About scMitoV

   Increasing evidence suggests that mitochondrial variants have a significant impact on human disease. The emergence and development of single-cell technology enable us to investigate the mitochondrial variants at the individual cell and cell type levels. Therefore, we established scMitoV, which aims to offer a comprehensive atlas of mitochondrial variants at single-cell resolution across different tissues and diseases.
   The current version of the scMitoV database includes 865 samples (562 disease and 303 normal samples) from 77 datasets, covering 21 human tissues and 37 primary diseases. These included 23 cancers, 4 neurodegenerative diseases, 6 metabolic diseases, and 4 autoimmune diseases. We identified disease-related mitochondrial variants by comparing the disease group and the normal group in different cell types for each disease.

   In addition, we described the characteristics of each disease's mtDNA mutation in several aspects. First, we systematically characterized the mutation frequencies at each genomic location in both disease and normal samples. We compared the proportion of mutation types in different cell types in the disease group. Additionally, we depicted the mutations in different cell types in both disease and normal samples. scMitoV will serve as a significant asset for disease research, providing insight into the complex molecular and cellular changes that characterize various diseases, and an important tool for finding potential mitochondrial biomarkers and drug targets.