ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for SNAP91

Gene summary

Gene information	Gene symbol	SNAP91
	Gene ID	9892
	Gene name	synaptosome associated protein 91
	Synonyms	AP180\|CALM
	Cytomap	6q14.2
	Type of gene	protein-coding
	Description	clathrin coat assembly protein AP18091 kDa synaptosomal-associated proteinassembly protein, 180kDaclathrin coat-associated protein AP180phosphoprotein F1-20synaptosomal-associated protein, 91kDa homologsynaptosome associated protein 91kDa
	Modification date	20200313
	UniProtAcc	A0A0A0MRM7, E5RFC6, E5RFU0, E5RGP8, E5RGY9, E5RHK9, E5RIJ5, E5RJY3, E5RK51, E5RK53, E9PDG8, H0UI15, H0YBT2, O60641,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for SNAP91

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000065609

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	UP	ENST00000521616.5	SNAP91-214:nonsense_mediated_decay:SNAP91	2.920452e+01	2.834975e+00	1.423430e-05	3.441464e-03
CB	UP	ENST00000523484.6	SNAP91-220:protein_coding:SNAP91	2.814461e+01	9.712813e-01	2.628023e-14	7.778414e-12
CB	UP	ENST00000523448.5	SNAP91-219:protein_coding:SNAP91	2.579797e+01	9.676245e-01	1.103188e-07	2.309272e-06
CB	UP	ENST00000369694.6	SNAP91-204:protein_coding:SNAP91	2.125689e+03	1.120881e+00	9.042934e-07	1.376662e-05
CB	UP	ENST00000518312.5	SNAP91-207:nonsense_mediated_decay:SNAP91	1.010553e+02	8.499380e-01	2.897705e-05	2.589877e-04
CB	UP	ENST00000521616.5	SNAP91-214:nonsense_mediated_decay:SNAP91	1.330928e+01	1.134498e+00	5.814160e-05	4.674499e-04
CB	UP	ENST00000522248.5	SNAP91-217:nonsense_mediated_decay:SNAP91	4.297540e+00	9.875216e-01	5.951464e-05	4.771568e-04

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SNAP91

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_117708	chr6	83593636:83593741:83594374:83594481:83601271:83601438	83594374:83594481
exon_skip_122071	chr6	83686128:83686223:83690223:83690436:83707798:83707927	83690223:83690436
exon_skip_125491	chr6	83662347:83662422:83665439:83665581:83707798:83707927	83665439:83665581
exon_skip_134886	chr6	83601271:83601438:83601585:83601599:83605685:83605733	83601585:83601599
exon_skip_138670	chr6	83601271:83601438:83601585:83601599:83605685:83605698	83601585:83601599
exon_skip_146550	chr6	83554215:83554285:83556143:83556245:83560104:83560142	83556143:83556245
exon_skip_149382	chr6	83592455:83592538:83592946:83593017:83593182:83593259	83592946:83593017
exon_skip_162016	chr6	83610650:83610677:83616969:83617039:83623301:83623342	83616969:83617039
exon_skip_163551	chr6	83659088:83659092:83661502:83661604:83662347:83662422	83661502:83661604
exon_skip_175774	chr6	83592946:83593017:83593182:83593259:83593478:83593610	83593182:83593259
exon_skip_188281	chr6	83582222:83582356:83591211:83591294:83592455:83592538	83591211:83591294
exon_skip_188662	chr6	83616969:83617039:83623301:83623342:83641096:83641197	83623301:83623342
exon_skip_190479	chr6	83605685:83605803:83607699:83607808:83610650:83610677	83607699:83607808
exon_skip_201737	chr6	83665514:83665581:83707798:83707957:83709326:83709381	83707798:83707957
exon_skip_202408	chr6	83610650:83610677:83616969:83617039:83623301:83623338	83616969:83617039
exon_skip_20709	chr6	83582222:83582356:83591211:83591294:83592946:83592982	83591211:83591294
exon_skip_207774	chr6	83658999:83659092:83661502:83661604:83662347:83662422	83661502:83661604
exon_skip_224365	chr6	83554215:83554285:83556143:83556245:83560104:83560136	83556143:83556245
exon_skip_232585	chr6	83593636:83593741:83594374:83594481:83601271:83601397	83594374:83594481
exon_skip_239414	chr6	83616969:83617039:83623301:83623342:83641096:83641201	83623301:83623342
exon_skip_242258	chr6	83560104:83560208:83560864:83560947:83575010:83575121	83560864:83560947
exon_skip_256348	chr6	83610650:83610677:83614857:83614862:83616969:83617039	83614857:83614862
exon_skip_270028	chr6	83592946:83593017:83593182:83593259:83593478:83593506	83593182:83593259
exon_skip_271995	chr6	83560864:83560947:83575010:83575121:83576023:83576053	83575010:83575121
exon_skip_28456	chr6	83656832:83656865:83658999:83659092:83661502:83661604	83658999:83659092
exon_skip_286617	chr6	83592946:83593017:83593182:83593259:83593478:83593741	83593182:83593259
exon_skip_289847	chr6	83591211:83591294:83592455:83592538:83592946:83592982	83592455:83592538
exon_skip_41457	chr6	83601271:83601438:83601585:83601599:83605685:83605803	83601585:83601599
exon_skip_56646	chr6	83665514:83665581:83707798:83707957:83709122:83709408	83707798:83707957
exon_skip_58462	chr6	83610650:83610677:83616969:83617039:83641096:83641202	83616969:83617039
exon_skip_60116	chr6	83616969:83617039:83623301:83623342:83641096:83641202	83623301:83623342
exon_skip_67925	chr6	83593636:83593741:83594374:83594481:83601271:83601402	83594374:83594481
exon_skip_70527	chr6	83554218:83554285:83556143:83556245:83560104:83560208	83556143:83556245
exon_skip_92630	chr6	83554215:83554285:83556143:83556245:83560104:83560208	83556143:83556245

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for SNAP91

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000439399	83707798	83707957	3UTR-3CDS
ENST00000369694	83556143	83556245	5CDS-5UTR
ENST00000439399	83556143	83556245	5CDS-5UTR
ENST00000521743	83556143	83556245	5CDS-5UTR
ENST00000369694	83575010	83575121	Frame-shift
ENST00000439399	83575010	83575121	Frame-shift
ENST00000521743	83575010	83575121	Frame-shift
ENST00000369694	83658999	83659092	Frame-shift
ENST00000439399	83658999	83659092	Frame-shift
ENST00000521743	83658999	83659092	Frame-shift
ENST00000369694	83661502	83661604	Frame-shift
ENST00000439399	83661502	83661604	Frame-shift
ENST00000521743	83661502	83661604	Frame-shift
ENST00000369694	83665439	83665581	Frame-shift
ENST00000439399	83665439	83665581	Frame-shift
ENST00000521743	83665439	83665581	Frame-shift
ENST00000369694	83591211	83591294	In-frame
ENST00000439399	83591211	83591294	In-frame
ENST00000521743	83591211	83591294	In-frame
ENST00000369694	83592455	83592538	In-frame
ENST00000439399	83592455	83592538	In-frame
ENST00000521743	83592455	83592538	In-frame
ENST00000369694	83592946	83593017	In-frame
ENST00000439399	83592946	83593017	In-frame
ENST00000521743	83592946	83593017	In-frame
ENST00000369694	83593182	83593259	In-frame
ENST00000439399	83593182	83593259	In-frame
ENST00000521743	83593182	83593259	In-frame
ENST00000369694	83594374	83594481	In-frame
ENST00000439399	83594374	83594481	In-frame
ENST00000521743	83594374	83594481	In-frame
ENST00000369694	83601585	83601599	In-frame
ENST00000439399	83601585	83601599	In-frame
ENST00000521743	83601585	83601599	In-frame
ENST00000369694	83614857	83614862	In-frame
ENST00000439399	83614857	83614862	In-frame
ENST00000521743	83614857	83614862	In-frame
ENST00000369694	83623301	83623342	In-frame
ENST00000439399	83623301	83623342	In-frame
ENST00000521743	83623301	83623342	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000369694	83556143	83556245	5CDS-5UTR
ENST00000439399	83556143	83556245	5CDS-5UTR
ENST00000521743	83556143	83556245	5CDS-5UTR
ENST00000369694	83661502	83661604	Frame-shift
ENST00000439399	83661502	83661604	Frame-shift
ENST00000521743	83661502	83661604	Frame-shift
ENST00000369694	83665439	83665581	Frame-shift
ENST00000439399	83665439	83665581	Frame-shift
ENST00000521743	83665439	83665581	Frame-shift
ENST00000369694	83591211	83591294	In-frame
ENST00000439399	83591211	83591294	In-frame
ENST00000521743	83591211	83591294	In-frame
ENST00000369694	83592455	83592538	In-frame
ENST00000439399	83592455	83592538	In-frame
ENST00000521743	83592455	83592538	In-frame
ENST00000369694	83593182	83593259	In-frame
ENST00000439399	83593182	83593259	In-frame
ENST00000521743	83593182	83593259	In-frame
ENST00000369694	83594374	83594481	In-frame
ENST00000439399	83594374	83594481	In-frame
ENST00000521743	83594374	83594481	In-frame
ENST00000369694	83601585	83601599	In-frame
ENST00000439399	83601585	83601599	In-frame
ENST00000521743	83601585	83601599	In-frame
ENST00000369694	83614857	83614862	In-frame
ENST00000439399	83614857	83614862	In-frame
ENST00000521743	83614857	83614862	In-frame
ENST00000369694	83623301	83623342	In-frame
ENST00000439399	83623301	83623342	In-frame
ENST00000521743	83623301	83623342	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000369694	83556143	83556245	5CDS-5UTR
ENST00000439399	83556143	83556245	5CDS-5UTR
ENST00000521743	83556143	83556245	5CDS-5UTR
ENST00000369694	83575010	83575121	Frame-shift
ENST00000439399	83575010	83575121	Frame-shift
ENST00000521743	83575010	83575121	Frame-shift
ENST00000369694	83607699	83607808	Frame-shift
ENST00000439399	83607699	83607808	Frame-shift
ENST00000521743	83607699	83607808	Frame-shift
ENST00000369694	83658999	83659092	Frame-shift
ENST00000439399	83658999	83659092	Frame-shift
ENST00000521743	83658999	83659092	Frame-shift
ENST00000369694	83661502	83661604	Frame-shift
ENST00000439399	83661502	83661604	Frame-shift
ENST00000521743	83661502	83661604	Frame-shift
ENST00000369694	83665439	83665581	Frame-shift
ENST00000439399	83665439	83665581	Frame-shift
ENST00000521743	83665439	83665581	Frame-shift
ENST00000369694	83560864	83560947	In-frame
ENST00000439399	83560864	83560947	In-frame
ENST00000521743	83560864	83560947	In-frame
ENST00000369694	83591211	83591294	In-frame
ENST00000439399	83591211	83591294	In-frame
ENST00000521743	83591211	83591294	In-frame
ENST00000369694	83592455	83592538	In-frame
ENST00000439399	83592455	83592538	In-frame
ENST00000521743	83592455	83592538	In-frame
ENST00000369694	83593182	83593259	In-frame
ENST00000439399	83593182	83593259	In-frame
ENST00000521743	83593182	83593259	In-frame
ENST00000369694	83594374	83594481	In-frame
ENST00000439399	83594374	83594481	In-frame
ENST00000521743	83594374	83594481	In-frame
ENST00000369694	83601585	83601599	In-frame
ENST00000439399	83601585	83601599	In-frame
ENST00000521743	83601585	83601599	In-frame
ENST00000369694	83614857	83614862	In-frame
ENST00000439399	83614857	83614862	In-frame
ENST00000521743	83614857	83614862	In-frame
ENST00000369694	83623301	83623342	In-frame
ENST00000439399	83623301	83623342	In-frame
ENST00000521743	83623301	83623342	In-frame

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Infer the effects of exon skipping event on protein functional features for SNAP91

p-ENSG00000065609_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000369694	4466	907	83623301	83623342	1080	1120	255	268
ENST00000439399	4469	907	83623301	83623342	1083	1123	255	268
ENST00000521743	4280	907	83623301	83623342	900	940	255	268
ENST00000369694	4466	907	83594374	83594481	1639	1745	441	477
ENST00000439399	4469	907	83594374	83594481	1642	1748	441	477
ENST00000521743	4280	907	83594374	83594481	1459	1565	441	477
ENST00000369694	4466	907	83593182	83593259	2011	2087	565	591
ENST00000439399	4469	907	83593182	83593259	2014	2090	565	591
ENST00000521743	4280	907	83593182	83593259	1831	1907	565	591
ENST00000369694	4466	907	83592946	83593017	2089	2159	591	615
ENST00000439399	4469	907	83592946	83593017	2092	2162	591	615
ENST00000521743	4280	907	83592946	83593017	1909	1979	591	615
ENST00000369694	4466	907	83592455	83592538	2161	2243	615	643
ENST00000439399	4469	907	83592455	83592538	2164	2246	615	643
ENST00000521743	4280	907	83592455	83592538	1981	2063	615	643
ENST00000369694	4466	907	83591211	83591294	2245	2327	643	671
ENST00000439399	4469	907	83591211	83591294	2248	2330	643	671
ENST00000521743	4280	907	83591211	83591294	2065	2147	643	671

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000369694	4466	907	83623301	83623342	1080	1120	255	268
ENST00000439399	4469	907	83623301	83623342	1083	1123	255	268
ENST00000521743	4280	907	83623301	83623342	900	940	255	268
ENST00000369694	4466	907	83594374	83594481	1639	1745	441	477
ENST00000439399	4469	907	83594374	83594481	1642	1748	441	477
ENST00000521743	4280	907	83594374	83594481	1459	1565	441	477
ENST00000369694	4466	907	83593182	83593259	2011	2087	565	591
ENST00000439399	4469	907	83593182	83593259	2014	2090	565	591
ENST00000521743	4280	907	83593182	83593259	1831	1907	565	591
ENST00000369694	4466	907	83592455	83592538	2161	2243	615	643
ENST00000439399	4469	907	83592455	83592538	2164	2246	615	643
ENST00000521743	4280	907	83592455	83592538	1981	2063	615	643
ENST00000369694	4466	907	83591211	83591294	2245	2327	643	671
ENST00000439399	4469	907	83591211	83591294	2248	2330	643	671
ENST00000521743	4280	907	83591211	83591294	2065	2147	643	671

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000369694	4466	907	83623301	83623342	1080	1120	255	268
ENST00000439399	4469	907	83623301	83623342	1083	1123	255	268
ENST00000521743	4280	907	83623301	83623342	900	940	255	268
ENST00000369694	4466	907	83594374	83594481	1639	1745	441	477
ENST00000439399	4469	907	83594374	83594481	1642	1748	441	477
ENST00000521743	4280	907	83594374	83594481	1459	1565	441	477
ENST00000369694	4466	907	83593182	83593259	2011	2087	565	591
ENST00000439399	4469	907	83593182	83593259	2014	2090	565	591
ENST00000521743	4280	907	83593182	83593259	1831	1907	565	591
ENST00000369694	4466	907	83592455	83592538	2161	2243	615	643
ENST00000439399	4469	907	83592455	83592538	2164	2246	615	643
ENST00000521743	4280	907	83592455	83592538	1981	2063	615	643
ENST00000369694	4466	907	83591211	83591294	2245	2327	643	671
ENST00000439399	4469	907	83591211	83591294	2248	2330	643	671
ENST00000521743	4280	907	83591211	83591294	2065	2147	643	671
ENST00000369694	4466	907	83560864	83560947	2757	2839	814	841
ENST00000439399	4469	907	83560864	83560947	2760	2842	814	841
ENST00000521743	4280	907	83560864	83560947	2577	2659	814	841

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O60641	255	268	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	255	268	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	255	268	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	255	268	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	255	268	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	255	268	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	255	268	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	255	268	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	255	268	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	361	583	Compositional bias	Note=Ala-rich
O60641	441	477	361	583	Compositional bias	Note=Ala-rich
O60641	441	477	361	583	Compositional bias	Note=Ala-rich
O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	565	591	361	583	Compositional bias	Note=Ala-rich
O60641	565	591	361	583	Compositional bias	Note=Ala-rich
O60641	565	591	361	583	Compositional bias	Note=Ala-rich
O60641	591	615	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	591	615	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	591	615	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	591	615	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	591	615	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	591	615	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	591	615	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	591	615	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	591	615	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	591	615	596	596	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	591	615	596	596	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	591	615	596	596	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	591	615	602	602	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	591	615	602	602	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	591	615	602	602	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O60641	255	268	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	255	268	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	255	268	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	255	268	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	255	268	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	255	268	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	255	268	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	255	268	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	255	268	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	361	583	Compositional bias	Note=Ala-rich
O60641	441	477	361	583	Compositional bias	Note=Ala-rich
O60641	441	477	361	583	Compositional bias	Note=Ala-rich
O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	565	591	361	583	Compositional bias	Note=Ala-rich
O60641	565	591	361	583	Compositional bias	Note=Ala-rich
O60641	565	591	361	583	Compositional bias	Note=Ala-rich
O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O60641	255	268	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	255	268	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	255	268	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	255	268	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	255	268	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	255	268	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	255	268	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	255	268	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	255	268	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	441	477	361	583	Compositional bias	Note=Ala-rich
O60641	441	477	361	583	Compositional bias	Note=Ala-rich
O60641	441	477	361	583	Compositional bias	Note=Ala-rich
O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	565	591	361	583	Compositional bias	Note=Ala-rich
O60641	565	591	361	583	Compositional bias	Note=Ala-rich
O60641	565	591	361	583	Compositional bias	Note=Ala-rich
O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05140
O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	814	841	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	814	841	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	814	841	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O60641	814	841	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	814	841	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	814	841	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
O60641	814	841	809	897	Compositional bias	Note=Pro-rich
O60641	814	841	809	897	Compositional bias	Note=Pro-rich
O60641	814	841	809	897	Compositional bias	Note=Pro-rich

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3'-UTR located exon skipping events that lost miRNA binding sites in SNAP91

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for SNAP91

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for SNAP91

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

ADstage

MSBB

IFG

exon_skip_125491

4.279790e-01

2.308843e-02

chr6

83662347

83662422

83665439

83665581

83707798

83707927

CDR

MSBB

IFG

exon_skip_286617

3.909235e-01

3.969282e-02

chr6

83592946

83593017

83593182

83593259

83593478

83593741

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SNAP91

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for SNAP91

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	PCBP1	exon_skip_232585	-4.022461e-01	1.614330e-07
CB	HNRNPA2B1	exon_skip_232585	-5.218283e-01	2.051903e-12
CB	SRSF5	exon_skip_232585	-4.469728e-01	3.927732e-09
CB	HNRNPF	exon_skip_232585	-4.013488e-01	1.729912e-07
HCC	RBM6	exon_skip_92630	-5.141063e-01	1.755579e-19
HCC	UNK	exon_skip_92630	-4.074312e-01	3.857601e-12
HCC	KHDRBS2	exon_skip_92630	4.581485e-01	2.593557e-15
HCC	KHDRBS3	exon_skip_92630	-4.201916e-01	6.876504e-13
HCC	PTBP1	exon_skip_92630	-5.785601e-01	2.410726e-25
HCC	HNRNPF	exon_skip_41457	-5.097355e-01	8.492099e-19
HCC	RBM5	exon_skip_256348	-5.626118e-01	1.087458e-23
PCC	HNRNPF	exon_skip_134886	-4.892252e-01	9.827036e-14
PG	KHDRBS3	exon_skip_92630	4.429498e-01	5.332552e-10
PG	RALYL	exon_skip_92630	4.842210e-01	6.536763e-12
TC	SRSF2	exon_skip_224365	4.297249e-01	2.166167e-08
TC	KHDRBS2	exon_skip_224365	7.435602e-01	1.038621e-28
TC	KHDRBS3	exon_skip_224365	6.393838e-01	2.634327e-19
TC	NUP42	exon_skip_224365	6.149908e-01	1.332025e-17
TC	RALYL	exon_skip_224365	7.868950e-01	4.199495e-34
TC	PTBP1	exon_skip_224365	-5.012973e-01	2.637494e-11
TC	CELF1	exon_skip_224365	5.197949e-01	3.562264e-12
TC	YBX2	exon_skip_224365	4.254002e-01	3.098480e-08
TC	NOVA1	exon_skip_224365	6.438690e-01	1.231841e-19
TC	ILF2	exon_skip_138670	4.933001e-01	8.036480e-11
TC	ESRP1	exon_skip_138670	6.034090e-01	1.208707e-16
TC	SRSF9	exon_skip_256348	4.110795e-01	1.076821e-07

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RelatedDrugs for SNAP91

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SNAP91

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for SNAP91

Gene structures and expression levels for SNAP91

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SNAP91

Open reading frame (ORF) annotation in the exon skipping event for SNAP91

Infer the effects of exon skipping event on protein functional features for SNAP91

3'-UTR located exon skipping events that lost miRNA binding sites in SNAP91

SNVs in the skipped exons for SNAP91

AD stage-associated exon skippint events for SNAP91

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SNAP91

Correlation with RNA binding proteins (RBPs) for SNAP91

RelatedDrugs for SNAP91

RelatedDiseases for SNAP91