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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for RASSF2 |
Gene summary |
Gene information | Gene symbol | RASSF2 | Gene ID | 9770 |
Gene name | Ras association domain family member 2 | |
Synonyms | CENP-34|RASFADIN | |
Cytomap | 20p13 | |
Type of gene | protein-coding | |
Description | ras association domain-containing protein 2Ras association (RalGDS/AF-6) domain family 2Ras association (RalGDS/AF-6) domain family member 2centromere protein 34 | |
Modification date | 20200313 | |
UniProtAcc | P50749, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
RASSF2 | GO:0031954 | positive regulation of protein autophosphorylation | 19962960 |
RASSF2 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation | 19962960 |
RASSF2 | GO:0043065 | positive regulation of apoptotic process | 19962960 |
RASSF2 | GO:0045860 | positive regulation of protein kinase activity | 19962960 |
RASSF2 | GO:0046330 | positive regulation of JNK cascade | 19962960 |
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Gene structures and expression levels for RASSF2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000478553.1 | RASSF2-203:lncRNA:RASSF2 | 3.948465e+01 | 8.377221e-01 | 3.046774e-04 | 6.199076e-03 |
CB | DOWN | ENST00000478553.1 | RASSF2-203:lncRNA:RASSF2 | 1.328982e+02 | -1.426752e+00 | 6.033403e-04 | 3.380860e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RASSF2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_111416 | chr20 | 4800972:4801062:4822329:4822403:4823557:4823608 | 4822329:4822403 |
exon_skip_145598 | chr20 | 4790451:4790611:4792539:4792627:4795815:4795966 | 4792539:4792627 |
exon_skip_161682 | chr20 | 4790451:4790611:4792539:4792627:4795815:4795962 | 4792539:4792627 |
exon_skip_9186 | chr20 | 4798010:4798085:4800972:4801062:4822329:4822403 | 4800972:4801062 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RASSF2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000379400 | 4800972 | 4801062 | 3UTR-3CDS |
ENST00000379400 | 4822329 | 4822403 | 3UTR-3UTR |
ENST00000379376 | 4792539 | 4792627 | Frame-shift |
ENST00000379400 | 4792539 | 4792627 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000379400 | 4822329 | 4822403 | 3UTR-3UTR |
ENST00000379376 | 4792539 | 4792627 | Frame-shift |
ENST00000379400 | 4792539 | 4792627 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000379400 | 4822329 | 4822403 | 3UTR-3UTR |
ENST00000379376 | 4792539 | 4792627 | Frame-shift |
ENST00000379400 | 4792539 | 4792627 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for RASSF2 |
p-ENSG00000101265_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in RASSF2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000379400 | 4822329 | 4822403 | hsa-miR-6128 | chr20:4822393-4822400 | 8mer-1a | chr20:4822381-4822401 | 159.00 | -23.57 |
Mayo | ENST00000379400 | 4822329 | 4822403 | hsa-miR-6746-5p | chr20:4822363-4822370 | 8mer-1a | chr20:4822350-4822371 | 169.00 | -28.55 |
Mayo | ENST00000379400 | 4822329 | 4822403 | hsa-miR-6771-5p | chr20:4822364-4822371 | 8mer-1a | chr20:4822350-4822371 | 169.00 | -28.55 |
MSBB | ENST00000379400 | 4822329 | 4822403 | hsa-miR-6128 | chr20:4822393-4822400 | 8mer-1a | chr20:4822381-4822401 | 159.00 | -23.57 |
MSBB | ENST00000379400 | 4822329 | 4822403 | hsa-miR-6746-5p | chr20:4822363-4822370 | 8mer-1a | chr20:4822350-4822371 | 169.00 | -28.55 |
MSBB | ENST00000379400 | 4822329 | 4822403 | hsa-miR-6771-5p | chr20:4822364-4822371 | 8mer-1a | chr20:4822350-4822371 | 169.00 | -28.55 |
ROSMAP | ENST00000379400 | 4822329 | 4822403 | hsa-miR-6128 | chr20:4822393-4822400 | 8mer-1a | chr20:4822381-4822401 | 159.00 | -23.57 |
ROSMAP | ENST00000379400 | 4822329 | 4822403 | hsa-miR-6746-5p | chr20:4822363-4822370 | 8mer-1a | chr20:4822350-4822371 | 169.00 | -28.55 |
ROSMAP | ENST00000379400 | 4822329 | 4822403 | hsa-miR-6771-5p | chr20:4822364-4822371 | 8mer-1a | chr20:4822350-4822371 | 169.00 | -28.55 |
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SNVs in the skipped exons for RASSF2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RASSF2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RASSF2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RASSF2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for RASSF2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RASSF2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |