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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CTIF |
 Gene summary |
| Gene information | Gene symbol | CTIF | Gene ID | 9811 |
| Gene name | cap binding complex dependent translation initiation factor | |
| Synonyms | Gm672|KIAA0427 | |
| Cytomap | 18q21.1 | |
| Type of gene | protein-coding | |
| Description | CBP80/20-dependent translation initiation factor | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 22001921(Amyloid Protein-Mediated Differential DNA Methylation Status Regulates Gene Expression in Alzheimer's Disease Model Cell Line) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CTIF |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000134030
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000590422.1 | CTIF-208:lncRNA:CTIF | 7.276609e+01 | -2.623656e+00 | 8.991191e-05 | 6.770663e-04 |
| TC | DOWN | ENST00000590422.1 | CTIF-208:lncRNA:CTIF | 1.188354e+02 | -1.195923e+00 | 4.716383e-03 | 3.208540e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CTIF |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103074 | chr18 | 48761390:48761689:48817221:48817376:48857588:48857641 | 48817221:48817376 |
| exon_skip_159227 | chr18 | 48619538:48619745:48625189:48625236:48636614:48636685 | 48625189:48625236 |
| exon_skip_181821 | chr18 | 48757919:48758405:48761390:48761689:48817221:48817376 | 48761390:48761689 |
| exon_skip_186116 | chr18 | 48539210:48539312:48539758:48539831:48619538:48619745 | 48539758:48539831 |
| exon_skip_196777 | chr18 | 48817221:48817376:48857588:48857641:48859344:48860565 | 48857588:48857641 |
| exon_skip_21307 | chr18 | 48817221:48817376:48857588:48857641:48859344:48860074 | 48857588:48857641 |
| exon_skip_254827 | chr18 | 48817221:48817376:48857588:48857641:48859344:48859469 | 48857588:48857641 |
| exon_skip_26164 | chr18 | 48619538:48619745:48625189:48625236:48636614:48636684 | 48625189:48625236 |
| exon_skip_26798 | chr18 | 48619538:48619745:48636614:48636685:48663752:48663811 | 48636614:48636685 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CTIF |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for CTIF |
p-ENSG00000134030_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CTIF |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CTIF |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CTIF |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CTIF |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CTIF |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | ZNF638 | exon_skip_186116 | -5.085644e-01 | 7.706115e-12 |
| CB | RBM6 | exon_skip_186116 | -4.446920e-01 | 4.295909e-09 |
| IFG | DAZAP1 | exon_skip_186116 | 5.626509e-01 | 4.207585e-03 |
| IFG | ELAVL1 | exon_skip_186116 | 7.942922e-01 | 3.583805e-06 |
| IFG | ZNF638 | exon_skip_186116 | 6.483676e-01 | 6.113018e-04 |
| IFG | RBM6 | exon_skip_186116 | 5.093694e-01 | 1.101133e-02 |
| IFG | MBNL1 | exon_skip_186116 | 6.461889e-01 | 6.466554e-04 |
| IFG | PCBP1 | exon_skip_186116 | 5.086085e-01 | 1.115171e-02 |
| IFG | RALYL | exon_skip_186116 | 4.474956e-01 | 2.833213e-02 |
| IFG | SRSF4 | exon_skip_186116 | 5.105697e-01 | 1.079283e-02 |
| IFG | TRA2A | exon_skip_159227 | -5.217532e-01 | 4.405161e-03 |
| IFG | SRSF1 | exon_skip_159227 | -4.311806e-01 | 2.197291e-02 |
| STG | MBNL1 | exon_skip_159227 | 4.324721e-01 | 2.312244e-05 |
| STG | ILF2 | exon_skip_159227 | 5.384703e-01 | 5.243169e-08 |
| STG | SRSF1 | exon_skip_159227 | 4.404393e-01 | 1.565199e-05 |
| STG | SRSF9 | exon_skip_159227 | 4.597757e-01 | 5.823317e-06 |
| STG | NOVA1 | exon_skip_159227 | 4.579188e-01 | 6.420223e-06 |
| TC | ILF2 | exon_skip_26164 | 4.705237e-01 | 3.423186e-10 |
| TC | EWSR1 | exon_skip_26164 | 4.100221e-01 | 7.268653e-08 |
| TC | NOVA1 | exon_skip_26164 | 5.297908e-01 | 5.862041e-13 |
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RelatedDrugs for CTIF |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTIF |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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