ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for THRAP3

Gene summary

Gene information	Gene symbol	THRAP3
	Gene ID	9967
	Gene name	thyroid hormone receptor associated protein 3
	Synonyms	BCLAF2\|TRAP150
	Cytomap	1p34.3
	Type of gene	protein-coding
	Description	thyroid hormone receptor-associated protein 3BCLAF1 and THRAP3 family member 2TR-associated protein, 150-kDathyroid hormone receptor-associated protein complex 150 kDa componentthyroid hormone receptor-associated protein, 150 kDa subunit
	Modification date	20200313
	UniProtAcc	A0A3B3ITZ9, Q05D20, Q6P0P7, Q6PJV4, Q7Z5U1, Q9Y2W1,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
THRAP3	GO:0000956	nuclear-transcribed mRNA catabolic process	20123736
THRAP3	GO:0006367	transcription initiation from RNA polymerase II promoter	12218053
THRAP3	GO:0045893	positive regulation of transcription, DNA-templated	10198638
THRAP3	GO:0045944	positive regulation of transcription by RNA polymerase II	12037571

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Gene structures and expression levels for THRAP3

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000054118

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

ENST

Transcript info.

Base mean exp.

log2FC(AD/control)

P-value

Adjc. p-value

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for THRAP3

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_101020	chr1	36293851:36293935:36296583:36296770:36300886:36301084	36296583:36296770
exon_skip_167287	chr1	36292598:36292709:36293851:36293935:36296583:36296770	36293851:36293935
exon_skip_182007	chr1	36224443:36224505:36259382:36259484:36282533:36282700	36259382:36259484
exon_skip_230537	chr1	36282533:36282700:36286368:36287270:36289060:36289764	36286368:36287270
exon_skip_280017	chr1	36225412:36225463:36259382:36259484:36282533:36282700	36259382:36259484
exon_skip_65213	chr1	36224971:36225102:36259382:36259484:36282533:36282700	36259382:36259484
exon_skip_71249	chr1	36224443:36224505:36225412:36225463:36259382:36259484	36225412:36225463
exon_skip_89726	chr1	36224443:36224505:36225412:36225463:36259382:36259456	36225412:36225463

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for THRAP3

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000354618	36259382	36259484	5UTR-5UTR
ENST00000469141	36259382	36259484	5UTR-5UTR
ENST00000354618	36293851	36293935	Frame-shift
ENST00000469141	36293851	36293935	Frame-shift
ENST00000354618	36296583	36296770	Frame-shift
ENST00000469141	36296583	36296770	Frame-shift
ENST00000354618	36286368	36287270	In-frame
ENST00000469141	36286368	36287270	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000354618	36259382	36259484	5UTR-5UTR

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000354618	36259382	36259484	5UTR-5UTR
ENST00000469141	36259382	36259484	5UTR-5UTR
ENST00000354618	36293851	36293935	Frame-shift
ENST00000469141	36293851	36293935	Frame-shift
ENST00000354618	36296583	36296770	Frame-shift
ENST00000469141	36296583	36296770	Frame-shift
ENST00000354618	36286368	36287270	In-frame
ENST00000469141	36286368	36287270	In-frame

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Infer the effects of exon skipping event on protein functional features for THRAP3

p-ENSG00000054118_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000354618	4449	955	36286368	36287270	363	1264	46	346
ENST00000469141	3356	955	36286368	36287270	479	1380	46	346

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000354618	4449	955	36286368	36287270	363	1264	46	346
ENST00000469141	3356	955	36286368	36287270	479	1380	46	346

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y2W1	46	346	2	955	Chain	ID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1	46	346	2	955	Chain	ID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1	46	346	7	339	Compositional bias	Note=Ser-rich
Q9Y2W1	46	346	7	339	Compositional bias	Note=Ser-rich
Q9Y2W1	46	346	12	161	Compositional bias	Note=Arg-rich
Q9Y2W1	46	346	12	161	Compositional bias	Note=Arg-rich
Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:25114211;Dbxref=PMID:25114211
Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:25114211;Dbxref=PMID:25114211
Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	215	215	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	215	215	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	221	221	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	221	221	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	252	252	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	252	252	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	333	333	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	333	333	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	346	346	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	346	346	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	66	66	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	66	66	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	101	101	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	101	101	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	108	108	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	108	108	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	220	220	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	220	220	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	221	221	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
Q9Y2W1	46	346	221	221	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
Q9Y2W1	46	346	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y2W1	46	346	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y2W1	46	346	237	237	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9Y2W1	46	346	237	237	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9Y2W1	46	346	240	240	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
Q9Y2W1	46	346	240	240	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
Q9Y2W1	46	346	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:00002
Q9Y2W1	46	346	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:00002
Q9Y2W1	46	346	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163,E
Q9Y2W1	46	346	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163,E
Q9Y2W1	46	346	252	252	Modified residue	Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	252	252	Modified residue	Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMe
Q9Y2W1	46	346	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMe
Q9Y2W1	46	346	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
Q9Y2W1	46	346	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
Q9Y2W1	46	346	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID
Q9Y2W1	46	346	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID
Q9Y2W1	46	346	320	320	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569,E
Q9Y2W1	46	346	320	320	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569,E
Q9Y2W1	46	346	323	323	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	323	323	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	324	324	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	324	324	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	328	328	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	328	328	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
Q9Y2W1	46	346	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
Q9Y2W1	46	346	346	346	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	346	346	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	201	201	Natural variant	ID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:10198638,ECO:0000269\|PubMed:15489334,ECO:0000269\|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
Q9Y2W1	46	346	201	201	Natural variant	ID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:10198638,ECO:0000269\|PubMed:15489334,ECO:0000269\|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
Q9Y2W1	46	346	2	190	Region	Note=Required for mRNA splicing activation
Q9Y2W1	46	346	2	190	Region	Note=Required for mRNA splicing activation

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y2W1	46	346	2	955	Chain	ID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1	46	346	2	955	Chain	ID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1	46	346	7	339	Compositional bias	Note=Ser-rich
Q9Y2W1	46	346	7	339	Compositional bias	Note=Ser-rich
Q9Y2W1	46	346	12	161	Compositional bias	Note=Arg-rich
Q9Y2W1	46	346	12	161	Compositional bias	Note=Arg-rich
Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:25114211;Dbxref=PMID:25114211
Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:25114211;Dbxref=PMID:25114211
Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	215	215	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	215	215	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	221	221	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	221	221	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	252	252	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	252	252	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	333	333	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	333	333	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	346	346	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	346	346	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1	46	346	66	66	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	66	66	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	101	101	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	101	101	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	108	108	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	108	108	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	220	220	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	220	220	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	221	221	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
Q9Y2W1	46	346	221	221	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
Q9Y2W1	46	346	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y2W1	46	346	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y2W1	46	346	237	237	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9Y2W1	46	346	237	237	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9Y2W1	46	346	240	240	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
Q9Y2W1	46	346	240	240	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
Q9Y2W1	46	346	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:00002
Q9Y2W1	46	346	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:00002
Q9Y2W1	46	346	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163,E
Q9Y2W1	46	346	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163,E
Q9Y2W1	46	346	252	252	Modified residue	Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	252	252	Modified residue	Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1	46	346	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMe
Q9Y2W1	46	346	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMe
Q9Y2W1	46	346	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
Q9Y2W1	46	346	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
Q9Y2W1	46	346	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID
Q9Y2W1	46	346	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID
Q9Y2W1	46	346	320	320	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569,E
Q9Y2W1	46	346	320	320	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569,E
Q9Y2W1	46	346	323	323	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	323	323	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	324	324	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	324	324	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W1	46	346	328	328	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	328	328	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
Q9Y2W1	46	346	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
Q9Y2W1	46	346	346	346	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	346	346	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q569Z6
Q9Y2W1	46	346	201	201	Natural variant	ID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:10198638,ECO:0000269\|PubMed:15489334,ECO:0000269\|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
Q9Y2W1	46	346	201	201	Natural variant	ID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:10198638,ECO:0000269\|PubMed:15489334,ECO:0000269\|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
Q9Y2W1	46	346	2	190	Region	Note=Required for mRNA splicing activation
Q9Y2W1	46	346	2	190	Region	Note=Required for mRNA splicing activation

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3'-UTR located exon skipping events that lost miRNA binding sites in THRAP3

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for THRAP3

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for THRAP3

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for THRAP3

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for THRAP3

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	ZNF638	exon_skip_182007	-5.180135e-01	4.342634e-12
CB	TRA2A	exon_skip_182007	-5.307330e-01	1.028880e-12
CB	HNRNPA2B1	exon_skip_182007	-5.537566e-01	6.480226e-14
CB	SRSF2	exon_skip_85651	-4.175579e-01	4.352874e-08
CB	TIA1	exon_skip_85651	-5.199331e-01	2.166088e-12
CB	HNRNPDL	exon_skip_85651	-4.768003e-01	2.105131e-10
CB	NUP42	exon_skip_85651	-5.641967e-01	9.602318e-15
CB	CPEB1	exon_skip_85651	-4.609374e-01	9.712189e-10
HCC	DAZAP1	exon_skip_254685	4.713575e-01	1.661792e-16
HCC	RBMS2	exon_skip_254685	5.037530e-01	5.659224e-19
HCC	MSI1	exon_skip_254685	4.114639e-01	1.405240e-12
IFG	NUP42	exon_skip_182007	-4.961743e-01	8.481887e-03
IFG	RALYL	exon_skip_182007	-4.119472e-01	3.275341e-02
PCC	RBMS2	exon_skip_254685	4.749110e-01	1.944486e-13
PCC	G3BP2	exon_skip_254685	-4.865349e-01	4.069564e-14
TC	G3BP2	exon_skip_65719	-4.103457e-01	7.082442e-08

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RelatedDrugs for THRAP3

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for THRAP3

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for THRAP3

Gene structures and expression levels for THRAP3

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for THRAP3

Open reading frame (ORF) annotation in the exon skipping event for THRAP3

Infer the effects of exon skipping event on protein functional features for THRAP3

3'-UTR located exon skipping events that lost miRNA binding sites in THRAP3

SNVs in the skipped exons for THRAP3

AD stage-associated exon skippint events for THRAP3

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for THRAP3

Correlation with RNA binding proteins (RBPs) for THRAP3

RelatedDrugs for THRAP3

RelatedDiseases for THRAP3