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| Evidence for indirect activation through the double-negative loop |
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Previous studies from PubMed for hsa-mir-194-2 and BHMT2 |
| Context | PubMed: hsa-mir-194-2 [Title/Abstract] AND BHMT2 [Title/Abstract] - miRNA-gene (PMID) |
miRNA summary for hsa-mir-194-2 |
 miRNA summary |
| miRNA information | miRNA id | hsa-mir-194-2 | miRBase accession | MI0000732 |
| Gene name | Homo sapiens miR-194-2 stem-loop | |
| ENTREZ | MIR194-2 | |
| HGNC | MIR194-2 | |
| RFAM | ||
| TARGETS | hsa-miR-194 | |
| microRNA.org | hsa-mir-194-2 |
| The genes that are negatively correlated in more than 10 cancer types with hsa-mir-194-2 without positive correlation in any cancer types of TCGA (Spearman correlation, p-value<3.5*10^(-9)). |
| The genes that are positively correlated in more than 10 cancer types with hsa-mir-194-2 without negative correlation in any cancer types of TCGA. |
| HNF1A, |
| The genes that have both of positive and negative correlation in more than two cancer types in TCGA with hsa-mir-194-2. |
| PAQR8, BHMT2, CUBN, ETNK2, TRNT1, |
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Gene summary for BHMT2 |
| Gene summary |
| Gene information | Gene symbol | BHMT2 | Gene ID | 23743 |
| Gene name | betaine--homocysteine S-methyltransferase 2 | |
| Synonyms | - | |
| Cytomap | 5q14.1 | |
| Type of gene | protein-coding | |
| Description | S-methylmethionine--homocysteine S-methyltransferase BHMT2SMM-hcy methyltransferasebetaine-homocysteine methyltransferase 2 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9H2M3 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| BHMT2 | GO:0006577 | amino-acid betaine metabolic process | 18230605 |
| BHMT2 | GO:0033477 | S-methylmethionine metabolic process | 18230605 |
| BHMT2 | GO:0046500 | S-adenosylmethionine metabolic process | 18230605 |
| BHMT2 | GO:0071267 | L-methionine salvage | 18230605 |
| The miRNAs that are negatively correlated in more than 10 cancer types with BHMT2 without positive correlation in any cancer types of TCGA (Spearman correlation, p-value<3.5*10^(-9)). |
| hsa-mir-141, |
| The miRNAs that are positively correlated in more than 10 cancer types with BHMT2 without negative correlation in any cancer types of TCGA. |
| hsa-mir-100, hsa-mir-143, |
| The miRNAs that have both of positive and negative correlation in more than two cancer types in TCGA with BHMT2. |
| hsa-mir-192, hsa-mir-193b, hsa-mir-194-1, hsa-mir-194-2, |
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hsa-mir-194-2 binding sites on BHMT2 |
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| miRNA binding site in promoter region of gene of plus strand (TSS +/- 2kb regions). |
| Gene | miRNA family | Start | End | Group type | miRNA | seed seq. with additional 2bp | miRNA seed seq. |
| miRNA binding site in promoter region of gene of minus strand (TSS +/- 2kb regions). |
| Gene | miRNA family | Start | End | Group type | miRNA | seed seq. with additional 2bp | miRNA seed seq. |
| miRNA binding site in coding region (CDS). |
| Gene | miRNA family | Start | End | Group type | miRNA | seed seq. with additional 2bp | miRNA seed seq. |
| miRNA binding site in 3'UTR region. |
| Gene | miRNA family | Site type | Context++ score | Context++ score percentile | Weighted context++ score | Weighted context++ score percentile | miRNA |
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Expression for hsa-mir-194-2 and BHMT2 |
| miRNA expression in normal and different tumor stage. |
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| Gene expression in normal and different tumor stage. |
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miRNA-gene correlation bewteen hsa-mir-194-2 and BHMT2 |
| - miRNA-gene expression correlation across pan-cancer (TCGA_t, Spearman). |
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| - miRNA-gene expression correlation across pan-cancer' matched normals (TCGA_n, Spearman). |
| - miRNA-gene expression correlation across human cancer cell-lines (CCLE, Spearman). |
| Correlation significant in less than 2 tissue types, see the download page. |
| - miRNA-gene expression correlation across healthy human tissues (GTEx, Spearman). |
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Host gene information for hsa-mir-194-2 |
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| - Host gene information for this miRNA. |
| miRNA | Gene | Chr | miRNA start | miRNA end | miRNA strand | Gene start | Gene end | Gene strand | Is positive correlation | Rdistance | Is conserved | Observed >=10 cancer types |
| hsa-mir-194-2 | MIR194-2HG | chr11 | 64891355 | 64891439 | - | 64889560 | 64893449 | - | FALSE | 0.46 | FALSE | FALSE |
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Evidence for indirect activation through the double-negative loop between hsa-mir-194-2 and BHMT2 |
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| Intermediate target genes that are negatively correlated with both of paired miRNA and gene (Spearman correlation, p-value<3.5*10^(-9)). |
| Gene | miRNA | # cancer types with significant correlation | Intermediate genes with double negative correlation |
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Evidence for co-transcription of both miRNA and gene for hsa-mir-194-2 gene and BHMT2 |
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| Intermediate target genes that are positively correlated with both of paired miRNA and gene (Spearman correlation, p-value<3.5*10^(-9)). |
| Gene | miRNA | # cancer types with significant correlation | Intermediate genes with double positive correlation |
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Super-enhancer score for hsa-mir-194-2 and BHMT2 |
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| H3K27ac enrichment score for this miRNA (TSS +/- 50kb) |
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| H3K27ac enrichment score for this gene (TSS +/- 50kb) |
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Clinical relevance of hsa-mir-194-2 and BHMT2 |
| Survival analysis using log-rank test based on miRNA expression. |
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| Survival analysis using log-rank test based on gene expression. |
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| Cox regression analysis for miRNA-gene pair. |
| Cox regression significant in less than 7 cancer types. |
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Related Drugs for hsa-mir-194-2 |
| Small molecule information for this miRNA in human (SM2miR, 2015-04-27) |
| miRNA | miRBase | Small molecule | FDA | DB | CID | Detection method | Condition | PMID | Year | Expression_pattern_of_miRNA |
| miR-194-2 | MIMAT0000460 | Diethylstilbestrol | approved | DB00255 | 448537 | Microarray | mammosphere-derived epithelial cells (MDEC) | 19549897 | 2009 | up-regulated |
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Related Drugs for BHMT2 |
| Approved drug information for this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | BHMT2 | Q9H2M3 | DB00134 | Methionine | S-methylmethionine--homocysteine S-methyltransferase BHMT2 | small molecule | approved|nutraceutical |
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Related Diseases for hsa-mir-194-2 |
| Diseases associated with this miRNA. (HMDD v3.2) |
| Category | miRNA | Disease name | PMID |
| other | hsa-mir-194-2 | Multiple Myeloma | 20951946 |
| other | hsa-mir-194-2 | Colorectal Carcinoma | 21722265 |
| other | hsa-mir-194-2 | Gastric Neoplasms | 21845495 |
| target gene | hsa-mir-194-2 | Endometrial Neoplasms | 21851624 |
| target gene | hsa-mir-194-2 | Colorectal Carcinoma | 22028325 |
| target gene | hsa-mir-194-2 | Breast Neoplasms | 22829924 |
| tissue_expression_ns | hsa-mir-194-2 | Ischemia-Reperfusion Injury | 20651252 |
| tissue_expression_up | hsa-mir-194-2 | Prostate Neoplasms | 18949015 |
| tissue_expression_up | hsa-mir-194-2 | "Adenocarcinoma, Endometrial" | 19065659 |
| tissue_expression_up | hsa-mir-194-2 | Endometriosis | 19074548 |
| tissue_expression_up | hsa-mir-194-2 | "Carcinoma, Adrenocortical" | 19351815 |
| tissue_expression_up | hsa-mir-194-2 | Liver Failure | 21692939 |
| tissue_expression_up | hsa-mir-194-2 | Pancreatic Neoplasms | 21953293 |
| tissue_expression_up | hsa-mir-194-2 | Ovarian Neoplasms | 23766361 |
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Related Diseases for BHMT2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| BHMT2 | C0008924 | Cleft Lip | 1 | CTD_human |
| BHMT2 | C0008925 | Cleft Palate | 1 | CTD_human |
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