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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CD79B |
Gene summary |
Gene information | Gene symbol | CD79B | Gene ID | 974 |
Gene name | CD79b molecule | |
Synonyms | AGM6|B29|IGB | |
Cytomap | 17q23.3 | |
Type of gene | protein-coding | |
Description | B-cell antigen receptor complex-associated protein beta chainB-cell-specific glycoprotein B29CD79b antigen (immunoglobulin-associated beta)CD79b molecule, immunoglobulin-associated betaIg-betaimmunoglobulin-associated B29 protein | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CD79B |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CD79B |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_203946 | chr17 | 63929770:63929888:63930074:63930385:63931335:63931385 | 63930074:63930385 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CD79B |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000006750 | 63930074 | 63930385 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000006750 | 63930074 | 63930385 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CD79B |
p-ENSG00000007312_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000006750 | 1286 | 229 | 63930074 | 63930385 | 212 | 522 | 39 | 143 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000006750 | 1286 | 229 | 63930074 | 63930385 | 212 | 522 | 39 | 143 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P40259 | 39 | 143 | 41 | 144 | Alternative sequence | ID=VSP_002477;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7643857,ECO:0000303|Ref.6;Dbxref=PMID:7643857 |
P40259 | 39 | 143 | 47 | 49 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 51 | 56 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 61 | 66 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 75 | 84 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 96 | 100 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 102 | 109 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 118 | 125 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 132 | 134 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 138 | 143 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 29 | 229 | Chain | ID=PRO_0000014560;Note=B-cell antigen receptor complex-associated protein beta chain |
P40259 | 39 | 143 | 43 | 126 | Disulfide bond | Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:20696394;Dbxref=PMID:20696394 |
P40259 | 39 | 143 | 65 | 122 | Disulfide bond | Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:20696394;Dbxref=PMID:20696394 |
P40259 | 39 | 143 | 136 | 136 | Disulfide bond | Note=Interchain (with C-119 in alpha chain);Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:20696394;Dbxref=PMID:20696394 |
P40259 | 39 | 143 | 38 | 138 | Domain | Note=Ig-like V-type |
P40259 | 39 | 143 | 73 | 73 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 101 | 101 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 127 | 127 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 128 | 128 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 137 | 137 | Natural variant | ID=VAR_057833;Note=In AGM6. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17675462;Dbxref=dbSNP:rs121912424,PMID:17675462 |
P40259 | 39 | 143 | 58 | 58 | Sequence conflict | Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P40259 | 39 | 143 | 58 | 58 | Sequence conflict | Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P40259 | 39 | 143 | 84 | 84 | Sequence conflict | Note=E->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P40259 | 39 | 143 | 29 | 159 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 93 | 95 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 114 | 116 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 127 | 129 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P40259 | 39 | 143 | 41 | 144 | Alternative sequence | ID=VSP_002477;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7643857,ECO:0000303|Ref.6;Dbxref=PMID:7643857 |
P40259 | 39 | 143 | 47 | 49 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 51 | 56 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 61 | 66 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 75 | 84 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 96 | 100 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 102 | 109 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 118 | 125 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 132 | 134 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 138 | 143 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 29 | 229 | Chain | ID=PRO_0000014560;Note=B-cell antigen receptor complex-associated protein beta chain |
P40259 | 39 | 143 | 43 | 126 | Disulfide bond | Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:20696394;Dbxref=PMID:20696394 |
P40259 | 39 | 143 | 65 | 122 | Disulfide bond | Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:20696394;Dbxref=PMID:20696394 |
P40259 | 39 | 143 | 136 | 136 | Disulfide bond | Note=Interchain (with C-119 in alpha chain);Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:20696394;Dbxref=PMID:20696394 |
P40259 | 39 | 143 | 38 | 138 | Domain | Note=Ig-like V-type |
P40259 | 39 | 143 | 73 | 73 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 101 | 101 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 127 | 127 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 128 | 128 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 137 | 137 | Natural variant | ID=VAR_057833;Note=In AGM6. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17675462;Dbxref=dbSNP:rs121912424,PMID:17675462 |
P40259 | 39 | 143 | 58 | 58 | Sequence conflict | Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P40259 | 39 | 143 | 58 | 58 | Sequence conflict | Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P40259 | 39 | 143 | 84 | 84 | Sequence conflict | Note=E->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P40259 | 39 | 143 | 29 | 159 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
P40259 | 39 | 143 | 93 | 95 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 114 | 116 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
P40259 | 39 | 143 | 127 | 129 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CD79B |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CD79B |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CD79B |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CD79B |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CD79B |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CD79B |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD79B |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |