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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RANBP2 |
 Gene summary |
| Gene information | Gene symbol | RANBP2 | Gene ID | 5903 |
| Gene name | RAN binding protein 2 | |
| Synonyms | ADANE|ANE1|IIAE3|NUP358|TRP1|TRP2 | |
| Cytomap | 2q13 | |
| Type of gene | protein-coding | |
| Description | E3 SUMO-protein ligase RanBP2358 kDa nucleoporinE3 SUMO-protein transferase RanBP2P270acute necrotizing encephalopathy 1 (autosomal dominant)nuclear pore complex protein Nup358nucleoporin 358nucleoporin Nup358ran-binding protein 2transformation-r | |
| Modification date | 20180523 | |
| UniProtAcc | P49792 | |
| Context | PubMed: RANBP2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RANBP2 | GO:0016925 | protein sumoylation | 17264123|22155184 |
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Exon skipping events across known transcript of Ensembl for RANBP2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RANBP2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RANBP2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_328524 | 2 | 109352559:109352705:109356944:109357137:109363166:109363254 | 109356944:109357137 | ENSG00000153201.11 | ENST00000283195.6 |
| exon_skip_328526 | 2 | 109374868:109375004:109378556:109378651:109379692:109382503 | 109378556:109378651 | ENSG00000153201.11 | ENST00000283195.6 |
| exon_skip_328529 | 2 | 109378556:109378651:109379692:109384844:109388156:109388327 | 109379692:109384844 | ENSG00000153201.11 | ENST00000283195.6 |
| exon_skip_328534 | 2 | 109389323:109389502:109392187:109392392:109393585:109393687 | 109392187:109392392 | ENSG00000153201.11 | ENST00000283195.6 |
| exon_skip_328539 | 2 | 109392187:109392392:109393585:109393687:109397724:109397885 | 109393585:109393687 | ENSG00000153201.11 | ENST00000283195.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RANBP2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_328524 | 2 | 109352559:109352705:109356944:109357137:109363166:109363254 | 109356944:109357137 | ENSG00000153201.11 | ENST00000283195.6 |
| exon_skip_328526 | 2 | 109374868:109375004:109378556:109378651:109379692:109382503 | 109378556:109378651 | ENSG00000153201.11 | ENST00000283195.6 |
| exon_skip_328529 | 2 | 109378556:109378651:109379692:109384844:109388156:109388327 | 109379692:109384844 | ENSG00000153201.11 | ENST00000283195.6 |
| exon_skip_328534 | 2 | 109389323:109389502:109392187:109392392:109393585:109393687 | 109392187:109392392 | ENSG00000153201.11 | ENST00000283195.6 |
| exon_skip_328539 | 2 | 109392187:109392392:109393585:109393687:109397724:109397885 | 109393585:109393687 | ENSG00000153201.11 | ENST00000283195.6 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RANBP2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000283195 | 109356944 | 109357137 | Frame-shift |
| ENST00000283195 | 109378556 | 109378651 | Frame-shift |
| ENST00000283195 | 109379692 | 109384844 | Frame-shift |
| ENST00000283195 | 109392187 | 109392392 | Frame-shift |
| ENST00000283195 | 109393585 | 109393687 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000283195 | 109356944 | 109357137 | Frame-shift |
| ENST00000283195 | 109378556 | 109378651 | Frame-shift |
| ENST00000283195 | 109379692 | 109384844 | Frame-shift |
| ENST00000283195 | 109392187 | 109392392 | Frame-shift |
| ENST00000283195 | 109393585 | 109393687 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RANBP2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000283195 | 11728 | 3224 | 109393585 | 109393687 | 8624 | 8725 | 2832 | 2866 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000283195 | 11728 | 3224 | 109393585 | 109393687 | 8624 | 8725 | 2832 | 2866 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P49792 | 2832 | 2866 | 1 | 3224 | Chain | ID=PRO_0000204913;Note=E3 SUMO-protein ligase RanBP2 |
| P49792 | 2832 | 2866 | 1001 | 3206 | Region | Note=22 X 2 AA repeats of F-G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P49792 | 2832 | 2866 | 2840 | 2841 | Repeat | Note=16;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P49792 | 2832 | 2866 | 2842 | 2843 | Repeat | Note=17;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P49792 | 2832 | 2866 | 2863 | 2864 | Repeat | Note=18;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P49792 | 2832 | 2866 | 1 | 3224 | Chain | ID=PRO_0000204913;Note=E3 SUMO-protein ligase RanBP2 |
| P49792 | 2832 | 2866 | 1001 | 3206 | Region | Note=22 X 2 AA repeats of F-G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P49792 | 2832 | 2866 | 2840 | 2841 | Repeat | Note=16;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P49792 | 2832 | 2866 | 2842 | 2843 | Repeat | Note=17;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P49792 | 2832 | 2866 | 2863 | 2864 | Repeat | Note=18;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for RANBP2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
RANBP2_BRCA_exon_skip_328529_psi_boxplot.png |
RANBP2_ESCA_exon_skip_328529_psi_boxplot.png |
RANBP2_LIHC_exon_skip_328529_psi_boxplot.png |
RANBP2_PAAD_exon_skip_328529_psi_boxplot.png |
RANBP2_READ_exon_skip_328529_psi_boxplot.png |
RANBP2_STAD_exon_skip_328529_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| STAD | TCGA-HU-8602-01 | exon_skip_328529 | 109379693 | 109384844 | 109379723 | 109379723 | Frame_Shift_Del | C | - | p.P909fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_328529 | 109379693 | 109384844 | 109379851 | 109379851 | Frame_Shift_Del | A | - | p.G952fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328529 | 109379693 | 109384844 | 109379941 | 109379941 | Frame_Shift_Del | A | - | p.T982fs |
| UCEC | TCGA-D1-A163-01 | exon_skip_328529 | 109379693 | 109384844 | 109380063 | 109380064 | Frame_Shift_Del | CA | - | p.A1023fs |
| UCEC | TCGA-D1-A163-01 | exon_skip_328529 | 109379693 | 109384844 | 109380063 | 109380064 | Frame_Shift_Del | CA | - | p.T1025fs |
| KIRP | TCGA-MH-A55W-01 | exon_skip_328529 | 109379693 | 109384844 | 109380179 | 109380179 | Frame_Shift_Del | A | - | p.N1062fs |
| KIRP | TCGA-MH-A55W-01 | exon_skip_328529 | 109379693 | 109384844 | 109380179 | 109380179 | Frame_Shift_Del | A | - | p.S1061fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328529 | 109379693 | 109384844 | 109380295 | 109380295 | Frame_Shift_Del | T | - | p.N1100fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328529 | 109379693 | 109384844 | 109380321 | 109380321 | Frame_Shift_Del | T | - | p.I1109fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_328529 | 109379693 | 109384844 | 109380354 | 109380354 | Frame_Shift_Del | A | - | p.Q1120fs |
| STAD | TCGA-HU-A4G8-01 | exon_skip_328529 | 109379693 | 109384844 | 109380652 | 109380652 | Frame_Shift_Del | A | - | p.V1219fs |
| STAD | TCGA-HU-8602-01 | exon_skip_328529 | 109379693 | 109384844 | 109380873 | 109380873 | Frame_Shift_Del | T | - | p.L1293fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328529 | 109379693 | 109384844 | 109380906 | 109380906 | Frame_Shift_Del | T | - | p.I1304fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_328529 | 109379693 | 109384844 | 109381394 | 109381394 | Frame_Shift_Del | C | - | p.P1467fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_328529 | 109379693 | 109384844 | 109381467 | 109381467 | Frame_Shift_Del | A | - | p.Q1491fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328529 | 109379693 | 109384844 | 109381591 | 109381591 | Frame_Shift_Del | A | - | p.L1532fs |
| UCEC | TCGA-D1-A103-01 | exon_skip_328529 | 109379693 | 109384844 | 109381824 | 109381824 | Frame_Shift_Del | G | - | p.D1611fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_328529 | 109379693 | 109384844 | 109381967 | 109381967 | Frame_Shift_Del | T | - | p.F1658fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_328529 | 109379693 | 109384844 | 109382595 | 109382595 | Frame_Shift_Del | A | - | p.E1867fs |
| PRAD | TCGA-YL-A8SK-01 | exon_skip_328529 | 109379693 | 109384844 | 109382805 | 109382805 | Frame_Shift_Del | T | - | p.I1937fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_328529 | 109379693 | 109384844 | 109382922 | 109382922 | Frame_Shift_Del | A | - | p.E1976fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_328529 | 109379693 | 109384844 | 109383152 | 109383152 | Frame_Shift_Del | A | - | p.K2053fs |
| KIRC | TCGA-CJ-4904-01 | exon_skip_328529 | 109379693 | 109384844 | 109383536 | 109383536 | Frame_Shift_Del | A | - | p.K2181fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328529 | 109379693 | 109384844 | 109383757 | 109383757 | Frame_Shift_Del | A | - | p.R2254fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_328529 | 109379693 | 109384844 | 109383757 | 109383757 | Frame_Shift_Del | A | - | p.R2254fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_328529 | 109379693 | 109384844 | 109383990 | 109383990 | Frame_Shift_Del | T | - | p.V2332fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328529 | 109379693 | 109384844 | 109384116 | 109384116 | Frame_Shift_Del | G | - | p.R2374fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328529 | 109379693 | 109384844 | 109384168 | 109384168 | Frame_Shift_Del | T | - | p.T2391fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_328529 | 109379693 | 109384844 | 109384184 | 109384184 | Frame_Shift_Del | G | - | p.G2397fs |
| ESCA | TCGA-L5-A893-01 | exon_skip_328529 | 109379693 | 109384844 | 109384333 | 109384333 | Frame_Shift_Del | T | - | p.D2446fs |
| ESCA | TCGA-L5-A893-01 | exon_skip_328529 | 109379693 | 109384844 | 109384333 | 109384333 | Frame_Shift_Del | T | - | p.S2447fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_328529 | 109379693 | 109384844 | 109384578 | 109384578 | Frame_Shift_Del | A | - | p.E2528fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_328529 | 109379693 | 109384844 | 109384578 | 109384578 | Frame_Shift_Del | A | - | p.E2528fs |
| STAD | TCGA-BR-8078-01 | exon_skip_328529 | 109379693 | 109384844 | 109384718 | 109384718 | Frame_Shift_Del | A | - | p.P2574fs |
| UCEC | TCGA-D1-A163-01 | exon_skip_328529 | 109379693 | 109384844 | 109380715 | 109380716 | Frame_Shift_Ins | - | A | p.L1240fs |
| STAD | TCGA-D7-A4YY-01 | exon_skip_328529 | 109379693 | 109384844 | 109381418 | 109381419 | Frame_Shift_Ins | - | T | p.V1475fs |
| STAD | TCGA-D7-A4YY-01 | exon_skip_328529 | 109379693 | 109384844 | 109381419 | 109381420 | Frame_Shift_Ins | - | T | p.V1475fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_328529 | 109379693 | 109384844 | 109381898 | 109381899 | Frame_Shift_Ins | - | A | p.K1635fs |
| SKCM | TCGA-D3-A8GM-06 | exon_skip_328524 | 109356945 | 109357137 | 109357090 | 109357090 | Nonsense_Mutation | C | T | p.R310* |
| BRCA | TCGA-AR-A0TX-01 | exon_skip_328529 | 109379693 | 109384844 | 109380099 | 109380099 | Nonsense_Mutation | C | G | p.S1035* |
| CESC | TCGA-Q1-A5R2-01 | exon_skip_328529 | 109379693 | 109384844 | 109380099 | 109380099 | Nonsense_Mutation | C | G | p.S1035* |
| LUAD | TCGA-17-Z001-01 | exon_skip_328529 | 109379693 | 109384844 | 109380884 | 109380884 | Nonsense_Mutation | A | T | p.K1297* |
| SKCM | TCGA-GN-A8LK-06 | exon_skip_328529 | 109379693 | 109384844 | 109381214 | 109381214 | Nonsense_Mutation | C | T | p.R1407* |
| BLCA | TCGA-E7-A4XJ-01 | exon_skip_328529 | 109379693 | 109384844 | 109381658 | 109381658 | Nonsense_Mutation | C | T | p.R1555* |
| STAD | TCGA-BR-A4QL-01 | exon_skip_328529 | 109379693 | 109384844 | 109381658 | 109381658 | Nonsense_Mutation | C | T | p.R1555* |
| READ | TCGA-F5-6814-01 | exon_skip_328529 | 109379693 | 109384844 | 109382601 | 109382601 | Nonsense_Mutation | C | A | p.S1869X |
| UCEC | TCGA-B5-A0JY-01 | exon_skip_328529 | 109379693 | 109384844 | 109383155 | 109383155 | Nonsense_Mutation | G | T | p.E2054* |
| PAAD | TCGA-IB-7651-01 | exon_skip_328529 | 109379693 | 109384844 | 109383227 | 109383227 | Nonsense_Mutation | G | T | p.E2078* |
| PAAD | TCGA-IB-7651-01 | exon_skip_328529 | 109379693 | 109384844 | 109383227 | 109383227 | Nonsense_Mutation | G | T | p.E2078X |
| BLCA | TCGA-DK-A3IT-01 | exon_skip_328529 | 109379693 | 109384844 | 109383783 | 109383783 | Nonsense_Mutation | C | G | p.S2263* |
| PCPG | TCGA-QR-A6GW-01 | exon_skip_328529 | 109379693 | 109384844 | 109384207 | 109384207 | Nonsense_Mutation | G | A | p.W2404* |
| LUSC | TCGA-66-2785-01 | exon_skip_328529 | 109379693 | 109384844 | 109384287 | 109384287 | Nonsense_Mutation | C | A | p.S2431* |
| BLCA | TCGA-GV-A3QG-01 | exon_skip_328529 | 109379693 | 109384844 | 109379691 | 109379691 | Splice_Site | A | G | p.G900_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-L5-A893-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_328529 | |
| Skipped exon start: 109379693 | |
| Skipped exon end: 109384844 | |
| Mutation start: 109384333 | |
| Mutation end: 109384333 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: T | |
| Mutation seq: - | |
| AAchange: p.D2446fs | |
| Sample: TCGA-L5-A893-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_328529 | |
| Skipped exon start: 109379693 | |
| Skipped exon end: 109384844 | |
| Mutation start: 109384333 | |
| Mutation end: 109384333 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: T | |
| Mutation seq: - | |
| AAchange: p.S2447fs | |
exon_skip_328529_ESCA_TCGA-L5-A893-01.png | |
 | Sample: TCGA-HU-A4G8-01 |
| Cancer type: STAD | |
| ESID: exon_skip_328529 | |
| Skipped exon start: 109379693 | |
| Skipped exon end: 109384844 | |
| Mutation start: 109380652 | |
| Mutation end: 109380652 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: A | |
| Mutation seq: - | |
| AAchange: p.V1219fs | |
exon_skip_115627_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_285856_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_308974_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_328529_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_374468_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_374469_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_45545_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_49506_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_507604_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_513485_STAD_TCGA-HU-A4G8-01.png | |
exon_skip_92194_STAD_TCGA-HU-A4G8-01.png | |
 | Sample: TCGA-HU-8602-01 |
| Cancer type: STAD | |
| ESID: exon_skip_328529 | |
| Skipped exon start: 109379693 | |
| Skipped exon end: 109384844 | |
| Mutation start: 109380873 | |
| Mutation end: 109380873 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: T | |
| Mutation seq: - | |
| AAchange: p.L1293fs | |
| Sample: TCGA-HU-8602-01 |
| Cancer type: STAD | |
| ESID: exon_skip_328529 | |
| Skipped exon start: 109379693 | |
| Skipped exon end: 109384844 | |
| Mutation start: 109379723 | |
| Mutation end: 109379723 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: C | |
| Mutation seq: - | |
| AAchange: p.P909fs | |
exon_skip_110606_STAD_TCGA-HU-8602-01.png | |
exon_skip_12723_STAD_TCGA-HU-8602-01.png | |
exon_skip_12741_STAD_TCGA-HU-8602-01.png | |
exon_skip_129202_STAD_TCGA-HU-8602-01.png | |
exon_skip_142361_STAD_TCGA-HU-8602-01.png | |
exon_skip_17013_STAD_TCGA-HU-8602-01.png | |
exon_skip_28391_STAD_TCGA-HU-8602-01.png | |
exon_skip_328529_STAD_TCGA-HU-8602-01.png | |
exon_skip_35193_STAD_TCGA-HU-8602-01.png | |
exon_skip_364609_STAD_TCGA-HU-8602-01.png | |
exon_skip_3733_STAD_TCGA-HU-8602-01.png | |
exon_skip_3734_STAD_TCGA-HU-8602-01.png | |
exon_skip_424540_STAD_TCGA-HU-8602-01.png | |
exon_skip_443675_STAD_TCGA-HU-8602-01.png | |
exon_skip_466134_STAD_TCGA-HU-8602-01.png | |
exon_skip_475115_STAD_TCGA-HU-8602-01.png | |
exon_skip_482067_STAD_TCGA-HU-8602-01.png | |
exon_skip_489785_STAD_TCGA-HU-8602-01.png | |
exon_skip_489794_STAD_TCGA-HU-8602-01.png | |
exon_skip_493826_STAD_TCGA-HU-8602-01.png | |
exon_skip_493827_STAD_TCGA-HU-8602-01.png | |
exon_skip_51385_STAD_TCGA-HU-8602-01.png | |
exon_skip_81726_STAD_TCGA-HU-8602-01.png | |
exon_skip_84502_STAD_TCGA-HU-8602-01.png | |
exon_skip_96034_STAD_TCGA-HU-8602-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 109379693 | 109384844 | 109379821 | 109379822 | Frame_Shift_Del | TG | - | p.A943fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 109379693 | 109384844 | 109379824 | 109379824 | Frame_Shift_Del | A | - | p.A943fs |
| NK92MI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109383269 | 109383270 | Frame_Shift_Del | AC | - | p.T2092fs |
| HEC1A_ENDOMETRIUM | 109379693 | 109384844 | 109383586 | 109383587 | Frame_Shift_Del | GG | - | p.G2198fs |
| MZ7MEL_SKIN | 109379693 | 109384844 | 109381418 | 109381419 | Frame_Shift_Ins | - | T | p.V1475fs |
| LMSU_STOMACH | 109379693 | 109384844 | 109382881 | 109382882 | Frame_Shift_Ins | - | A | p.K1963fs |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109379820 | 109379822 | In_Frame_Del | CTG | - | p.A943del |
| TCCSUP_URINARY_TRACT | 109379693 | 109384844 | 109381047 | 109381049 | In_Frame_Del | AAG | - | p.E1352del |
| CCK81_LARGE_INTESTINE | 109379693 | 109384844 | 109382652 | 109382654 | In_Frame_Del | AAG | - | p.E1887del |
| JHH7_LIVER | 109356945 | 109357137 | 109356949 | 109356949 | Missense_Mutation | G | A | p.D263N |
| HCT15_LARGE_INTESTINE | 109356945 | 109357137 | 109357001 | 109357001 | Missense_Mutation | C | A | p.A280D |
| SNU175_LARGE_INTESTINE | 109356945 | 109357137 | 109357069 | 109357069 | Missense_Mutation | C | T | p.H303Y |
| TE125T_FIBROBLAST | 109379693 | 109384844 | 109379700 | 109379700 | Missense_Mutation | T | G | p.V902G |
| 2313287_STOMACH | 109379693 | 109384844 | 109379709 | 109379709 | Missense_Mutation | T | C | p.M905T |
| SNUC2B_LARGE_INTESTINE | 109379693 | 109384844 | 109379720 | 109379720 | Missense_Mutation | C | T | p.P909S |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109379748 | 109379748 | Missense_Mutation | C | T | p.P918L |
| SNU1040_LARGE_INTESTINE | 109379693 | 109384844 | 109379766 | 109379766 | Missense_Mutation | C | T | p.P924L |
| JHUEM7_ENDOMETRIUM | 109379693 | 109384844 | 109379772 | 109379772 | Missense_Mutation | T | C | p.V926A |
| NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109379797 | 109379797 | Missense_Mutation | C | G | p.F934L |
| VAESBJ_SOFT_TISSUE | 109379693 | 109384844 | 109379847 | 109379847 | Missense_Mutation | C | T | p.T951M |
| HCC2998_LARGE_INTESTINE | 109379693 | 109384844 | 109379855 | 109379855 | Missense_Mutation | C | A | p.L954I |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109379927 | 109379927 | Missense_Mutation | C | T | p.P978S |
| HS839T_FIBROBLAST | 109379693 | 109384844 | 109379982 | 109379982 | Missense_Mutation | C | T | p.S996F |
| C33A_CERVIX | 109379693 | 109384844 | 109380062 | 109380062 | Missense_Mutation | G | A | p.A1023T |
| JHUEM1_ENDOMETRIUM | 109379693 | 109384844 | 109380177 | 109380177 | Missense_Mutation | G | A | p.S1061N |
| KMM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109380180 | 109380180 | Missense_Mutation | A | G | p.N1062S |
| HCT15_LARGE_INTESTINE | 109379693 | 109384844 | 109380198 | 109380198 | Missense_Mutation | G | A | p.G1068D |
| KYSE410_OESOPHAGUS | 109379693 | 109384844 | 109380293 | 109380293 | Missense_Mutation | A | G | p.N1100D |
| YD38_UPPER_AERODIGESTIVE_TRACT | 109379693 | 109384844 | 109380339 | 109380339 | Missense_Mutation | T | C | p.M1115T |
| SUM159PT_BREAST | 109379693 | 109384844 | 109380375 | 109380375 | Missense_Mutation | G | A | p.R1127Q |
| MC116_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109380414 | 109380414 | Missense_Mutation | C | T | p.S1140L |
| DMS273_LUNG | 109379693 | 109384844 | 109380417 | 109380417 | Missense_Mutation | T | C | p.V1141A |
| HCC15_LUNG | 109379693 | 109384844 | 109380480 | 109380480 | Missense_Mutation | A | G | p.H1162R |
| KYSE150_OESOPHAGUS | 109379693 | 109384844 | 109380538 | 109380538 | Missense_Mutation | G | C | p.K1181N |
| LK2_LUNG | 109379693 | 109384844 | 109380543 | 109380543 | Missense_Mutation | A | T | p.E1183V |
| NCIH1688_LUNG | 109379693 | 109384844 | 109380559 | 109380559 | Missense_Mutation | G | T | p.E1188D |
| NBTU110_AUTONOMIC_GANGLIA | 109379693 | 109384844 | 109380577 | 109380577 | Missense_Mutation | C | A | p.F1194L |
| HEC59_ENDOMETRIUM | 109379693 | 109384844 | 109380588 | 109380588 | Missense_Mutation | G | A | p.R1198H |
| U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109380588 | 109380588 | Missense_Mutation | G | A | p.R1198H |
| TUR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109380588 | 109380588 | Missense_Mutation | G | A | p.R1198H |
| HCC2998_LARGE_INTESTINE | 109379693 | 109384844 | 109380608 | 109380608 | Missense_Mutation | G | A | p.D1205N |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109380638 | 109380638 | Missense_Mutation | G | A | p.G1215R |
| HT115_LARGE_INTESTINE | 109379693 | 109384844 | 109380656 | 109380656 | Missense_Mutation | A | C | p.I1221L |
| TGW_AUTONOMIC_GANGLIA | 109379693 | 109384844 | 109380707 | 109380707 | Missense_Mutation | C | A | p.Q1238K |
| NMCG1_CENTRAL_NERVOUS_SYSTEM | 109379693 | 109384844 | 109380780 | 109380780 | Missense_Mutation | G | A | p.R1262K |
| HEC50B_ENDOMETRIUM | 109379693 | 109384844 | 109380813 | 109380813 | Missense_Mutation | A | G | p.D1273G |
| HOP92_LUNG | 109379693 | 109384844 | 109380813 | 109380813 | Missense_Mutation | A | G | p.D1273G |
| Y79_AUTONOMIC_GANGLIA | 109379693 | 109384844 | 109380877 | 109380877 | Missense_Mutation | T | A | p.F1294L |
| COV504_OVARY | 109379693 | 109384844 | 109380889 | 109380889 | Missense_Mutation | T | A | p.F1298L |
| NCIH650_LUNG | 109379693 | 109384844 | 109381052 | 109381052 | Missense_Mutation | G | T | p.G1353W |
| NCIH1693_LUNG | 109379693 | 109384844 | 109381151 | 109381151 | Missense_Mutation | G | T | p.V1386F |
| NCIH1819_LUNG | 109379693 | 109384844 | 109381151 | 109381151 | Missense_Mutation | G | T | p.V1386F |
| NCIH596_LUNG | 109379693 | 109384844 | 109381193 | 109381193 | Missense_Mutation | A | C | p.S1400R |
| MZ7MEL_SKIN | 109379693 | 109384844 | 109381194 | 109381194 | Missense_Mutation | G | A | p.S1400N |
| LAN6_AUTONOMIC_GANGLIA | 109379693 | 109384844 | 109381251 | 109381251 | Missense_Mutation | G | T | p.W1419L |
| COV434_OVARY | 109379693 | 109384844 | 109381260 | 109381260 | Missense_Mutation | G | A | p.S1422N |
| YD38_UPPER_AERODIGESTIVE_TRACT | 109379693 | 109384844 | 109381293 | 109381293 | Missense_Mutation | C | G | p.S1433C |
| NCIH2342_LUNG | 109379693 | 109384844 | 109381341 | 109381341 | Missense_Mutation | C | G | p.S1449C |
| ANGMCSS_CENTRAL_NERVOUS_SYSTEM | 109379693 | 109384844 | 109381411 | 109381411 | Missense_Mutation | C | G | p.F1472L |
| HSC1_SKIN | 109379693 | 109384844 | 109381430 | 109381430 | Missense_Mutation | A | G | p.K1479E |
| CW2_LARGE_INTESTINE | 109379693 | 109384844 | 109381509 | 109381509 | Missense_Mutation | C | T | p.P1505L |
| 42MGBA_CENTRAL_NERVOUS_SYSTEM | 109379693 | 109384844 | 109381544 | 109381544 | Missense_Mutation | A | G | p.T1517A |
| KPNYS_AUTONOMIC_GANGLIA | 109379693 | 109384844 | 109381701 | 109381701 | Missense_Mutation | C | T | p.P1569L |
| NCIH520_LUNG | 109379693 | 109384844 | 109381708 | 109381708 | Missense_Mutation | A | T | p.K1571N |
| HEC108_ENDOMETRIUM | 109379693 | 109384844 | 109381851 | 109381851 | Missense_Mutation | A | G | p.N1619S |
| KYSE140_OESOPHAGUS | 109379693 | 109384844 | 109381851 | 109381851 | Missense_Mutation | A | G | p.N1619S |
| OSC20_UPPER_AERODIGESTIVE_TRACT | 109379693 | 109384844 | 109381851 | 109381851 | Missense_Mutation | A | G | p.N1619S |
| SNUC2B_LARGE_INTESTINE | 109379693 | 109384844 | 109381853 | 109381853 | Missense_Mutation | G | A | p.E1620K |
| NCIH630_LARGE_INTESTINE | 109379693 | 109384844 | 109381863 | 109381863 | Missense_Mutation | C | T | p.A1623V |
| CL11_LARGE_INTESTINE | 109379693 | 109384844 | 109382282 | 109382282 | Missense_Mutation | G | A | p.A1763T |
| KARPAS1106P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109382448 | 109382448 | Missense_Mutation | C | T | p.P1818L |
| NB10_AUTONOMIC_GANGLIA | 109379693 | 109384844 | 109382489 | 109382489 | Missense_Mutation | T | C | p.S1832P |
| TGW_AUTONOMIC_GANGLIA | 109379693 | 109384844 | 109382530 | 109382530 | Missense_Mutation | C | A | p.F1845L |
| SNU81_LARGE_INTESTINE | 109379693 | 109384844 | 109382561 | 109382561 | Missense_Mutation | G | A | p.E1856K |
| 5637_URINARY_TRACT | 109379693 | 109384844 | 109382583 | 109382583 | Missense_Mutation | A | T | p.H1863L |
| SNU886_LIVER | 109379693 | 109384844 | 109382584 | 109382584 | Missense_Mutation | T | A | p.H1863Q |
| SW872_SOFT_TISSUE | 109379693 | 109384844 | 109382601 | 109382601 | Missense_Mutation | C | T | p.S1869L |
| NCIH2347_LUNG | 109379693 | 109384844 | 109382625 | 109382625 | Missense_Mutation | C | T | p.S1877F |
| SKLU1_LUNG | 109379693 | 109384844 | 109382681 | 109382681 | Missense_Mutation | G | A | p.D1896N |
| HS698T_FIBROBLAST | 109379693 | 109384844 | 109382683 | 109382683 | Missense_Mutation | T | G | p.D1896E |
| SKMEL3_SKIN | 109379693 | 109384844 | 109382732 | 109382732 | Missense_Mutation | G | A | p.E1913K |
| CAL120_BREAST | 109379693 | 109384844 | 109382790 | 109382790 | Missense_Mutation | A | G | p.N1932S |
| GP5D_LARGE_INTESTINE | 109379693 | 109384844 | 109382804 | 109382804 | Missense_Mutation | A | G | p.I1937V |
| C33A_CERVIX | 109379693 | 109384844 | 109382876 | 109382876 | Missense_Mutation | T | A | p.F1961I |
| 639V_URINARY_TRACT | 109379693 | 109384844 | 109382883 | 109382883 | Missense_Mutation | A | T | p.K1963I |
| NCIH630_LARGE_INTESTINE | 109379693 | 109384844 | 109382954 | 109382954 | Missense_Mutation | G | A | p.A1987T |
| P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109383003 | 109383003 | Missense_Mutation | A | G | p.Y2003C |
| RPMI8866_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109383063 | 109383063 | Missense_Mutation | T | G | p.V2023G |
| TOV21G_OVARY | 109379693 | 109384844 | 109383110 | 109383110 | Missense_Mutation | C | T | p.R2039W |
| RERFGC1B_STOMACH | 109379693 | 109384844 | 109383207 | 109383207 | Missense_Mutation | T | C | p.L2071P |
| KYSE150_OESOPHAGUS | 109379693 | 109384844 | 109383230 | 109383230 | Missense_Mutation | C | A | p.Q2079K |
| C80_LARGE_INTESTINE | 109379693 | 109384844 | 109383264 | 109383264 | Missense_Mutation | C | T | p.T2090M |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109383267 | 109383267 | Missense_Mutation | C | A | p.T2091N |
| HEC108_ENDOMETRIUM | 109379693 | 109384844 | 109383270 | 109383270 | Missense_Mutation | C | T | p.T2092M |
| HS940T_FIBROBLAST | 109379693 | 109384844 | 109383335 | 109383335 | Missense_Mutation | G | A | p.D2114N |
| SNU1040_LARGE_INTESTINE | 109379693 | 109384844 | 109383390 | 109383390 | Missense_Mutation | C | T | p.A2132V |
| ESS1_ENDOMETRIUM | 109379693 | 109384844 | 109383395 | 109383395 | Missense_Mutation | G | A | p.E2134K |
| MDAMB231_BREAST | 109379693 | 109384844 | 109383557 | 109383557 | Missense_Mutation | C | G | p.Q2188E |
| LUDLU1_LUNG | 109379693 | 109384844 | 109383603 | 109383603 | Missense_Mutation | C | T | p.A2203V |
| SCC25_UPPER_AERODIGESTIVE_TRACT | 109379693 | 109384844 | 109383617 | 109383617 | Missense_Mutation | G | C | p.D2208H |
| SKMEL5_SKIN | 109379693 | 109384844 | 109383638 | 109383638 | Missense_Mutation | C | G | p.P2215A |
| KMS18_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109383698 | 109383698 | Missense_Mutation | G | C | p.D2235H |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109383788 | 109383788 | Missense_Mutation | A | G | p.T2265A |
| M14_SKIN | 109379693 | 109384844 | 109383825 | 109383825 | Missense_Mutation | C | T | p.P2277L |
| MDAMB435S_SKIN | 109379693 | 109384844 | 109383825 | 109383825 | Missense_Mutation | C | T | p.P2277L |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109383839 | 109383839 | Missense_Mutation | G | A | p.A2282T |
| T84_LARGE_INTESTINE | 109379693 | 109384844 | 109383887 | 109383887 | Missense_Mutation | G | T | p.D2298Y |
| SW756_CERVIX | 109379693 | 109384844 | 109383914 | 109383914 | Missense_Mutation | G | A | p.G2307R |
| MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109384035 | 109384035 | Missense_Mutation | G | T | p.G2347V |
| HEC251_ENDOMETRIUM | 109379693 | 109384844 | 109384078 | 109384078 | Missense_Mutation | G | T | p.Q2361H |
| MINO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 109379693 | 109384844 | 109384211 | 109384211 | Missense_Mutation | G | A | p.A2406T |
| HCT15_LARGE_INTESTINE | 109379693 | 109384844 | 109384216 | 109384216 | Missense_Mutation | T | G | p.C2407W |
| HEC108_ENDOMETRIUM | 109379693 | 109384844 | 109384340 | 109384340 | Missense_Mutation | A | G | p.I2449V |
| HEC251_ENDOMETRIUM | 109379693 | 109384844 | 109384364 | 109384364 | Missense_Mutation | A | G | p.S2457G |
| OAW42_OVARY | 109379693 | 109384844 | 109384572 | 109384572 | Missense_Mutation | G | A | p.S2526N |
| RVH421_SKIN | 109379693 | 109384844 | 109384589 | 109384589 | Missense_Mutation | C | T | p.P2532S |
| RVH421_SKIN | 109379693 | 109384844 | 109384589 | 109384590 | Missense_Mutation | CC | TT | p.P2532L |
| RVH421_SKIN | 109379693 | 109384844 | 109384590 | 109384590 | Missense_Mutation | C | T | p.P2532L |
| HCC2450_LUNG | 109379693 | 109384844 | 109384743 | 109384743 | Missense_Mutation | C | G | p.S2583C |
| SNU1040_LARGE_INTESTINE | 109379693 | 109384844 | 109384781 | 109384781 | Missense_Mutation | C | T | p.L2596F |
| ES2_OVARY | 109379693 | 109384844 | 109384797 | 109384797 | Missense_Mutation | C | G | p.P2601R |
| MELHO_SKIN | 109379693 | 109384844 | 109384803 | 109384803 | Missense_Mutation | A | G | p.E2603G |
| KMH2_THYROID | 109392188 | 109392392 | 109392194 | 109392194 | Missense_Mutation | C | A | p.Q2767K |
| CASKI_CERVIX | 109392188 | 109392392 | 109392197 | 109392197 | Missense_Mutation | A | G | p.T2768A |
| SNU1040_LARGE_INTESTINE | 109392188 | 109392392 | 109392254 | 109392254 | Missense_Mutation | G | A | p.V2787I |
| OE19_OESOPHAGUS | 109392188 | 109392392 | 109392336 | 109392336 | Missense_Mutation | A | G | p.D2814G |
| VMRCLCD_LUNG | 109392188 | 109392392 | 109392374 | 109392374 | Missense_Mutation | A | T | p.T2827S |
| CCK81_LARGE_INTESTINE | 109379693 | 109384844 | 109381658 | 109381658 | Nonsense_Mutation | C | T | p.R1555* |
| HS578T_BREAST | 109379693 | 109384844 | 109382196 | 109382196 | Nonsense_Mutation | T | A | p.L1734* |
| NUGC3_STOMACH | 109393586 | 109393687 | 109393687 | 109393687 | Splice_Site | G | T | p.D2867Y |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RANBP2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RANBP2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RANBP2 |
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RelatedDrugs for RANBP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RANBP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| RANBP2 | C0018199 | Granuloma, Plasma Cell | 1 | CTD_human |
| RANBP2 | C2675556 | ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3 | 1 | CTD_human;ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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