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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TSPAN32 |
 Gene summary |
| Gene information | Gene symbol | TSPAN32 | Gene ID | 10077 |
| Gene name | tetraspanin 32 | |
| Synonyms | ART1|PHEMX|PHMX|TSSC6 | |
| Cytomap | 11p15.5 | |
| Type of gene | protein-coding | |
| Description | tetraspanin-32pan-hematopoietic expression proteinprotein Phemxtumor-suppressing STF cDNA 6tumor-suppressing subchromosomal transferable fragment cDNA 6tumor-suppressing subtransferable candidate 6 | |
| Modification date | 20180523 | |
| UniProtAcc | Q96QS1 | |
| Context | PubMed: TSPAN32 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for TSPAN32 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TSPAN32 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TSPAN32 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_56189 | 11 | 2324097:2324188:2324639:2324711:2325336:2325434 | 2324639:2324711 | ENSG00000064201.11 | ENST00000461200.1 |
| exon_skip_56190 | 11 | 2325336:2325434:2329965:2330040:2334883:2334938 | 2329965:2330040 | ENSG00000064201.11 | ENST00000493924.1,ENST00000182290.4,ENST00000479508.1,ENST00000451520.2,ENST00000339046.4,ENST00000446063.2,ENST00000461200.1,ENST00000381121.3,ENST00000493948.1,ENST00000498313.1,ENST00000484104.1 |
| exon_skip_56193 | 11 | 2335714:2335801:2337458:2337542:2337805:2337897 | 2337458:2337542 | ENSG00000064201.11 | ENST00000182290.4,ENST00000451520.2,ENST00000381117.1,ENST00000339046.4,ENST00000381121.3 |
| exon_skip_56195 | 11 | 2337458:2337542:2337805:2337897:2338573:2338755 | 2337805:2337897 | ENSG00000064201.11 | ENST00000182290.4,ENST00000451520.2,ENST00000381117.1 |
| exon_skip_56196 | 11 | 2337458:2337542:2337805:2337897:2339092:2339154 | 2337805:2337897 | ENSG00000064201.11 | ENST00000381121.3 |
| exon_skip_56204 | 11 | 2337865:2337897:2338573:2338755:2339092:2339154 | 2338573:2338755 | ENSG00000064201.11 | ENST00000182290.4,ENST00000451520.2,ENST00000381117.1,ENST00000446063.2,ENST00000461200.1 |
| exon_skip_56205 | 11 | 2337825:2337897:2338575:2338755:2339092:2339154 | 2338575:2338755 | ENSG00000064201.11 | ENST00000493924.1,ENST00000339046.4 |
| exon_skip_56207 | 11 | 2337865:2337897:2338656:2338755:2339092:2339154 | 2338656:2338755 | ENSG00000064201.11 | ENST00000486011.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TSPAN32 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_56189 | 11 | 2324097:2324188:2324639:2324711:2325336:2325434 | 2324639:2324711 | ENSG00000064201.11 | ENST00000461200.1 |
| exon_skip_56190 | 11 | 2325336:2325434:2329965:2330040:2334883:2334938 | 2329965:2330040 | ENSG00000064201.11 | ENST00000461200.1,ENST00000182290.4,ENST00000446063.2,ENST00000493924.1,ENST00000484104.1,ENST00000479508.1,ENST00000498313.1,ENST00000381121.3,ENST00000493948.1,ENST00000339046.4,ENST00000451520.2 |
| exon_skip_56193 | 11 | 2335714:2335801:2337458:2337542:2337805:2337897 | 2337458:2337542 | ENSG00000064201.11 | ENST00000182290.4,ENST00000381121.3,ENST00000339046.4,ENST00000451520.2,ENST00000381117.1 |
| exon_skip_56195 | 11 | 2337458:2337542:2337805:2337897:2338573:2338755 | 2337805:2337897 | ENSG00000064201.11 | ENST00000182290.4,ENST00000451520.2,ENST00000381117.1 |
| exon_skip_56196 | 11 | 2337458:2337542:2337805:2337897:2339092:2339154 | 2337805:2337897 | ENSG00000064201.11 | ENST00000381121.3 |
| exon_skip_56200 | 11 | 2337458:2337542:2337861:2337897:2338573:2338755 | 2337861:2337897 | ENSG00000064201.11 | ENST00000446063.2 |
| exon_skip_56204 | 11 | 2337865:2337897:2338573:2338755:2339092:2339154 | 2338573:2338755 | ENSG00000064201.11 | ENST00000461200.1,ENST00000182290.4,ENST00000446063.2,ENST00000451520.2,ENST00000381117.1 |
| exon_skip_56205 | 11 | 2337825:2337897:2338575:2338755:2339092:2339154 | 2338575:2338755 | ENSG00000064201.11 | ENST00000493924.1,ENST00000339046.4 |
| exon_skip_56207 | 11 | 2337865:2337897:2338656:2338755:2339092:2339154 | 2338656:2338755 | ENSG00000064201.11 | ENST00000486011.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TSPAN32 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000182290 | 2337805 | 2337897 | Frame-shift |
| ENST00000182290 | 2338573 | 2338755 | Frame-shift |
| ENST00000182290 | 2329965 | 2330040 | In-frame |
| ENST00000182290 | 2337458 | 2337542 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000182290 | 2337805 | 2337897 | Frame-shift |
| ENST00000182290 | 2338573 | 2338755 | Frame-shift |
| ENST00000182290 | 2329965 | 2330040 | In-frame |
| ENST00000182290 | 2337458 | 2337542 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TSPAN32 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000182290 | 1335 | 320 | 2329965 | 2330040 | 417 | 491 | 93 | 118 |
| ENST00000182290 | 1335 | 320 | 2337458 | 2337542 | 681 | 764 | 181 | 209 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000182290 | 1335 | 320 | 2329965 | 2330040 | 417 | 491 | 93 | 118 |
| ENST00000182290 | 1335 | 320 | 2337458 | 2337542 | 681 | 764 | 181 | 209 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96QS1 | 93 | 118 | 1 | 320 | Chain | ID=PRO_0000219278;Note=Tetraspanin-32 |
| Q96QS1 | 93 | 118 | 90 | 110 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96QS1 | 181 | 209 | 155 | 320 | Alternative sequence | ID=VSP_003934;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10950922;Dbxref=PMID:10950922 |
| Q96QS1 | 181 | 209 | 1 | 320 | Chain | ID=PRO_0000219278;Note=Tetraspanin-32 |
| Q96QS1 | 181 | 209 | 203 | 223 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96QS1 | 93 | 118 | 1 | 320 | Chain | ID=PRO_0000219278;Note=Tetraspanin-32 |
| Q96QS1 | 93 | 118 | 90 | 110 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96QS1 | 181 | 209 | 155 | 320 | Alternative sequence | ID=VSP_003934;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10950922;Dbxref=PMID:10950922 |
| Q96QS1 | 181 | 209 | 1 | 320 | Chain | ID=PRO_0000219278;Note=Tetraspanin-32 |
| Q96QS1 | 181 | 209 | 203 | 223 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for TSPAN32 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_56190 | 2329966 | 2330040 | 2330031 | 2330031 | Frame_Shift_Del | C | - | p.S115fs |
| BRCA | TCGA-AR-A256-01 | exon_skip_56195 exon_skip_56196 | 2337806 | 2337897 | 2337833 | 2337849 | Frame_Shift_Del | CTGTGGTTTGCCATCCG | - | p.F221fs |
| LGG | TCGA-HT-A619-01 | exon_skip_56195 exon_skip_56196 | 2337806 | 2337897 | 2337873 | 2337874 | Frame_Shift_Ins | - | G | p.K232fs |
| LGG | TCGA-HT-A619-01 | exon_skip_56195 exon_skip_56196 | 2337806 | 2337897 | 2337873 | 2337874 | Frame_Shift_Ins | - | G | p.R232fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DMS454_LUNG | 2329966 | 2330040 | 2330033 | 2330033 | Missense_Mutation | C | A | p.P116H |
| MCC26_SKIN | 2337459 | 2337542 | 2337519 | 2337519 | Missense_Mutation | A | T | p.T202S |
| SNGM_ENDOMETRIUM | 2337459 | 2337542 | 2337528 | 2337528 | Missense_Mutation | G | T | p.G205C |
| MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 2337459 | 2337542 | 2337528 | 2337528 | Missense_Mutation | G | A | p.G205S |
| HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 2337459 | 2337542 | 2337534 | 2337534 | Missense_Mutation | G | T | p.A207S |
| TE5_OESOPHAGUS | 2337459 | 2337542 | 2337534 | 2337534 | Missense_Mutation | G | T | p.A207S |
| IALM_LUNG | 2337459 | 2337542 | 2337534 | 2337534 | Missense_Mutation | G | T | p.A207S |
| PK59_PANCREAS | 2337459 | 2337542 | 2337534 | 2337534 | Missense_Mutation | G | T | p.A207S |
| LNCAPCLONEFGC_PROSTATE | 2337806 | 2337897 | 2337834 | 2337834 | Missense_Mutation | T | C | p.L219P |
| HS819T_FIBROBLAST | 2337806 | 2337897 | 2337870 | 2337870 | Missense_Mutation | G | C | p.R231P |
| BONNA12_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 2338576 | 2338755 | 2338650 | 2338650 | Missense_Mutation | G | A | p.E266K |
| BONNA12_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 2338574 | 2338755 | 2338650 | 2338650 | Missense_Mutation | G | A | p.E266K |
| ZR7530_BREAST | 2338576 | 2338755 | 2338722 | 2338722 | Missense_Mutation | C | G | p.L290V |
| ZR7530_BREAST | 2338574 | 2338755 | 2338722 | 2338722 | Missense_Mutation | C | G | p.L290V |
| ZR7530_BREAST | 2338657 | 2338755 | 2338722 | 2338722 | Missense_Mutation | C | G | p.L290V |
| KMBC2_URINARY_TRACT | 2338576 | 2338755 | 2338753 | 2338753 | Missense_Mutation | G | C | p.R300T |
| KMBC2_URINARY_TRACT | 2338574 | 2338755 | 2338753 | 2338753 | Missense_Mutation | G | C | p.R300T |
| KMBC2_URINARY_TRACT | 2338657 | 2338755 | 2338753 | 2338753 | Missense_Mutation | G | C | p.R300T |
| 5637_URINARY_TRACT | 2338576 | 2338755 | 2338753 | 2338753 | Missense_Mutation | G | A | p.R300K |
| 5637_URINARY_TRACT | 2338574 | 2338755 | 2338753 | 2338753 | Missense_Mutation | G | A | p.R300K |
| 5637_URINARY_TRACT | 2338657 | 2338755 | 2338753 | 2338753 | Missense_Mutation | G | A | p.R300K |
| MET2B | 2338576 | 2338755 | 2338755 | 2338755 | Splice_Site | G | A | p.A301T |
| MET2B | 2338574 | 2338755 | 2338755 | 2338755 | Splice_Site | G | A | p.A301T |
| MET2B | 2338657 | 2338755 | 2338755 | 2338755 | Splice_Site | G | A | p.A301T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TSPAN32 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TSPAN32 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TSPAN32 |
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RelatedDrugs for TSPAN32 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSPAN32 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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