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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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3'-UTR located exon skipping events lost miRNA binding sites

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SNVs in the skipped exons with depth of coverage

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AD stage-associated exon skipping events

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Correlation with RNA binding proteins (RBPs)

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Related drugs with this gene

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Related diseases with this gene

Gene summary for MORF4L2

check button Gene summary
Gene informationGene symbol

MORF4L2

Gene ID

9643

Gene namemortality factor 4 like 2
SynonymsMORFL2|MRGX
Cytomap

Xq22.2

Type of geneprotein-coding
Descriptionmortality factor 4-like protein 2MORF-related gene X proteinMSL3-2 proteinprotein MSL3-2transcription factor-like protein MRGX
Modification date20200313
UniProtAcc

A0A0A0MT59,

Q15014,

Q5JXX1,

Q5JXX2,

Q5JXX6,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Gene structures and expression levels for MORF4L2

check buttonSkipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

ENSG00000123562
check button Differentially expressed gene analysis across multiple brain tissues between AD and control.
Tissue typeDEG directionBase mean exp.log2FC(AD/control)P-valueAdj. p-value

check button Differentially expressed isoform analysis across multiple brain tissues between AD and control.
gencode gene structure
Tissue typeDEG directionENSTTranscript info.Base mean exp.log2FC(AD/control)P-valueAdjc. p-value
CBUPENST00000474653.5MORF4L2-212:lncRNA:MORF4L21.028167e+029.410694e-014.402297e-125.082854e-10

check button Landscape of isoform expressions across multiple brain tissues between AD and control.
gencode gene structure

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MORF4L2

check button Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).
boxplot

check button All exon skipping events in AD cohorts.
Exon skip IDchrExons involved in exon skippingSkipped exon
exon_skip_105997chrX103676979:103677051:103678499:103678651:103685171:103685260103678499:103678651
exon_skip_137588chrX103676983:103677051:103678499:103678651:103685171:103685260103678499:103678651
exon_skip_139677chrX103678499:103678600:103684681:103684729:103685171:103685260103684681:103684729
exon_skip_139745chrX103676983:103677051:103678499:103678651:103684681:103684729103678499:103678651
exon_skip_141130chrX103676979:103677051:103678499:103678600:103685171:103685260103678499:103678600
exon_skip_144917chrX103676983:103677051:103678499:103678620:103684681:103684729103678499:103678620
exon_skip_14566chrX103676979:103677051:103678499:103678600:103684681:103684729103678499:103678600
exon_skip_147728chrX103676979:103677051:103678499:103678620:103684681:103684729103678499:103678620
exon_skip_175380chrX103676979:103677051:103678499:103678600:103685171:103685199103678499:103678600
exon_skip_175401chrX103678499:103678600:103685171:103685260:103686631:103686684103685171:103685260
exon_skip_183675chrX103678568:103678651:103684681:103684729:103685171:103685260103684681:103684729
exon_skip_18793chrX103678501:103678600:103684681:103684729:103685171:103685260103684681:103684729
exon_skip_204795chrX103676983:103677051:103678499:103678600:103684681:103684729103678499:103678600
exon_skip_210429chrX103678499:103678651:103684681:103684729:103685171:103685260103684681:103684729
exon_skip_236929chrX103676979:103677051:103678499:103678651:103685171:103685199103678499:103678651
exon_skip_278728chrX103676979:103677051:103678499:103678651:103684681:103684729103678499:103678651
exon_skip_58031chrX103676983:103677051:103678499:103678600:103685171:103685260103678499:103678600
exon_skip_69317chrX103678568:103678620:103684681:103684729:103685171:103685260103684681:103684729
exon_skip_85911chrX103678568:103678600:103684681:103684729:103685171:103685260103684681:103684729
exon_skip_97078chrX103678499:103678620:103684681:103684729:103685171:103685260103684681:103684729

check button Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.
psi tcga
Exon skipping informationTissue typeAvg(PSIs) in ADAvg(PSIs) in controlDifference (PSI)Adj. p-value
exon_skip_141130MSBB_PG5.615278e-014.140741e-011.474537e-012.996938e-06


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Open reading frame (ORF) annotation in the exon skipping event for MORF4L2

check button Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003604581036784991036786003UTR-3UTR
ENST000004221541036784991036786513UTR-3UTR
ENST000004331761036784991036786513UTR-3UTR
ENST000004410761036784991036786513UTR-3UTR

check button Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003604581036784991036786003UTR-3UTR
ENST000004221541036784991036786513UTR-3UTR
ENST000004331761036784991036786513UTR-3UTR
ENST000004410761036784991036786513UTR-3UTR

check button Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003604581036784991036786003UTR-3UTR
ENST000004221541036784991036786513UTR-3UTR
ENST000004331761036784991036786513UTR-3UTR
ENST000004410761036784991036786513UTR-3UTR

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Infer the effects of exon skipping event on protein functional features for MORF4L2

p-ENSG00000123562_img4.png
boxplot

check button Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Lost protein functional features of individual exon skipping events in ROSMAP.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature

check button Lost protein functional features of individual exon skipping events in MSBB.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature

check button Lost protein functional features of individual exon skipping events in Mayo.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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3'-UTR located exon skipping events that lost miRNA binding sites in MORF4L2

check button 3'-UTR exon skipping evnets lost miRNA binding.
Tissue typeENSTExon skip startExon skip endmicroRNABinding site by TargetScanBinding type by TargetScanBdinding site by miRandaScore of miRandaEnergy by miRanda
MayoENST00000360458103678499103678600hsa-miR-6502-3pchrX:103678569-1036785768mer-1achrX:103678562-103678582149.00-27.38
MayoENST00000441076103678499103678651hsa-miR-6502-3pchrX:103678569-1036785768mer-1achrX:103678562-103678582149.00-27.38
MayoENST00000360458103678499103678600hsa-miR-4646-5pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
MayoENST00000441076103678499103678651hsa-miR-4646-5pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
MayoENST00000360458103678499103678600hsa-miR-204-3pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
MayoENST00000441076103678499103678651hsa-miR-204-3pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
MayoENST00000360458103678499103678600hsa-miR-532-3pchrX:103678587-1036785948mer-1achrX:103678575-103678595154.00-21.46
MayoENST00000441076103678499103678651hsa-miR-532-3pchrX:103678587-1036785948mer-1achrX:103678575-103678595154.00-21.46
MayoENST00000441076103678499103678651hsa-miR-1912-5pchrX:103678623-1036786308mer-1achrX:103678608-103678630150.00-15.58
MayoENST00000360458103678499103678600hsa-miR-452-3pchrX:103678542-1036785498mer-1achrX:103678527-103678549151.00-11.25
MayoENST00000441076103678499103678651hsa-miR-452-3pchrX:103678542-1036785498mer-1achrX:103678527-103678549151.00-11.25
MayoENST00000360458103678499103678600hsa-miR-3202chrX:103678515-1036785228mer-1achrX:103678501-103678522159.00-21.63
MayoENST00000441076103678499103678651hsa-miR-3202chrX:103678515-1036785228mer-1achrX:103678501-103678522159.00-21.63
MSBBENST00000360458103678499103678600hsa-miR-6502-3pchrX:103678569-1036785768mer-1achrX:103678562-103678582149.00-27.38
MSBBENST00000441076103678499103678651hsa-miR-6502-3pchrX:103678569-1036785768mer-1achrX:103678562-103678582149.00-27.38
MSBBENST00000360458103678499103678600hsa-miR-4646-5pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
MSBBENST00000441076103678499103678651hsa-miR-4646-5pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
MSBBENST00000360458103678499103678600hsa-miR-204-3pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
MSBBENST00000441076103678499103678651hsa-miR-204-3pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
MSBBENST00000360458103678499103678600hsa-miR-532-3pchrX:103678587-1036785948mer-1achrX:103678575-103678595154.00-21.46
MSBBENST00000441076103678499103678651hsa-miR-532-3pchrX:103678587-1036785948mer-1achrX:103678575-103678595154.00-21.46
MSBBENST00000441076103678499103678651hsa-miR-1912-5pchrX:103678623-1036786308mer-1achrX:103678608-103678630150.00-15.58
MSBBENST00000360458103678499103678600hsa-miR-452-3pchrX:103678542-1036785498mer-1achrX:103678527-103678549151.00-11.25
MSBBENST00000441076103678499103678651hsa-miR-452-3pchrX:103678542-1036785498mer-1achrX:103678527-103678549151.00-11.25
MSBBENST00000360458103678499103678600hsa-miR-3202chrX:103678515-1036785228mer-1achrX:103678501-103678522159.00-21.63
MSBBENST00000441076103678499103678651hsa-miR-3202chrX:103678515-1036785228mer-1achrX:103678501-103678522159.00-21.63
ROSMAPENST00000360458103678499103678600hsa-miR-6502-3pchrX:103678569-1036785768mer-1achrX:103678562-103678582149.00-27.38
ROSMAPENST00000441076103678499103678651hsa-miR-6502-3pchrX:103678569-1036785768mer-1achrX:103678562-103678582149.00-27.38
ROSMAPENST00000360458103678499103678600hsa-miR-4646-5pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
ROSMAPENST00000441076103678499103678651hsa-miR-4646-5pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
ROSMAPENST00000360458103678499103678600hsa-miR-204-3pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
ROSMAPENST00000441076103678499103678651hsa-miR-204-3pchrX:103678538-1036785458mer-1achrX:103678525-103678545158.00-21.92
ROSMAPENST00000360458103678499103678600hsa-miR-532-3pchrX:103678587-1036785948mer-1achrX:103678575-103678595154.00-21.46
ROSMAPENST00000441076103678499103678651hsa-miR-532-3pchrX:103678587-1036785948mer-1achrX:103678575-103678595154.00-21.46
ROSMAPENST00000441076103678499103678651hsa-miR-1912-5pchrX:103678623-1036786308mer-1achrX:103678608-103678630150.00-15.58
ROSMAPENST00000360458103678499103678600hsa-miR-452-3pchrX:103678542-1036785498mer-1achrX:103678527-103678549151.00-11.25
ROSMAPENST00000441076103678499103678651hsa-miR-452-3pchrX:103678542-1036785498mer-1achrX:103678527-103678549151.00-11.25
ROSMAPENST00000360458103678499103678600hsa-miR-3202chrX:103678515-1036785228mer-1achrX:103678501-103678522159.00-21.63
ROSMAPENST00000441076103678499103678651hsa-miR-3202chrX:103678515-1036785228mer-1achrX:103678501-103678522159.00-21.63

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SNVs in the skipped exons for MORF4L2

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Depth of Coverage in the skipped exon of the mutated samples.

check button - Sashimi plot in the skipped exon of the mutated samples.

check button - Non-synonymous mutations located in the skipped exons.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

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AD stage-associated exon skippint events for MORF4L2

check button Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).
AD stage infoCohortTissueSE idCoefficient P-valueChromosomeStrandE1 startE1 endSkipped startSkipped endE2 startE2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MORF4L2

check button sQTL information located at the skipped exons.
Tissue typeExon skip IDSNP idLocationP-valueFDR
CBexon_skip_204795rs5945696chrX:1036815781.518477e-042.409421e-02

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Correlation with RNA binding proteins (RBPs) for MORF4L2

check button Correlated RBP and related information.
Tissue typeRBP nameExon skip IDCorrelation coeifficientP-value
CBDAZAP1exon_skip_58031-4.266011e-012.057644e-08
CBPABPN1exon_skip_58031-4.597197e-011.088680e-09
CBZNF638exon_skip_58031-5.121321e-015.200742e-12
CBTRA2Aexon_skip_58031-5.082213e-018.001158e-12
CBPABPN1exon_skip_130297-4.060027e-011.098684e-07
CBZNF638exon_skip_130297-4.310907e-011.406806e-08
CBTRA2Aexon_skip_130297-4.571002e-011.389651e-09
FLHNRNPH2exon_skip_141130-4.119619e-011.639245e-09
FLELAVL4exon_skip_105997-4.278654e-014.403101e-10
HCCDAZAP1exon_skip_1411304.312939e-018.553464e-14
HCCRBM5exon_skip_1411304.654502e-014.396236e-16
HCCIGF2BP2exon_skip_1411304.142585e-019.576971e-13
HCCPCBP4exon_skip_1411304.098326e-011.754847e-12
HCCPTBP1exon_skip_1059974.702212e-012.277885e-16
IFGRBM47exon_skip_1411304.333565e-012.124022e-02
IFGHNRNPA0exon_skip_141130-4.515379e-011.586637e-02
IFGNUP42exon_skip_141130-4.108622e-012.986356e-02
IFGELAVL4exon_skip_128462-4.164054e-013.073097e-02
IFGELAVL4exon_skip_105997-6.585288e-011.390852e-04
IFGRBM47exon_skip_1059974.084048e-013.095618e-02
IFGG3BP2exon_skip_105997-6.055721e-016.384832e-04
IFGHNRNPA0exon_skip_105997-4.331827e-012.129800e-02
IFGRALYLexon_skip_105997-6.612727e-011.274984e-04
IFGHNRNPH2exon_skip_105997-4.606958e-011.361893e-02
IFGNOVA1exon_skip_105997-5.705286e-011.523509e-03
PCCELAVL4exon_skip_105997-4.621249e-011.148332e-12
PCCPTBP1exon_skip_1059974.119788e-013.915413e-10
PGIGF2BP2exon_skip_1411304.241927e-014.732721e-10
PGHNRNPH2exon_skip_141130-4.293352e-012.765197e-10
PGELAVL4exon_skip_105997-6.961043e-011.990839e-28
PGELAVL1exon_skip_105997-4.069023e-017.513774e-09
PGHNRNPKexon_skip_105997-4.217374e-011.840531e-09
PGG3BP2exon_skip_105997-6.513268e-015.944945e-24
PGHNRNPA0exon_skip_105997-4.513405e-018.990620e-11
PGRALYLexon_skip_105997-6.128876e-011.134788e-20
PGHNRNPLexon_skip_105997-4.099889e-015.638811e-09
PGEWSR1exon_skip_105997-4.326130e-016.278690e-10
PGHNRNPH2exon_skip_105997-5.631420e-014.882180e-17
PGNOVA1exon_skip_105997-4.422639e-012.340472e-10
STGELAVL4exon_skip_105997-4.092384e-011.007086e-04
STGRALYLexon_skip_105997-4.311389e-013.801385e-05
STGNOVA1exon_skip_105997-4.264892e-014.701407e-05
TCNUP42exon_skip_14566-4.692059e-011.581399e-09
TCHNRNPA0exon_skip_175380-6.922116e-013.789892e-24
TCNUP42exon_skip_175380-7.210181e-015.875789e-27
TCSRSF9exon_skip_175380-4.026148e-011.306813e-07
TCHNRNPH2exon_skip_175380-6.892516e-017.059216e-24
TCELAVL4exon_skip_145647-7.684502e-011.910692e-32
TCHNRNPA0exon_skip_145647-6.092304e-011.250942e-17
TCHNRNPDexon_skip_145647-4.993400e-011.801782e-11
TCNUP42exon_skip_145647-6.273223e-016.951749e-19
TCRALYLexon_skip_145647-8.137997e-014.436490e-39
TCPTBP3exon_skip_145647-4.396108e-016.028775e-09
TCHNRNPH2exon_skip_145647-6.139938e-015.950862e-18
TCELAVL4exon_skip_278728-6.379825e-011.597605e-15
TCG3BP2exon_skip_278728-4.832718e-011.307096e-08
TCNUP42exon_skip_278728-4.745157e-012.582577e-08
TCRALYLexon_skip_278728-6.179476e-012.078510e-14
TCHNRNPH2exon_skip_278728-4.362912e-014.077729e-07
TCELAVL4exon_skip_236929-8.493575e-011.057553e-45
TCG3BP2exon_skip_236929-7.127264e-014.103228e-26
TCHNRNPA0exon_skip_236929-6.878180e-019.515232e-24
TCHNRNPDexon_skip_236929-5.762256e-011.554261e-15
TCNUP42exon_skip_236929-7.222912e-014.332757e-27
TCRALYLexon_skip_236929-8.829444e-019.340392e-54
TCPTBP1exon_skip_2369294.719220e-012.986010e-10
TCPTBP3exon_skip_236929-4.391242e-016.293076e-09
TCEWSR1exon_skip_236929-4.071312e-019.154130e-08
TCHNRNPH2exon_skip_236929-6.923298e-013.696353e-24
TCNOVA1exon_skip_236929-6.904109e-015.537920e-24
TCRBFOX2exon_skip_859114.694134e-013.813820e-10
TCG3BP2exon_skip_859115.069520e-017.898268e-12
TCPUM1exon_skip_859114.258634e-011.974758e-08
TCHNRNPDexon_skip_859115.235379e-011.218166e-12

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RelatedDrugs for MORF4L2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MORF4L2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource