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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TMED10 |
 Gene summary |
| Gene information | Gene symbol | TMED10 | Gene ID | 10972 |
| Gene name | transmembrane p24 trafficking protein 10 | |
| Synonyms | P24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1 | |
| Cytomap | 14q24.3 | |
| Type of gene | protein-coding | |
| Description | transmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21 | |
| Modification date | 20180523 | |
| UniProtAcc | P49755 | |
| Context | PubMed: TMED10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TMED10 | GO:0006886 | intracellular protein transport | 20427317 |
| TMED10 | GO:0035964 | COPI-coated vesicle budding | 10052452 |
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Exon skipping events across known transcript of Ensembl for TMED10 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TMED10 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TMED10 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_114672 | 14 | 75601490:75601709:75602365:75602589:75614366:75614440 | 75602365:75602589 | ENSG00000170348.4 | ENST00000555036.1 |
| exon_skip_114673 | 14 | 75601490:75601709:75602462:75602589:75614366:75614440 | 75602462:75602589 | ENSG00000170348.4 | ENST00000556969.1,ENST00000557670.1,ENST00000303575.4 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENSG00000170348.4 | ENST00000555873.1 |
| exon_skip_114675 | 14 | 75602462:75602589:75614366:75614440:75618734:75618846 | 75614366:75614440 | ENSG00000170348.4 | ENST00000303575.4 |
| exon_skip_114681 | 14 | 75614366:75614440:75618734:75618846:75643057:75643300 | 75618734:75618846 | ENSG00000170348.4 | ENST00000555873.1,ENST00000555085.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TMED10 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_114672 | 14 | 75601490:75601709:75602365:75602589:75614366:75614440 | 75602365:75602589 | ENSG00000170348.4 | ENST00000555036.1 |
| exon_skip_114673 | 14 | 75601490:75601709:75602462:75602589:75614366:75614440 | 75602462:75602589 | ENSG00000170348.4 | ENST00000303575.4,ENST00000556969.1,ENST00000557670.1 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENSG00000170348.4 | ENST00000555873.1 |
| exon_skip_114675 | 14 | 75602462:75602589:75614366:75614440:75618734:75618846 | 75614366:75614440 | ENSG00000170348.4 | ENST00000303575.4 |
| exon_skip_114681 | 14 | 75614366:75614440:75618734:75618846:75643057:75643300 | 75618734:75618846 | ENSG00000170348.4 | ENST00000555873.1,ENST00000555085.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TMED10 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000303575 | 75602462 | 75602589 | Frame-shift |
| ENST00000303575 | 75614366 | 75614440 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000303575 | 75602462 | 75602589 | Frame-shift |
| ENST00000303575 | 75614366 | 75614440 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TMED10 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TMED10 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_114675 | 75614367 | 75614440 | 75614398 | 75614398 | Frame_Shift_Del | T | - | p.K127fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_114681 | 75618735 | 75618846 | 75618781 | 75618781 | Frame_Shift_Del | A | - | p.F97fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_114681 | 75618735 | 75618846 | 75618811 | 75618811 | Frame_Shift_Del | T | - | p.K87fs |
| UCEC | TCGA-AX-A0J0-01 | exon_skip_114672 | 75602366 | 75602589 | 75602547 | 75602547 | Nonsense_Mutation | G | A | p.R152* |
| UCEC | TCGA-AX-A0J0-01 | exon_skip_114673 | 75602463 | 75602589 | 75602547 | 75602547 | Nonsense_Mutation | G | A | p.R152* |
| PAAD | TCGA-IB-7651-01 | exon_skip_114681 | 75618735 | 75618846 | 75618848 | 75618848 | Splice_Site | T | C | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-AX-A0J0-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_114672 | |
| Skipped exon start: 75602366 | |
| Skipped exon end: 75602589 | |
| Mutation start: 75602547 | |
| Mutation end: 75602547 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R152* | |
| Sample: TCGA-AX-A0J0-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_114673 | |
| Skipped exon start: 75602463 | |
| Skipped exon end: 75602589 | |
| Mutation start: 75602547 | |
| Mutation end: 75602547 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R152* | |
exon_skip_114672_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_145114_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_148176_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_148178_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_26303_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_316320_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_366628_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_422781_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_440271_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_47562_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_500520_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_60290_UCEC_TCGA-AX-A0J0-01.png | |
exon_skip_60294_UCEC_TCGA-AX-A0J0-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JHUEM1_ENDOMETRIUM | 75602366 | 75602589 | 75602534 | 75602536 | In_Frame_Del | TCT | - | p.E155del |
| JHUEM1_ENDOMETRIUM | 75602463 | 75602589 | 75602534 | 75602536 | In_Frame_Del | TCT | - | p.E155del |
| CCK81_LARGE_INTESTINE | 75602366 | 75602589 | 75602474 | 75602474 | Missense_Mutation | C | T | p.R176H |
| CCK81_LARGE_INTESTINE | 75602463 | 75602589 | 75602474 | 75602474 | Missense_Mutation | C | T | p.R176H |
| HDLM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 75602366 | 75602589 | 75602583 | 75602583 | Missense_Mutation | T | C | p.K140E |
| HDLM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 75602463 | 75602589 | 75602583 | 75602583 | Missense_Mutation | T | C | p.K140E |
| SNU175_LARGE_INTESTINE | 75614367 | 75614440 | 75614431 | 75614431 | Missense_Mutation | C | T | p.R116Q |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 75618735 | 75618846 | 75618816 | 75618816 | Missense_Mutation | A | C | p.S86A |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TMED10 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | ACC | rs1047418 | chr14:75605792 | A/G | 7.66e-05 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | GBM | rs1047418 | chr14:75605792 | A/G | 2.80e-23 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | CESC | rs1047418 | chr14:75605792 | A/G | 7.66e-14 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | COAD | rs1047418 | chr14:75605792 | A/G | 4.72e-30 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | BLCA | rs1047418 | chr14:75605792 | A/G | 6.78e-19 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | ESCA | rs1047418 | chr14:75605792 | A/G | 2.45e-14 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | HNSC | rs1047418 | chr14:75605792 | A/G | 2.24e-46 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | LAML | rs1047418 | chr14:75605792 | A/G | 1.25e-04 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | KIRP | rs1047418 | chr14:75605792 | A/G | 8.41e-14 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | LGG | rs1047418 | chr14:75605792 | A/G | 3.41e-85 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | KIRC | rs1047418 | chr14:75605792 | A/G | 2.26e-51 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | LUAD | rs1047418 | chr14:75605792 | A/G | 5.64e-49 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | MESO | rs1047418 | chr14:75605792 | A/G | 6.03e-07 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | LUSC | rs1047418 | chr14:75605792 | A/G | 1.69e-64 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | OV | rs1047418 | chr14:75605792 | A/G | 4.23e-32 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | READ | rs1047418 | chr14:75605792 | A/G | 3.45e-12 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | PCPG | rs1047418 | chr14:75605792 | A/G | 4.58e-27 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | PAAD | rs1047418 | chr14:75605792 | A/G | 1.06e-12 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | PRAD | rs1047418 | chr14:75605792 | A/G | 1.54e-72 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | SARC | rs1047418 | chr14:75605792 | A/G | 1.70e-20 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | THYM | rs1047418 | chr14:75605792 | A/G | 1.57e-05 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | TGCT | rs1047418 | chr14:75605792 | A/G | 3.27e-17 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | SKCM | rs1047418 | chr14:75605792 | A/G | 3.05e-11 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | STAD | rs1047418 | chr14:75605792 | A/G | 1.81e-21 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | THCA | rs1047418 | chr14:75605792 | A/G | 1.58e-66 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | UVM | rs1047418 | chr14:75605792 | A/G | 3.90e-10 |
| exon_skip_114674 | 14 | 75602462:75602589:75605776:75605874:75614366:75614440 | 75605776:75605874 | ENST00000555873.1 | UCEC | rs1047418 | chr14:75605792 | A/G | 3.32e-15 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TMED10 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TMED10 |
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RelatedDrugs for TMED10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMED10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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