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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FEZ2 |
 Gene summary |
| Gene information | Gene symbol | FEZ2 | Gene ID | 9637 |
| Gene name | fasciculation and elongation protein zeta 2 | |
| Synonyms | HUM3CL | |
| Cytomap | 2p22.2 | |
| Type of gene | protein-coding | |
| Description | fasciculation and elongation protein zeta-2pre-T/NK cell associated protein (3Cl)zygin 2zygin II | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for FEZ2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000171055
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000441005.5 | FEZ2-209:protein_coding:FEZ2 | 1.437080e+01 | 3.416543e+00 | 8.366798e-05 | 5.423474e-03 |
| CB | UP | ENST00000451623.5 | FEZ2-210:nonsense_mediated_decay:FEZ2 | 1.272873e+02 | 9.359197e-01 | 5.314987e-07 | 8.752863e-06 |
| CB | DOWN | ENST00000441005.5 | FEZ2-209:protein_coding:FEZ2 | 2.162624e+02 | -2.460528e+00 | 4.032372e-06 | 4.880586e-05 |
| TC | DOWN | ENST00000441005.5 | FEZ2-209:protein_coding:FEZ2 | 2.587603e+02 | -1.596454e+00 | 5.099944e-04 | 5.846066e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FEZ2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_107446 | chr2 | 36555688:36555748:36555977:36556060:36558438:36558511 | 36555977:36556060 |
| exon_skip_132865 | chr2 | 36558438:36558513:36560785:36560865:36561338:36561498 | 36560785:36560865 |
| exon_skip_133282 | chr2 | 36553164:36553179:36554170:36554262:36555683:36555748 | 36554170:36554262 |
| exon_skip_135192 | chr2 | 36555688:36555748:36558438:36558513:36560785:36560845 | 36558438:36558513 |
| exon_skip_143570 | chr2 | 36583450:36583469:36590903:36591011:36597877:36598166 | 36590903:36591011 |
| exon_skip_165896 | chr2 | 36581290:36581431:36583353:36583469:36590903:36591011 | 36583353:36583469 |
| exon_skip_179770 | chr2 | 36581290:36581431:36581505:36581590:36583353:36583469 | 36581505:36581590 |
| exon_skip_180283 | chr2 | 36555688:36555748:36558438:36558513:36578597:36578673 | 36558438:36558513 |
| exon_skip_215375 | chr2 | 36552947:36553179:36554170:36554262:36555683:36555748 | 36554170:36554262 |
| exon_skip_239260 | chr2 | 36555688:36555748:36558438:36558513:36578597:36578832 | 36558438:36558513 |
| exon_skip_249838 | chr2 | 36583353:36583469:36590903:36591011:36597877:36598166 | 36590903:36591011 |
| exon_skip_292915 | chr2 | 36558438:36558513:36560785:36560865:36578597:36578832 | 36560785:36560865 |
| exon_skip_45940 | chr2 | 36558438:36558513:36560785:36560865:36578597:36578673 | 36560785:36560865 |
| exon_skip_61512 | chr2 | 36555683:36555748:36555977:36556060:36558438:36558513 | 36555977:36556060 |
| exon_skip_64619 | chr2 | 36558439:36558513:36560785:36560865:36578597:36578832 | 36560785:36560865 |
| exon_skip_67369 | chr2 | 36558438:36558513:36560785:36560865:36578597:36578621 | 36560785:36560865 |
| exon_skip_7741 | chr2 | 36555688:36555748:36555977:36556060:36558438:36558513 | 36555977:36556060 |
| exon_skip_9854 | chr2 | 36555688:36555748:36558438:36558513:36578597:36578621 | 36558438:36558513 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_292915 | MSBB_STG | 6.675758e-01 | 7.725000e-01 | -1.049242e-01 | 5.842981e-03 |
| exon_skip_292915 | MSBB_PG | 6.025694e-01 | 7.100000e-01 | -1.074306e-01 | 7.402668e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for FEZ2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000405912 | 36558438 | 36558513 | Frame-shift |
| ENST00000405912 | 36590903 | 36591011 | Frame-shift |
| ENST00000405912 | 36583353 | 36583469 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000405912 | 36558438 | 36558513 | Frame-shift |
| ENST00000405912 | 36590903 | 36591011 | Frame-shift |
| ENST00000405912 | 36583353 | 36583469 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000405912 | 36558438 | 36558513 | Frame-shift |
| ENST00000405912 | 36590903 | 36591011 | Frame-shift |
| ENST00000405912 | 36583353 | 36583469 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FEZ2 |
p-ENSG00000171055_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000405912 | 1948 | 353 | 36583353 | 36583469 | 376 | 491 | 125 | 163 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000405912 | 1948 | 353 | 36583353 | 36583469 | 376 | 491 | 125 | 163 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000405912 | 1948 | 353 | 36583353 | 36583469 | 376 | 491 | 125 | 163 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UHY8 | 125 | 163 | 1 | 353 | Chain | ID=PRO_0000189528;Note=Fasciculation and elongation protein zeta-2 |
| Q9UHY8 | 125 | 163 | 153 | 153 | Disulfide bond | Note=Interchain;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UHY8 | 125 | 163 | 135 | 135 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UHY8 | 125 | 163 | 1 | 353 | Chain | ID=PRO_0000189528;Note=Fasciculation and elongation protein zeta-2 |
| Q9UHY8 | 125 | 163 | 153 | 153 | Disulfide bond | Note=Interchain;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UHY8 | 125 | 163 | 135 | 135 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UHY8 | 125 | 163 | 1 | 353 | Chain | ID=PRO_0000189528;Note=Fasciculation and elongation protein zeta-2 |
| Q9UHY8 | 125 | 163 | 153 | 153 | Disulfide bond | Note=Interchain;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UHY8 | 125 | 163 | 135 | 135 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
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3'-UTR located exon skipping events that lost miRNA binding sites in FEZ2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FEZ2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FEZ2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FEZ2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FEZ2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | CNOT4 | exon_skip_239260 | -4.352304e-01 | 1.519010e-08 |
| CB | RALYL | exon_skip_64619 | 4.192919e-01 | 3.776785e-08 |
| DLPFC | CNOT4 | exon_skip_292915 | 4.385239e-01 | 7.668442e-13 |
| DLPFC | HNRNPK | exon_skip_292915 | 4.601346e-01 | 3.898724e-14 |
| DLPFC | RALYL | exon_skip_292915 | 6.462523e-01 | 4.008842e-30 |
| DLPFC | EWSR1 | exon_skip_292915 | 4.502533e-01 | 1.562571e-13 |
| DLPFC | SRSF5 | exon_skip_292915 | 4.659898e-01 | 1.676430e-14 |
| DLPFC | HNRNPH2 | exon_skip_292915 | 5.555565e-01 | 4.425554e-21 |
| DLPFC | EIF4B | exon_skip_292915 | 4.255321e-01 | 4.164502e-12 |
| DLPFC | ESRP1 | exon_skip_292915 | 5.372305e-01 | 1.427301e-19 |
| DLPFC | SART3 | exon_skip_292915 | 4.410048e-01 | 5.505287e-13 |
| DLPFC | NOVA1 | exon_skip_292915 | 6.637399e-01 | 3.100419e-32 |
| FL | HNRNPK | exon_skip_292915 | 5.956962e-01 | 4.088947e-20 |
| FL | RALYL | exon_skip_292915 | 7.054165e-01 | 1.143353e-30 |
| FL | HNRNPH2 | exon_skip_292915 | 5.304449e-01 | 1.517406e-15 |
| FL | EIF4B | exon_skip_292915 | 5.748706e-01 | 1.517209e-18 |
| FL | ESRP1 | exon_skip_292915 | 4.548075e-01 | 2.401079e-11 |
| FL | SART3 | exon_skip_292915 | 4.484590e-01 | 4.876879e-11 |
| FL | NOVA1 | exon_skip_292915 | 5.484160e-01 | 1.049256e-16 |
| HCC | RBM5 | exon_skip_292915 | -5.036015e-01 | 5.819972e-19 |
| HCC | IGF2BP2 | exon_skip_292915 | -4.393675e-01 | 2.594063e-14 |
| HCC | PABPC1 | exon_skip_292915 | -4.128733e-01 | 1.158676e-12 |
| IFG | HNRNPK | exon_skip_41076 | -5.840014e-01 | 2.176111e-03 |
| IFG | PABPC1 | exon_skip_41076 | -4.653773e-01 | 1.906374e-02 |
| IFG | SART3 | exon_skip_41076 | -5.252968e-01 | 7.008275e-03 |
| IFG | IGF2BP3 | exon_skip_292915 | -5.022030e-01 | 6.464619e-03 |
| IFG | EIF4B | exon_skip_292915 | 4.862673e-01 | 8.697796e-03 |
| PCC | RBMS2 | exon_skip_269670 | -5.138687e-01 | 9.434837e-16 |
| PCC | ELAVL4 | exon_skip_269670 | 5.028031e-01 | 4.774994e-15 |
| PCC | PTBP1 | exon_skip_269670 | -5.834851e-01 | 7.937535e-21 |
| PCC | CPEB1 | exon_skip_269670 | 4.805830e-01 | 1.043712e-13 |
| PCC | HNRNPF | exon_skip_269670 | -4.694064e-01 | 4.535867e-13 |
| PCC | RALYL | exon_skip_292915 | 4.974023e-01 | 7.728999e-15 |
| PCC | PABPC1 | exon_skip_292915 | -4.536788e-01 | 2.594943e-12 |
| PG | HNRNPK | exon_skip_292915 | 4.810247e-01 | 4.908418e-13 |
| PG | RALYL | exon_skip_292915 | 6.355485e-01 | 3.875724e-24 |
| PG | HNRNPH2 | exon_skip_292915 | 5.752898e-01 | 4.172602e-19 |
| PG | SART3 | exon_skip_292915 | 4.106177e-01 | 1.409918e-09 |
| PG | NOVA1 | exon_skip_292915 | 4.639256e-01 | 4.027188e-12 |
| STG | HNRNPK | exon_skip_292915 | 4.974713e-01 | 6.094323e-07 |
| STG | RALYL | exon_skip_292915 | 6.363020e-01 | 1.586951e-11 |
| STG | HNRNPH2 | exon_skip_292915 | 6.125791e-01 | 1.395029e-10 |
| STG | SART3 | exon_skip_292915 | 4.187045e-01 | 4.007970e-05 |
| STG | NOVA1 | exon_skip_292915 | 5.680986e-01 | 5.221408e-09 |
| TC | RALYL | exon_skip_67369 | 6.156803e-01 | 4.560674e-18 |
| TC | EWSR1 | exon_skip_67369 | 4.326302e-01 | 1.108526e-08 |
| TC | SRSF5 | exon_skip_67369 | 4.695244e-01 | 3.772927e-10 |
| TC | HNRNPH2 | exon_skip_67369 | 5.650607e-01 | 7.047705e-15 |
| TC | ESRP1 | exon_skip_67369 | 4.776908e-01 | 1.688179e-10 |
| TC | NOVA1 | exon_skip_67369 | 7.768775e-01 | 1.471192e-33 |
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RelatedDrugs for FEZ2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FEZ2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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