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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for IL22RA2 |
 Gene summary |
| Gene information | Gene symbol | IL22RA2 | Gene ID | 116379 |
| Gene name | interleukin 22 receptor subunit alpha 2 | |
| Synonyms | CRF2-10|CRF2-S1|CRF2X|IL-22BP|IL-22R-alpha-2|IL-22RA2|ZCYTOR16 | |
| Cytomap | 6q23.3 | |
| Type of gene | protein-coding | |
| Description | interleukin-22 receptor subunit alpha-2cytokine receptor class-II member 10cytokine receptor family type 2, soluble 1interleukin 22 receptor, alpha 2interleukin 22-binding protein | |
| Modification date | 20180523 | |
| UniProtAcc | Q969J5 | |
| Context | PubMed: IL22RA2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for IL22RA2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for IL22RA2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for IL22RA2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_462612 | 6 | 137464967:137466910:137468858:137469028:137476077:137476256 | 137468858:137469028 | ENSG00000164485.10 | ENST00000349184.4,ENST00000296980.2 |
| exon_skip_462614 | 6 | 137476077:137476256:137477895:137477991:137479483:137479619 | 137477895:137477991 | ENSG00000164485.10 | ENST00000296980.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for IL22RA2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_462614 | 6 | 137476077:137476256:137477895:137477991:137479483:137479619 | 137477895:137477991 | ENSG00000164485.10 | ENST00000296980.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for IL22RA2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296980 | 137468858 | 137469028 | Frame-shift |
| ENST00000296980 | 137477895 | 137477991 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296980 | 137477895 | 137477991 | In-frame |
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Infer the effects of exon skipping event on protein functional features for IL22RA2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296980 | 2903 | 263 | 137477895 | 137477991 | 499 | 594 | 66 | 97 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296980 | 2903 | 263 | 137477895 | 137477991 | 499 | 594 | 66 | 97 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q969J5 | 66 | 97 | 67 | 98 | Alternative sequence | ID=VSP_013105;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11390453,ECO:0000303|PubMed:11390454,ECO:0000303|PubMed:11481447,ECO:0000303|PubMed:11 |
| Q969J5 | 66 | 97 | 59 | 66 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G9V |
| Q969J5 | 66 | 97 | 22 | 263 | Chain | ID=PRO_0000011016;Note=Interleukin-22 receptor subunit alpha-2 |
| Q969J5 | 66 | 97 | 26 | 68 | Domain | Note=Fibronectin type-III 1 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q969J5 | 66 | 97 | 67 | 98 | Alternative sequence | ID=VSP_013105;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11390453,ECO:0000303|PubMed:11390454,ECO:0000303|PubMed:11481447,ECO:0000303|PubMed:11 |
| Q969J5 | 66 | 97 | 59 | 66 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G9V |
| Q969J5 | 66 | 97 | 22 | 263 | Chain | ID=PRO_0000011016;Note=Interleukin-22 receptor subunit alpha-2 |
| Q969J5 | 66 | 97 | 26 | 68 | Domain | Note=Fibronectin type-III 1 |
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SNVs in the skipped exons for IL22RA2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DLBC | TCGA-FF-A7CQ-01 | exon_skip_462612 | 137468859 | 137469028 | 137468925 | 137468926 | Frame_Shift_Ins | - | T | p.N192fs |
| ESCA | TCGA-L7-A6VZ-01 | exon_skip_462612 | 137468859 | 137469028 | 137468892 | 137468892 | Nonsense_Mutation | G | T | p.Y203* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| 22RV1_PROSTATE | 137468859 | 137469028 | 137468926 | 137468926 | Frame_Shift_Del | T | - | p.N192fs |
| DOV13_OVARY | 137468859 | 137469028 | 137468926 | 137468926 | Frame_Shift_Del | T | - | p.N192fs |
| HEC59_ENDOMETRIUM | 137468859 | 137469028 | 137468926 | 137468926 | Frame_Shift_Del | T | - | p.N192fs |
| HCT15_LARGE_INTESTINE | 137468859 | 137469028 | 137468926 | 137468926 | Frame_Shift_Del | T | - | p.N192fs |
| HS294T_SKIN | 137468859 | 137469028 | 137468926 | 137468926 | Frame_Shift_Del | T | - | p.N192fs |
| HT115_LARGE_INTESTINE | 137468859 | 137469028 | 137468885 | 137468885 | Missense_Mutation | A | C | p.F206V |
| 5637_URINARY_TRACT | 137468859 | 137469028 | 137468903 | 137468903 | Missense_Mutation | C | T | p.E200K |
| HEC251_ENDOMETRIUM | 137468859 | 137469028 | 137468928 | 137468928 | Missense_Mutation | T | G | p.K191N |
| CHLA266_SOFT_TISSUE | 137468859 | 137469028 | 137468933 | 137468934 | Missense_Mutation | CC | TT | p.E190K |
| JHUEM7_ENDOMETRIUM | 137468859 | 137469028 | 137468939 | 137468939 | Missense_Mutation | G | C | p.Q188E |
| JHU028_LUNG | 137468859 | 137469028 | 137468996 | 137468996 | Missense_Mutation | G | T | p.Q169K |
| SNU1040_LARGE_INTESTINE | 137477896 | 137477991 | 137477977 | 137477977 | Missense_Mutation | C | A | p.S71I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IL22RA2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL22RA2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL22RA2 |
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RelatedDrugs for IL22RA2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IL22RA2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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