ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for NCOR1

Gene summary

Gene information	Gene symbol	NCOR1
	Gene ID	9611
	Gene name	nuclear receptor corepressor 1
	Synonyms	N-CoR\|N-CoR1\|PPP1R109\|TRAC1\|hN-CoR
	Cytomap	17p12-p11.2
	Type of gene	protein-coding
	Description	nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1
	Modification date	20200313
	UniProtAcc	A0A024RD47, A0A088AWL3, A5PKW7, C9JAP0, E7EVK1, E7EVU5, E7EW50, H0Y459, J3KRE4, J3KS29, J3KS51, J3KT44, J3QKP0, O75376, Q05CG3, Q3B773, Q6NTH1, Q6PDT8, Q6PGR4, Q86W52, S4R380,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
NCOR1	GO:0046329	negative regulation of JNK cascade	11931768

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Gene structures and expression levels for NCOR1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000141027

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	DOWN	ENST00000464381.5	NCOR1-212:retained_intron:NCOR1	4.851846e+02	-1.145752e+00	4.434273e-13	7.546176e-11
CB	UP	ENST00000395851.5	NCOR1-204:protein_coding:NCOR1	1.143227e+03	8.802183e-01	5.577876e-04	3.162038e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCOR1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_121058	chr17	16164979:16165161:16171803:16171995:16186554:16186687	16171803:16171995
exon_skip_12648	chr17	16065485:16065694:16067894:16068121:16070165:16070525	16067894:16068121
exon_skip_12809	chr17	16171863:16171995:16186554:16186687:16194462:16194611	16186554:16186687
exon_skip_133750	chr17	16158760:16158873:16164979:16165161:16171803:16171995	16164979:16165161
exon_skip_138734	chr17	16073429:16073569:16075534:16075702:16079964:16080007	16075534:16075702
exon_skip_142590	chr17	16164979:16165161:16171803:16172020:16186554:16186687	16171803:16172020
exon_skip_145403	chr17	16065485:16065691:16067894:16068121:16070165:16070525	16067894:16068121
exon_skip_148532	chr17	16039517:16039654:16040441:16040494:16046990:16047093	16040441:16040494
exon_skip_187344	chr17	16139008:16139186:16143606:16143696:16146376:16146548	16143606:16143696
exon_skip_193517	chr17	16119423:16119485:16121052:16121269:16126082:16126206	16121052:16121269
exon_skip_214615	chr17	16058587:16058599:16061401:16061894:16062105:16062270	16061401:16061894
exon_skip_224409	chr17	16039517:16039654:16040441:16040491:16046951:16047035	16040441:16040491
exon_skip_231638	chr17	16032473:16032483:16034765:16034941:16039433:16039654	16034765:16034941
exon_skip_241284	chr17	16039517:16039654:16040441:16040494:16046951:16047035	16040441:16040494
exon_skip_250065	chr17	16058471:16058599:16061758:16061894:16062105:16062270	16061758:16061894
exon_skip_258372	chr17	16194462:16194639:16198601:16198719:16215362:16215401	16198601:16198719
exon_skip_259339	chr17	16079964:16080064:16080408:16080509:16080607:16080727	16080408:16080509
exon_skip_271470	chr17	16149451:16149517:16151590:16151616:16151946:16151998	16151590:16151616
exon_skip_271490	chr17	16032473:16032483:16034765:16034944:16039433:16039654	16034765:16034944
exon_skip_287380	chr17	16098367:16098496:16101250:16101805:16108786:16108912	16101250:16101805
exon_skip_42400	chr17	16058471:16058599:16061401:16061894:16062105:16062270	16061401:16061894
exon_skip_45902	chr17	16098367:16098496:16101250:16101757:16108786:16108912	16101250:16101757
exon_skip_4866	chr17	16058587:16058599:16061758:16061894:16062105:16062270	16061758:16061894
exon_skip_66305	chr17	16121052:16121269:16126082:16126206:16137311:16137412	16126082:16126206
exon_skip_70643	chr17	16065485:16065694:16067894:16068121:16070165:16070298	16067894:16068121
exon_skip_72063	chr17	16186554:16186687:16194462:16194639:16215362:16215401	16194462:16194639
exon_skip_83839	chr17	16153339:16153395:16158760:16158873:16164979:16165161	16158760:16158873
exon_skip_88450	chr17	16086399:16086442:16087172:16087345:16091863:16091918	16087172:16087345

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for NCOR1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000268712	16061401	16061894	Frame-shift
ENST00000268712	16121052	16121269	Frame-shift
ENST00000268712	16126082	16126206	Frame-shift
ENST00000268712	16143606	16143696	Frame-shift
ENST00000268712	16171803	16171995	Frame-shift
ENST00000268712	16186554	16186687	Frame-shift
ENST00000268712	16034765	16034944	In-frame
ENST00000268712	16040441	16040494	In-frame
ENST00000268712	16067894	16068121	In-frame
ENST00000268712	16080408	16080509	In-frame
ENST00000268712	16158760	16158873	In-frame
ENST00000268712	16164979	16165161	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000268712	16061401	16061894	Frame-shift
ENST00000268712	16143606	16143696	Frame-shift
ENST00000268712	16171803	16171995	Frame-shift
ENST00000268712	16040441	16040494	In-frame
ENST00000268712	16067894	16068121	In-frame
ENST00000268712	16164979	16165161	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000268712	16061401	16061894	Frame-shift
ENST00000268712	16075534	16075702	Frame-shift
ENST00000268712	16101250	16101757	Frame-shift
ENST00000268712	16121052	16121269	Frame-shift
ENST00000268712	16126082	16126206	Frame-shift
ENST00000268712	16143606	16143696	Frame-shift
ENST00000268712	16171803	16171995	Frame-shift
ENST00000268712	16034765	16034944	In-frame
ENST00000268712	16040441	16040494	In-frame
ENST00000268712	16067894	16068121	In-frame
ENST00000268712	16080408	16080509	In-frame
ENST00000268712	16158760	16158873	In-frame
ENST00000268712	16164979	16165161	In-frame

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Infer the effects of exon skipping event on protein functional features for NCOR1

p-ENSG00000141027_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000268712	10737	2440	16164979	16165161	694	875	145	205
ENST00000268712	10737	2440	16158760	16158873	877	989	206	243
ENST00000268712	10737	2440	16080408	16080509	3557	3657	1099	1133
ENST00000268712	10737	2440	16067894	16068121	4772	4998	1504	1580
ENST00000268712	10737	2440	16040441	16040494	6938	6990	2226	2244
ENST00000268712	10737	2440	16034765	16034944	7214	7392	2318	2378

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000268712	10737	2440	16164979	16165161	694	875	145	205
ENST00000268712	10737	2440	16067894	16068121	4772	4998	1504	1580
ENST00000268712	10737	2440	16040441	16040494	6938	6990	2226	2244

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000268712	10737	2440	16164979	16165161	694	875	145	205
ENST00000268712	10737	2440	16158760	16158873	877	989	206	243
ENST00000268712	10737	2440	16080408	16080509	3557	3657	1099	1133
ENST00000268712	10737	2440	16067894	16068121	4772	4998	1504	1580
ENST00000268712	10737	2440	16040441	16040494	6938	6990	2226	2244
ENST00000268712	10737	2440	16034765	16034944	7214	7392	2318	2378

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O75376	145	205	37	145	Alternative sequence	ID=VSP_046468;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	145	205	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	145	205	174	216	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O75376	145	205	172	172	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
O75376	145	205	1	373	Region	Note=Interaction with ZBTB33 and HEXIM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:14527417,ECO:0000269\|PubMed:17452463;Dbxref=PMID:14527417,PMID:17452463
O75376	206	243	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	206	243	174	216	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O75376	206	243	224	224	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:23186163,PMID:24275569
O75376	206	243	1	373	Region	Note=Interaction with ZBTB33 and HEXIM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:14527417,ECO:0000269\|PubMed:17452463;Dbxref=PMID:14527417,PMID:17452463
O75376	1099	1133	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	1099	1133	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	1099	1133	1106	1106	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:25114211;Dbxref=PMID:25114211
O75376	1099	1133	1106	1106	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25772364,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID
O75376	1099	1133	1111	1111	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
O75376	1099	1133	988	1816	Region	Note=Interaction with ETO
O75376	1504	1580	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	1504	1580	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	1504	1580	1518	1518	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
O75376	1504	1580	988	1816	Region	Note=Interaction with ETO
O75376	1504	1580	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
O75376	1504	1580	1508	1509	Sequence conflict	Note=SS->PP;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75376	1504	1580	1561	1561	Sequence conflict	Note=R->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75376	1504	1580	1567	1567	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75376	2226	2244	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	2226	2244	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	2226	2244	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
O75376	2226	2244	2212	2273	Region	Note=ID2;Ontology_term=ECO:0000250;evidence=ECO:0000250
O75376	2318	2378	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	2318	2378	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	2318	2378	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O75376	145	205	37	145	Alternative sequence	ID=VSP_046468;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	145	205	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	145	205	174	216	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O75376	145	205	172	172	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
O75376	145	205	1	373	Region	Note=Interaction with ZBTB33 and HEXIM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:14527417,ECO:0000269\|PubMed:17452463;Dbxref=PMID:14527417,PMID:17452463
O75376	1504	1580	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	1504	1580	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	1504	1580	1518	1518	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
O75376	1504	1580	988	1816	Region	Note=Interaction with ETO
O75376	1504	1580	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
O75376	1504	1580	1508	1509	Sequence conflict	Note=SS->PP;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75376	1504	1580	1561	1561	Sequence conflict	Note=R->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75376	1504	1580	1567	1567	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75376	2226	2244	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	2226	2244	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	2226	2244	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
O75376	2226	2244	2212	2273	Region	Note=ID2;Ontology_term=ECO:0000250;evidence=ECO:0000250

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O75376	145	205	37	145	Alternative sequence	ID=VSP_046468;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	145	205	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	145	205	174	216	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O75376	145	205	172	172	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
O75376	145	205	1	373	Region	Note=Interaction with ZBTB33 and HEXIM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:14527417,ECO:0000269\|PubMed:17452463;Dbxref=PMID:14527417,PMID:17452463
O75376	206	243	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	206	243	174	216	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O75376	206	243	224	224	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:23186163,PMID:24275569
O75376	206	243	1	373	Region	Note=Interaction with ZBTB33 and HEXIM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:14527417,ECO:0000269\|PubMed:17452463;Dbxref=PMID:14527417,PMID:17452463
O75376	1099	1133	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	1099	1133	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	1099	1133	1106	1106	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:25114211;Dbxref=PMID:25114211
O75376	1099	1133	1106	1106	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25772364,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID
O75376	1099	1133	1111	1111	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
O75376	1099	1133	988	1816	Region	Note=Interaction with ETO
O75376	1504	1580	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	1504	1580	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	1504	1580	1518	1518	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
O75376	1504	1580	988	1816	Region	Note=Interaction with ETO
O75376	1504	1580	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
O75376	1504	1580	1508	1509	Sequence conflict	Note=SS->PP;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75376	1504	1580	1561	1561	Sequence conflict	Note=R->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75376	1504	1580	1567	1567	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75376	2226	2244	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	2226	2244	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	2226	2244	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
O75376	2226	2244	2212	2273	Region	Note=ID2;Ontology_term=ECO:0000250;evidence=ECO:0000250
O75376	2318	2378	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
O75376	2318	2378	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
O75376	2318	2378	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250

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3'-UTR located exon skipping events that lost miRNA binding sites in NCOR1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for NCOR1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for NCOR1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOR1

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for NCOR1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	TARDBP	exon_skip_258372	-4.207957e-01	7.458329e-08
IFG	PABPC3	exon_skip_271470	-5.655625e-01	1.710137e-03

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RelatedDrugs for NCOR1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for NCOR1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for NCOR1

Gene structures and expression levels for NCOR1

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCOR1

Open reading frame (ORF) annotation in the exon skipping event for NCOR1

Infer the effects of exon skipping event on protein functional features for NCOR1

3'-UTR located exon skipping events that lost miRNA binding sites in NCOR1

SNVs in the skipped exons for NCOR1

AD stage-associated exon skippint events for NCOR1

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOR1

Correlation with RNA binding proteins (RBPs) for NCOR1

RelatedDrugs for NCOR1

RelatedDiseases for NCOR1