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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SLC25A25 |
 Gene summary |
| Gene information | Gene symbol | SLC25A25 | Gene ID | 114789 |
| Gene name | solute carrier family 25 member 25 | |
| Synonyms | MCSC|PCSCL|SCAMC-2 | |
| Cytomap | 9q34.11 | |
| Type of gene | protein-coding | |
| Description | calcium-binding mitochondrial carrier protein SCaMC-2mitochondrial ATP-Mg/Pi carrier protein 3mitochondrial Ca(2+)-dependent solute carrier protein 3short calcium-binding mitochondrial carrier 2small calcium-binding mitochondrial carrier 2solute carr | |
| Modification date | 20180523 | |
| UniProtAcc | Q6KCM7 | |
| Context | PubMed: SLC25A25 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SLC25A25 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLC25A25 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLC25A25 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_499406 | 9 | 130860815:130861004:130861553:130861664:130863374:130863501 | 130861553:130861664 | ENSG00000148339.8 | ENST00000472769.1 |
| exon_skip_499409 | 9 | 130863587:130863675:130864358:130864394:130864648:130864760 | 130864358:130864394 | ENSG00000148339.8 | ENST00000373069.5,ENST00000373066.5 |
| exon_skip_499410 | 9 | 130864648:130864760:130865959:130866118:130868007:130868160 | 130865959:130866118 | ENSG00000148339.8 | ENST00000373069.5,ENST00000373064.5,ENST00000373066.5,ENST00000433501.1,ENST00000432073.2,ENST00000373068.2 |
| exon_skip_499411 | 9 | 130866000:130866118:130868007:130868160:130868428:130868536 | 130868007:130868160 | ENSG00000148339.8 | ENST00000373069.5,ENST00000373064.5,ENST00000373066.5,ENST00000433501.1,ENST00000432073.2,ENST00000373068.2 |
| exon_skip_499415 | 9 | 130868007:130868160:130868428:130868536:130868631:130868799 | 130868428:130868536 | ENSG00000148339.8 | ENST00000373069.5,ENST00000373064.5,ENST00000373066.5,ENST00000433501.1,ENST00000432073.2,ENST00000373068.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLC25A25 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_499406 | 9 | 130860815:130861004:130861553:130861664:130863374:130863501 | 130861553:130861664 | ENSG00000148339.8 | ENST00000472769.1 |
| exon_skip_499409 | 9 | 130863587:130863675:130864358:130864394:130864648:130864760 | 130864358:130864394 | ENSG00000148339.8 | ENST00000373069.5,ENST00000373066.5 |
| exon_skip_499410 | 9 | 130864648:130864760:130865959:130866118:130868007:130868160 | 130865959:130866118 | ENSG00000148339.8 | ENST00000373068.2,ENST00000373069.5,ENST00000373066.5,ENST00000432073.2,ENST00000373064.5,ENST00000433501.1 |
| exon_skip_499411 | 9 | 130866000:130866118:130868007:130868160:130868428:130868536 | 130868007:130868160 | ENSG00000148339.8 | ENST00000373068.2,ENST00000373069.5,ENST00000373066.5,ENST00000432073.2,ENST00000373064.5,ENST00000433501.1 |
| exon_skip_499415 | 9 | 130868007:130868160:130868428:130868536:130868631:130868799 | 130868428:130868536 | ENSG00000148339.8 | ENST00000373068.2,ENST00000373069.5,ENST00000373066.5,ENST00000432073.2,ENST00000373064.5,ENST00000433501.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLC25A25 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373064 | 130865959 | 130866118 | In-frame |
| ENST00000373064 | 130868007 | 130868160 | In-frame |
| ENST00000373064 | 130868428 | 130868536 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373064 | 130865959 | 130866118 | In-frame |
| ENST00000373064 | 130868007 | 130868160 | In-frame |
| ENST00000373064 | 130868428 | 130868536 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLC25A25 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000373064 | 3491 | 469 | 130865959 | 130866118 | 750 | 908 | 162 | 215 |
| ENST00000373064 | 3491 | 469 | 130868007 | 130868160 | 909 | 1061 | 215 | 266 |
| ENST00000373064 | 3491 | 469 | 130868428 | 130868536 | 1062 | 1169 | 266 | 302 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000373064 | 3491 | 469 | 130865959 | 130866118 | 750 | 908 | 162 | 215 |
| ENST00000373064 | 3491 | 469 | 130868007 | 130868160 | 909 | 1061 | 215 | 266 |
| ENST00000373064 | 3491 | 469 | 130868428 | 130868536 | 1062 | 1169 | 266 | 302 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SLC25A25 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
SLC25A25_ESCA_exon_skip_499409_psi_boxplot.png |
SLC25A25_LIHC_exon_skip_499409_psi_boxplot.png |
SLC25A25_PAAD_exon_skip_499410_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_499409 | 130864359 | 130864394 | 130864379 | 130864379 | Frame_Shift_Del | G | - | p.W152fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_499410 | 130865960 | 130866118 | 130865963 | 130865963 | Frame_Shift_Del | T | - | p.F196fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_499411 | 130868008 | 130868160 | 130868074 | 130868074 | Frame_Shift_Del | G | - | p.G270fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_499411 | 130868008 | 130868160 | 130868116 | 130868116 | Frame_Shift_Del | A | - | p.K284fs |
| PRAD | TCGA-CH-5769-01 | exon_skip_499410 | 130865960 | 130866118 | 130866086 | 130866087 | Frame_Shift_Ins | - | C | p.P237fs |
| LIHC | TCGA-BC-A10S-01 | exon_skip_499415 | 130868429 | 130868536 | 130868488 | 130868489 | Frame_Shift_Ins | - | G | p.V319fs |
| ESCA | TCGA-IC-A6RE-01 | exon_skip_499409 | 130864359 | 130864394 | 130864363 | 130864363 | Nonsense_Mutation | C | T | p.R147X |
| ESCA | TCGA-IC-A6RE-01 | exon_skip_499409 | 130864359 | 130864394 | 130864363 | 130864363 | Nonsense_Mutation | C | T | p.R161* |
| UCEC | TCGA-BS-A0UJ-01 | exon_skip_499410 | 130865960 | 130866118 | 130865958 | 130865958 | Splice_Site | A | G | e5-2 |
| PAAD | TCGA-IB-7651-01 | exon_skip_499410 | 130865960 | 130866118 | 130865959 | 130865959 | Splice_Site | G | A | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-IB-7651-01 |
| Cancer type: PAAD | |
| ESID: exon_skip_499410 | |
| Skipped exon start: 130865960 | |
| Skipped exon end: 130866118 | |
| Mutation start: 130865959 | |
| Mutation end: 130865959 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: . | |
exon_skip_113241_PAAD_TCGA-IB-7651-01.png | |
exon_skip_115380_PAAD_TCGA-IB-7651-01.png | |
exon_skip_124564_PAAD_TCGA-IB-7651-01.png | |
exon_skip_135806_PAAD_TCGA-IB-7651-01.png | |
exon_skip_139341_PAAD_TCGA-IB-7651-01.png | |
exon_skip_153733_PAAD_TCGA-IB-7651-01.png | |
exon_skip_155805_PAAD_TCGA-IB-7651-01.png | |
exon_skip_18053_PAAD_TCGA-IB-7651-01.png | |
exon_skip_18056_PAAD_TCGA-IB-7651-01.png | |
exon_skip_23067_PAAD_TCGA-IB-7651-01.png | |
exon_skip_287059_PAAD_TCGA-IB-7651-01.png | |
exon_skip_294631_PAAD_TCGA-IB-7651-01.png | |
exon_skip_298512_PAAD_TCGA-IB-7651-01.png | |
exon_skip_306900_PAAD_TCGA-IB-7651-01.png | |
exon_skip_307723_PAAD_TCGA-IB-7651-01.png | |
exon_skip_315960_PAAD_TCGA-IB-7651-01.png | |
exon_skip_324675_PAAD_TCGA-IB-7651-01.png | |
exon_skip_330351_PAAD_TCGA-IB-7651-01.png | |
exon_skip_334330_PAAD_TCGA-IB-7651-01.png | |
exon_skip_341784_PAAD_TCGA-IB-7651-01.png | |
exon_skip_343314_PAAD_TCGA-IB-7651-01.png | |
exon_skip_348329_PAAD_TCGA-IB-7651-01.png | |
exon_skip_354232_PAAD_TCGA-IB-7651-01.png | |
exon_skip_370626_PAAD_TCGA-IB-7651-01.png | |
exon_skip_377740_PAAD_TCGA-IB-7651-01.png | |
exon_skip_385032_PAAD_TCGA-IB-7651-01.png | |
exon_skip_390031_PAAD_TCGA-IB-7651-01.png | |
exon_skip_422548_PAAD_TCGA-IB-7651-01.png | |
exon_skip_424536_PAAD_TCGA-IB-7651-01.png | |
exon_skip_431753_PAAD_TCGA-IB-7651-01.png | |
exon_skip_432982_PAAD_TCGA-IB-7651-01.png | |
exon_skip_435489_PAAD_TCGA-IB-7651-01.png | |
exon_skip_435729_PAAD_TCGA-IB-7651-01.png | |
exon_skip_441705_PAAD_TCGA-IB-7651-01.png | |
exon_skip_448879_PAAD_TCGA-IB-7651-01.png | |
exon_skip_468347_PAAD_TCGA-IB-7651-01.png | |
exon_skip_494000_PAAD_TCGA-IB-7651-01.png | |
exon_skip_494029_PAAD_TCGA-IB-7651-01.png | |
exon_skip_499410_PAAD_TCGA-IB-7651-01.png | |
exon_skip_499695_PAAD_TCGA-IB-7651-01.png | |
exon_skip_499697_PAAD_TCGA-IB-7651-01.png | |
exon_skip_79905_PAAD_TCGA-IB-7651-01.png | |
exon_skip_80096_PAAD_TCGA-IB-7651-01.png | |
exon_skip_95924_PAAD_TCGA-IB-7651-01.png | |
 | Sample: TCGA-IC-A6RE-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_499409 | |
| Skipped exon start: 130864359 | |
| Skipped exon end: 130864394 | |
| Mutation start: 130864363 | |
| Mutation end: 130864363 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.R147X | |
| Sample: TCGA-IC-A6RE-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_499409 | |
| Skipped exon start: 130864359 | |
| Skipped exon end: 130864394 | |
| Mutation start: 130864363 | |
| Mutation end: 130864363 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.R161* | |
exon_skip_379913_ESCA_TCGA-IC-A6RE-01.png | |
exon_skip_499409_ESCA_TCGA-IC-A6RE-01.png | |
exon_skip_68768_ESCA_TCGA-IC-A6RE-01.png | |
exon_skip_80515_ESCA_TCGA-IC-A6RE-01.png | |
 | Sample: TCGA-G3-A3CJ-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_499409 | |
| Skipped exon start: 130864359 | |
| Skipped exon end: 130864394 | |
| Mutation start: 130864379 | |
| Mutation end: 130864379 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: G | |
| Mutation seq: - | |
| AAchange: p.W152fs | |
exon_skip_101516_LIHC_TCGA-G3-A3CJ-01.png | |
exon_skip_106378_LIHC_TCGA-G3-A3CJ-01.png | |
exon_skip_106524_LIHC_TCGA-G3-A3CJ-01.png | |
exon_skip_109529_LIHC_TCGA-G3-A3CJ-01.png | |
exon_skip_109778_LIHC_TCGA-G3-A3CJ-01.png | |
exon_skip_11286_LIHC_TCGA-G3-A3CJ-01.png | |
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exon_skip_11349_LIHC_TCGA-G3-A3CJ-01.png | |
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| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| PECAPJ34CLONEC12_UPPER_AERODIGESTIVE_TRACT | 130865960 | 130866118 | 130866093 | 130866094 | Frame_Shift_Del | TG | - | p.L207fs |
| EN_ENDOMETRIUM | 130865960 | 130866118 | 130866086 | 130866087 | Frame_Shift_Ins | - | C | p.A205fs |
| SNU1040_LARGE_INTESTINE | 130868008 | 130868160 | 130868014 | 130868014 | Missense_Mutation | G | A | p.A218T |
| MCC26_SKIN | 130868008 | 130868160 | 130868093 | 130868093 | Missense_Mutation | G | A | p.R244Q |
| MFE319_ENDOMETRIUM | 130868008 | 130868160 | 130868128 | 130868128 | Missense_Mutation | G | A | p.E256K |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 130868008 | 130868160 | 130868152 | 130868152 | Missense_Mutation | T | C | p.Y264H |
| HCT15_LARGE_INTESTINE | 130868429 | 130868536 | 130868505 | 130868505 | Missense_Mutation | C | A | p.A292D |
| CHP134_AUTONOMIC_GANGLIA | 130868429 | 130868536 | 130868518 | 130868518 | Missense_Mutation | C | A | p.S296R |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC25A25 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC25A25 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC25A25 |
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RelatedDrugs for SLC25A25 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC25A25 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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