ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for TLK2

Gene summary

Gene information	Gene symbol	TLK2
	Gene ID	11011
	Gene name	tousled like kinase 2
	Synonyms	HsHPK\|PKU-ALPHA
	Cytomap	17q23.2
	Type of gene	protein-coding
	Description	serine/threonine-protein kinase tousled-like 2
	Modification date	20180519
	UniProtAcc	Q86UE8
	Context	PubMed: TLK2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TLK2	GO:0001672	regulation of chromatin assembly or disassembly	12660173
TLK2	GO:0006468	protein phosphorylation	12660173
TLK2	GO:0006974	cellular response to DNA damage stimulus	12660173
TLK2	GO:0018105	peptidyl-serine phosphorylation	20016786
TLK2	GO:0035556	intracellular signal transduction	12660173
TLK2	GO:0071480	cellular response to gamma radiation	12660173

Top

Exon skipping events across known transcript of Ensembl for TLK2 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Gene isoform structures and expression levels for TLK2

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

Top

Exon skipping events with PSIs in TCGA for TLK2

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_155115	17	60558484:60558567:60584741:60584810:60585768:60585872	60584741:60584810	ENSG00000146872.13	ENST00000577616.1,ENST00000583690.2
exon_skip_155116	17	60558484:60558567:60585768:60585914:60598133:60598205	60585768:60585914	ENSG00000146872.13	ENST00000583843.1,ENST00000582809.1
exon_skip_155117	17	60558484:60558567:60598133:60598205:60599564:60599629	60598133:60598205	ENSG00000146872.13	ENST00000326270.9,ENST00000581041.1,ENST00000343388.7,ENST00000579450.1,ENST00000542523.1,ENST00000582195.1,ENST00000346027.5
exon_skip_155119	17	60599564:60599634:60600494:60600538:60613530:60613698	60600494:60600538	ENSG00000146872.13	ENST00000581041.1,ENST00000343388.7,ENST00000583843.1,ENST00000542523.1
exon_skip_155120	17	60600494:60600538:60601596:60601692:60613530:60613698	60601596:60601692	ENSG00000146872.13	ENST00000326270.9,ENST00000346027.5,ENST00000582809.1
exon_skip_155122	17	60600494:60600538:60613530:60613698:60629662:60629700	60613530:60613698	ENSG00000146872.13	ENST00000343388.7,ENST00000583843.1,ENST00000542523.1
exon_skip_155123	17	60601596:60601692:60613530:60613698:60629662:60629700	60613530:60613698	ENSG00000146872.13	ENST00000326270.9,ENST00000346027.5,ENST00000582809.1
exon_skip_155124	17	60613530:60613698:60629662:60629758:60631023:60631116	60629662:60629758	ENSG00000146872.13	ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000580705.1,ENST00000346027.5,ENST00000582809.1
exon_skip_155126	17	60613530:60613698:60631023:60631116:60637376:60637395	60631023:60631116	ENSG00000146872.13	ENST00000581041.1
exon_skip_155130	17	60629665:60629758:60631023:60631116:60637376:60637395	60631023:60631116	ENSG00000146872.13	ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000580705.1,ENST00000346027.5,ENST00000582809.1
exon_skip_155131	17	60631023:60631116:60637376:60637487:60642361:60642498	60637376:60637487	ENSG00000146872.13	ENST00000326270.9,ENST00000581041.1,ENST00000343388.7,ENST00000542523.1,ENST00000346027.5,ENST00000582809.1
exon_skip_155132	17	60642361:60642498:60650575:60650728:60654069:60654089	60650575:60650728	ENSG00000146872.13	ENST00000581041.1,ENST00000578697.1,ENST00000343388.7,ENST00000542523.1,ENST00000346027.5,ENST00000582809.1
exon_skip_155133	17	60650575:60650728:60651705:60651771:60654069:60654089	60651705:60651771	ENSG00000146872.13	ENST00000326270.9
exon_skip_155134	17	60654069:60654136:60655837:60655935:60657471:60657553	60655837:60655935	ENSG00000146872.13	ENST00000326270.9,ENST00000581041.1,ENST00000343388.7,ENST00000542523.1,ENST00000346027.5,ENST00000582809.1
exon_skip_155137	17	60657471:60657553:60663495:60663587:60673945:60674035	60663495:60663587	ENSG00000146872.13	ENST00000326270.9,ENST00000581041.1,ENST00000343388.7,ENST00000542523.1,ENST00000346027.5,ENST00000582809.1
exon_skip_155138	17	60663495:60663587:60673945:60674035:60678011:60678128	60673945:60674035	ENSG00000146872.13	ENST00000326270.9,ENST00000581041.1,ENST00000343388.7,ENST00000542523.1,ENST00000346027.5,ENST00000582809.1
exon_skip_155141	17	60673945:60674035:60674580:60674619:60678011:60678128	60674580:60674619	ENSG00000146872.13	ENST00000582660.1
exon_skip_155144	17	60678011:60678181:60679402:60679541:60683490:60683549	60679402:60679541	ENSG00000146872.13	ENST00000326270.9,ENST00000581041.1,ENST00000343388.7,ENST00000542523.1,ENST00000346027.5,ENST00000582809.1
exon_skip_155145	17	60683490:60683602:60685401:60685509:60689752:60689934	60685401:60685509	ENSG00000146872.13	ENST00000583310.1,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000346027.5,ENST00000582809.1

PSI values of skipped exons in TCGA.

Top

Exon skipping events with PSIs in GTEx for TLK2

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_155115	17	60558484:60558567:60584741:60584810:60585768:60585872	60584741:60584810	ENSG00000146872.13	ENST00000577616.1,ENST00000583690.2
exon_skip_155116	17	60558484:60558567:60585768:60585914:60598133:60598205	60585768:60585914	ENSG00000146872.13	ENST00000582809.1,ENST00000583843.1
exon_skip_155117	17	60558484:60558567:60598133:60598205:60599564:60599629	60598133:60598205	ENSG00000146872.13	ENST00000579450.1,ENST00000582195.1,ENST00000346027.5,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000581041.1
exon_skip_155119	17	60599564:60599634:60600494:60600538:60613530:60613698	60600494:60600538	ENSG00000146872.13	ENST00000583843.1,ENST00000343388.7,ENST00000542523.1,ENST00000581041.1
exon_skip_155120	17	60600494:60600538:60601596:60601692:60613530:60613698	60601596:60601692	ENSG00000146872.13	ENST00000582809.1,ENST00000346027.5,ENST00000326270.9
exon_skip_155122	17	60600494:60600538:60613530:60613698:60629662:60629700	60613530:60613698	ENSG00000146872.13	ENST00000583843.1,ENST00000343388.7,ENST00000542523.1
exon_skip_155123	17	60601596:60601692:60613530:60613698:60629662:60629700	60613530:60613698	ENSG00000146872.13	ENST00000582809.1,ENST00000346027.5,ENST00000326270.9
exon_skip_155124	17	60613530:60613698:60629662:60629758:60631023:60631116	60629662:60629758	ENSG00000146872.13	ENST00000582809.1,ENST00000580705.1,ENST00000346027.5,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1
exon_skip_155126	17	60613530:60613698:60631023:60631116:60637376:60637395	60631023:60631116	ENSG00000146872.13	ENST00000581041.1
exon_skip_155130	17	60629665:60629758:60631023:60631116:60637376:60637395	60631023:60631116	ENSG00000146872.13	ENST00000582809.1,ENST00000580705.1,ENST00000346027.5,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1
exon_skip_155131	17	60631023:60631116:60637376:60637487:60642361:60642498	60637376:60637487	ENSG00000146872.13	ENST00000582809.1,ENST00000346027.5,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000581041.1
exon_skip_155132	17	60642361:60642498:60650575:60650728:60654069:60654089	60650575:60650728	ENSG00000146872.13	ENST00000582809.1,ENST00000346027.5,ENST00000343388.7,ENST00000542523.1,ENST00000581041.1,ENST00000578697.1
exon_skip_155133	17	60650575:60650728:60651705:60651771:60654069:60654089	60651705:60651771	ENSG00000146872.13	ENST00000326270.9
exon_skip_155134	17	60654069:60654136:60655837:60655935:60657471:60657553	60655837:60655935	ENSG00000146872.13	ENST00000582809.1,ENST00000346027.5,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000581041.1
exon_skip_155137	17	60657471:60657553:60663495:60663587:60673945:60674035	60663495:60663587	ENSG00000146872.13	ENST00000582809.1,ENST00000346027.5,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000581041.1
exon_skip_155138	17	60663495:60663587:60673945:60674035:60678011:60678128	60673945:60674035	ENSG00000146872.13	ENST00000582809.1,ENST00000346027.5,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000581041.1
exon_skip_155141	17	60673945:60674035:60674580:60674619:60678011:60678128	60674580:60674619	ENSG00000146872.13	ENST00000582660.1
exon_skip_155144	17	60678011:60678181:60679402:60679541:60683490:60683549	60679402:60679541	ENSG00000146872.13	ENST00000582809.1,ENST00000346027.5,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000581041.1
exon_skip_155145	17	60683490:60683602:60685401:60685509:60689752:60689934	60685401:60685509	ENSG00000146872.13	ENST00000582809.1,ENST00000346027.5,ENST00000326270.9,ENST00000343388.7,ENST00000542523.1,ENST00000583310.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for TLK2

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000326270	60655837	60655935	Frame-shift
ENST00000326270	60663495	60663587	Frame-shift
ENST00000326270	60679402	60679541	Frame-shift
ENST00000326270	60598133	60598205	In-frame
ENST00000326270	60601596	60601692	In-frame
ENST00000326270	60613530	60613698	In-frame
ENST00000326270	60629662	60629758	In-frame
ENST00000326270	60631023	60631116	In-frame
ENST00000326270	60637376	60637487	In-frame
ENST00000326270	60651705	60651771	In-frame
ENST00000326270	60673945	60674035	In-frame
ENST00000326270	60685401	60685509	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000326270	60655837	60655935	Frame-shift
ENST00000326270	60663495	60663587	Frame-shift
ENST00000326270	60679402	60679541	Frame-shift
ENST00000326270	60598133	60598205	In-frame
ENST00000326270	60601596	60601692	In-frame
ENST00000326270	60613530	60613698	In-frame
ENST00000326270	60629662	60629758	In-frame
ENST00000326270	60631023	60631116	In-frame
ENST00000326270	60637376	60637487	In-frame
ENST00000326270	60651705	60651771	In-frame
ENST00000326270	60673945	60674035	In-frame
ENST00000326270	60685401	60685509	In-frame

Top

Infer the effects of exon skipping event on protein functional features for TLK2

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000326270	3529	772	60598133	60598205	350	421	27	51
ENST00000326270	3529	772	60601596	60601692	536	631	89	121
ENST00000326270	3529	772	60613530	60613698	632	799	121	177
ENST00000326270	3529	772	60629662	60629758	800	895	177	209
ENST00000326270	3529	772	60631023	60631116	896	988	209	240
ENST00000326270	3529	772	60637376	60637487	989	1099	240	277
ENST00000326270	3529	772	60651705	60651771	1390	1455	374	395
ENST00000326270	3529	772	60673945	60674035	1795	1884	509	538
ENST00000326270	3529	772	60685401	60685509	2306	2413	679	715

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000326270	3529	772	60598133	60598205	350	421	27	51
ENST00000326270	3529	772	60601596	60601692	536	631	89	121
ENST00000326270	3529	772	60613530	60613698	632	799	121	177
ENST00000326270	3529	772	60629662	60629758	800	895	177	209
ENST00000326270	3529	772	60631023	60631116	896	988	209	240
ENST00000326270	3529	772	60637376	60637487	989	1099	240	277
ENST00000326270	3529	772	60651705	60651771	1390	1455	374	395
ENST00000326270	3529	772	60673945	60674035	1795	1884	509	538
ENST00000326270	3529	772	60685401	60685509	2306	2413	679	715

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q86UE8	27	51	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	89	121	90	121	Alternative sequence	ID=VSP_050572;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9427565;Dbxref=PMID:9427565
Q86UE8	89	121	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	89	121	94	94	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163
Q86UE8	89	121	99	99	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
Q86UE8	89	121	115	115	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q86UE8	89	121	117	117	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q86UE8	89	121	95	95	Natural variant	ID=VAR_041218;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs2598147,PMID:17344846
Q86UE8	89	121	108	108	Natural variant	ID=VAR_041219;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q86UE8	89	121	109	109	Natural variant	ID=VAR_041220;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q86UE8	121	177	90	121	Alternative sequence	ID=VSP_050572;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9427565;Dbxref=PMID:9427565
Q86UE8	121	177	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	121	177	134	134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163
Q86UE8	121	177	173	173	Natural variant	ID=VAR_041221;Note=In a gastric adenocarcinoma sample%3B somatic mutation. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q86UE8	121	177	161	161	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q86UE8	177	209	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	177	209	207	207	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q86UE8	209	240	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	209	240	225	276	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q86UE8	240	277	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	240	277	225	276	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q86UE8	240	277	262	262	Natural variant	ID=VAR_041222;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs762409144,PMID:17344846
Q86UE8	374	395	375	396	Alternative sequence	ID=VSP_050573;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10523312,ECO:0000303\|PubMed:9427565;Dbxref=PMID:10523312,PMID:9427565
Q86UE8	374	395	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	509	538	529	534	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	509	538	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	509	538	462	741	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q86UE8	509	538	502	519	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	680	682	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	706	708	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	679	715	462	741	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q86UE8	679	715	687	693	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	712	721	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	694	698	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q86UE8	27	51	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	89	121	90	121	Alternative sequence	ID=VSP_050572;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9427565;Dbxref=PMID:9427565
Q86UE8	89	121	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	89	121	94	94	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163
Q86UE8	89	121	99	99	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
Q86UE8	89	121	115	115	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q86UE8	89	121	117	117	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q86UE8	89	121	95	95	Natural variant	ID=VAR_041218;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs2598147,PMID:17344846
Q86UE8	89	121	108	108	Natural variant	ID=VAR_041219;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q86UE8	89	121	109	109	Natural variant	ID=VAR_041220;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q86UE8	121	177	90	121	Alternative sequence	ID=VSP_050572;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9427565;Dbxref=PMID:9427565
Q86UE8	121	177	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	121	177	134	134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163
Q86UE8	121	177	173	173	Natural variant	ID=VAR_041221;Note=In a gastric adenocarcinoma sample%3B somatic mutation. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q86UE8	121	177	161	161	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q86UE8	177	209	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	177	209	207	207	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q86UE8	209	240	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	209	240	225	276	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q86UE8	240	277	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	240	277	225	276	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q86UE8	240	277	262	262	Natural variant	ID=VAR_041222;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs762409144,PMID:17344846
Q86UE8	374	395	375	396	Alternative sequence	ID=VSP_050573;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10523312,ECO:0000303\|PubMed:9427565;Dbxref=PMID:10523312,PMID:9427565
Q86UE8	374	395	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	509	538	529	534	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	509	538	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	509	538	462	741	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q86UE8	509	538	502	519	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	680	682	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	706	708	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
Q86UE8	679	715	462	741	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q86UE8	679	715	687	693	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	712	721	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y
Q86UE8	679	715	694	698	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5O0Y

Top

SNVs in the skipped exons for TLK2

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
PAAD	TCGA-IB-AAUT-01	exon_skip_155122 exon_skip_155123	60613531	60613698	60613640	60613640	Frame_Shift_Del	G	-	p.R158fs
COAD	TCGA-AA-3492-01	exon_skip_155126 exon_skip_155130	60631024	60631116	60631040	60631040	Frame_Shift_Del	A	-	p.E215fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_155126 exon_skip_155130	60631024	60631116	60631040	60631040	Frame_Shift_Del	A	-	p.E66fs
UCEC	TCGA-B5-A11E-01	exon_skip_155131	60637377	60637487	60637440	60637440	Nonsense_Mutation	C	T	p.R262*
COAD	TCGA-CA-6717-01	exon_skip_155132	60650576	60650728	60650613	60650613	Nonsense_Mutation	G	T	p.E336X
LIHC	TCGA-2Y-A9H9-01	exon_skip_155145	60685402	60685509	60685417	60685417	Nonsense_Mutation	C	T	p.Q663X

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
D502MG_CENTRAL_NERVOUS_SYSTEM	60629663	60629758	60629704	60629705	Frame_Shift_Del	AG	-	p.E192fs
HCC202_BREAST	60663496	60663587	60663510	60663511	Frame_Shift_Del	AG	-	p.E484fs
LN229_CENTRAL_NERVOUS_SYSTEM	60631024	60631116	60631082	60631084	In_Frame_Del	AGA	-	p.K231del
SNU387_LIVER	60598134	60598205	60598163	60598163	Missense_Mutation	G	C	p.Q37H
SW48_LARGE_INTESTINE	60598134	60598205	60598179	60598179	Missense_Mutation	G	A	p.G43R
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	60598134	60598205	60598197	60598197	Missense_Mutation	G	A	p.E49K
SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	60600495	60600538	60600503	60600503	Missense_Mutation	A	G	p.T78A
BICR18_UPPER_AERODIGESTIVE_TRACT	60601597	60601692	60601613	60601613	Missense_Mutation	C	G	p.A95G
NCIH630_LARGE_INTESTINE	60613531	60613698	60613586	60613586	Missense_Mutation	C	T	p.T140M
2313287_STOMACH	60637377	60637487	60637441	60637441	Missense_Mutation	G	A	p.R262Q
IGROV1_OVARY	60637377	60637487	60637441	60637441	Missense_Mutation	G	A	p.R262Q
SNU1_STOMACH	60637377	60637487	60637441	60637441	Missense_Mutation	G	A	p.R262Q
HEC1A_ENDOMETRIUM	60650576	60650728	60650581	60650581	Missense_Mutation	A	G	p.Q325R
HEC1_ENDOMETRIUM	60650576	60650728	60650581	60650581	Missense_Mutation	A	G	p.Q325R
HEC1B_ENDOMETRIUM	60650576	60650728	60650581	60650581	Missense_Mutation	A	G	p.Q325R
VMRCLCP_LUNG	60650576	60650728	60650609	60650609	Missense_Mutation	G	C	p.E334D
P32ISH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	60650576	60650728	60650613	60650613	Missense_Mutation	G	A	p.E336K
NB17_AUTONOMIC_GANGLIA	60650576	60650728	60650701	60650701	Missense_Mutation	G	T	p.S365I
CW2_LARGE_INTESTINE	60651706	60651771	60651733	60651733	Missense_Mutation	G	T	p.K383N
LS411N_LARGE_INTESTINE	60655838	60655935	60655889	60655889	Missense_Mutation	C	A	p.L436I
MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	60663496	60663587	60663572	60663572	Missense_Mutation	A	G	p.K504R
MDAMB361_BREAST	60673946	60674035	60673977	60673977	Missense_Mutation	G	C	p.E520Q
FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	60679403	60679541	60679430	60679430	Missense_Mutation	C	T	p.A605V
DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	60631024	60631116	60631112	60631112	Nonsense_Mutation	T	A	p.L239*
HEC6_ENDOMETRIUM	60601597	60601692	60601691	60601691	Splice_Site	C	T	p.P121L

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TLK2

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TLK2

Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TLK2

Top

RelatedDrugs for TLK2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
	Q86UE8	DB12010	Fostamatinib	Serine/threonine-protein kinase tousled-like 2	small molecule	approved\|investigational

Top

RelatedDiseases for TLK2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact