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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DOCK4 |
 Gene summary |
| Gene information | Gene symbol | DOCK4 | Gene ID | 9732 |
| Gene name | dedicator of cytokinesis 4 | |
| Synonyms | - | |
| Cytomap | 7q31.1 | |
| Type of gene | protein-coding | |
| Description | dedicator of cytokinesis protein 4 | |
| Modification date | 20200327 | |
| UniProtAcc | A0A024R749, A0A2X0SFR8, A0A590UJ51, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DOCK4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000128512
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| DLPFC | DOWN | ENST00000417165.1 | DOCK4-201:protein_coding:DOCK4 | 3.147026e+00 | -1.018941e+00 | 1.688398e-05 | 2.056293e-03 |
| DLPFC | DOWN | ENST00000450156.6 | DOCK4-208:protein_coding:DOCK4 | 5.246731e+01 | -1.818944e+00 | 6.200670e-05 | 5.106157e-03 |
| DLPFC | DOWN | ENST00000437129.5 | DOCK4-205:protein_coding:DOCK4 | 5.009620e+00 | -9.187960e-01 | 1.497197e-03 | 4.386409e-02 |
| PCC | DOWN | ENST00000417165.1 | DOCK4-201:protein_coding:DOCK4 | 7.397035e+00 | -8.399886e-01 | 3.430992e-05 | 2.983176e-03 |
| PCC | DOWN | ENST00000450156.6 | DOCK4-208:protein_coding:DOCK4 | 1.567493e+02 | -1.251598e+00 | 1.969579e-03 | 3.875267e-02 |
| PG | UP | ENST00000492436.5 | DOCK4-213:lncRNA:DOCK4 | 4.876417e+00 | 3.142196e+00 | 3.318780e-04 | 6.590860e-03 |
| CB | UP | ENST00000664131.1 | DOCK4-219:protein_coding:DOCK4 | 6.248209e+01 | 1.480601e+00 | 3.203753e-08 | 8.092811e-07 |
| CB | UP | ENST00000428053.5 | DOCK4-203:nonsense_mediated_decay:DOCK4 | 1.839291e+00 | 2.514004e+00 | 4.817385e-08 | 1.142789e-06 |
| CB | DOWN | ENST00000658652.1 | DOCK4-217:protein_coding:DOCK4 | 8.479763e+02 | -1.081380e+00 | 4.450664e-05 | 3.724670e-04 |
| CB | UP | ENST00000476846.5 | DOCK4-211:lncRNA:DOCK4 | 1.767019e+01 | 8.000602e-01 | 1.428205e-04 | 1.003489e-03 |
| TC | DOWN | ENST00000417165.1 | DOCK4-201:protein_coding:DOCK4 | 4.086545e+00 | -1.085479e+00 | 1.308076e-04 | 2.002325e-03 |
| TC | DOWN | ENST00000437129.5 | DOCK4-205:protein_coding:DOCK4 | 2.673507e+00 | -1.805361e+00 | 4.978469e-03 | 3.342534e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DOCK4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_128558 | chr7 | 111726824:111728720:111732226:111732287:111736917:111736989 | 111732226:111732287 |
| exon_skip_13280 | chr7 | 111732226:111732287:111735054:111735167:111736917:111736987 | 111735054:111735167 |
| exon_skip_135336 | chr7 | 111769657:111769677:111778276:111778369:111783857:111783952 | 111778276:111778369 |
| exon_skip_152090 | chr7 | 111778276:111778369:111782864:111782924:111783857:111783952 | 111782864:111782924 |
| exon_skip_162250 | chr7 | 111728421:111728720:111732226:111732287:111735054:111735167 | 111732226:111732287 |
| exon_skip_162545 | chr7 | 111739396:111739477:111741094:111741214:111741540:111741661 | 111741094:111741214 |
| exon_skip_163020 | chr7 | 111872467:111872564:111877030:111877186:111895612:111895718 | 111877030:111877186 |
| exon_skip_166464 | chr7 | 111739134:111739243:111739396:111739477:111741094:111741214 | 111739396:111739477 |
| exon_skip_185988 | chr7 | 111834588:111834686:111840763:111840870:111844763:111844897 | 111840763:111840870 |
| exon_skip_204856 | chr7 | 111769657:111769677:111778276:111778369:111782864:111782924 | 111778276:111778369 |
| exon_skip_215075 | chr7 | 111783857:111783952:111784097:111784123:111784384:111784426 | 111784097:111784123 |
| exon_skip_228424 | chr7 | 111783857:111783952:111784097:111784123:111788662:111788747 | 111784097:111784123 |
| exon_skip_280157 | chr7 | 111741540:111741661:111742013:111742132:111746334:111746417 | 111742013:111742132 |
| exon_skip_285441 | chr7 | 111998448:111998503:112000494:112000534:112004048:112004131 | 112000494:112000534 |
| exon_skip_4311 | chr7 | 111732226:111732287:111736917:111736989:111739134:111739243 | 111736917:111736989 |
| exon_skip_60566 | chr7 | 111747267:111747443:111755515:111755601:111758624:111758790 | 111755515:111755601 |
| exon_skip_64336 | chr7 | 111834588:111834686:111844763:111844897:111846999:111847126 | 111844763:111844897 |
| exon_skip_82516 | chr7 | 111728421:111728720:111736917:111736989:111739134:111739243 | 111736917:111736989 |
| exon_skip_92123 | chr7 | 111728421:111728720:111732226:111732287:111736917:111736989 | 111732226:111732287 |
| exon_skip_95099 | chr7 | 111732226:111732287:111735054:111735167:111736917:111736989 | 111735054:111735167 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_228424 | MSBB_PG | 3.188618e-01 | 5.017778e-01 | -1.829160e-01 | 1.256523e-04 |
| exon_skip_286199 | Mayo_CB | 7.889024e-01 | 8.980282e-01 | -1.091257e-01 | 3.992646e-08 |
| exon_skip_95099 | Mayo_CB | 5.206173e-01 | 6.794444e-01 | -1.588272e-01 | 4.717891e-09 |
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Open reading frame (ORF) annotation in the exon skipping event for DOCK4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000437633 | 111732226 | 111732287 | Frame-shift |
| ENST00000437633 | 111739396 | 111739477 | Frame-shift |
| ENST00000437633 | 111741094 | 111741214 | Frame-shift |
| ENST00000437633 | 111778276 | 111778369 | Frame-shift |
| ENST00000437633 | 111782864 | 111782924 | Frame-shift |
| ENST00000437633 | 111877030 | 111877186 | Frame-shift |
| ENST00000437633 | 112000494 | 112000534 | Frame-shift |
| ENST00000437633 | 111735054 | 111735167 | In-frame |
| ENST00000437633 | 111742013 | 111742132 | In-frame |
| ENST00000437633 | 111755515 | 111755601 | In-frame |
| ENST00000437633 | 111844763 | 111844897 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000437633 | 111732226 | 111732287 | Frame-shift |
| ENST00000437633 | 111741094 | 111741214 | Frame-shift |
| ENST00000437633 | 111778276 | 111778369 | Frame-shift |
| ENST00000437633 | 111782864 | 111782924 | Frame-shift |
| ENST00000437633 | 111877030 | 111877186 | Frame-shift |
| ENST00000437633 | 112000494 | 112000534 | Frame-shift |
| ENST00000437633 | 111735054 | 111735167 | In-frame |
| ENST00000437633 | 111755515 | 111755601 | In-frame |
| ENST00000437633 | 111844763 | 111844897 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000437633 | 111732226 | 111732287 | Frame-shift |
| ENST00000437633 | 111739396 | 111739477 | Frame-shift |
| ENST00000437633 | 111741094 | 111741214 | Frame-shift |
| ENST00000437633 | 111778276 | 111778369 | Frame-shift |
| ENST00000437633 | 111782864 | 111782924 | Frame-shift |
| ENST00000437633 | 111877030 | 111877186 | Frame-shift |
| ENST00000437633 | 112000494 | 112000534 | Frame-shift |
| ENST00000437633 | 111735054 | 111735167 | In-frame |
| ENST00000437633 | 111742013 | 111742132 | In-frame |
| ENST00000437633 | 111755515 | 111755601 | In-frame |
| ENST00000437633 | 111844763 | 111844897 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DOCK4 |
p-ENSG00000128512_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000437633 | 6229 | 1966 | 111844763 | 111844897 | 2859 | 2992 | 867 | 911 |
| ENST00000437633 | 6229 | 1966 | 111755515 | 111755601 | 4560 | 4645 | 1434 | 1462 |
| ENST00000437633 | 6229 | 1966 | 111742013 | 111742132 | 4908 | 5026 | 1550 | 1589 |
| ENST00000437633 | 6229 | 1966 | 111735054 | 111735167 | 5536 | 5648 | 1759 | 1797 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000437633 | 6229 | 1966 | 111844763 | 111844897 | 2859 | 2992 | 867 | 911 |
| ENST00000437633 | 6229 | 1966 | 111755515 | 111755601 | 4560 | 4645 | 1434 | 1462 |
| ENST00000437633 | 6229 | 1966 | 111735054 | 111735167 | 5536 | 5648 | 1759 | 1797 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000437633 | 6229 | 1966 | 111844763 | 111844897 | 2859 | 2992 | 867 | 911 |
| ENST00000437633 | 6229 | 1966 | 111755515 | 111755601 | 4560 | 4645 | 1434 | 1462 |
| ENST00000437633 | 6229 | 1966 | 111742013 | 111742132 | 4908 | 5026 | 1550 | 1589 |
| ENST00000437633 | 6229 | 1966 | 111735054 | 111735167 | 5536 | 5648 | 1759 | 1797 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N1I0 | 867 | 911 | 1 | 1687 | Alternative sequence | ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8N1I0 | 867 | 911 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1434 | 1462 | 1 | 1687 | Alternative sequence | ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8N1I0 | 1434 | 1462 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1434 | 1462 | 1190 | 1596 | Domain | Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984 |
| Q8N1I0 | 1550 | 1589 | 1 | 1687 | Alternative sequence | ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8N1I0 | 1550 | 1589 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1550 | 1589 | 1190 | 1596 | Domain | Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984 |
| Q8N1I0 | 1550 | 1589 | 1570 | 1570 | Natural variant | ID=VAR_057519;Note=R->K;Dbxref=dbSNP:rs3757650 |
| Q8N1I0 | 1550 | 1589 | 1580 | 1580 | Natural variant | ID=VAR_057520;Note=F->L;Dbxref=dbSNP:rs3757651 |
| Q8N1I0 | 1759 | 1797 | 1760 | 1797 | Alternative sequence | ID=VSP_007706;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9872452;Dbxref=PMID:9872452 |
| Q8N1I0 | 1759 | 1797 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1759 | 1797 | 1642 | 1863 | Compositional bias | Note=Ser-rich |
| Q8N1I0 | 1759 | 1797 | 1769 | 1769 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P59764 |
| Q8N1I0 | 1759 | 1797 | 1788 | 1794 | Motif | Note=SH3-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N1I0 | 867 | 911 | 1 | 1687 | Alternative sequence | ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8N1I0 | 867 | 911 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1434 | 1462 | 1 | 1687 | Alternative sequence | ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8N1I0 | 1434 | 1462 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1434 | 1462 | 1190 | 1596 | Domain | Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984 |
| Q8N1I0 | 1759 | 1797 | 1760 | 1797 | Alternative sequence | ID=VSP_007706;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9872452;Dbxref=PMID:9872452 |
| Q8N1I0 | 1759 | 1797 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1759 | 1797 | 1642 | 1863 | Compositional bias | Note=Ser-rich |
| Q8N1I0 | 1759 | 1797 | 1769 | 1769 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P59764 |
| Q8N1I0 | 1759 | 1797 | 1788 | 1794 | Motif | Note=SH3-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N1I0 | 867 | 911 | 1 | 1687 | Alternative sequence | ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8N1I0 | 867 | 911 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1434 | 1462 | 1 | 1687 | Alternative sequence | ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8N1I0 | 1434 | 1462 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1434 | 1462 | 1190 | 1596 | Domain | Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984 |
| Q8N1I0 | 1550 | 1589 | 1 | 1687 | Alternative sequence | ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8N1I0 | 1550 | 1589 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1550 | 1589 | 1190 | 1596 | Domain | Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984 |
| Q8N1I0 | 1550 | 1589 | 1570 | 1570 | Natural variant | ID=VAR_057519;Note=R->K;Dbxref=dbSNP:rs3757650 |
| Q8N1I0 | 1550 | 1589 | 1580 | 1580 | Natural variant | ID=VAR_057520;Note=F->L;Dbxref=dbSNP:rs3757651 |
| Q8N1I0 | 1759 | 1797 | 1760 | 1797 | Alternative sequence | ID=VSP_007706;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9872452;Dbxref=PMID:9872452 |
| Q8N1I0 | 1759 | 1797 | 1 | 1966 | Chain | ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4 |
| Q8N1I0 | 1759 | 1797 | 1642 | 1863 | Compositional bias | Note=Ser-rich |
| Q8N1I0 | 1759 | 1797 | 1769 | 1769 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P59764 |
| Q8N1I0 | 1759 | 1797 | 1788 | 1794 | Motif | Note=SH3-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in DOCK4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DOCK4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DOCK4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_163020 | -5.402441e-01 | 3.000494e-03 | chr7 | - | 111872467 | 111872564 | 111877030 | 111877186 | 111895612 | 111895718 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DOCK4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DOCK4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | ELAVL1 | exon_skip_286199 | -4.048047e-01 | 2.102960e-07 |
| CB | RBM6 | exon_skip_286199 | -4.630948e-01 | 1.665554e-09 |
| CB | CNOT4 | exon_skip_286199 | -5.031970e-01 | 3.377487e-11 |
| CB | MATR3 | exon_skip_286199 | -4.008680e-01 | 2.824383e-07 |
| CB | PCBP1 | exon_skip_286199 | -4.351110e-01 | 1.904538e-08 |
| CB | PCBP4 | exon_skip_286199 | 5.480859e-01 | 2.252941e-13 |
| CB | TRA2A | exon_skip_286199 | -5.429627e-01 | 4.145741e-13 |
| CB | SNRPA | exon_skip_286199 | -4.718520e-01 | 7.418459e-10 |
| CB | FUBP1 | exon_skip_286199 | -5.319145e-01 | 1.491850e-12 |
| CB | KHSRP | exon_skip_286199 | -4.150468e-01 | 9.588714e-08 |
| CB | RBM45 | exon_skip_286199 | 5.650245e-01 | 2.781277e-14 |
| CB | PTBP1 | exon_skip_286199 | -4.839170e-01 | 2.343565e-10 |
| CB | HNRNPL | exon_skip_286199 | -4.009334e-01 | 2.810663e-07 |
| CB | RBM6 | exon_skip_95099 | -4.995296e-01 | 4.928216e-11 |
| CB | CNOT4 | exon_skip_95099 | -5.155159e-01 | 9.181080e-12 |
| CB | PCBP1 | exon_skip_95099 | -4.397559e-01 | 1.290273e-08 |
| CB | PCBP4 | exon_skip_95099 | 4.368636e-01 | 1.645436e-08 |
| CB | TRA2A | exon_skip_95099 | -5.520939e-01 | 1.388018e-13 |
| CB | RBM23 | exon_skip_95099 | -4.192427e-01 | 6.897846e-08 |
| CB | RALYL | exon_skip_228424 | 5.179341e-01 | 3.480898e-11 |
| CB | HNRNPA2B1 | exon_skip_285441 | -4.059663e-01 | 1.368995e-06 |
| CB | PABPC4 | exon_skip_285441 | 4.391622e-01 | 1.381126e-07 |
| FL | MSI1 | exon_skip_228424 | -5.123599e-01 | 9.440270e-12 |
| FL | ELAVL4 | exon_skip_228424 | 6.329982e-01 | 9.860736e-19 |
| FL | RALYL | exon_skip_228424 | 5.625748e-01 | 2.575189e-14 |
| HCC | MSI1 | exon_skip_95099 | 5.403085e-01 | 5.121963e-22 |
| HCC | RBM6 | exon_skip_95099 | 5.217804e-01 | 2.144930e-20 |
| HCC | SRSF11 | exon_skip_95099 | 4.442459e-01 | 1.388922e-14 |
| HCC | RBM5 | exon_skip_95099 | 4.944300e-01 | 3.561423e-18 |
| HCC | PCBP4 | exon_skip_95099 | 5.775093e-01 | 1.357353e-25 |
| HCC | SRSF5 | exon_skip_95099 | 4.826498e-01 | 2.807023e-17 |
| HCC | DAZAP1 | exon_skip_228424 | -6.420029e-01 | 9.070463e-33 |
| HCC | RBMS3 | exon_skip_228424 | -5.244498e-01 | 1.758294e-20 |
| HCC | MSI1 | exon_skip_228424 | -6.992196e-01 | 6.026471e-41 |
| HCC | ZNF326 | exon_skip_228424 | -6.491616e-01 | 1.072889e-33 |
| HCC | RBM6 | exon_skip_228424 | -7.065138e-01 | 3.946427e-42 |
| HCC | PCBP1 | exon_skip_228424 | -4.663054e-01 | 5.552627e-16 |
| HCC | RC3H1 | exon_skip_228424 | -4.095129e-01 | 2.426628e-12 |
| IFG | PCBP4 | exon_skip_95099 | 4.063527e-01 | 3.189312e-02 |
| IFG | DAZAP1 | exon_skip_228424 | -4.503976e-01 | 1.616651e-02 |
| IFG | ELAVL4 | exon_skip_228424 | 5.784358e-01 | 1.262690e-03 |
| IFG | ZNF326 | exon_skip_228424 | -4.644377e-01 | 1.278012e-02 |
| IFG | RBM6 | exon_skip_228424 | -4.126596e-01 | 2.908431e-02 |
| IFG | RALYL | exon_skip_228424 | 5.381563e-01 | 3.136843e-03 |
| PCC | PCBP4 | exon_skip_95099 | 4.577574e-01 | 3.612607e-12 |
| PCC | RBMS3 | exon_skip_228424 | -4.163730e-01 | 9.553333e-10 |
| PCC | MSI1 | exon_skip_228424 | -6.034193e-01 | 4.005028e-21 |
| PCC | ELAVL4 | exon_skip_228424 | 5.064006e-01 | 2.333908e-14 |
| PCC | ZNF326 | exon_skip_228424 | -4.416269e-01 | 6.600632e-11 |
| PCC | RBM6 | exon_skip_228424 | -4.960315e-01 | 9.345270e-14 |
| PCC | RALYL | exon_skip_228424 | 4.757862e-01 | 1.230191e-12 |
| PG | MSI1 | exon_skip_228424 | -5.251789e-01 | 2.703956e-13 |
| PG | ELAVL4 | exon_skip_228424 | 6.528111e-01 | 8.964465e-22 |
| PG | PCBP1 | exon_skip_228424 | 5.115250e-01 | 1.382726e-12 |
| PG | RALYL | exon_skip_228424 | 5.673620e-01 | 1.070255e-15 |
| STG | MSI1 | exon_skip_228424 | -4.285141e-01 | 2.148511e-04 |
| STG | ELAVL4 | exon_skip_228424 | 4.064806e-01 | 4.799886e-04 |
| STG | RALYL | exon_skip_228424 | 4.178790e-01 | 3.188731e-04 |
| TC | MSI1 | exon_skip_13280 | 4.176255e-01 | 5.823612e-08 |
| TC | ENOX1 | exon_skip_13280 | -4.146509e-01 | 7.382831e-08 |
| TC | NUP42 | exon_skip_13280 | -6.394296e-01 | 2.614131e-19 |
| TC | MSI1 | exon_skip_228424 | -4.234426e-01 | 7.425145e-08 |
| TC | ELAVL4 | exon_skip_228424 | 8.088118e-01 | 1.032680e-35 |
| TC | RBM6 | exon_skip_228424 | -4.117642e-01 | 1.816242e-07 |
| TC | PCBP1 | exon_skip_228424 | 4.129431e-01 | 1.661970e-07 |
| TC | RALYL | exon_skip_228424 | 8.207473e-01 | 1.445491e-37 |
| TC | PTBP3 | exon_skip_228424 | 5.561385e-01 | 1.796014e-13 |
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RelatedDrugs for DOCK4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DOCK4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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