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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PIM2 |
 Gene summary |
| Gene information | Gene symbol | PIM2 | Gene ID | 11040 |
| Gene name | Pim-2 proto-oncogene, serine/threonine kinase | |
| Synonyms | - | |
| Cytomap | Xp11.23 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase pim-2pim-2 oncogenepim-2hproto-oncogene Pim-2 (serine threonine kinase) | |
| Modification date | 20180523 | |
| UniProtAcc | Q9P1W9 | |
| Context | PubMed: PIM2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PIM2 | GO:0000082 | G1/S transition of mitotic cell cycle | 20307683 |
| PIM2 | GO:0006468 | protein phosphorylation | 18593906 |
| PIM2 | GO:0008285 | negative regulation of cell proliferation | 20307683 |
| PIM2 | GO:0043066 | negative regulation of apoptotic process | 18675992 |
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Exon skipping events across known transcript of Ensembl for PIM2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PIM2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PIM2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_514771 | X | 48771380:48771571:48771671:48771848:48772296:48772665 | 48771671:48771848 | ENSG00000102096.9 | ENST00000376509.4 |
| exon_skip_514778 | X | 48771672:48771848:48772296:48772669:48775057:48775108 | 48772296:48772669 | ENSG00000102096.9 | ENST00000376509.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PIM2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_514771 | X | 48771380:48771571:48771671:48771848:48772296:48772665 | 48771671:48771848 | ENSG00000102096.9 | ENST00000376509.4 |
| exon_skip_514778 | X | 48771672:48771848:48772296:48772669:48775057:48775108 | 48772296:48772669 | ENSG00000102096.9 | ENST00000376509.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PIM2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000376509 | 48772296 | 48772669 | Frame-shift |
| ENST00000376509 | 48771671 | 48771848 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000376509 | 48772296 | 48772669 | Frame-shift |
| ENST00000376509 | 48771671 | 48771848 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PIM2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000376509 | 2092 | 311 | 48771671 | 48771848 | 786 | 962 | 198 | 257 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000376509 | 2092 | 311 | 48771671 | 48771848 | 786 | 962 | 198 | 257 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P1W9 | 198 | 257 | 1 | 311 | Chain | ID=PRO_0000086532;Note=Serine/threonine-protein kinase pim-2 |
| Q9P1W9 | 198 | 257 | 32 | 286 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9P1W9 | 198 | 257 | 201 | 203 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
| Q9P1W9 | 198 | 257 | 206 | 211 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
| Q9P1W9 | 198 | 257 | 216 | 233 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
| Q9P1W9 | 198 | 257 | 241 | 246 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
| Q9P1W9 | 198 | 257 | 257 | 266 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P1W9 | 198 | 257 | 1 | 311 | Chain | ID=PRO_0000086532;Note=Serine/threonine-protein kinase pim-2 |
| Q9P1W9 | 198 | 257 | 32 | 286 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9P1W9 | 198 | 257 | 201 | 203 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
| Q9P1W9 | 198 | 257 | 206 | 211 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
| Q9P1W9 | 198 | 257 | 216 | 233 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
| Q9P1W9 | 198 | 257 | 241 | 246 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
| Q9P1W9 | 198 | 257 | 257 | 266 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q |
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SNVs in the skipped exons for PIM2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
PIM2_LIHC_exon_skip_514778_psi_boxplot.png |
PIM2_LUAD_exon_skip_514778_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_514771 | 48771672 | 48771848 | 48771684 | 48771684 | Frame_Shift_Del | G | - | p.H254fs |
| LUAD | TCGA-62-A46O-01 | exon_skip_514771 | 48771672 | 48771848 | 48771840 | 48771840 | Frame_Shift_Del | C | - | p.V202fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_514778 | 48772297 | 48772669 | 48772330 | 48772330 | Frame_Shift_Del | G | - | p.L189fs |
| SKCM | TCGA-W3-AA1Q-06 | exon_skip_514778 | 48772297 | 48772669 | 48772498 | 48772499 | Frame_Shift_Del | TC | - | p.EK131fs |
| LIHC | TCGA-DD-A1EA-01 | exon_skip_514778 | 48772297 | 48772669 | 48772473 | 48772474 | Frame_Shift_Ins | - | T | p.P140fs |
| LUAD | TCGA-95-7039-01 | exon_skip_514778 | 48772297 | 48772669 | 48772296 | 48772296 | Splice_Site | C | - | p.G199_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-DD-A1EA-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_514778 | |
| Skipped exon start: 48772297 | |
| Skipped exon end: 48772669 | |
| Mutation start: 48772473 | |
| Mutation end: 48772474 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: T | |
| AAchange: p.P140fs | |
exon_skip_514778_LIHC_TCGA-DD-A1EA-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| PACADD137_PANCREAS | 48771672 | 48771848 | 48771734 | 48771734 | Missense_Mutation | G | A | p.P237L |
| H4_CENTRAL_NERVOUS_SYSTEM | 48772297 | 48772669 | 48772312 | 48772312 | Missense_Mutation | A | T | p.Y194N |
| HEC59_ENDOMETRIUM | 48772297 | 48772669 | 48772471 | 48772471 | Missense_Mutation | G | A | p.R141C |
| LN229_CENTRAL_NERVOUS_SYSTEM | 48772297 | 48772669 | 48772513 | 48772513 | Missense_Mutation | C | G | p.D127H |
| NCIH720_LUNG | 48772297 | 48772669 | 48772513 | 48772513 | Missense_Mutation | C | G | p.D127H |
| CCK81_LARGE_INTESTINE | 48772297 | 48772669 | 48772528 | 48772528 | Missense_Mutation | C | T | p.A122T |
| MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 48772297 | 48772669 | 48772539 | 48772539 | Missense_Mutation | C | T | p.R118Q |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PIM2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PIM2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PIM2 |
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RelatedDrugs for PIM2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIM2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PIM2 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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