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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CEP350 |
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Gene information | Gene symbol | CEP350 | Gene ID | 9857 |
Gene name | centrosomal protein 350 | |
Synonyms | CAP350|GM133 | |
Cytomap | 1q25.2 | |
Type of gene | protein-coding | |
Description | centrosome-associated protein 350centrosomal protein 350kDa | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CEP350 |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000429851.5 | CEP350-205:protein_coding:CEP350 | 3.103790e+02 | 8.815488e-01 | 3.428282e-03 | 1.440460e-02 |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CEP350 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_11949 | chr1 | 179990507:179990621:179992062:179992221:179996553:179996963 | 179992062:179992221 |
exon_skip_124606 | chr1 | 180048536:180048705:180052224:180052316:180052970:180053166 | 180052224:180052316 |
exon_skip_143911 | chr1 | 180053750:180053934:180054415:180054502:180062220:180062366 | 180054415:180054502 |
exon_skip_155301 | chr1 | 180003174:180003287:180006454:180006567:180011929:180012075 | 180006454:180006567 |
exon_skip_187719 | chr1 | 180087578:180087717:180090714:180090796:180092614:180094616 | 180090714:180090796 |
exon_skip_238901 | chr1 | 180048542:180048705:180052224:180052316:180052970:180053166 | 180052224:180052316 |
exon_skip_24645 | chr1 | 180048539:180048705:180052224:180052316:180052970:180053166 | 180052224:180052316 |
exon_skip_252041 | chr1 | 179987243:179987286:179992062:179992221:179996553:179996963 | 179992062:179992221 |
exon_skip_2823 | chr1 | 179987243:179987286:179990507:179990621:179992062:179992221 | 179990507:179990621 |
exon_skip_282854 | chr1 | 180084018:180084178:180087578:180087717:180090714:180090748 | 180087578:180087717 |
exon_skip_32088 | chr1 | 180041662:180041802:180043056:180043192:180044051:180044173 | 180043056:180043192 |
exon_skip_76354 | chr1 | 180033862:180034082:180036926:180037089:180041138:180041248 | 180036926:180037089 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_189425 | MSBB_PG | 2.286719e-01 | 3.664151e-01 | -1.377432e-01 | 2.549514e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for CEP350 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000367607 | 179990507 | 179990621 | Frame-shift |
ENST00000367607 | 179992062 | 179992221 | Frame-shift |
ENST00000367607 | 180036926 | 180037089 | Frame-shift |
ENST00000367607 | 180043056 | 180043192 | Frame-shift |
ENST00000367607 | 180087578 | 180087717 | Frame-shift |
ENST00000367607 | 180006454 | 180006567 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000367607 | 179990507 | 179990621 | Frame-shift |
ENST00000367607 | 179992062 | 179992221 | Frame-shift |
ENST00000367607 | 180087578 | 180087717 | Frame-shift |
ENST00000367607 | 180006454 | 180006567 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000367607 | 179990507 | 179990621 | Frame-shift |
ENST00000367607 | 180043056 | 180043192 | Frame-shift |
ENST00000367607 | 180054415 | 180054502 | Frame-shift |
ENST00000367607 | 180087578 | 180087717 | Frame-shift |
ENST00000367607 | 180090714 | 180090796 | Frame-shift |
ENST00000367607 | 180006454 | 180006567 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CEP350 |
p-ENSG00000135837_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000367607 | 13508 | 3117 | 180006454 | 180006567 | 1552 | 1664 | 378 | 415 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000367607 | 13508 | 3117 | 180006454 | 180006567 | 1552 | 1664 | 378 | 415 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000367607 | 13508 | 3117 | 180006454 | 180006567 | 1552 | 1664 | 378 | 415 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q5VT06 | 378 | 415 | 1 | 3117 | Chain | ID=PRO_0000233291;Note=Centrosome-associated protein 350 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q5VT06 | 378 | 415 | 1 | 3117 | Chain | ID=PRO_0000233291;Note=Centrosome-associated protein 350 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q5VT06 | 378 | 415 | 1 | 3117 | Chain | ID=PRO_0000233291;Note=Centrosome-associated protein 350 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CEP350 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CEP350 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CEP350 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CEP350 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CEP350 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | DAZAP1 | exon_skip_2823 | -4.175955e-01 | 4.628916e-06 |
CB | TRA2A | exon_skip_2823 | -4.777440e-01 | 1.000802e-07 |
CB | SAMD4A | exon_skip_24645 | -4.470555e-01 | 6.875634e-08 |
CB | FXR2 | exon_skip_24645 | -4.108929e-01 | 8.984805e-07 |
CB | RBM4B | exon_skip_24645 | -4.592431e-01 | 2.697501e-08 |
CB | HNRNPK | exon_skip_189425 | 4.601532e-01 | 4.102133e-08 |
CB | PCBP2 | exon_skip_189425 | 4.456466e-01 | 1.207602e-07 |
CB | RALYL | exon_skip_189425 | 5.797617e-01 | 6.054210e-13 |
CB | NOVA1 | exon_skip_189425 | 4.020302e-01 | 2.328890e-06 |
FL | HNRNPK | exon_skip_189425 | 5.397358e-01 | 2.233008e-15 |
FL | FUBP1 | exon_skip_189425 | 4.562519e-01 | 6.721053e-11 |
FL | PUM1 | exon_skip_189425 | 4.774327e-01 | 6.361442e-12 |
FL | RALYL | exon_skip_189425 | 6.537927e-01 | 6.192645e-24 |
FL | CELF1 | exon_skip_189425 | 4.578663e-01 | 5.647347e-11 |
FL | NOVA1 | exon_skip_189425 | 5.296529e-01 | 9.054072e-15 |
HCC | RBM3 | exon_skip_2823 | 4.257530e-01 | 3.656217e-12 |
HCC | SAMD4A | exon_skip_124606 | -4.527391e-01 | 1.923736e-14 |
HCC | RBMS2 | exon_skip_189425 | -5.934551e-01 | 4.911819e-26 |
HCC | RBMS3 | exon_skip_189425 | -4.460191e-01 | 4.593389e-14 |
HCC | ZNF638 | exon_skip_189425 | -4.553632e-01 | 1.157646e-14 |
HCC | PCBP4 | exon_skip_189425 | -4.552547e-01 | 1.176596e-14 |
HCC | FUBP3 | exon_skip_189425 | -4.159369e-01 | 2.944892e-12 |
HCC | FUBP1 | exon_skip_189425 | -4.525299e-01 | 1.766049e-14 |
IFG | IGF2BP2 | exon_skip_189425 | -4.549641e-01 | 1.710550e-02 |
IFG | PUM1 | exon_skip_189425 | 4.332935e-01 | 2.396229e-02 |
IFG | RALYL | exon_skip_189425 | 5.439819e-01 | 3.356236e-03 |
IFG | NOVA1 | exon_skip_189425 | 4.964822e-01 | 8.434855e-03 |
PCC | RBM3 | exon_skip_2823 | 4.043368e-01 | 1.143631e-08 |
PCC | RBMS2 | exon_skip_189425 | -6.397726e-01 | 6.445908e-23 |
PCC | RBMS3 | exon_skip_189425 | -4.297035e-01 | 8.403327e-10 |
PCC | RALYL | exon_skip_189425 | 4.899443e-01 | 1.105126e-12 |
PG | RBMS2 | exon_skip_189425 | -4.289268e-01 | 1.697337e-09 |
PG | HNRNPK | exon_skip_189425 | 4.035574e-01 | 1.769811e-08 |
PG | PUM1 | exon_skip_189425 | 5.015095e-01 | 6.416693e-13 |
PG | RALYL | exon_skip_189425 | 6.338977e-01 | 9.895338e-22 |
PG | CELF1 | exon_skip_189425 | 4.612654e-01 | 6.364915e-11 |
PG | NOVA1 | exon_skip_189425 | 4.888323e-01 | 2.914289e-12 |
STG | IGF2BP2 | exon_skip_189425 | -5.169280e-01 | 4.798812e-07 |
STG | HNRNPK | exon_skip_189425 | 4.734713e-01 | 5.399485e-06 |
STG | PUM1 | exon_skip_189425 | 4.284152e-01 | 4.792838e-05 |
STG | RALYL | exon_skip_189425 | 6.755157e-01 | 1.807774e-12 |
STG | CELF1 | exon_skip_189425 | 4.154112e-01 | 8.516427e-05 |
STG | NOVA1 | exon_skip_189425 | 4.885862e-01 | 2.415387e-06 |
TC | RBMS2 | exon_skip_189425 | -4.100457e-01 | 8.641992e-07 |
TC | HNRNPK | exon_skip_189425 | 4.715920e-01 | 8.841605e-09 |
TC | PUM1 | exon_skip_189425 | 6.075685e-01 | 7.038233e-15 |
TC | RALYL | exon_skip_189425 | 6.602458e-01 | 4.029786e-18 |
TC | CELF1 | exon_skip_189425 | 5.149032e-01 | 1.952613e-10 |
TC | NOVA1 | exon_skip_189425 | 5.806708e-01 | 1.918286e-13 |
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RelatedDrugs for CEP350 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CEP350 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |