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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for LZTS3 |
Gene summary |
Gene information | Gene symbol | LZTS3 | Gene ID | 9762 |
Gene name | leucine zipper tumor suppressor family member 3 | |
Synonyms | PROSAPIP1 | |
Cytomap | 20p13 | |
Type of gene | protein-coding | |
Description | leucine zipper putative tumor suppressor 3ProSAP/Shank-interacting protein 1leucine zipper, putative tumor suppressor family member 3proline rich synapse associated protein interacting protein 1 | |
Modification date | 20200313 | |
UniProtAcc | O60299, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for LZTS3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000360342.7 | LZTS3-203:protein_coding:LZTS3 | 3.445304e+02 | -1.470439e+00 | 2.940039e-11 | 2.330199e-09 |
CB | DOWN | ENST00000645462.1 | LZTS3-204:protein_coding:LZTS3 | 3.445304e+02 | -1.470439e+00 | 2.940039e-11 | 2.330199e-09 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for LZTS3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_222014 | chr20 | 3166705:3167181:3167738:3167961:3173455:3173546 | 3167738:3167961 |
exon_skip_247141 | chr20 | 3166977:3167181:3167738:3167961:3173455:3173546 | 3167738:3167961 |
exon_skip_284156 | chr20 | 3165110:3165152:3165497:3165628:3165767:3166360 | 3165497:3165628 |
exon_skip_31229 | chr20 | 3162618:3165152:3165497:3165628:3165767:3166360 | 3165497:3165628 |
exon_skip_54174 | chr20 | 3167123:3167181:3167738:3167961:3173455:3173546 | 3167738:3167961 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_222014 | Mayo_CB | 5.450000e-01 | 7.057143e-01 | -1.607143e-01 | 1.852227e-07 |
exon_skip_262588 | Mayo_CB | 1.751852e-01 | 3.142029e-01 | -1.390177e-01 | 9.701146e-08 |
exon_skip_112266 | Mayo_CB | 5.762195e-01 | 7.249351e-01 | -1.487156e-01 | 1.742981e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for LZTS3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000337576 | 3167738 | 3167961 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000337576 | 3167738 | 3167961 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000337576 | 3167738 | 3167961 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for LZTS3 |
p-ENSG00000088899_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in LZTS3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000337576 | 3167738 | 3167961 | hsa-miR-10392-3p | chr20:3167815-3167822 | 8mer-1a | chr20:3167808-3167832 | 164.00 | -28.32 |
Mayo | ENST00000337576 | 3167738 | 3167961 | hsa-miR-18a-3p | chr20:3167753-3167760 | 8mer-1a | chr20:3167746-3167767 | 172.00 | -31.57 |
Mayo | ENST00000337576 | 3167738 | 3167961 | hsa-miR-3181 | chr20:3167897-3167904 | 8mer-1a | chr20:3167882-3167904 | 145.00 | -30.09 |
Mayo | ENST00000337576 | 3167738 | 3167961 | hsa-miR-24-3p | chr20:3167932-3167939 | 8mer-1a | chr20:3167931-3167947 | 157.00 | -24.55 |
Mayo | ENST00000337576 | 3167738 | 3167961 | hsa-miR-4751 | chr20:3167825-3167832 | 8mer-1a | chr20:3167808-3167832 | 164.00 | -28.32 |
Mayo | ENST00000337576 | 3167738 | 3167961 | hsa-miR-4436b-5p | chr20:3167760-3167767 | 8mer-1a | chr20:3167746-3167767 | 172.00 | -31.57 |
Mayo | ENST00000337576 | 3167738 | 3167961 | hsa-miR-1224-5p | chr20:3167826-3167833 | 8mer-1a | chr20:3167815-3167833 | 151.00 | -24.25 |
Mayo | ENST00000337576 | 3167738 | 3167961 | hsa-miR-3978 | chr20:3167799-3167806 | 8mer-1a | chr20:3167782-3167806 | 147.00 | -15.32 |
MSBB | ENST00000337576 | 3167738 | 3167961 | hsa-miR-10392-3p | chr20:3167815-3167822 | 8mer-1a | chr20:3167808-3167832 | 164.00 | -28.32 |
MSBB | ENST00000337576 | 3167738 | 3167961 | hsa-miR-18a-3p | chr20:3167753-3167760 | 8mer-1a | chr20:3167746-3167767 | 172.00 | -31.57 |
MSBB | ENST00000337576 | 3167738 | 3167961 | hsa-miR-3181 | chr20:3167897-3167904 | 8mer-1a | chr20:3167882-3167904 | 145.00 | -30.09 |
MSBB | ENST00000337576 | 3167738 | 3167961 | hsa-miR-24-3p | chr20:3167932-3167939 | 8mer-1a | chr20:3167931-3167947 | 157.00 | -24.55 |
MSBB | ENST00000337576 | 3167738 | 3167961 | hsa-miR-4751 | chr20:3167825-3167832 | 8mer-1a | chr20:3167808-3167832 | 164.00 | -28.32 |
MSBB | ENST00000337576 | 3167738 | 3167961 | hsa-miR-4436b-5p | chr20:3167760-3167767 | 8mer-1a | chr20:3167746-3167767 | 172.00 | -31.57 |
MSBB | ENST00000337576 | 3167738 | 3167961 | hsa-miR-1224-5p | chr20:3167826-3167833 | 8mer-1a | chr20:3167815-3167833 | 151.00 | -24.25 |
MSBB | ENST00000337576 | 3167738 | 3167961 | hsa-miR-3978 | chr20:3167799-3167806 | 8mer-1a | chr20:3167782-3167806 | 147.00 | -15.32 |
ROSMAP | ENST00000337576 | 3167738 | 3167961 | hsa-miR-10392-3p | chr20:3167815-3167822 | 8mer-1a | chr20:3167808-3167832 | 164.00 | -28.32 |
ROSMAP | ENST00000337576 | 3167738 | 3167961 | hsa-miR-18a-3p | chr20:3167753-3167760 | 8mer-1a | chr20:3167746-3167767 | 172.00 | -31.57 |
ROSMAP | ENST00000337576 | 3167738 | 3167961 | hsa-miR-3181 | chr20:3167897-3167904 | 8mer-1a | chr20:3167882-3167904 | 145.00 | -30.09 |
ROSMAP | ENST00000337576 | 3167738 | 3167961 | hsa-miR-24-3p | chr20:3167932-3167939 | 8mer-1a | chr20:3167931-3167947 | 157.00 | -24.55 |
ROSMAP | ENST00000337576 | 3167738 | 3167961 | hsa-miR-4751 | chr20:3167825-3167832 | 8mer-1a | chr20:3167808-3167832 | 164.00 | -28.32 |
ROSMAP | ENST00000337576 | 3167738 | 3167961 | hsa-miR-4436b-5p | chr20:3167760-3167767 | 8mer-1a | chr20:3167746-3167767 | 172.00 | -31.57 |
ROSMAP | ENST00000337576 | 3167738 | 3167961 | hsa-miR-1224-5p | chr20:3167826-3167833 | 8mer-1a | chr20:3167815-3167833 | 151.00 | -24.25 |
ROSMAP | ENST00000337576 | 3167738 | 3167961 | hsa-miR-3978 | chr20:3167799-3167806 | 8mer-1a | chr20:3167782-3167806 | 147.00 | -15.32 |
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SNVs in the skipped exons for LZTS3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for LZTS3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LZTS3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for LZTS3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | DAZAP1 | exon_skip_222014 | -4.800844e-01 | 1.518826e-10 |
CB | TARDBP | exon_skip_222014 | -5.386643e-01 | 2.408069e-13 |
CB | ELAVL1 | exon_skip_222014 | -5.069213e-01 | 9.221901e-12 |
CB | PCBP1 | exon_skip_222014 | -5.476846e-01 | 7.958524e-14 |
CB | PCBP4 | exon_skip_222014 | 6.393789e-01 | 1.187176e-19 |
CB | HNRNPF | exon_skip_222014 | -4.668392e-01 | 5.549064e-10 |
CB | RBM4B | exon_skip_222014 | -6.154980e-01 | 5.974422e-18 |
CB | TARDBP | exon_skip_2472 | -4.077386e-01 | 2.453010e-07 |
CB | RBM6 | exon_skip_2472 | -4.404313e-01 | 1.899856e-08 |
CB | PCBP1 | exon_skip_2472 | -4.775897e-01 | 7.331538e-10 |
CB | PCBP4 | exon_skip_2472 | 6.428719e-01 | 9.656351e-19 |
CB | NUP42 | exon_skip_2472 | 5.071758e-01 | 4.094941e-11 |
CB | HNRNPF | exon_skip_2472 | -4.055887e-01 | 2.875476e-07 |
CB | RBM4B | exon_skip_2472 | -5.062245e-01 | 4.512577e-11 |
CB | TARDBP | exon_skip_262588 | -4.926101e-01 | 1.521547e-10 |
CB | RBM6 | exon_skip_262588 | -5.202082e-01 | 8.936111e-12 |
CB | PCBP1 | exon_skip_262588 | -4.485648e-01 | 8.578747e-09 |
CB | PCBP4 | exon_skip_262588 | 6.083593e-01 | 1.489919e-16 |
CB | NUP42 | exon_skip_262588 | 5.310680e-01 | 2.726240e-12 |
CB | HNRNPF | exon_skip_262588 | -4.010456e-01 | 3.660158e-07 |
CB | RBM4B | exon_skip_262588 | -6.052760e-01 | 2.320858e-16 |
CB | TARDBP | exon_skip_112266 | -5.190202e-01 | 2.402659e-12 |
CB | PCBP1 | exon_skip_112266 | -5.210838e-01 | 1.899947e-12 |
CB | PCBP4 | exon_skip_112266 | 6.359728e-01 | 2.120095e-19 |
CB | HNRNPF | exon_skip_112266 | -4.385044e-01 | 7.417117e-09 |
CB | RBM4B | exon_skip_112266 | -6.026863e-01 | 4.276943e-17 |
HCC | SRSF2 | exon_skip_222014 | 4.453652e-01 | 2.878995e-14 |
HCC | HNRNPK | exon_skip_222014 | 4.332908e-01 | 1.654757e-13 |
HCC | PCBP4 | exon_skip_222014 | 4.355819e-01 | 1.193791e-13 |
HCC | HNRNPA0 | exon_skip_222014 | 4.270441e-01 | 3.980992e-13 |
HCC | SRSF5 | exon_skip_222014 | 4.541435e-01 | 7.725035e-15 |
HCC | HNRNPH2 | exon_skip_222014 | 4.534743e-01 | 8.551334e-15 |
HCC | SRSF2 | exon_skip_262588 | 4.355918e-01 | 5.943167e-13 |
HCC | SRSF5 | exon_skip_262588 | 4.033654e-01 | 3.685336e-11 |
IFG | ELAVL1 | exon_skip_222014 | -4.405481e-01 | 1.895966e-02 |
IFG | PCBP1 | exon_skip_222014 | -4.551309e-01 | 1.495058e-02 |
IFG | PCBP4 | exon_skip_2472 | 4.600927e-01 | 3.584786e-02 |
IFG | TARDBP | exon_skip_262588 | -5.209656e-01 | 6.354822e-03 |
IFG | RBM6 | exon_skip_262588 | -5.017974e-01 | 9.003887e-03 |
IFG | RBM5 | exon_skip_262588 | -4.846829e-01 | 1.209400e-02 |
IFG | PCBP1 | exon_skip_262588 | -4.600241e-01 | 1.804892e-02 |
IFG | PCBP2 | exon_skip_262588 | -4.018487e-01 | 4.185550e-02 |
IFG | SNRPA | exon_skip_262588 | -5.096764e-01 | 7.820929e-03 |
IFG | PABPC1 | exon_skip_262588 | -4.799729e-01 | 1.308390e-02 |
IFG | TARDBP | exon_skip_112266 | -5.107491e-01 | 5.481628e-03 |
IFG | RBM6 | exon_skip_112266 | -4.042175e-01 | 3.289215e-02 |
IFG | PCBP1 | exon_skip_112266 | -4.078894e-01 | 3.118942e-02 |
PCC | SRSF2 | exon_skip_54174 | 4.004557e-01 | 5.043955e-09 |
PCC | HNRNPK | exon_skip_54174 | 4.074963e-01 | 2.548536e-09 |
TC | PCBP4 | exon_skip_247141 | 4.080337e-01 | 1.241293e-07 |
TC | SRSF2 | exon_skip_77837 | 4.270000e-01 | 5.548328e-07 |
TC | SRSF2 | exon_skip_187279 | 5.018320e-01 | 3.105961e-10 |
TC | PCBP4 | exon_skip_66726 | 4.460900e-01 | 5.337539e-09 |
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RelatedDrugs for LZTS3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LZTS3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |