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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STK38 |
 Gene summary |
| Gene information | Gene symbol | STK38 | Gene ID | 11329 |
| Gene name | serine/threonine kinase 38 | |
| Synonyms | NDR|NDR1 | |
| Cytomap | 6p21.31 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 38NDR1 protein kinaseNdr Ser/Thr kinase-like proteinnuclear Dbf2-related kinase 1 | |
| Modification date | 20180523 | |
| UniProtAcc | Q15208 | |
| Context | PubMed: STK38 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STK38 | GO:0006464 | cellular protein modification process | 7761441 |
| STK38 | GO:0006468 | protein phosphorylation | 12493777 |
| STK38 | GO:0035556 | intracellular signal transduction | 12493777 |
| STK38 | GO:0043407 | negative regulation of MAP kinase activity | 17906693 |
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Exon skipping events across known transcript of Ensembl for STK38 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STK38 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STK38 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_459041 | 6 | 36465556:36465652:36466139:36466263:36467649:36467767 | 36466139:36466263 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459049 | 6 | 36466139:36466263:36467649:36467767:36474359:36474421 | 36467649:36467767 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459056 | 6 | 36474359:36474421:36475276:36475379:36483114:36483269 | 36475276:36475379 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459059 | 6 | 36483114:36483269:36485493:36485617:36489510:36489594 | 36485493:36485617 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459060 | 6 | 36485493:36485617:36489510:36489594:36492117:36492240 | 36489510:36489594 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459062 | 6 | 36492117:36492240:36493367:36493419:36507848:36507981 | 36493367:36493419 | ENSG00000112079.8 | ENST00000229812.7 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STK38 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_459041 | 6 | 36465556:36465652:36466139:36466263:36467649:36467767 | 36466139:36466263 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459049 | 6 | 36466139:36466263:36467649:36467767:36474359:36474421 | 36467649:36467767 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459056 | 6 | 36474359:36474421:36475276:36475379:36483114:36483269 | 36475276:36475379 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459059 | 6 | 36483114:36483269:36485493:36485617:36489510:36489594 | 36485493:36485617 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459060 | 6 | 36485493:36485617:36489510:36489594:36492117:36492240 | 36489510:36489594 | ENSG00000112079.8 | ENST00000229812.7 |
| exon_skip_459062 | 6 | 36492117:36492240:36493367:36493419:36507848:36507981 | 36493367:36493419 | ENSG00000112079.8 | ENST00000229812.7 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STK38 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000229812 | 36466139 | 36466263 | Frame-shift |
| ENST00000229812 | 36467649 | 36467767 | Frame-shift |
| ENST00000229812 | 36475276 | 36475379 | Frame-shift |
| ENST00000229812 | 36485493 | 36485617 | Frame-shift |
| ENST00000229812 | 36493367 | 36493419 | Frame-shift |
| ENST00000229812 | 36489510 | 36489594 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000229812 | 36466139 | 36466263 | Frame-shift |
| ENST00000229812 | 36467649 | 36467767 | Frame-shift |
| ENST00000229812 | 36475276 | 36475379 | Frame-shift |
| ENST00000229812 | 36485493 | 36485617 | Frame-shift |
| ENST00000229812 | 36493367 | 36493419 | Frame-shift |
| ENST00000229812 | 36489510 | 36489594 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STK38 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000229812 | 3593 | 465 | 36489510 | 36489594 | 593 | 676 | 102 | 130 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000229812 | 3593 | 465 | 36489510 | 36489594 | 593 | 676 | 102 | 130 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15208 | 102 | 130 | 118 | 118 | Binding site | Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:12493777,ECO:0000269|PubMed:7761441;Dbxref=PMID:12493777,PMID:7761441 |
| Q15208 | 102 | 130 | 2 | 465 | Chain | ID=PRO_0000086718;Note=Serine/threonine-protein kinase 38 |
| Q15208 | 102 | 130 | 89 | 382 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000312;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000312|EMBL:CAA84485.1 |
| Q15208 | 102 | 130 | 118 | 118 | Mutagenesis | Note=Loss of autophosphorylation and kinase activity. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12493777,ECO:0000269|PubMed:7761441;Dbxref=PMID:12493777,PMID:7761441 |
| Q15208 | 102 | 130 | 95 | 103 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:O95835,ECO:0000255|PROSITE-ProRule:PRU00159 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15208 | 102 | 130 | 118 | 118 | Binding site | Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:12493777,ECO:0000269|PubMed:7761441;Dbxref=PMID:12493777,PMID:7761441 |
| Q15208 | 102 | 130 | 2 | 465 | Chain | ID=PRO_0000086718;Note=Serine/threonine-protein kinase 38 |
| Q15208 | 102 | 130 | 89 | 382 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000312;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000312|EMBL:CAA84485.1 |
| Q15208 | 102 | 130 | 118 | 118 | Mutagenesis | Note=Loss of autophosphorylation and kinase activity. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12493777,ECO:0000269|PubMed:7761441;Dbxref=PMID:12493777,PMID:7761441 |
| Q15208 | 102 | 130 | 95 | 103 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:O95835,ECO:0000255|PROSITE-ProRule:PRU00159 |
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SNVs in the skipped exons for STK38 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_459041 | 36466140 | 36466263 | 36466143 | 36466143 | Frame_Shift_Del | A | - | p.L358fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_459041 | 36466140 | 36466263 | 36466236 | 36466236 | Frame_Shift_Del | G | - | p.P327fs |
| STAD | TCGA-BR-6452-01 | exon_skip_459060 | 36489511 | 36489594 | 36489556 | 36489556 | Nonsense_Mutation | A | T | p.Y115* |
| READ | TCGA-F5-6814-01 | exon_skip_459062 | 36493368 | 36493419 | 36493406 | 36493406 | Nonsense_Mutation | C | A | p.E49X |
| OV | TCGA-31-1950-01 | exon_skip_459041 | 36466140 | 36466263 | 36466139 | 36466139 | Splice_Site | C | T | p.R359_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36493368 | 36493419 | 36493385 | 36493387 | In_Frame_Del | CTT | - | p.E55del |
| HEC108_ENDOMETRIUM | 36466140 | 36466263 | 36466260 | 36466260 | Missense_Mutation | T | C | p.Y319C |
| LNCAPCLONEFGC_PROSTATE | 36485494 | 36485617 | 36485564 | 36485564 | Missense_Mutation | C | A | p.W148C |
| SNU175_LARGE_INTESTINE | 36485494 | 36485617 | 36485578 | 36485578 | Missense_Mutation | C | T | p.A144T |
| HEC1A_ENDOMETRIUM | 36489511 | 36489594 | 36489539 | 36489539 | Missense_Mutation | C | A | p.R121L |
| HEC1_ENDOMETRIUM | 36489511 | 36489594 | 36489539 | 36489539 | Missense_Mutation | C | A | p.R121L |
| HEC1B_ENDOMETRIUM | 36489511 | 36489594 | 36489539 | 36489539 | Missense_Mutation | C | A | p.R121L |
| SNU81_LARGE_INTESTINE | 36493368 | 36493419 | 36493376 | 36493376 | Missense_Mutation | C | A | p.D59Y |
| HEC251_ENDOMETRIUM | 36493368 | 36493419 | 36493413 | 36493413 | Missense_Mutation | C | A | p.K46N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK38 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK38 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK38 |
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RelatedDrugs for STK38 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q15208 | DB12010 | Fostamatinib | Serine/threonine-protein kinase 38 | small molecule | approved|investigational |
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RelatedDiseases for STK38 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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