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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STRAP |
 Gene summary |
| Gene information | Gene symbol | STRAP | Gene ID | 11171 |
| Gene name | serine/threonine kinase receptor associated protein | |
| Synonyms | MAWD|PT-WD|UNRIP | |
| Cytomap | 12p12.3 | |
| Type of gene | protein-coding | |
| Description | serine-threonine kinase receptor-associated proteinMAP activator with WD repeatsWD-40 repeat protein PT-WDunr-interacting protein | |
| Modification date | 20180522 | |
| UniProtAcc | Q9Y3F4 | |
| Context | PubMed: STRAP [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STRAP | GO:0000387 | spliceosomal snRNP assembly | 18984161 |
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Exon skipping events across known transcript of Ensembl for STRAP from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STRAP |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STRAP |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_80401 | 12 | 16035328:16035753:16036016:16036055:16036474:16036610 | 16036016:16036055 | ENSG00000023734.6 | ENST00000025399.6 |
| exon_skip_80403 | 12 | 16035328:16035753:16036474:16036610:16042861:16042939 | 16036474:16036610 | ENSG00000023734.6 | ENST00000419869.2 |
| exon_skip_80404 | 12 | 16036016:16036055:16036474:16036610:16042861:16042943 | 16036474:16036610 | ENSG00000023734.6 | ENST00000025399.6 |
| exon_skip_80405 | 12 | 16046980:16047077:16048292:16048430:16050815:16050952 | 16048292:16048430 | ENSG00000023734.6 | ENST00000538352.1,ENST00000419869.2,ENST00000541731.1,ENST00000025399.6 |
| exon_skip_80407 | 12 | 16052837:16052987:16053880:16053946:16055850:16055948 | 16053880:16053946 | ENSG00000023734.6 | ENST00000538352.1,ENST00000419869.2,ENST00000541731.1,ENST00000025399.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STRAP |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_80401 | 12 | 16035328:16035753:16036016:16036055:16036474:16036610 | 16036016:16036055 | ENSG00000023734.6 | ENST00000025399.6 |
| exon_skip_80403 | 12 | 16035328:16035753:16036474:16036610:16042861:16042939 | 16036474:16036610 | ENSG00000023734.6 | ENST00000419869.2 |
| exon_skip_80404 | 12 | 16036016:16036055:16036474:16036610:16042861:16042943 | 16036474:16036610 | ENSG00000023734.6 | ENST00000025399.6 |
| exon_skip_80405 | 12 | 16046980:16047077:16048292:16048430:16050815:16050952 | 16048292:16048430 | ENSG00000023734.6 | ENST00000541731.1,ENST00000538352.1,ENST00000025399.6,ENST00000419869.2 |
| exon_skip_80407 | 12 | 16052837:16052987:16053880:16053946:16055850:16055948 | 16053880:16053946 | ENSG00000023734.6 | ENST00000541731.1,ENST00000538352.1,ENST00000025399.6,ENST00000419869.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STRAP |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000419869 | 16036474 | 16036610 | Frame-shift |
| ENST00000419869 | 16048292 | 16048430 | In-frame |
| ENST00000419869 | 16053880 | 16053946 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000419869 | 16036474 | 16036610 | Frame-shift |
| ENST00000419869 | 16048292 | 16048430 | In-frame |
| ENST00000419869 | 16053880 | 16053946 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STRAP |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000419869 | 1883 | 350 | 16048292 | 16048430 | 814 | 951 | 167 | 212 |
| ENST00000419869 | 1883 | 350 | 16053880 | 16053946 | 1239 | 1304 | 308 | 330 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000419869 | 1883 | 350 | 16048292 | 16048430 | 814 | 951 | 167 | 212 |
| ENST00000419869 | 1883 | 350 | 16053880 | 16053946 | 1239 | 1304 | 308 | 330 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y3F4 | 167 | 212 | 1 | 350 | Chain | ID=PRO_0000051230;Note=Serine-threonine kinase receptor-associated protein |
| Q9Y3F4 | 167 | 212 | 141 | 179 | Repeat | Note=WD 4 |
| Q9Y3F4 | 167 | 212 | 180 | 212 | Repeat | Note=WD 5 |
| Q9Y3F4 | 308 | 330 | 1 | 350 | Chain | ID=PRO_0000051230;Note=Serine-threonine kinase receptor-associated protein |
| Q9Y3F4 | 308 | 330 | 312 | 312 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y3F4 | 167 | 212 | 1 | 350 | Chain | ID=PRO_0000051230;Note=Serine-threonine kinase receptor-associated protein |
| Q9Y3F4 | 167 | 212 | 141 | 179 | Repeat | Note=WD 4 |
| Q9Y3F4 | 167 | 212 | 180 | 212 | Repeat | Note=WD 5 |
| Q9Y3F4 | 308 | 330 | 1 | 350 | Chain | ID=PRO_0000051230;Note=Serine-threonine kinase receptor-associated protein |
| Q9Y3F4 | 308 | 330 | 312 | 312 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
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SNVs in the skipped exons for STRAP |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MESO | TCGA-SC-A6LN-01 | exon_skip_80405 | 16048293 | 16048430 | 16048340 | 16048341 | Frame_Shift_Del | AT | - | p.N183fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_80405 | 16048293 | 16048430 | 16048413 | 16048413 | Frame_Shift_Del | T | - | p.A207fs |
| PAAD | TCGA-FB-A7DR-01 | exon_skip_80404 exon_skip_80403 | 16036475 | 16036610 | 16036495 | 16036495 | Nonsense_Mutation | C | T | p.Q45* |
| BLCA | TCGA-GV-A6ZA-01 | exon_skip_80405 | 16048293 | 16048430 | 16048298 | 16048298 | Nonsense_Mutation | G | A | p.W169* |
| UCEC | TCGA-BS-A0UF-01 | exon_skip_80405 | 16048293 | 16048430 | 16048318 | 16048318 | Nonsense_Mutation | G | T | p.E176* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ASH3_THYROID | 16036475 | 16036610 | 16036499 | 16036500 | Frame_Shift_Ins | - | AGAT | p.-47fs |
| ETK1_BILIARY_TRACT | 16036475 | 16036610 | 16036517 | 16036517 | Missense_Mutation | T | C | p.I52T |
| CP66MEL_SKIN | 16036475 | 16036610 | 16036553 | 16036553 | Missense_Mutation | G | A | p.G64D |
| S117_SOFT_TISSUE | 16048293 | 16048430 | 16048300 | 16048300 | Missense_Mutation | G | C | p.D170H |
| COLO783_SKIN | 16048293 | 16048430 | 16048369 | 16048369 | Missense_Mutation | C | T | p.P193S |
| BT12_SOFT_TISSUE | 16048293 | 16048430 | 16048406 | 16048406 | Missense_Mutation | C | G | p.S205C |
| HCC1438_LUNG | 16048293 | 16048430 | 16048375 | 16048375 | Nonsense_Mutation | G | T | p.G195* |
| HEC251_ENDOMETRIUM | 16048293 | 16048430 | 16048429 | 16048429 | Splice_Site | A | G | p.S213G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STRAP |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STRAP |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STRAP |
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RelatedDrugs for STRAP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STRAP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| STRAP | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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