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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for NEK6

check button Gene summary
Gene informationGene symbol

NEK6

Gene ID

10783

Gene nameNIMA related kinase 6
SynonymsSID6-1512
Cytomap

9q33.3

Type of geneprotein-coding
Descriptionserine/threonine-protein kinase Nek6NIMA (never in mitosis gene a)-related kinase 6never in mitosis A-related kinase 6nimA-related protein kinase 6protein kinase SID6-1512putative serine-threonine protein kinase
Modification date20180522
UniProtAcc

Q9HC98

ContextPubMed: NEK6 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
NEK6

GO:0006468

protein phosphorylation

12840024

NEK6

GO:0007059

chromosome segregation

14563848

NEK6

GO:0018105

peptidyl-serine phosphorylation

19001501

NEK6

GO:0030071

regulation of mitotic metaphase/anaphase transition

14563848

NEK6

GO:0046777

protein autophosphorylation

14563848|20873783


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Exon skipping events across known transcript of Ensembl for NEK6 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for NEK6

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for NEK6

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_4989489127020248:127020364:127055127:127055292:127064214:127064333127055127:127055292ENSG00000119408.12ENST00000373600.3
exon_skip_4989509127020248:127020364:127064214:127064333:127074787:127074928127064214:127064333ENSG00000119408.12ENST00000320246.5
exon_skip_4989629127020539:127020640:127064214:127064333:127074787:127074928127064214:127064333ENSG00000119408.12ENST00000545174.1,ENST00000444973.1
exon_skip_4989709127023751:127023862:127064214:127064333:127074787:127074928127064214:127064333ENSG00000119408.12ENST00000425237.1
exon_skip_4989739127048718:127048769:127055127:127055292:127064214:127064333127055127:127055292ENSG00000119408.12ENST00000423785.1
exon_skip_4989769127054261:127054367:127055127:127055292:127064214:127064333127055127:127055292ENSG00000119408.12ENST00000394199.2
exon_skip_4989809127064214:127064333:127074787:127074928:127076201:127076264127074787:127074928ENSG00000119408.12ENST00000447379.1,ENST00000545174.1,ENST00000423785.1,ENST00000373603.1,ENST00000444973.1,ENST00000394199.2,ENST00000546191.1,ENST00000373600.3,ENST00000540326.1,ENST00000425237.1,ENST00000539416.1,ENST00000422297.1,ENST00000320246.5,ENST00000373596.1
exon_skip_4989849127076201:127076264:127083737:127083848:127088608:127088684127083737:127083848ENSG00000119408.12ENST00000447379.1,ENST00000545174.1,ENST00000423785.1,ENST00000373603.1,ENST00000444973.1,ENST00000394199.2,ENST00000546191.1,ENST00000373600.3,ENST00000540326.1,ENST00000425237.1,ENST00000539416.1,ENST00000422297.1,ENST00000320246.5,ENST00000373596.1
exon_skip_4989859127088608:127088717:127089616:127089724:127101849:127101886127089616:127089724ENSG00000119408.12ENST00000545174.1,ENST00000373603.1,ENST00000444973.1,ENST00000394199.2,ENST00000546191.1,ENST00000373600.3,ENST00000540326.1,ENST00000425237.1,ENST00000539416.1,ENST00000454453.1,ENST00000422297.1,ENST00000320246.5
exon_skip_4989879127089616:127089724:127101849:127101944:127109987:127110076127101849:127101944ENSG00000119408.12ENST00000545174.1,ENST00000373603.1,ENST00000394199.2,ENST00000546191.1,ENST00000373600.3,ENST00000540326.1,ENST00000539416.1,ENST00000454453.1,ENST00000320246.5
exon_skip_4989889127101849:127101944:127109987:127110101:127113115:127114717127109987:127110101ENSG00000119408.12ENST00000545174.1,ENST00000373603.1,ENST00000394199.2,ENST00000546191.1,ENST00000373600.3,ENST00000540326.1,ENST00000539416.1,ENST00000320246.5

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for NEK6

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_4989489127020248:127020364:127055127:127055292:127064214:127064333127055127:127055292ENSG00000119408.12ENST00000373600.3
exon_skip_4989509127020248:127020364:127064214:127064333:127074787:127074928127064214:127064333ENSG00000119408.12ENST00000320246.5
exon_skip_4989629127020539:127020640:127064214:127064333:127074787:127074928127064214:127064333ENSG00000119408.12ENST00000545174.1,ENST00000444973.1
exon_skip_4989709127023751:127023862:127064214:127064333:127074787:127074928127064214:127064333ENSG00000119408.12ENST00000425237.1
exon_skip_4989739127048718:127048769:127055127:127055292:127064214:127064333127055127:127055292ENSG00000119408.12ENST00000423785.1
exon_skip_4989769127054261:127054367:127055127:127055292:127064214:127064333127055127:127055292ENSG00000119408.12ENST00000394199.2
exon_skip_4989809127064214:127064333:127074787:127074928:127076201:127076264127074787:127074928ENSG00000119408.12ENST00000373603.1,ENST00000540326.1,ENST00000373600.3,ENST00000320246.5,ENST00000545174.1,ENST00000444973.1,ENST00000373596.1,ENST00000425237.1,ENST00000423785.1,ENST00000394199.2,ENST00000546191.1,ENST00000422297.1,ENST00000539416.1,ENST00000447379.1
exon_skip_4989849127076201:127076264:127083737:127083848:127088608:127088684127083737:127083848ENSG00000119408.12ENST00000373603.1,ENST00000540326.1,ENST00000373600.3,ENST00000320246.5,ENST00000545174.1,ENST00000444973.1,ENST00000373596.1,ENST00000425237.1,ENST00000423785.1,ENST00000394199.2,ENST00000546191.1,ENST00000422297.1,ENST00000539416.1,ENST00000447379.1
exon_skip_4989859127088608:127088717:127089616:127089724:127101849:127101886127089616:127089724ENSG00000119408.12ENST00000373603.1,ENST00000540326.1,ENST00000373600.3,ENST00000320246.5,ENST00000545174.1,ENST00000444973.1,ENST00000454453.1,ENST00000425237.1,ENST00000394199.2,ENST00000546191.1,ENST00000422297.1,ENST00000539416.1
exon_skip_4989879127089616:127089724:127101849:127101944:127109987:127110076127101849:127101944ENSG00000119408.12ENST00000373603.1,ENST00000540326.1,ENST00000373600.3,ENST00000320246.5,ENST00000545174.1,ENST00000454453.1,ENST00000394199.2,ENST00000546191.1,ENST00000539416.1
exon_skip_4989889127101849:127101944:127109987:127110101:127113115:127114717127109987:127110101ENSG00000119408.12ENST00000373603.1,ENST00000540326.1,ENST00000373600.3,ENST00000320246.5,ENST00000545174.1,ENST00000394199.2,ENST00000546191.1,ENST00000539416.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for NEK6

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003202461270642141270643335CDS-5UTR
ENST000005451741270642141270643335CDS-5UTR
ENST00000320246127101849127101944Frame-shift
ENST00000373603127101849127101944Frame-shift
ENST00000545174127101849127101944Frame-shift
ENST00000546191127101849127101944Frame-shift
ENST00000320246127074787127074928In-frame
ENST00000373603127074787127074928In-frame
ENST00000545174127074787127074928In-frame
ENST00000546191127074787127074928In-frame
ENST00000320246127083737127083848In-frame
ENST00000373603127083737127083848In-frame
ENST00000545174127083737127083848In-frame
ENST00000546191127083737127083848In-frame
ENST00000320246127089616127089724In-frame
ENST00000373603127089616127089724In-frame
ENST00000545174127089616127089724In-frame
ENST00000546191127089616127089724In-frame
ENST00000320246127109987127110101In-frame
ENST00000373603127109987127110101In-frame
ENST00000545174127109987127110101In-frame
ENST00000546191127109987127110101In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003202461270642141270643335CDS-5UTR
ENST000005451741270642141270643335CDS-5UTR
ENST00000320246127101849127101944Frame-shift
ENST00000373603127101849127101944Frame-shift
ENST00000545174127101849127101944Frame-shift
ENST00000546191127101849127101944Frame-shift
ENST00000320246127074787127074928In-frame
ENST00000373603127074787127074928In-frame
ENST00000545174127074787127074928In-frame
ENST00000546191127074787127074928In-frame
ENST00000320246127083737127083848In-frame
ENST00000373603127083737127083848In-frame
ENST00000545174127083737127083848In-frame
ENST00000546191127083737127083848In-frame
ENST00000320246127089616127089724In-frame
ENST00000373603127089616127089724In-frame
ENST00000545174127089616127089724In-frame
ENST00000546191127089616127089724In-frame
ENST00000320246127109987127110101In-frame
ENST00000373603127109987127110101In-frame
ENST00000545174127109987127110101In-frame
ENST00000546191127109987127110101In-frame

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Infer the effects of exon skipping event on protein functional features for NEK6

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000032024634643131270747871270749282363763077
ENST0000037360334643131270747871270749282363763077
ENST0000054517425903131270747871270749282313713077
ENST0000054619125973131270747871270749282383783077
ENST00000320246346431312708373712708384844055098135
ENST00000373603346431312708373712708384844055098135
ENST00000545174259031312708373712708384843554598135
ENST00000546191259731312708373712708384844255298135
ENST000003202463464313127089616127089724660767171207
ENST000003736033464313127089616127089724660767171207
ENST000005451742590313127089616127089724655762171207
ENST000005461912597313127089616127089724662769171207
ENST000003202463464313127109987127110101863976239277
ENST000003736033464313127109987127110101863976239277
ENST000005451742590313127109987127110101858971239277
ENST000005461912597313127109987127110101865978239277

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000032024634643131270747871270749282363763077
ENST0000037360334643131270747871270749282363763077
ENST0000054517425903131270747871270749282313713077
ENST0000054619125973131270747871270749282383783077
ENST00000320246346431312708373712708384844055098135
ENST00000373603346431312708373712708384844055098135
ENST00000545174259031312708373712708384843554598135
ENST00000546191259731312708373712708384844255298135
ENST000003202463464313127089616127089724660767171207
ENST000003736033464313127089616127089724660767171207
ENST000005451742590313127089616127089724655762171207
ENST000005461912597313127089616127089724662769171207
ENST000003202463464313127109987127110101863976239277
ENST000003736033464313127109987127110101863976239277
ENST000005451742590313127109987127110101858971239277
ENST000005461912597313127109987127110101865978239277

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9HC9830777474Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830777474Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830777474Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830777474Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9830771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9830771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9830771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC98307745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98307745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98307745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98307745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830773737Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC9830773737Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC9830773737Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC9830773737Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC9830777474MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777474MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777474MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777474MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777575MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777575MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777575MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777575MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830775159Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830775159Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830775159Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830775159Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC983077144RegionNote=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
Q9HC983077144RegionNote=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
Q9HC983077144RegionNote=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
Q9HC983077144RegionNote=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
Q9HC98981351313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC98981351313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC98981351313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC98981351313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC989813545310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC989813545310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC989813545310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC989813545310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9898135108108MutagenesisNote=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
Q9HC9898135108108MutagenesisNote=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
Q9HC9898135108108MutagenesisNote=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
Q9HC9898135108108MutagenesisNote=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
Q9HC9898135108108SiteNote=Autoinhibitory
Q9HC9898135108108SiteNote=Autoinhibitory
Q9HC9898135108108SiteNote=Autoinhibitory
Q9HC9898135108108SiteNote=Autoinhibitory
Q9HC98171207172172Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
Q9HC98171207172172Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
Q9HC98171207172172Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
Q9HC98171207172172Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
Q9HC981712071313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC981712071313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC981712071313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC981712071313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9817120745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9817120745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9817120745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9817120745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98171207202202Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC98171207202202Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC98171207202202Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC98171207202202Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC98171207206206Modified residueNote=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12
Q9HC98171207206206Modified residueNote=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12
Q9HC98171207206206Modified residueNote=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12
Q9HC98171207206206Modified residueNote=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12
Q9HC982392771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC982392771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC982392771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC982392771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9823927745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9823927745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9823927745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9823927745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98239277267270RegionNote=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
Q9HC98239277267270RegionNote=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
Q9HC98239277267270RegionNote=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
Q9HC98239277267270RegionNote=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9HC9830777474Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830777474Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830777474Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830777474Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9830771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9830771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9830771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC98307745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98307745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98307745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98307745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830773737Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC9830773737Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC9830773737Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC9830773737Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC9830777474MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777474MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777474MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777474MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777575MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777575MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777575MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830777575MutagenesisNote=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
Q9HC9830775159Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830775159Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830775159Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9830775159Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC983077144RegionNote=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
Q9HC983077144RegionNote=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
Q9HC983077144RegionNote=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
Q9HC983077144RegionNote=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
Q9HC98981351313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC98981351313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC98981351313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC98981351313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC989813545310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC989813545310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC989813545310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC989813545310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9898135108108MutagenesisNote=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
Q9HC9898135108108MutagenesisNote=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
Q9HC9898135108108MutagenesisNote=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
Q9HC9898135108108MutagenesisNote=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
Q9HC9898135108108SiteNote=Autoinhibitory
Q9HC9898135108108SiteNote=Autoinhibitory
Q9HC9898135108108SiteNote=Autoinhibitory
Q9HC9898135108108SiteNote=Autoinhibitory
Q9HC98171207172172Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
Q9HC98171207172172Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
Q9HC98171207172172Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
Q9HC98171207172172Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
Q9HC981712071313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC981712071313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC981712071313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC981712071313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9817120745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9817120745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9817120745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9817120745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98171207202202Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC98171207202202Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC98171207202202Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC98171207202202Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
Q9HC98171207206206Modified residueNote=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12
Q9HC98171207206206Modified residueNote=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12
Q9HC98171207206206Modified residueNote=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12
Q9HC98171207206206Modified residueNote=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12
Q9HC982392771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC982392771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC982392771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC982392771313ChainID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
Q9HC9823927745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9823927745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9823927745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC9823927745310DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9HC98239277267270RegionNote=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
Q9HC98239277267270RegionNote=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
Q9HC98239277267270RegionNote=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
Q9HC98239277267270RegionNote=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906


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SNVs in the skipped exons for NEK6

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A3A0-01exon_skip_498987
127101850127101944127101922127101922Frame_Shift_DelC-p.S266fs
STADTCGA-HU-A4H8-01exon_skip_498988
127109988127110101127110068127110068Frame_Shift_DelC-p.Y300fs
UCECTCGA-B5-A0JR-01exon_skip_498984
127083738127083848127083824127083825Frame_Shift_Ins-Tp.A161fs
LUADTCGA-44-7667-01exon_skip_498987
127101850127101944127101941127101941Nonsense_MutationCAp.Y272*
HNSCTCGA-CN-4739-01exon_skip_498985
127089617127089724127089616127089616Splice_SiteGAp.D172_splice

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LNCAPCLONEFGC_PROSTATE127109988127110101127110068127110068Frame_Shift_DelC-p.Y266fs
EN_ENDOMETRIUM127109988127110101127110067127110068Frame_Shift_Ins-Cp.YP266fs
HT115_LARGE_INTESTINE127074788127074928127074855127074855Missense_MutationGAp.R53Q
HA7RCC_KIDNEY127083738127083848127083760127083760Missense_MutationTGp.I106S
MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE127089617127089724127089637127089637Missense_MutationTGp.F179V
RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE127089617127089724127089709127089709Missense_MutationGAp.A203T
HS255T_FIBROBLAST127089617127089724127089716127089716Missense_MutationAGp.H205R
SNU407_LARGE_INTESTINE127101850127101944127101856127101856Missense_MutationCTp.T210M
MFE319_ENDOMETRIUM127109988127110101127110039127110039Missense_MutationCAp.L257M
22RV1_PROSTATE127109988127110101127110096127110096Missense_MutationGAp.E276K
HOP92_LUNG127109988127110101127110096127110096Missense_MutationGAp.E276K
RAJI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE127109988127110101127110096127110096Missense_MutationGAp.E276K
HEC59_ENDOMETRIUM127074788127074928127074928127074928Splice_SiteGTp.Q77H
HEC1_ENDOMETRIUM127089617127089724127089724127089724Splice_SiteGTp.V208L

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NEK6

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NEK6


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NEK6


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RelatedDrugs for NEK6

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEK6

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
NEK6C0023893Liver Cirrhosis, Experimental1CTD_human