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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF337 |
 Gene summary |
| Gene information | Gene symbol | ZNF337 | Gene ID | 26152 |
| Gene name | zinc finger protein 337 | |
| Synonyms | - | |
| Cytomap | 20p11.21 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 337 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9Y3M9 | |
| Context | PubMed: ZNF337 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF337 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF337 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF337 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_355631 | 20 | 25657584:25657673:25666202:25666298:25666631:25666758 | 25666202:25666298 | ENSG00000130684.9 | ENST00000481610.1,ENST00000376436.1,ENST00000252979.5 |
| exon_skip_355636 | 20 | 25657584:25657673:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENSG00000130684.9 | ENST00000538750.1 |
| exon_skip_355640 | 20 | 25666202:25666298:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENSG00000130684.9 | ENST00000252979.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF337 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_355631 | 20 | 25657584:25657673:25666202:25666298:25666631:25666758 | 25666202:25666298 | ENSG00000130684.9 | ENST00000376436.1,ENST00000252979.5,ENST00000481610.1 |
| exon_skip_355636 | 20 | 25657584:25657673:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENSG00000130684.9 | ENST00000538750.1 |
| exon_skip_355640 | 20 | 25666202:25666298:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENSG00000130684.9 | ENST00000252979.5 |
| exon_skip_355641 | 20 | 25666202:25666298:25666631:25666885:25667026:25667102 | 25666631:25666885 | ENSG00000130684.9 | ENST00000481610.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF337 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000252979 | 25666631 | 25666758 | Frame-shift |
| ENST00000252979 | 25666202 | 25666298 | In-frame |
| ENST00000376436 | 25666202 | 25666298 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000252979 | 25666631 | 25666758 | Frame-shift |
| ENST00000252979 | 25666202 | 25666298 | In-frame |
| ENST00000376436 | 25666202 | 25666298 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF337 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000252979 | 3222 | 751 | 25666202 | 25666298 | 287 | 382 | 51 | 83 |
| ENST00000376436 | 3630 | 751 | 25666202 | 25666298 | 695 | 790 | 51 | 83 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000252979 | 3222 | 751 | 25666202 | 25666298 | 287 | 382 | 51 | 83 |
| ENST00000376436 | 3630 | 751 | 25666202 | 25666298 | 695 | 790 | 51 | 83 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y3M9 | 51 | 83 | 52 | 83 | Alternative sequence | ID=VSP_055949;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9Y3M9 | 51 | 83 | 52 | 83 | Alternative sequence | ID=VSP_055949;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9Y3M9 | 51 | 83 | 1 | 751 | Chain | ID=PRO_0000047540;Note=Zinc finger protein 337 |
| Q9Y3M9 | 51 | 83 | 1 | 751 | Chain | ID=PRO_0000047540;Note=Zinc finger protein 337 |
| Q9Y3M9 | 51 | 83 | 12 | 83 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
| Q9Y3M9 | 51 | 83 | 12 | 83 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y3M9 | 51 | 83 | 52 | 83 | Alternative sequence | ID=VSP_055949;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9Y3M9 | 51 | 83 | 52 | 83 | Alternative sequence | ID=VSP_055949;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9Y3M9 | 51 | 83 | 1 | 751 | Chain | ID=PRO_0000047540;Note=Zinc finger protein 337 |
| Q9Y3M9 | 51 | 83 | 1 | 751 | Chain | ID=PRO_0000047540;Note=Zinc finger protein 337 |
| Q9Y3M9 | 51 | 83 | 12 | 83 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
| Q9Y3M9 | 51 | 83 | 12 | 83 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
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SNVs in the skipped exons for ZNF337 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_355631 | 25666203 | 25666298 | 25666210 | 25666210 | Frame_Shift_Del | G | - | p.P81fs |
| HNSC | TCGA-CN-5359-01 | exon_skip_355631 | 25666203 | 25666298 | 25666234 | 25666234 | Frame_Shift_Del | T | - | p.E73fs |
| HNSC | TCGA-CN-5359-01 | exon_skip_355631 | 25666203 | 25666298 | 25666234 | 25666234 | Frame_Shift_Del | T | - | p.E74fs |
| BRCA | TCGA-AO-A1KO-01 | exon_skip_355636 exon_skip_355640 | 25666632 | 25666758 | 25666719 | 25666720 | Frame_Shift_Del | GG | - | p.Q23fs |
| COAD | TCGA-AD-6889-01 | exon_skip_355631 | 25666203 | 25666298 | 25666239 | 25666239 | Nonsense_Mutation | C | A | p.G72X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 25666203 | 25666298 | 25666221 | 25666221 | Missense_Mutation | G | A | p.R78W |
| NCIH854_LUNG | 25666203 | 25666298 | 25666238 | 25666238 | Missense_Mutation | C | T | p.G72E |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 25666203 | 25666298 | 25666266 | 25666266 | Missense_Mutation | G | A | p.R63W |
| KM12_LARGE_INTESTINE | 25666203 | 25666298 | 25666278 | 25666278 | Missense_Mutation | C | T | p.E59K |
| SKUT1_SOFT_TISSUE | 25666632 | 25666758 | 25666664 | 25666664 | Missense_Mutation | G | A | p.T41I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF337 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_355636 | 20 | 25657584:25657673:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENST00000538750.1 | LGG | rs6115256 | chr20:25666642 | C/T | 3.36e-03 |
| exon_skip_355636 | 20 | 25657584:25657673:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENST00000538750.1 | PRAD | rs926487 | chr20:25666737 | C/T | 1.91e-03 |
| exon_skip_355636 | 20 | 25657584:25657673:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENST00000538750.1 | STAD | rs6115256 | chr20:25666642 | C/T | 1.89e-04 |
| exon_skip_355640 | 20 | 25666202:25666298:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENST00000252979.5 | LGG | rs6115256 | chr20:25666642 | C/T | 3.36e-03 |
| exon_skip_355640 | 20 | 25666202:25666298:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENST00000252979.5 | PRAD | rs926487 | chr20:25666737 | C/T | 1.91e-03 |
| exon_skip_355640 | 20 | 25666202:25666298:25666631:25666758:25667026:25667102 | 25666631:25666758 | ENST00000252979.5 | STAD | rs6115256 | chr20:25666642 | C/T | 1.89e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF337 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF337 |
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RelatedDrugs for ZNF337 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF337 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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