187 | 11 | 3660240:3660265:3660871:3661601:3663035:3663094 | 3660871:3661601 | ENSG00000167311.9 | ENST00000359918.4 |
| exon_skip_68188 | 11 | 3660240:3660265:3661075:3661601:3663035:3663094 | 3661075:3661601 | ENSG00000167311.9 | ENST00000397067.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ART5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_68180 | 11 | 3659994:3660149:3660232:3660265:3661075:3661601 | 3660232:3660265 | ENSG00000167311.9 | ENST00000397067.3 |
| exon_skip_68187 | 11 | 3660240:3660265:3660871:3661601:3663035:3663094 | 3660871:3661601 | ENSG00000167311.9 | ENST00000359918.4 |
| exon_skip_68188 | 11 | 3660240:3660265:3661075:3661601:3663035:3663094 | 3661075:3661601 | ENSG00000167311.9 | ENST00000397067.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ART5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359918 | 3660871 | 3661601 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359918 | 3660871 | 3661601 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ART5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ART5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_68180 | 3660233 | 3660265 | 3660250 | 3660250 | Frame_Shift_Del | C | - | p.G268fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_68187 | 3660872 | 3661601 | 3660891 | 3660891 | Frame_Shift_Del | A | - | p.F256fs |
| UCEC | TCGA-A5-A0GB-01 | exon_skip_68187 | 3660872 | 3661601 | 3660967 | 3660967 | Frame_Shift_Del | A | - | p.L231fs |
| COAD | TCGA-AZ-6598-01 | exon_skip_68187 | 3660872 | 3661601 | 3660980 | 3660980 | Frame_Shift_Del | G | - | p.H227fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_68187 | 3660872 | 3661601 | 3660980 | 3660980 | Frame_Shift_Del | G | - | p.H227fs |
| STAD | TCGA-BR-8591-01 | exon_skip_68187 | 3660872 | 3661601 | 3660980 | 3660980 | Frame_Shift_Del | G | - | p.H227fs |
| STAD | TCGA-HF-7132-01 | exon_skip_68187 | 3660872 | 3661601 | 3660980 | 3660980 | Frame_Shift_Del | G | - | p.H227fs |
| UCEC | TCGA-D1-A177-01 | exon_skip_68187 | 3660872 | 3661601 | 3660980 | 3660980 | Frame_Shift_Del | G | - | p.H227fs |
| THYM | TCGA-3G-AB19-01 | exon_skip_68187 | 3660872 | 3661601 | 3661054 | 3661057 | Frame_Shift_Del | AGAG | - | p.201_202del |
| THYM | TCGA-3G-AB19-01 | exon_skip_68187 | 3660872 | 3661601 | 3661054 | 3661057 | Frame_Shift_Del | AGAG | - | p.SL201fs |
| BRCA | TCGA-E9-A1NI-01 | exon_skip_68187 | 3660872 | 3661601 | 3660979 | 3660980 | Frame_Shift_Ins | - | G | p.H227fs |
| KIRC | TCGA-A3-3382-01 | exon_skip_68187 | 3660872 | 3661601 | 3660979 | 3660980 | Frame_Shift_Ins | - | G | p.*227fs |
| LUAD | TCGA-MP-A4TE-01 | exon_skip_68187 | 3660872 | 3661601 | 3660979 | 3660980 | Frame_Shift_Ins | - | G | p.*227fs |
| STAD | TCGA-D7-A4YV-01 | exon_skip_68187 | 3660872 | 3661601 | 3660979 | 3660980 | Frame_Shift_Ins | - | GG | p.H227fs |
| UCEC | TCGA-B5-A0K2-01 | exon_skip_68187 | 3660872 | 3661601 | 3660979 | 3660980 | Frame_Shift_Ins | - | G | p.H227fs |
| STAD | TCGA-D7-A4YV-01 | exon_skip_68187 | 3660872 | 3661601 | 3660980 | 3660981 | Frame_Shift_Ins | - | GG | p.H227fs |
| SKCM | TCGA-D9-A6EC-06 | exon_skip_68187 | 3660872 | 3661601 | 3660959 | 3660959 | Nonsense_Mutation | T | A | p.R234* |
| SKCM | TCGA-D9-A6EC-06 | exon_skip_68187 | 3660872 | 3661601 | 3660959 | 3660959 | Nonsense_Mutation | T | A | p.R234X |
| CHOL | TCGA-ZH-A8Y5-01 | exon_skip_68187 | 3660872 | 3661601 | 3661209 | 3661209 | Nonsense_Mutation | G | T | p.C150* |
| CHOL | TCGA-ZH-A8Y5-01 | exon_skip_68188 | 3661076 | 3661601 | 3661209 | 3661209 | Nonsense_Mutation | G | T | p.C150* |
| COAD | TCGA-AD-6964-01 | exon_skip_68187 | 3660872 | 3661601 | 3661226 | 3661226 | Nonsense_Mutation | G | A | p.R145X |
| COAD | TCGA-AD-6964-01 | exon_skip_68188 | 3661076 | 3661601 | 3661226 | 3661226 | Nonsense_Mutation | G | A | p.R145X |
| UCEC | TCGA-B5-A0JY-01 | exon_skip_68187 | 3660872 | 3661601 | 3661226 | 3661226 | Nonsense_Mutation | G | A | p.R145* |
| UCEC | TCGA-B5-A0JY-01 | exon_skip_68188 | 3661076 | 3661601 | 3661226 | 3661226 | Nonsense_Mutation | G | A | p.R145* |
| COAD | TCGA-AZ-4315-01 | exon_skip_68187 | 3660872 | 3661601 | 3661421 | 3661421 | Nonsense_Mutation | G | A | p.R80X |
| COAD | TCGA-AZ-4315-01 | exon_skip_68188 | 3661076 | 3661601 | 3661421 | 3661421 | Nonsense_Mutation | G | A | p.R80X |
| OV | TCGA-13-1501-01 | exon_skip_68187 | 3660872 | 3661601 | 3661421 | 3661421 | Nonsense_Mutation | G | A | p.R80* |
| OV | TCGA-13-1501-01 | exon_skip_68188 | 3661076 | 3661601 | 3661421 | 3661421 | Nonsense_Mutation | G | A | p.R80* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC151_ENDOMETRIUM | 3660872 | 3661601 | 3661502 | 3661502 | Frame_Shift_Del | G | - | p.L54fs |
| HEC151_ENDOMETRIUM | 3661076 | 3661601 | 3661502 | 3661502 | Frame_Shift_Del | G | - | p.L54fs |
| SNU349_KIDNEY | 3660872 | 3661601 | 3661502 | 3661502 | Frame_Shift_Del | G | - | p.L54fs |
| SNU349_KIDNEY | 3661076 | 3661601 | 3661502 | 3661502 | Frame_Shift_Del | G | - | p.L54fs |
| HCC2108_LUNG | 3660872 | 3661601 | 3661588 | 3661589 | In_Frame_Ins | - | TGA | p.24_24P>LT |
| HCC2108_LUNG | 3661076 | 3661601 | 3661588 | 3661589 | In_Frame_Ins | - | TGA | p.24_24P>LT |
| MORCPR_LUNG | 3660872 | 3661601 | 3661588 | 3661589 | In_Frame_Ins | - | TGA | p.24_24P>LT |
| MORCPR_LUNG | 3661076 | 3661601 | 3661588 | 3661589 | In_Frame_Ins | - | TGA | p.24_24P>LT |
| NCIH2110_LUNG | 3660872 | 3661601 | 3661084 | 3661084 | Missense_Mutation | T | A | p.H192L |
| NCIH2110_LUNG | 3661076 | 3661601 | 3661084 | 3661084 | Missense_Mutation | T | A | p.H192L |
| LNZTA3WT4_CENTRAL_NERVOUS_SYSTEM | 3660872 | 3661601 | 3661162 | 3661162 | Missense_Mutation | C | G | p.R166P |
| LNZTA3WT4_CENTRAL_NERVOUS_SYSTEM | 3661076 | 3661601 | 3661162 | 3661162 | Missense_Mutation | C | G | p.R166P |
| ISTSL1_LUNG | 3660872 | 3661601 | 3661177 | 3661177 | Missense_Mutation | C | A | p.G161V |
| ISTSL1_LUNG | 3661076 | 3661601 | 3661177 | 3661177 | Missense_Mutation | C | A | p.G161V |
| JHOC5_OVARY | 3660872 | 3661601 | 3661205 | 3661205 | Missense_Mutation | T | C | p.R152G |
| JHOC5_OVARY | 3661076 | 3661601 | 3661205 | 3661205 | Missense_Mutation | T | C | p.R152G |
| NCIH1770_LUNG | 3660872 | 3661601 | 3661273 | 3661273 | Missense_Mutation | G | A | p.P129L |
| NCIH1770_LUNG | 3661076 | 3661601 | 3661273 | 3661273 | Missense_Mutation | G | A | p.P129L |
| NCIH2106_LUNG | 3660872 | 3661601 | 3661273 | 3661273 | Missense_Mutation | G | A | p.P129L |
| NCIH2106_LUNG | 3661076 | 3661601 | 3661273 | 3661273 | Missense_Mutation | G | A | p.P129L |
| MZ7B_MATCHED_NORMAL_TISSUE | 3660872 | 3661601 | 3661307 | 3661307 | Missense_Mutation | C | T | p.G118R |
| MZ7B_MATCHED_NORMAL_TISSUE | 3661076 | 3661601 | 3661307 | 3661307 | Missense_Mutation | C | T | p.G118R |
| MZ7MEL_SKIN | 3660872 | 3661601 | 3661307 | 3661307 | Missense_Mutation | C | T | p.G118R |
| MZ7MEL_SKIN | 3661076 | 3661601 | 3661307 | 3661307 | Missense_Mutation | C | T | p.G118R |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3660872 | 3661601 | 3661313 | 3661313 | Missense_Mutation | T | C | p.T116A |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3661076 | 3661601 | 3661313 | 3661313 | Missense_Mutation | T | C | p.T116A |
| 22RV1_PROSTATE | 3660872 | 3661601 | 3661316 | 3661316 | Missense_Mutation | G | A | p.R115W |
| 22RV1_PROSTATE | 3661076 | 3661601 | 3661316 | 3661316 | Missense_Mutation | G | A | p.R115W |
| U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3660872 | 3661601 | 3661319 | 3661319 | Missense_Mutation | C | T | p.V114M |
| U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3661076 | 3661601 | 3661319 | 3661319 | Missense_Mutation | C | T | p.V114M |
| TUR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3660872 | 3661601 | 3661319 | 3661319 | Missense_Mutation | C | T | p.V114M |
| TUR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3661076 | 3661601 | 3661319 | 3661319 | Missense_Mutation | C | T | p.V114M |
| NH12_AUTONOMIC_GANGLIA | 3660872 | 3661601 | 3661321 | 3661321 | Missense_Mutation | G | A | p.A113V |
| NH12_AUTONOMIC_GANGLIA | 3661076 | 3661601 | 3661321 | 3661321 | Missense_Mutation | G | A | p.A113V |
| HEC151_ENDOMETRIUM | 3660872 | 3661601 | 3661403 | 3661403 | Missense_Mutation | G | A | p.P86S |
| HEC151_ENDOMETRIUM | 3661076 | 3661601 | 3661403 | 3661403 | Missense_Mutation | G | A | p.P86S |
| NCIH2286_LUNG | 3660872 | 3661601 | 3661429 | 3661429 | Missense_Mutation | T | C | p.D77G |
| NCIH2286_LUNG | 3661076 | 3661601 | 3661429 | 3661429 | Missense_Mutation | T | C | p.D77G |
| HCC2998_LARGE_INTESTINE | 3660872 | 3661601 | 3661459 | 3661459 | Missense_Mutation | G | T | p.S67Y |
| HCC2998_LARGE_INTESTINE | 3661076 | 3661601 | 3661459 | 3661459 | Missense_Mutation | G | T | p.S67Y |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3660872 | 3661601 | 3661466 | 3661466 | Missense_Mutation | G | A | p.R65W |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3661076 | 3661601 | 3661466 | 3661466 | Missense_Mutation | G | A | p.R65W |
| ISTMES1_PLEURA | 3660872 | 3661601 | 3661589 | 3661589 | Missense_Mutation | G | T | p.P24T |
| ISTMES1_PLEURA | 3661076 | 3661601 | 3661589 | 3661589 | Missense_Mutation | G | T | p.P24T |
| SUDHL5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3660872 | 3661601 | 3661589 | 3661589 | Missense_Mutation | G | T | p.P24T |
| SUDHL5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3661076 | 3661601 | 3661589 | 3661589 | Missense_Mutation | G | T | p.P24T |
| UMUC3_URINARY_TRACT | 3660872 | 3661601 | 3661589 | 3661589 | Missense_Mutation | G | T | p.P24T |
| UMUC3_URINARY_TRACT | 3661076 | 3661601 | 3661589 | 3661589 | Missense_Mutation | G | T | p.P24T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ART5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ART5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ART5 |
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RelatedDrugs for ART5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ART5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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