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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ST18 |
 Gene summary |
| Gene information | Gene symbol | ST18 | Gene ID | 9705 |
| Gene name | ST18 C2H2C-type zinc finger transcription factor | |
| Synonyms | NZF-3|NZF3|ZC2H2C3|ZC2HC10|ZNF387 | |
| Cytomap | 8q11.23 | |
| Type of gene | protein-coding | |
| Description | suppression of tumorigenicity 18 proteinST18, C2H2C-type zinc fingerneural zinc finger transcription factor 3suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)suppression of tumorigenicity 18, zinc fingerzinc finger protein 387 | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ST18 | GO:0008285 | negative regulation of cell proliferation | 15489893 |
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Gene structures and expression levels for ST18 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000147488
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000519118.5 | ST18-209:protein_coding:ST18 | 2.023448e+01 | 8.641879e-01 | 2.845466e-04 | 5.900197e-03 |
| PG | UP | ENST00000520811.5 | ST18-214:lncRNA:ST18 | 2.919453e+00 | 1.213638e+00 | 1.692211e-03 | 2.121008e-02 |
| CB | DOWN | ENST00000519201.5 | ST18-210:lncRNA:ST18 | 8.310435e-01 | -1.063908e+00 | 9.755209e-03 | 3.405569e-02 |
| TC | UP | ENST00000518053.5 | ST18-205:retained_intron:ST18 | 6.775336e+00 | 1.486542e+00 | 7.928476e-04 | 8.251566e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ST18 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101623 | chr8 | 52166852:52166986:52171569:52171623:52171792:52171833 | 52171569:52171623 |
| exon_skip_111144 | chr8 | 52230032:52230077:52246586:52246664:52249358:52249412 | 52246586:52246664 |
| exon_skip_11248 | chr8 | 52214220:52214257:52217813:52217901:52220741:52220783 | 52217813:52217901 |
| exon_skip_119622 | chr8 | 52118338:52118441:52126052:52126140:52131958:52132179 | 52126052:52126140 |
| exon_skip_137834 | chr8 | 52214220:52214257:52217746:52217901:52220741:52220848 | 52217746:52217901 |
| exon_skip_158983 | chr8 | 52163986:52164090:52165135:52165225:52166852:52166986 | 52165135:52165225 |
| exon_skip_16173 | chr8 | 52180294:52180312:52201062:52201376:52212079:52212109 | 52201062:52201376 |
| exon_skip_193055 | chr8 | 52220741:52220848:52221640:52221793:52230032:52230077 | 52221640:52221793 |
| exon_skip_201125 | chr8 | 52180294:52180312:52210030:52210117:52212079:52212109 | 52210030:52210117 |
| exon_skip_20352 | chr8 | 52221640:52221793:52230032:52230077:52254250:52254348 | 52230032:52230077 |
| exon_skip_210810 | chr8 | 52230032:52230077:52246586:52246664:52409328:52409452 | 52246586:52246664 |
| exon_skip_215488 | chr8 | 52180294:52180312:52201322:52201376:52212079:52212109 | 52201322:52201376 |
| exon_skip_246259 | chr8 | 52214203:52214257:52217813:52217901:52220741:52220848 | 52217813:52217901 |
| exon_skip_249153 | chr8 | 52166852:52166986:52171569:52171623:52171792:52172114 | 52171569:52171623 |
| exon_skip_249377 | chr8 | 52214220:52214257:52217742:52217901:52220741:52220848 | 52217742:52217901 |
| exon_skip_262480 | chr8 | 52214220:52214257:52217746:52217901:52220741:52220783 | 52217746:52217901 |
| exon_skip_263393 | chr8 | 52142930:52143045:52149732:52149977:52158898:52159104 | 52149732:52149977 |
| exon_skip_265894 | chr8 | 52158898:52159109:52161375:52161568:52163986:52164090 | 52161375:52161568 |
| exon_skip_281770 | chr8 | 52180122:52180312:52201062:52201376:52212079:52212109 | 52201062:52201376 |
| exon_skip_3929 | chr8 | 52166852:52166986:52171792:52172583:52180122:52180312 | 52171792:52172583 |
| exon_skip_53661 | chr8 | 52142930:52143045:52149732:52149977:52158898:52159109 | 52149732:52149977 |
| exon_skip_59574 | chr8 | 52230032:52230077:52246586:52246664:52248479:52248526 | 52246586:52246664 |
| exon_skip_61327 | chr8 | 52133239:52133301:52136590:52136658:52137421:52137483 | 52136590:52136658 |
| exon_skip_8753 | chr8 | 52118420:52118441:52126052:52126140:52131958:52132179 | 52126052:52126140 |
| exon_skip_93382 | chr8 | 52214220:52214257:52217742:52217901:52220741:52220783 | 52217742:52217901 |
| exon_skip_94436 | chr8 | 52206583:52206750:52210030:52210117:52212079:52212109 | 52210030:52210117 |
| exon_skip_95527 | chr8 | 52214220:52214257:52217813:52217901:52220741:52220848 | 52217813:52217901 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_137834 | Mayo_CB | 6.435135e-01 | 7.531034e-01 | -1.095899e-01 | 9.162571e-07 |
| exon_skip_63142 | Mayo_CB | 2.962963e-01 | 4.182759e-01 | -1.219796e-01 | 2.670581e-08 |
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Open reading frame (ORF) annotation in the exon skipping event for ST18 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276480 | 52221640 | 52221793 | 3UTR-3UTR |
| ENST00000276480 | 52126052 | 52126140 | Frame-shift |
| ENST00000276480 | 52149732 | 52149977 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276480 | 52221640 | 52221793 | 3UTR-3UTR |
| ENST00000276480 | 52126052 | 52126140 | Frame-shift |
| ENST00000276480 | 52165135 | 52165225 | Frame-shift |
| ENST00000276480 | 52136590 | 52136658 | In-frame |
| ENST00000276480 | 52149732 | 52149977 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276480 | 52221640 | 52221793 | 3UTR-3UTR |
| ENST00000276480 | 52126052 | 52126140 | Frame-shift |
| ENST00000276480 | 52161375 | 52161568 | Frame-shift |
| ENST00000276480 | 52165135 | 52165225 | Frame-shift |
| ENST00000276480 | 52136590 | 52136658 | In-frame |
| ENST00000276480 | 52149732 | 52149977 | In-frame |
| ENST00000276480 | 52171792 | 52172583 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ST18 |
p-ENSG00000147488_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276480 | 6204 | 1047 | 52149732 | 52149977 | 2491 | 2735 | 602 | 683 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276480 | 6204 | 1047 | 52149732 | 52149977 | 2491 | 2735 | 602 | 683 |
| ENST00000276480 | 6204 | 1047 | 52136590 | 52136658 | 2916 | 2983 | 744 | 766 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276480 | 6204 | 1047 | 52171792 | 52172583 | 962 | 1752 | 92 | 356 |
| ENST00000276480 | 6204 | 1047 | 52149732 | 52149977 | 2491 | 2735 | 602 | 683 |
| ENST00000276480 | 6204 | 1047 | 52136590 | 52136658 | 2916 | 2983 | 744 | 766 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O60284 | 602 | 683 | 1 | 1047 | Chain | ID=PRO_0000234030;Note=Suppression of tumorigenicity 18 protein |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O60284 | 602 | 683 | 1 | 1047 | Chain | ID=PRO_0000234030;Note=Suppression of tumorigenicity 18 protein |
| O60284 | 744 | 766 | 1 | 1047 | Chain | ID=PRO_0000234030;Note=Suppression of tumorigenicity 18 protein |
| O60284 | 744 | 766 | 715 | 758 | Zinc finger | Note=CCHHC-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143 |
| O60284 | 744 | 766 | 759 | 802 | Zinc finger | Note=CCHHC-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O60284 | 92 | 356 | 1 | 1047 | Chain | ID=PRO_0000234030;Note=Suppression of tumorigenicity 18 protein |
| O60284 | 602 | 683 | 1 | 1047 | Chain | ID=PRO_0000234030;Note=Suppression of tumorigenicity 18 protein |
| O60284 | 744 | 766 | 1 | 1047 | Chain | ID=PRO_0000234030;Note=Suppression of tumorigenicity 18 protein |
| O60284 | 744 | 766 | 715 | 758 | Zinc finger | Note=CCHHC-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143 |
| O60284 | 744 | 766 | 759 | 802 | Zinc finger | Note=CCHHC-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ST18 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000276480 | 52221640 | 52221793 | hsa-miR-9718 | chr8:52221777-52221784 | 8mer-1a | chr8:52221765-52221784 | 156.00 | -17.83 |
| Mayo | ENST00000276480 | 52221640 | 52221793 | hsa-miR-628-5p | chr8:52221777-52221784 | 8mer-1a | chr8:52221765-52221784 | 156.00 | -17.83 |
| Mayo | ENST00000276480 | 52221640 | 52221793 | hsa-miR-3185 | chr8:52221763-52221770 | 8mer-1a | chr8:52221763-52221784 | 152.00 | -14.66 |
| MSBB | ENST00000276480 | 52221640 | 52221793 | hsa-miR-9718 | chr8:52221777-52221784 | 8mer-1a | chr8:52221765-52221784 | 156.00 | -17.83 |
| MSBB | ENST00000276480 | 52221640 | 52221793 | hsa-miR-628-5p | chr8:52221777-52221784 | 8mer-1a | chr8:52221765-52221784 | 156.00 | -17.83 |
| MSBB | ENST00000276480 | 52221640 | 52221793 | hsa-miR-3185 | chr8:52221763-52221770 | 8mer-1a | chr8:52221763-52221784 | 152.00 | -14.66 |
| ROSMAP | ENST00000276480 | 52221640 | 52221793 | hsa-miR-9718 | chr8:52221777-52221784 | 8mer-1a | chr8:52221765-52221784 | 156.00 | -17.83 |
| ROSMAP | ENST00000276480 | 52221640 | 52221793 | hsa-miR-628-5p | chr8:52221777-52221784 | 8mer-1a | chr8:52221765-52221784 | 156.00 | -17.83 |
| ROSMAP | ENST00000276480 | 52221640 | 52221793 | hsa-miR-3185 | chr8:52221763-52221770 | 8mer-1a | chr8:52221763-52221784 | 152.00 | -14.66 |
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SNVs in the skipped exons for ST18 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ST18 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ST18 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ST18 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SFPQ | exon_skip_249377 | 4.552258e-01 | 2.512800e-07 |
| CB | RBM3 | exon_skip_249377 | 4.597905e-01 | 1.837468e-07 |
| CB | NUP42 | exon_skip_249377 | 5.007252e-01 | 8.962396e-09 |
| CB | RBM3 | exon_skip_137834 | 4.457063e-01 | 8.530774e-08 |
| CB | NUP42 | exon_skip_137834 | 4.858544e-01 | 3.520541e-09 |
| CB | RBM6 | exon_skip_63142 | -5.129437e-01 | 1.074971e-10 |
| CB | CNOT4 | exon_skip_63142 | -4.826658e-01 | 1.774941e-09 |
| CB | TIA1 | exon_skip_63142 | 4.419918e-01 | 5.118698e-08 |
| CB | TRA2A | exon_skip_63142 | -6.430752e-01 | 1.393925e-17 |
| CB | FUBP1 | exon_skip_63142 | -4.479119e-01 | 3.223523e-08 |
| CB | RBM4 | exon_skip_63142 | -7.056059e-01 | 3.065214e-22 |
| IFG | IGF2BP2 | exon_skip_53661 | -4.861446e-01 | 1.601168e-02 |
| IFG | RBM5 | exon_skip_210810 | -4.653011e-01 | 3.354101e-02 |
| IFG | TRA2A | exon_skip_210810 | -4.509641e-01 | 4.018865e-02 |
| IFG | FUBP1 | exon_skip_210810 | -4.696896e-01 | 3.168921e-02 |
| IFG | RBM4 | exon_skip_210810 | -5.806489e-01 | 5.781417e-03 |
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RelatedDrugs for ST18 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ST18 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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