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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MUC15 |
 Gene summary |
| Gene information | Gene symbol | MUC15 | Gene ID | 143662 |
| Gene name | mucin 15, cell surface associated | |
| Synonyms | MUC-15|PAS3|PASIII | |
| Cytomap | 11p14.2 | |
| Type of gene | protein-coding | |
| Description | mucin-15 | |
| Modification date | 20180519 | |
| UniProtAcc | Q8N387 | |
| Context | PubMed: MUC15 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for MUC15 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MUC15 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MUC15 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_69940 | 11 | 26582308:26582772:26584662:26584812:26586711:26587443 | 26584662:26584812 | ENSG00000169550.8 | ENST00000436318.2,ENST00000529533.1,ENST00000455601.2 |
| exon_skip_69942 | 11 | 26586711:26587443:26588598:26588686:26593587:26593668 | 26588598:26588686 | ENSG00000169550.8 | ENST00000527569.1,ENST00000529533.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MUC15 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_69940 | 11 | 26582308:26582772:26584662:26584812:26586711:26587443 | 26584662:26584812 | ENSG00000169550.8 | ENST00000455601.2,ENST00000436318.2,ENST00000529533.1 |
| exon_skip_69942 | 11 | 26586711:26587443:26588598:26588686:26593587:26593668 | 26588598:26588686 | ENSG00000169550.8 | ENST00000529533.1,ENST00000527569.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MUC15 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000455601 | 26584662 | 26584812 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000455601 | 26584662 | 26584812 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MUC15 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000455601 | 3173 | 334 | 26584662 | 26584812 | 814 | 963 | 231 | 281 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000455601 | 3173 | 334 | 26584662 | 26584812 | 814 | 963 | 231 | 281 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N387 | 231 | 281 | 232 | 281 | Alternative sequence | ID=VSP_010825;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12047385;Dbxref=PMID:12047385 |
| Q8N387 | 231 | 281 | 24 | 334 | Chain | ID=PRO_0000019288;Note=Mucin-15 |
| Q8N387 | 231 | 281 | 24 | 236 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8N387 | 231 | 281 | 258 | 334 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8N387 | 231 | 281 | 237 | 257 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N387 | 231 | 281 | 232 | 281 | Alternative sequence | ID=VSP_010825;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12047385;Dbxref=PMID:12047385 |
| Q8N387 | 231 | 281 | 24 | 334 | Chain | ID=PRO_0000019288;Note=Mucin-15 |
| Q8N387 | 231 | 281 | 24 | 236 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8N387 | 231 | 281 | 258 | 334 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8N387 | 231 | 281 | 237 | 257 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for MUC15 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_69940 | 26584663 | 26584812 | 26584717 | 26584717 | Frame_Shift_Del | T | - | p.R291fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_69940 | 26584663 | 26584812 | 26584717 | 26584717 | Frame_Shift_Del | T | - | p.R291fs |
| LUAD | TCGA-50-5044-01 | exon_skip_69940 | 26584663 | 26584812 | 26584813 | 26584813 | Splice_Site | C | G | p.E232_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DU145_PROSTATE | 26584663 | 26584812 | 26584668 | 26584668 | Missense_Mutation | T | C | p.E280G |
| SKES1_BONE | 26584663 | 26584812 | 26584698 | 26584698 | Missense_Mutation | G | A | p.S270F |
| SW684_SOFT_TISSUE | 26584663 | 26584812 | 26584716 | 26584716 | Missense_Mutation | C | T | p.R264K |
| SUDHL8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 26584663 | 26584812 | 26584785 | 26584785 | Missense_Mutation | C | T | p.G241E |
| SNU81_LARGE_INTESTINE | 26584663 | 26584812 | 26584806 | 26584806 | Missense_Mutation | C | A | p.R234I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MUC15 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MUC15 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MUC15 |
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RelatedDrugs for MUC15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MUC15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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