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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ARMCX2 |
Gene summary |
Gene information | Gene symbol | ARMCX2 | Gene ID | 9823 |
Gene name | armadillo repeat containing X-linked 2 | |
Synonyms | ALEX2|GASP9 | |
Cytomap | Xq22.1 | |
Type of gene | protein-coding | |
Description | armadillo repeat-containing X-linked protein 2ARM protein lost in epithelial cancers on chromosome X 2armadillo repeat protein ALEX2 | |
Modification date | 20200313 | |
UniProtAcc | A0A024RCG7, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ARMCX2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PCC | UP | ENST00000330154.6 | ARMCX2-202:protein_coding:ARMCX2 | 8.990795e+01 | 1.093111e+00 | 8.386687e-04 | 2.284257e-02 |
CB | UP | ENST00000496581.1 | ARMCX2-213:lncRNA:ARMCX2 | 6.367107e+00 | 8.767959e-01 | 1.594146e-07 | 3.147265e-06 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ARMCX2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_1318 | chrX | 101659076:101659148:101659419:101659501:101659758:101659796 | 101659419:101659501 |
exon_skip_144566 | chrX | 101658461:101658525:101659076:101659148:101659419:101659501 | 101659076:101659148 |
exon_skip_213453 | chrX | 101659076:101659136:101659419:101659501:101659758:101659796 | 101659419:101659501 |
exon_skip_233361 | chrX | 101658461:101658525:101659076:101659148:101659758:101659796 | 101659076:101659148 |
exon_skip_257499 | chrX | 101658081:101658142:101658461:101658525:101659076:101659136 | 101658461:101658525 |
exon_skip_285086 | chrX | 101658081:101658142:101658461:101658569:101659076:101659136 | 101658461:101658569 |
exon_skip_64911 | chrX | 101658130:101658142:101658461:101658569:101659076:101659136 | 101658461:101658569 |
exon_skip_83703 | chrX | 101658461:101658525:101659076:101659136:101659419:101659501 | 101659076:101659136 |
exon_skip_8830 | chrX | 101658130:101658142:101658461:101658525:101659076:101659136 | 101658461:101658525 |
exon_skip_98484 | chrX | 101659076:101659148:101659408:101659501:101659758:101659796 | 101659408:101659501 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_155511 | Mayo_CB | 4.515854e-01 | 5.816883e-01 | -1.301029e-01 | 5.881764e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for ARMCX2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000328766 | 101658461 | 101658569 | 3UTR-3UTR |
ENST00000356824 | 101658461 | 101658525 | 3UTR-3UTR |
ENST00000356824 | 101659076 | 101659148 | 3UTR-3UTR |
ENST00000356824 | 101659419 | 101659501 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000328766 | 101658461 | 101658569 | 3UTR-3UTR |
ENST00000356824 | 101658461 | 101658525 | 3UTR-3UTR |
ENST00000356824 | 101659419 | 101659501 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000328766 | 101658461 | 101658569 | 3UTR-3UTR |
ENST00000356824 | 101658461 | 101658525 | 3UTR-3UTR |
ENST00000356824 | 101659419 | 101659501 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ARMCX2 |
p-ENSG00000184867_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ARMCX2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000328766 | 101658461 | 101658569 | hsa-miR-4428 | chrX:101658483-101658490 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
Mayo | ENST00000356824 | 101658461 | 101658525 | hsa-miR-4428 | chrX:101658483-101658490 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
Mayo | ENST00000328766 | 101658461 | 101658569 | hsa-miR-6806-3p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
Mayo | ENST00000356824 | 101658461 | 101658525 | hsa-miR-6806-3p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
Mayo | ENST00000328766 | 101658461 | 101658569 | hsa-miR-3928-5p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
Mayo | ENST00000356824 | 101658461 | 101658525 | hsa-miR-3928-5p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
Mayo | ENST00000356824 | 101659419 | 101659501 | hsa-miR-885-3p | chrX:101659439-101659446 | 8mer-1a | chrX:101659438-101659460 | 147.00 | -19.59 |
Mayo | ENST00000328766 | 101658461 | 101658569 | hsa-miR-6828-3p | chrX:101658531-101658538 | 8mer-1a | chrX:101658526-101658547 | 157.00 | -14.99 |
Mayo | ENST00000328766 | 101658461 | 101658569 | hsa-miR-548ao-5p | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
Mayo | ENST00000356824 | 101658461 | 101658525 | hsa-miR-548ao-5p | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
Mayo | ENST00000356824 | 101659419 | 101659501 | hsa-miR-2052 | chrX:101659472-101659479 | 8mer-1a | chrX:101659460-101659479 | 148.00 | -7.68 |
Mayo | ENST00000328766 | 101658461 | 101658569 | hsa-miR-548ax | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
Mayo | ENST00000356824 | 101658461 | 101658525 | hsa-miR-548ax | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
MSBB | ENST00000328766 | 101658461 | 101658569 | hsa-miR-4428 | chrX:101658483-101658490 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
MSBB | ENST00000356824 | 101658461 | 101658525 | hsa-miR-4428 | chrX:101658483-101658490 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
MSBB | ENST00000328766 | 101658461 | 101658569 | hsa-miR-6806-3p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
MSBB | ENST00000356824 | 101658461 | 101658525 | hsa-miR-6806-3p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
MSBB | ENST00000328766 | 101658461 | 101658569 | hsa-miR-3928-5p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
MSBB | ENST00000356824 | 101658461 | 101658525 | hsa-miR-3928-5p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
MSBB | ENST00000356824 | 101659419 | 101659501 | hsa-miR-885-3p | chrX:101659439-101659446 | 8mer-1a | chrX:101659438-101659460 | 147.00 | -19.59 |
MSBB | ENST00000328766 | 101658461 | 101658569 | hsa-miR-6828-3p | chrX:101658531-101658538 | 8mer-1a | chrX:101658526-101658547 | 157.00 | -14.99 |
MSBB | ENST00000328766 | 101658461 | 101658569 | hsa-miR-548ao-5p | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
MSBB | ENST00000356824 | 101658461 | 101658525 | hsa-miR-548ao-5p | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
MSBB | ENST00000356824 | 101659419 | 101659501 | hsa-miR-2052 | chrX:101659472-101659479 | 8mer-1a | chrX:101659460-101659479 | 148.00 | -7.68 |
MSBB | ENST00000328766 | 101658461 | 101658569 | hsa-miR-548ax | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
MSBB | ENST00000356824 | 101658461 | 101658525 | hsa-miR-548ax | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
ROSMAP | ENST00000356824 | 101659076 | 101659148 | hsa-miR-30e-3p | chrX:101659094-101659101 | 8mer-1a | chrX:101659092-101659114 | 150.00 | -23.17 |
ROSMAP | ENST00000328766 | 101658461 | 101658569 | hsa-miR-4428 | chrX:101658483-101658490 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
ROSMAP | ENST00000356824 | 101658461 | 101658525 | hsa-miR-4428 | chrX:101658483-101658490 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
ROSMAP | ENST00000356824 | 101659076 | 101659148 | hsa-miR-3180-5p | chrX:101659136-101659143 | 8mer-1a | chrX:101659118-101659143 | 186.00 | -37.53 |
ROSMAP | ENST00000356824 | 101659076 | 101659148 | hsa-miR-1910-5p | chrX:101659091-101659098 | 8mer-1a | chrX:101659090-101659112 | 143.00 | -27.51 |
ROSMAP | ENST00000356824 | 101659076 | 101659148 | hsa-miR-6802-3p | chrX:101659107-101659114 | 8mer-1a | chrX:101659092-101659114 | 150.00 | -23.17 |
ROSMAP | ENST00000328766 | 101658461 | 101658569 | hsa-miR-6806-3p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
ROSMAP | ENST00000356824 | 101658461 | 101658525 | hsa-miR-6806-3p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
ROSMAP | ENST00000328766 | 101658461 | 101658569 | hsa-miR-3928-5p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
ROSMAP | ENST00000356824 | 101658461 | 101658525 | hsa-miR-3928-5p | chrX:101658505-101658512 | 8mer-1a | chrX:101658496-101658519 | 168.00 | -19.51 |
ROSMAP | ENST00000356824 | 101659419 | 101659501 | hsa-miR-885-3p | chrX:101659439-101659446 | 8mer-1a | chrX:101659438-101659460 | 147.00 | -19.59 |
ROSMAP | ENST00000328766 | 101658461 | 101658569 | hsa-miR-6828-3p | chrX:101658531-101658538 | 8mer-1a | chrX:101658526-101658547 | 157.00 | -14.99 |
ROSMAP | ENST00000356824 | 101659076 | 101659148 | hsa-miR-30a-3p | chrX:101659094-101659101 | 8mer-1a | chrX:101659092-101659114 | 150.00 | -23.17 |
ROSMAP | ENST00000328766 | 101658461 | 101658569 | hsa-miR-548ao-5p | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
ROSMAP | ENST00000356824 | 101658461 | 101658525 | hsa-miR-548ao-5p | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
ROSMAP | ENST00000356824 | 101659419 | 101659501 | hsa-miR-2052 | chrX:101659472-101659479 | 8mer-1a | chrX:101659460-101659479 | 148.00 | -7.68 |
ROSMAP | ENST00000356824 | 101659076 | 101659148 | hsa-miR-30d-3p | chrX:101659094-101659101 | 8mer-1a | chrX:101659092-101659114 | 150.00 | -23.17 |
ROSMAP | ENST00000328766 | 101658461 | 101658569 | hsa-miR-548ax | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
ROSMAP | ENST00000356824 | 101658461 | 101658525 | hsa-miR-548ax | chrX:101658488-101658495 | 8mer-1a | chrX:101658481-101658502 | 160.00 | -21.59 |
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SNVs in the skipped exons for ARMCX2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ARMCX2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ARMCX2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ARMCX2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | FUBP1 | exon_skip_100650 | -4.460787e-01 | 7.522730e-09 |
CB | RBM6 | exon_skip_155511 | -5.617918e-01 | 1.316210e-14 |
CB | PCBP4 | exon_skip_155511 | 4.891368e-01 | 6.065331e-11 |
CB | FUBP3 | exon_skip_155511 | 4.065214e-01 | 1.054744e-07 |
CB | RBM45 | exon_skip_155511 | 7.277942e-01 | 1.665184e-27 |
CB | NUP42 | exon_skip_155511 | 5.602954e-01 | 1.599470e-14 |
CB | PTBP1 | exon_skip_155511 | -4.050033e-01 | 1.188347e-07 |
CB | RBM4 | exon_skip_155511 | -5.578506e-01 | 2.194701e-14 |
CB | RBM6 | exon_skip_1318 | -4.203815e-01 | 1.273078e-07 |
CB | NUP42 | exon_skip_1318 | 5.403640e-01 | 1.927840e-12 |
CB | RBM4 | exon_skip_1318 | -4.398094e-01 | 2.787715e-08 |
DLPFC | KHDRBS2 | exon_skip_1318 | 4.228364e-01 | 4.337498e-12 |
HCC | RBM6 | exon_skip_98484 | -4.591652e-01 | 2.765720e-14 |
HCC | RBM5 | exon_skip_98484 | -4.087459e-01 | 2.298419e-11 |
HCC | HNRNPA2B1 | exon_skip_98484 | -4.279058e-01 | 2.034767e-12 |
HCC | HNRNPF | exon_skip_98484 | -5.000834e-01 | 4.918544e-17 |
HCC | ZC3H10 | exon_skip_98484 | -4.360188e-01 | 6.954150e-13 |
HCC | RBM6 | exon_skip_1318 | -5.561458e-01 | 2.101601e-23 |
HCC | RBM5 | exon_skip_1318 | -5.116566e-01 | 1.750960e-19 |
HCC | KHDRBS3 | exon_skip_1318 | -4.197234e-01 | 5.455252e-13 |
HCC | HNRNPA2B1 | exon_skip_1318 | -4.480266e-01 | 8.742318e-15 |
HCC | HNRNPF | exon_skip_1318 | -5.584980e-01 | 1.254908e-23 |
HCC | RBM4 | exon_skip_1318 | -4.834990e-01 | 2.775660e-17 |
HCC | ZC3H10 | exon_skip_1318 | -5.570082e-01 | 1.740419e-23 |
IFG | IGF2BP3 | exon_skip_1318 | -6.314977e-01 | 7.104197e-04 |
TC | G3BP2 | exon_skip_257499 | 4.029134e-01 | 1.841477e-07 |
TC | RALYL | exon_skip_257499 | 4.137572e-01 | 7.924737e-08 |
TC | RBM6 | exon_skip_155511 | -4.304699e-01 | 2.514101e-08 |
TC | G3BP2 | exon_skip_155511 | 4.584901e-01 | 2.237180e-09 |
TC | KHDRBS2 | exon_skip_155511 | 4.963342e-01 | 5.905944e-11 |
TC | RBM24 | exon_skip_155511 | 4.068907e-01 | 1.635453e-07 |
TC | NUP42 | exon_skip_155511 | 4.954804e-01 | 6.442658e-11 |
TC | RALYL | exon_skip_155511 | 4.694968e-01 | 8.134177e-10 |
TC | HNRNPH2 | exon_skip_155511 | 5.026187e-01 | 3.090233e-11 |
TC | KHDRBS2 | exon_skip_98484 | 5.468847e-01 | 1.677833e-11 |
TC | KHDRBS3 | exon_skip_98484 | 4.079957e-01 | 1.447860e-06 |
TC | NUP42 | exon_skip_98484 | 4.676993e-01 | 2.018964e-08 |
TC | HNRNPH2 | exon_skip_98484 | 4.590144e-01 | 3.959388e-08 |
TC | SRSF2 | exon_skip_1318 | 4.489052e-01 | 5.889450e-09 |
TC | RBM6 | exon_skip_1318 | -4.218228e-01 | 5.620564e-08 |
TC | ILF2 | exon_skip_1318 | 4.249905e-01 | 4.360865e-08 |
TC | KHDRBS2 | exon_skip_1318 | 6.449193e-01 | 2.327752e-19 |
TC | KHDRBS3 | exon_skip_1318 | 4.831888e-01 | 2.515557e-10 |
TC | NUP42 | exon_skip_1318 | 5.363107e-01 | 9.012776e-13 |
TC | HNRNPH2 | exon_skip_1318 | 5.731157e-01 | 9.811092e-15 |
TC | ESRP1 | exon_skip_1318 | 4.445035e-01 | 8.613821e-09 |
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RelatedDrugs for ARMCX2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARMCX2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |