ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for NCOR2

Gene summary

Gene information	Gene symbol	NCOR2
	Gene ID	9612
	Gene name	nuclear receptor corepressor 2
	Synonyms	CTG26\|N-CoR2\|SMAP270\|SMRT\|SMRTE\|SMRTE-tau\|TNRC14\|TRAC\|TRAC-1\|TRAC1
	Cytomap	12q24.31
	Type of gene	protein-coding
	Description	nuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressor
	Modification date	20200313
	UniProtAcc	A0A024RBS3, A0A024RBU9, A0A384DVL6, A0A481PGK9, C9J0Q5, C9J330, C9J7T7, C9JE98, C9JNV9, C9JQE8, H0YGK8, H7BZU2, H7C0P3, H7C184, H7C1J7, H7C1Y3, H7C2R5, Q9Y618,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for NCOR2

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000196498

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	UP	ENST00000443451.6	NCOR2-211:retained_intron:NCOR2	1.562869e+01	9.907393e-01	5.106634e-04	2.738178e-02
CB	DOWN	ENST00000418829.5	NCOR2-206:protein_coding:NCOR2	1.313672e+01	-8.575229e-01	1.140402e-03	5.773090e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCOR2

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_106510	chr12	124340294:124340443:124340602:124340694:124341823:124342055	124340602:124340694
exon_skip_112577	chr12	124333130:124333279:124334424:124335280:124335483:124335632	124334424:124335280
exon_skip_118737	chr12	124341823:124342074:124343005:124343226:124344597:124344951	124343005:124343226
exon_skip_128185	chr12	124334424:124334617:124335135:124335280:124335483:124335632	124335135:124335280
exon_skip_131120	chr12	124430686:124430787:124437930:124437996:124449815:124449867	124437930:124437996
exon_skip_13510	chr12	124437930:124437996:124449815:124449867:124466173:124466286	124449815:124449867
exon_skip_142580	chr12	124354478:124354582:124354837:124354939:124355432:124355571	124354837:124354939
exon_skip_142948	chr12	124340294:124340443:124340602:124340751:124341823:124341863	124340602:124340751
exon_skip_148033	chr12	124430641:124430787:124437930:124437996:124449815:124449867	124437930:124437996
exon_skip_163262	chr12	124326191:124326370:124327547:124327633:124330845:124330897	124327547:124327633
exon_skip_172996	chr12	124354093:124354196:124354478:124354582:124354837:124354924	124354478:124354582
exon_skip_174848	chr12	124372460:124372610:124374413:124374463:124378237:124378378	124374413:124374463
exon_skip_1770	chr12	124328532:124329157:124330845:124330898:124332319:124332345	124330845:124330898
exon_skip_184199	chr12	124326191:124326370:124327547:124327633:124330845:124330898	124327547:124327633
exon_skip_190049	chr12	124378237:124378384:124385745:124385887:124398119:124398181	124385745:124385887
exon_skip_202585	chr12	124437930:124437996:124449815:124449867:124457106:124457162	124449815:124449867
exon_skip_20484	chr12	124348174:124348314:124350587:124350737:124354093:124354196	124350587:124350737
exon_skip_212185	chr12	124354837:124354939:124355432:124355571:124356642:124356685	124355432:124355571
exon_skip_219884	chr12	124326321:124326370:124327409:124327633:124330845:124330898	124327409:124327633
exon_skip_23049	chr12	124326191:124326370:124330845:124330898:124332319:124332345	124330845:124330898
exon_skip_233619	chr12	124362126:124362297:124363679:124363799:124372022:124372610	124363679:124363799
exon_skip_238859	chr12	124332319:124332467:124333130:124333279:124334424:124334617	124333130:124333279
exon_skip_24029	chr12	124354093:124354196:124354478:124354582:124354837:124354939	124354478:124354582
exon_skip_246645	chr12	124326321:124326370:124327547:124327633:124330845:124330898	124327547:124327633
exon_skip_2468	chr12	124372460:124372610:124378237:124378384:124385745:124385887	124378237:124378384
exon_skip_247217	chr12	124437930:124437996:124449815:124449867:124466173:124466280	124449815:124449867
exon_skip_264100	chr12	124326191:124326370:124327409:124327633:124330845:124330898	124327409:124327633
exon_skip_278052	chr12	124449815:124449867:124457106:124457162:124466173:124466280	124457106:124457162
exon_skip_279315	chr12	124327547:124327633:124330845:124330898:124332319:124332345	124330845:124330898
exon_skip_281706	chr12	124426622:124426800:124429613:124429703:124430615:124430641	124429613:124429703
exon_skip_282468	chr12	124340294:124340443:124340602:124340751:124341823:124341843	124340602:124340751
exon_skip_284887	chr12	124372545:124372610:124374413:124374463:124378237:124378384	124374413:124374463
exon_skip_42269	chr12	124333130:124333279:124334424:124334617:124335135:124335181	124334424:124334617
exon_skip_45158	chr12	124340294:124340443:124340602:124340694:124341823:124341863	124340602:124340694
exon_skip_46420	chr12	124355432:124355571:124356642:124356806:124362126:124362294	124356642:124356806
exon_skip_47635	chr12	124355487:124355571:124356642:124356782:124362126:124362294	124356642:124356782
exon_skip_48979	chr12	124372460:124372610:124374413:124374463:124378237:124378384	124374413:124374463
exon_skip_5064	chr12	124355432:124355571:124356642:124356782:124362126:124362294	124356642:124356782
exon_skip_50946	chr12	124419959:124420055:124422501:124422555:124426622:124426800	124422501:124422555
exon_skip_54634	chr12	124483596:124483773:124486441:124486568:124495147:124495252	124486441:124486568
exon_skip_55188	chr12	124341823:124342074:124343005:124343226:124344597:124344874	124343005:124343226
exon_skip_59501	chr12	124449815:124449867:124457106:124457162:124466173:124466286	124457106:124457162
exon_skip_6547	chr12	124426622:124426800:124429613:124429706:124430615:124430641	124429613:124429706
exon_skip_70343	chr12	124326191:124326370:124327409:124327633:124330845:124330897	124327409:124327633
exon_skip_70721	chr12	124355487:124355571:124356642:124356806:124362126:124362294	124356642:124356806
exon_skip_79847	chr12	124344597:124344951:124346564:124346850:124347825:124347911	124346564:124346850
exon_skip_91487	chr12	124340294:124340443:124340602:124340694:124341823:124341843	124340602:124340694
exon_skip_94011	chr12	124363679:124363799:124372022:124372610:124378237:124378384	124372022:124372610

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for NCOR2

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000405201	124334424	124334617	Frame-shift
ENST00000405201	124346564	124346850	Frame-shift
ENST00000405201	124354837	124354939	Frame-shift
ENST00000405201	124355432	124355571	Frame-shift
ENST00000405201	124363679	124363799	Frame-shift
ENST00000405201	124429613	124429706	Frame-shift
ENST00000405201	124437930	124437996	Frame-shift
ENST00000405201	124327409	124327633	In-frame
ENST00000405201	124330845	124330898	In-frame
ENST00000405201	124340602	124340751	In-frame
ENST00000405201	124343005	124343226	In-frame
ENST00000405201	124354478	124354582	In-frame
ENST00000405201	124356642	124356782	In-frame
ENST00000405201	124374413	124374463	In-frame
ENST00000405201	124457106	124457162	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000405201	124429613	124429706	Frame-shift
ENST00000405201	124327409	124327633	In-frame
ENST00000405201	124340602	124340751	In-frame
ENST00000405201	124354478	124354582	In-frame
ENST00000405201	124356642	124356782	In-frame
ENST00000405201	124374413	124374463	In-frame
ENST00000405201	124457106	124457162	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000405201	124334424	124334617	Frame-shift
ENST00000405201	124335135	124335280	Frame-shift
ENST00000405201	124346564	124346850	Frame-shift
ENST00000405201	124350587	124350737	Frame-shift
ENST00000405201	124354837	124354939	Frame-shift
ENST00000405201	124355432	124355571	Frame-shift
ENST00000405201	124363679	124363799	Frame-shift
ENST00000405201	124385745	124385887	Frame-shift
ENST00000405201	124422501	124422555	Frame-shift
ENST00000405201	124429613	124429706	Frame-shift
ENST00000405201	124437930	124437996	Frame-shift
ENST00000405201	124449815	124449867	Frame-shift
ENST00000405201	124327409	124327633	In-frame
ENST00000405201	124330845	124330898	In-frame
ENST00000405201	124333130	124333279	In-frame
ENST00000405201	124340602	124340751	In-frame
ENST00000405201	124343005	124343226	In-frame
ENST00000405201	124354478	124354582	In-frame
ENST00000405201	124356642	124356782	In-frame
ENST00000405201	124374413	124374463	In-frame
ENST00000405201	124457106	124457162	In-frame

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Infer the effects of exon skipping event on protein functional features for NCOR2

p-ENSG00000196498_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000405201	8550	2514	124457106	124457162	707	762	235	253
ENST00000405201	8550	2514	124374413	124374463	2169	2218	722	739
ENST00000405201	8550	2514	124356642	124356782	3102	3241	1033	1080
ENST00000405201	8550	2514	124354478	124354582	3486	3589	1161	1196
ENST00000405201	8550	2514	124343005	124343226	4716	4936	1571	1645
ENST00000405201	8550	2514	124340602	124340751	5190	5338	1729	1779
ENST00000405201	8550	2514	124330845	124330898	6906	6958	2301	2319
ENST00000405201	8550	2514	124327409	124327633	6960	7183	2319	2394

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000405201	8550	2514	124457106	124457162	707	762	235	253
ENST00000405201	8550	2514	124374413	124374463	2169	2218	722	739
ENST00000405201	8550	2514	124356642	124356782	3102	3241	1033	1080
ENST00000405201	8550	2514	124354478	124354582	3486	3589	1161	1196
ENST00000405201	8550	2514	124340602	124340751	5190	5338	1729	1779
ENST00000405201	8550	2514	124327409	124327633	6960	7183	2319	2394

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000405201	8550	2514	124457106	124457162	707	762	235	253
ENST00000405201	8550	2514	124374413	124374463	2169	2218	722	739
ENST00000405201	8550	2514	124356642	124356782	3102	3241	1033	1080
ENST00000405201	8550	2514	124354478	124354582	3486	3589	1161	1196
ENST00000405201	8550	2514	124343005	124343226	4716	4936	1571	1645
ENST00000405201	8550	2514	124340602	124340751	5190	5338	1729	1779
ENST00000405201	8550	2514	124333130	124333279	6607	6755	2202	2251
ENST00000405201	8550	2514	124330845	124330898	6906	6958	2301	2319
ENST00000405201	8550	2514	124327409	124327633	6960	7183	2319	2394

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y618	235	253	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	235	253	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	235	253	242	245	Mutagenesis	Note=Abolishes interaction with TBL1X. HRIL->AEIA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21240272;Dbxref=PMID:21240272
Q9Y618	722	739	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	722	739	724	740	Alternative sequence	ID=VSP_036595;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10097068,ECO:0000303\|Ref.4;Dbxref=PMID:10097068
Q9Y618	722	739	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1033	1080	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1033	1080	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1161	1196	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1168	1168	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y618	1161	1196	1173	1173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1571	1645	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1571	1645	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1571	1645	1595	1595	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9WU42
Q9Y618	1571	1645	1619	1619	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1729	1779	1775	1775	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1778	1778	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
Q9Y618	2301	2319	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2319	2394	2350	2395	Alternative sequence	ID=VSP_003413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8813722,ECO:0000303\|Ref.4;Dbxref=PMID:8813722
Q9Y618	2319	2394	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2319	2394	2337	2347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5X8Q
Q9Y618	2319	2394	2339	2343	Motif	Note=CORNR box of ID2

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y618	235	253	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	235	253	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	235	253	242	245	Mutagenesis	Note=Abolishes interaction with TBL1X. HRIL->AEIA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21240272;Dbxref=PMID:21240272
Q9Y618	722	739	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	722	739	724	740	Alternative sequence	ID=VSP_036595;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10097068,ECO:0000303\|Ref.4;Dbxref=PMID:10097068
Q9Y618	722	739	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1033	1080	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1033	1080	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1161	1196	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1168	1168	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y618	1161	1196	1173	1173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1729	1779	1775	1775	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1778	1778	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
Q9Y618	2319	2394	2350	2395	Alternative sequence	ID=VSP_003413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8813722,ECO:0000303\|Ref.4;Dbxref=PMID:8813722
Q9Y618	2319	2394	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2319	2394	2337	2347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5X8Q
Q9Y618	2319	2394	2339	2343	Motif	Note=CORNR box of ID2

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y618	235	253	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	235	253	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	235	253	242	245	Mutagenesis	Note=Abolishes interaction with TBL1X. HRIL->AEIA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21240272;Dbxref=PMID:21240272
Q9Y618	722	739	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	722	739	724	740	Alternative sequence	ID=VSP_036595;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10097068,ECO:0000303\|Ref.4;Dbxref=PMID:10097068
Q9Y618	722	739	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1033	1080	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1033	1080	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1161	1196	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1168	1168	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y618	1161	1196	1173	1173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1571	1645	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1571	1645	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1571	1645	1595	1595	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9WU42
Q9Y618	1571	1645	1619	1619	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1729	1779	1775	1775	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1778	1778	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
Q9Y618	2202	2251	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2202	2251	2203	2203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
Q9Y618	2202	2251	2223	2223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID
Q9Y618	2301	2319	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2319	2394	2350	2395	Alternative sequence	ID=VSP_003413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8813722,ECO:0000303\|Ref.4;Dbxref=PMID:8813722
Q9Y618	2319	2394	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2319	2394	2337	2347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5X8Q
Q9Y618	2319	2394	2339	2343	Motif	Note=CORNR box of ID2

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3'-UTR located exon skipping events that lost miRNA binding sites in NCOR2

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for NCOR2

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for NCOR2

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOR2

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
HCC	exon_skip_5064	rs11057574	chr12:124301945	1.101744e-07	2.184915e-05
HCC	exon_skip_5064	rs10846644	chr12:124283241	8.767959e-07	1.448365e-04
HCC	exon_skip_5064	rs10773076	chr12:124285141	9.387821e-07	1.537779e-04

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Correlation with RNA binding proteins (RBPs) for NCOR2

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	CNOT4	exon_skip_45158	-4.129084e-01	1.027950e-07
CB	PCBP4	exon_skip_45158	4.715671e-01	6.697491e-10
CB	RBM45	exon_skip_45158	6.376551e-01	5.968769e-19
CB	RBM6	exon_skip_142948	-4.394554e-01	6.824812e-09
CB	CNOT4	exon_skip_142948	-5.273223e-01	9.253783e-13
CB	PCBP1	exon_skip_142948	-4.589679e-01	1.167926e-09
CB	PCBP4	exon_skip_142948	5.220018e-01	1.710671e-12
CB	RBM45	exon_skip_142948	6.581172e-01	4.272199e-21
CB	RBM23	exon_skip_142948	-4.605856e-01	1.003833e-09
CB	PCBP4	exon_skip_281706	4.337008e-01	2.383669e-08
CB	TRA2A	exon_skip_278052	4.567100e-01	1.440856e-09
HCC	DAZAP1	exon_skip_184199	4.814741e-01	3.004695e-17
HCC	MSI1	exon_skip_184199	4.222085e-01	3.154971e-13
HCC	HNRNPF	exon_skip_184199	4.563919e-01	1.884996e-15
TC	ESRP1	exon_skip_284887	4.667529e-01	4.933256e-10

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RelatedDrugs for NCOR2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for NCOR2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for NCOR2

Gene structures and expression levels for NCOR2

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCOR2

Open reading frame (ORF) annotation in the exon skipping event for NCOR2

Infer the effects of exon skipping event on protein functional features for NCOR2

3'-UTR located exon skipping events that lost miRNA binding sites in NCOR2

SNVs in the skipped exons for NCOR2

AD stage-associated exon skippint events for NCOR2

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOR2

Correlation with RNA binding proteins (RBPs) for NCOR2

RelatedDrugs for NCOR2

RelatedDiseases for NCOR2