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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DIDO1 |
 Gene summary |
| Gene information | Gene symbol | DIDO1 | Gene ID | 11083 |
| Gene name | death inducer-obliterator 1 | |
| Synonyms | BYE1|C20orf158|DATF-1|DATF1|DIDO2|DIDO3|DIO-1|DIO1|dJ885L7.8 | |
| Cytomap | 20q13.33 | |
| Type of gene | protein-coding | |
| Description | death-inducer obliterator 1death-associated transcription factor 1 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9BTC0 | |
| Context | PubMed: DIDO1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DIDO1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DIDO1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DIDO1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_358591 | 20 | 61522311:61522507:61523338:61523428:61524160:61524314 | 61523338:61523428 | ENSG00000101191.12 | ENST00000266070.4,ENST00000395343.1,ENST00000395335.2,ENST00000395340.1 |
| exon_skip_358592 | 20 | 61526161:61526266:61526400:61526517:61527584:61527744 | 61526400:61526517 | ENSG00000101191.12 | ENST00000266070.4,ENST00000395343.1,ENST00000395335.2,ENST00000395340.1 |
| exon_skip_358601 | 20 | 61542125:61542966:61545561:61545758:61557783:61557821 | 61545561:61545758 | ENSG00000101191.12 | ENST00000354665.4 |
| exon_skip_358602 | 20 | 61542125:61542966:61545561:61545758:61557790:61557823 | 61545561:61545758 | ENSG00000101191.12 | ENST00000370368.1,ENST00000395343.1,ENST00000395340.1 |
| exon_skip_358603 | 20 | 61542125:61542966:61545561:61545758:61569147:61569274 | 61545561:61545758 | ENSG00000101191.12 | ENST00000266071.5,ENST00000370371.4,ENST00000395335.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DIDO1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_358591 | 20 | 61522311:61522507:61523338:61523428:61524160:61524314 | 61523338:61523428 | ENSG00000101191.12 | ENST00000266070.4,ENST00000395343.1,ENST00000395340.1,ENST00000395335.2 |
| exon_skip_358592 | 20 | 61526161:61526266:61526400:61526517:61527584:61527744 | 61526400:61526517 | ENSG00000101191.12 | ENST00000266070.4,ENST00000395343.1,ENST00000395340.1,ENST00000395335.2 |
| exon_skip_358601 | 20 | 61542125:61542966:61545561:61545758:61557783:61557821 | 61545561:61545758 | ENSG00000101191.12 | ENST00000354665.4 |
| exon_skip_358602 | 20 | 61542125:61542966:61545561:61545758:61557790:61557823 | 61545561:61545758 | ENSG00000101191.12 | ENST00000395343.1,ENST00000395340.1,ENST00000370368.1 |
| exon_skip_358603 | 20 | 61542125:61542966:61545561:61545758:61569147:61569274 | 61545561:61545758 | ENSG00000101191.12 | ENST00000395335.2,ENST00000370371.4,ENST00000266071.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DIDO1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395340 | 61545561 | 61545758 | 3UTR-3UTR |
| ENST00000395340 | 61523338 | 61523428 | In-frame |
| ENST00000395340 | 61526400 | 61526517 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395340 | 61545561 | 61545758 | 3UTR-3UTR |
| ENST00000395340 | 61523338 | 61523428 | In-frame |
| ENST00000395340 | 61526400 | 61526517 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DIDO1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000395340 | 7568 | 2240 | 61526400 | 61526517 | 2479 | 2595 | 738 | 777 |
| ENST00000395340 | 7568 | 2240 | 61523338 | 61523428 | 3520 | 3609 | 1085 | 1115 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000395340 | 7568 | 2240 | 61526400 | 61526517 | 2479 | 2595 | 738 | 777 |
| ENST00000395340 | 7568 | 2240 | 61523338 | 61523428 | 3520 | 3609 | 1085 | 1115 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for DIDO1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BRCA | TCGA-C8-A132-01 | exon_skip_358591 | 61523339 | 61523428 | 61523338 | 61523338 | Splice_Site | C | G | e12+1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NY_BONE | 61526401 | 61526517 | 61526467 | 61526467 | Frame_Shift_Del | C | - | p.V755fs |
| NCIH1299_LUNG | 61523339 | 61523428 | 61523384 | 61523384 | Missense_Mutation | C | G | p.K1100N |
| DV90_LUNG | 61523339 | 61523428 | 61523389 | 61523389 | Missense_Mutation | G | A | p.P1099S |
| OVCA420_OVARY | 61523339 | 61523428 | 61523413 | 61523413 | Missense_Mutation | T | C | p.I1091V |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 61526401 | 61526517 | 61526408 | 61526408 | Missense_Mutation | G | A | p.A775V |
| NCIH1650_LUNG | 61526401 | 61526517 | 61526418 | 61526418 | Missense_Mutation | C | T | p.E772K |
| NCCSTCK140_STOMACH | 61526401 | 61526517 | 61526445 | 61526445 | Missense_Mutation | C | T | p.V763I |
| HCC366_LUNG | 61526401 | 61526517 | 61526477 | 61526477 | Missense_Mutation | G | A | p.A752V |
| SNU1040_LARGE_INTESTINE | 61526401 | 61526517 | 61526496 | 61526496 | Missense_Mutation | G | A | p.R746C |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DIDO1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DIDO1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DIDO1 |
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RelatedDrugs for DIDO1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DIDO1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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