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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for STK25

check button Gene summary
Gene informationGene symbol

STK25

Gene ID

10494

Gene nameserine/threonine kinase 25
SynonymsSOK1|YSK1
Cytomap

2q37.3

Type of geneprotein-coding
Descriptionserine/threonine-protein kinase 25Ste20, yeast homologste20-like kinaseste20/oxidant stress response kinase 1sterile 20/oxidant stress-response kinase 1
Modification date20180523
UniProtAcc

O00506

ContextPubMed: STK25 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
STK25

GO:0006468

protein phosphorylation

17657516

STK25

GO:0032874

positive regulation of stress-activated MAPK cascade

22652780

STK25

GO:0042542

response to hydrogen peroxide

22291017

STK25

GO:0046777

protein autophosphorylation

17657516

STK25

GO:0051645

Golgi localization

15037601


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Exon skipping events across known transcript of Ensembl for STK25 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for STK25

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for STK25

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3481832242435812:242435949:242436596:242436793:242437030:242437102242436596:242436793ENSG00000115694.10ENST00000478403.1
exon_skip_3481842242435812:242435949:242436714:242436793:242437030:242437102242436714:242436793ENSG00000115694.10ENST00000470438.1
exon_skip_3481852242437030:242437102:242437649:242437764:242438053:242438199242437649:242437764ENSG00000115694.10ENST00000487962.1,ENST00000478403.1,ENST00000405883.3,ENST00000535007.1,ENST00000316586.4,ENST00000405585.1,ENST00000401869.1,ENST00000543554.1,ENST00000403346.3
exon_skip_3481892242438157:242438199:242438403:242438589:242438671:242438735242438403:242438589ENSG00000115694.10ENST00000461760.1,ENST00000450497.1,ENST00000487962.1,ENST00000405883.3,ENST00000535007.1,ENST00000316586.4,ENST00000405585.1,ENST00000401869.1,ENST00000423004.1,ENST00000543554.1,ENST00000403346.3,ENST00000495143.1
exon_skip_3481912242438801:242438829:242439587:242439696:242447420:242447550242439587:242439696ENSG00000115694.10ENST00000424537.1
exon_skip_3481952242439674:242439696:242440154:242440211:242440892:242440941242440154:242440211ENSG00000115694.10ENST00000440109.1,ENST00000442307.1,ENST00000492127.1,ENST00000435225.1,ENST00000535007.1,ENST00000316586.4,ENST00000413760.1,ENST00000429279.1,ENST00000436402.1,ENST00000401869.1,ENST00000543554.1,ENST00000403346.3
exon_skip_3481962242439674:242439696:242440154:242440211:242447420:242447550242440154:242440211ENSG00000115694.10ENST00000405883.3,ENST00000405585.1
exon_skip_3481982242439674:242439696:242440154:242440262:242440892:242440941242440154:242440262ENSG00000115694.10ENST00000439101.1
exon_skip_3482002242439674:242439696:242440154:242440492:242440892:242440941242440154:242440492ENSG00000115694.10ENST00000450497.1
exon_skip_3482062242440194:242440211:242440892:242441123:242447420:242447550242440892:242441123ENSG00000115694.10ENST00000316586.4,ENST00000436402.1,ENST00000401869.1,ENST00000403346.3
exon_skip_3482072242440194:242440211:242440892:242441123:242447857:242447971242440892:242441123ENSG00000115694.10ENST00000442307.1
exon_skip_3482082242440194:242440211:242440892:242441123:242447919:242447997242440892:242441123ENSG00000115694.10ENST00000535007.1,ENST00000429279.1
exon_skip_3482092242440194:242440211:242440892:242441123:242448637:242448713242440892:242441123ENSG00000115694.10ENST00000440109.1,ENST00000413760.1,ENST00000543554.1
exon_skip_3482102242440194:242440211:242440892:242441214:242447420:242447550242440892:242441214ENSG00000115694.10ENST00000483603.1
exon_skip_3482112242440194:242440211:242447420:242447550:242447857:242447971242447420:242447550ENSG00000115694.10ENST00000405883.3
exon_skip_3482122242440194:242440211:242447420:242447550:242447919:242447997242447420:242447550ENSG00000115694.10ENST00000405585.1
exon_skip_3482142242440931:242441123:242443452:242443511:242447857:242447971242443452:242443511ENSG00000115694.10ENST00000420551.1
exon_skip_3482152242440931:242441123:242447420:242447550:242447857:242447971242447420:242447550ENSG00000115694.10ENST00000426941.1,ENST00000452891.1
exon_skip_3482162242440931:242441123:242447420:242447550:242447919:242447997242447420:242447550ENSG00000115694.10ENST00000495372.1,ENST00000403346.3,ENST00000436917.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for STK25

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3481832242435812:242435949:242436596:242436793:242437030:242437102242436596:242436793ENSG00000115694.10ENST00000478403.1
exon_skip_3481842242435812:242435949:242436714:242436793:242437030:242437102242436714:242436793ENSG00000115694.10ENST00000470438.1
exon_skip_3481852242437030:242437102:242437649:242437764:242438053:242438199242437649:242437764ENSG00000115694.10ENST00000316586.4,ENST00000403346.3,ENST00000401869.1,ENST00000405883.3,ENST00000487962.1,ENST00000405585.1,ENST00000543554.1,ENST00000478403.1,ENST00000535007.1
exon_skip_3481892242438157:242438199:242438403:242438589:242438671:242438735242438403:242438589ENSG00000115694.10ENST00000316586.4,ENST00000403346.3,ENST00000401869.1,ENST00000405883.3,ENST00000487962.1,ENST00000405585.1,ENST00000543554.1,ENST00000535007.1,ENST00000423004.1,ENST00000495143.1,ENST00000461760.1,ENST00000450497.1
exon_skip_3481912242438801:242438829:242439587:242439696:242447420:242447550242439587:242439696ENSG00000115694.10ENST00000424537.1
exon_skip_3481952242439674:242439696:242440154:242440211:242440892:242440941242440154:242440211ENSG00000115694.10ENST00000316586.4,ENST00000403346.3,ENST00000401869.1,ENST00000543554.1,ENST00000535007.1,ENST00000442307.1,ENST00000413760.1,ENST00000429279.1,ENST00000436402.1,ENST00000492127.1,ENST00000440109.1,ENST00000435225.1
exon_skip_3481962242439674:242439696:242440154:242440211:242447420:242447550242440154:242440211ENSG00000115694.10ENST00000405883.3,ENST00000405585.1
exon_skip_3481982242439674:242439696:242440154:242440262:242440892:242440941242440154:242440262ENSG00000115694.10ENST00000439101.1
exon_skip_3482002242439674:242439696:242440154:242440492:242440892:242440941242440154:242440492ENSG00000115694.10ENST00000450497.1
exon_skip_3482062242440194:242440211:242440892:242441123:242447420:242447550242440892:242441123ENSG00000115694.10ENST00000316586.4,ENST00000403346.3,ENST00000401869.1,ENST00000436402.1
exon_skip_3482072242440194:242440211:242440892:242441123:242447857:242447971242440892:242441123ENSG00000115694.10ENST00000442307.1
exon_skip_3482082242440194:242440211:242440892:242441123:242447919:242447997242440892:242441123ENSG00000115694.10ENST00000535007.1,ENST00000429279.1
exon_skip_3482092242440194:242440211:242440892:242441123:242448637:242448713242440892:242441123ENSG00000115694.10ENST00000543554.1,ENST00000413760.1,ENST00000440109.1
exon_skip_3482102242440194:242440211:242440892:242441214:242447420:242447550242440892:242441214ENSG00000115694.10ENST00000483603.1
exon_skip_3482112242440194:242440211:242447420:242447550:242447857:242447971242447420:242447550ENSG00000115694.10ENST00000405883.3
exon_skip_3482122242440194:242440211:242447420:242447550:242447919:242447997242447420:242447550ENSG00000115694.10ENST00000405585.1
exon_skip_3482142242440931:242441123:242443452:242443511:242447857:242447971242443452:242443511ENSG00000115694.10ENST00000420551.1
exon_skip_3482152242440931:242441123:242447420:242447550:242447857:242447971242447420:242447550ENSG00000115694.10ENST00000452891.1,ENST00000426941.1
exon_skip_3482162242440931:242441123:242447420:242447550:242447919:242447997242447420:242447550ENSG00000115694.10ENST00000403346.3,ENST00000436917.1,ENST00000495372.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for STK25

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000004033462424474202424475503UTR-3CDS
ENST00000316586242437649242437764Frame-shift
ENST00000401869242437649242437764Frame-shift
ENST00000403346242437649242437764Frame-shift
ENST00000316586242438403242438589In-frame
ENST00000401869242438403242438589In-frame
ENST00000403346242438403242438589In-frame
ENST00000316586242440154242440211In-frame
ENST00000401869242440154242440211In-frame
ENST00000403346242440154242440211In-frame
ENST00000316586242440892242441123In-frame
ENST00000401869242440892242441123In-frame
ENST00000403346242440892242441123In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000004033462424474202424475503UTR-3CDS
ENST00000316586242437649242437764Frame-shift
ENST00000401869242437649242437764Frame-shift
ENST00000403346242437649242437764Frame-shift
ENST00000316586242438403242438589In-frame
ENST00000401869242438403242438589In-frame
ENST00000403346242438403242438589In-frame
ENST00000316586242440154242440211In-frame
ENST00000401869242440154242440211In-frame
ENST00000403346242440154242440211In-frame
ENST00000316586242440892242441123In-frame
ENST00000401869242440892242441123In-frame
ENST00000403346242440892242441123In-frame

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Infer the effects of exon skipping event on protein functional features for STK25

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000031658646364262424408922424411233816111087
ENST0000040186922684262424408922424411233585881087
ENST0000040334622274262424408922424411233155451087
ENST00000316586463642624244015424244021161266887106
ENST00000401869226842624244015424244021158964587106
ENST00000403346222742624244015424244021154660287106
ENST0000031658646364262424384032424385899361121195257
ENST0000040186922684262424384032424385899131098195257
ENST0000040334622274262424384032424385898701055195257

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000031658646364262424408922424411233816111087
ENST0000040186922684262424408922424411233585881087
ENST0000040334622274262424408922424411233155451087
ENST00000316586463642624244015424244021161266887106
ENST00000401869226842624244015424244021158964587106
ENST00000403346222742624244015424244021154660287106
ENST0000031658646364262424384032424385899361121195257
ENST0000040186922684262424384032424385899131098195257
ENST0000040334622274262424384032424385898701055195257

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O005061087194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O005061087194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O005061087194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050610871187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050610871187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050610871187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050610872028Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610872028Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610872028Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610873039Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610873039Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610873039Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874552Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874552Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874552Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610878187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610878187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610878187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874949Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610874949Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610874949Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610871426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O0050610871426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O0050610871426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O00506108720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O00506108720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O00506108720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O005061087810HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O005061087810HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O005061087810HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610871619HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610871619HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610871619HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610876072HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610876072HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610876072HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874949MutagenesisNote=Loss of kinase activity and autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037601;Dbxref=PMID:15037601
O0050610874949MutagenesisNote=Loss of kinase activity and autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037601;Dbxref=PMID:15037601
O0050610874949MutagenesisNote=Loss of kinase activity and autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037601;Dbxref=PMID:15037601
O0050610876464Natural variantID=VAR_051674;Note=Q->H;Dbxref=dbSNP:rs34341643
O0050610876464Natural variantID=VAR_051674;Note=Q->H;Dbxref=dbSNP:rs34341643
O0050610876464Natural variantID=VAR_051674;Note=Q->H;Dbxref=dbSNP:rs34341643
O0050610872634Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610872634Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610872634Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610874042TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874042TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874042TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610875356TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610875356TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610875356TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050687106194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050687106194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050687106194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O00506871061187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O00506871061187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O00506871061187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O00506871068187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871068187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871068187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871069096Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871069096Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871069096Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871061426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O00506871061426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O00506871061426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O005068710620270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O005068710620270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O005068710620270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050687106103107HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050687106103107HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050687106103107HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O005061952571426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O005061952571426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O005061952571426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O0050619525720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050619525720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050619525720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O00506195257195210HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257195210HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257195210HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257220226HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257220226HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257220226HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257241250HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257241250HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257241250HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257255257HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257255257HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257255257HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257214217TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257214217TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257214217TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257227229TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257227229TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257227229TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O005061087194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O005061087194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O005061087194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050610871187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050610871187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050610871187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050610872028Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610872028Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610872028Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610873039Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610873039Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610873039Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874552Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874552Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874552Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610878187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610878187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610878187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874949Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610874949Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610874949Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610871426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O0050610871426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O0050610871426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O00506108720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O00506108720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O00506108720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O005061087810HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O005061087810HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O005061087810HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610871619HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610871619HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610871619HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610876072HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610876072HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610876072HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874949MutagenesisNote=Loss of kinase activity and autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037601;Dbxref=PMID:15037601
O0050610874949MutagenesisNote=Loss of kinase activity and autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037601;Dbxref=PMID:15037601
O0050610874949MutagenesisNote=Loss of kinase activity and autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037601;Dbxref=PMID:15037601
O0050610876464Natural variantID=VAR_051674;Note=Q->H;Dbxref=dbSNP:rs34341643
O0050610876464Natural variantID=VAR_051674;Note=Q->H;Dbxref=dbSNP:rs34341643
O0050610876464Natural variantID=VAR_051674;Note=Q->H;Dbxref=dbSNP:rs34341643
O0050610872634Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610872634Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610872634Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050610874042TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874042TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610874042TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610875356TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610875356TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050610875356TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050687106194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050687106194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O0050687106194Alternative sequenceID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O00506871061187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O00506871061187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O00506871061187Alternative sequenceID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O00506871068187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871068187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871068187Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871069096Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871069096Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871069096Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506871061426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O00506871061426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O00506871061426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O005068710620270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O005068710620270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O005068710620270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050687106103107HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050687106103107HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O0050687106103107HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O005061952571426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O005061952571426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O005061952571426ChainID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
O0050619525720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050619525720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O0050619525720270DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
O00506195257195210HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257195210HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257195210HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257220226HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257220226HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257220226HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257241250HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257241250HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257241250HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257255257HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257255257HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257255257HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257214217TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257214217TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257214217TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257227229TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257227229TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
O00506195257227229TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK


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SNVs in the skipped exons for STK25

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
STADTCGA-BR-6852-01exon_skip_348185
242437650242437764242437662242437662Frame_Shift_DelG-p.S341fs
LIHCTCGA-DD-A3A0-01exon_skip_348185
242437650242437764242437714242437714Frame_Shift_DelG-p.P323fs
STADTCGA-CG-5726-01exon_skip_348189
242438404242438589242438541242438541Frame_Shift_DelC-p.E212fs
LIHCTCGA-DD-A39Y-01exon_skip_348208
exon_skip_348209
exon_skip_348206
exon_skip_348207
242440893242441123242440926242440926Frame_Shift_DelG-p.P76fs
LIHCTCGA-DD-A39Y-01exon_skip_348208
exon_skip_348209
exon_skip_348206
exon_skip_348207
242440893242441123242440926242440926Frame_Shift_DelG-p.Y77fs
LIHCTCGA-DD-A39Y-01exon_skip_348210
242440893242441214242440926242440926Frame_Shift_DelG-p.P76fs
LIHCTCGA-DD-A39Y-01exon_skip_348210
242440893242441214242440926242440926Frame_Shift_DelG-p.Y77fs

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE242437650242437764242437714242437714Frame_Shift_DelG-p.P323fs
HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE242438404242438589242438541242438541Frame_Shift_DelC-p.E212fs
KM12_LARGE_INTESTINE242438404242438589242438541242438541Frame_Shift_DelC-p.E212fs
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE242437650242437764242437748242437748Missense_MutationCTp.D312N
LIM1215_LARGE_INTESTINE242438404242438589242438508242438508Missense_MutationCTp.V223I
CORL32_LUNG242438404242438589242438510242438510Missense_MutationCGp.R222P
COLO684_ENDOMETRIUM242439588242439696242439680242439680Missense_MutationAGp.L112P
CAR1_LARGE_INTESTINE242440155242440492242440166242440166Missense_MutationCTp.A103T
CAR1_LARGE_INTESTINE242440155242440211242440166242440166Missense_MutationCTp.A103T
CAR1_LARGE_INTESTINE242440155242440262242440166242440166Missense_MutationCTp.A103T
KM12_LARGE_INTESTINE242440893242441214242440916242440916Missense_MutationGAp.R80C
KM12_LARGE_INTESTINE242440893242441123242440916242440916Missense_MutationGAp.R80C
HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE242440893242441214242441005242441005Missense_MutationAGp.I50T
HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE242440893242441123242441005242441005Missense_MutationAGp.I50T
GP2D_LARGE_INTESTINE242440893242441214242441036242441036Missense_MutationTCp.N40D
GP2D_LARGE_INTESTINE242440893242441123242441036242441036Missense_MutationTCp.N40D
GP5D_LARGE_INTESTINE242440893242441214242441036242441036Missense_MutationTCp.N40D
GP5D_LARGE_INTESTINE242440893242441123242441036242441036Missense_MutationTCp.N40D
HUPT3_PANCREAS242447421242447550242447425242447425Missense_MutationTCp.N9S
RL952_ENDOMETRIUM242437650242437764242437650242437650Splice_SiteCTp.K344K
HT115_LARGE_INTESTINE242438404242438589242438404242438404Splice_SiteGAp.F257F

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK25

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK25


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK25


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RelatedDrugs for STK25

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK25

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource