|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for NRG2 |
 Gene summary |
| Gene information | Gene symbol | NRG2 | Gene ID | 9542 |
| Gene name | neuregulin 2 | |
| Synonyms | DON1|HRG2|NTAK | |
| Cytomap | 5q31.2 | |
| Type of gene | protein-coding | |
| Description | pro-neuregulin-2, membrane-bound isoformdivergent of neuregulin-1neural- and thymus-derived activator for ErbB kinasespro-NRG2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for NRG2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000158458
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000289422.11 | NRG2-202:protein_coding:NRG2 | 1.971911e+01 | 1.199684e+00 | 1.054444e-06 | 1.567883e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NRG2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_117166 | chr5 | 139855676:139855778:139859889:139859912:139865549:139865625 | 139859889:139859912 |
| exon_skip_119541 | chr5 | 139865115:139865173:139865549:139865625:139871721:139871803 | 139865549:139865625 |
| exon_skip_123607 | chr5 | 139859889:139859912:139865115:139865173:139871721:139871803 | 139865115:139865173 |
| exon_skip_128638 | chr5 | 139855676:139855778:139859889:139859912:139865115:139865173 | 139859889:139859912 |
| exon_skip_142830 | chr5 | 139865549:139865625:139871721:139871841:139880856:139880974 | 139871721:139871841 |
| exon_skip_144063 | chr5 | 139869538:139869718:139871044:139871148:139871721:139871803 | 139871044:139871148 |
| exon_skip_151642 | chr5 | 139869399:139869718:139871044:139871148:139871721:139871803 | 139871044:139871148 |
| exon_skip_201496 | chr5 | 139871721:139871841:139880856:139880974:139887340:139887511 | 139880856:139880974 |
| exon_skip_230436 | chr5 | 139852904:139853027:139855676:139855778:139880856:139880974 | 139855676:139855778 |
| exon_skip_275303 | chr5 | 139855676:139855778:139865115:139865173:139871721:139871803 | 139865115:139865173 |
| exon_skip_290385 | chr5 | 139855676:139855778:139865549:139865625:139871721:139871803 | 139865549:139865625 |
| exon_skip_54767 | chr5 | 139855676:139855778:139865115:139865173:139865549:139865625 | 139865115:139865173 |
| exon_skip_83947 | chr5 | 139859889:139859912:139865549:139865625:139871721:139871803 | 139865549:139865625 |
| exon_skip_97918 | chr5 | 139865549:139865625:139871721:139871841:139880856:139880970 | 139871721:139871841 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for NRG2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361474 | 139865549 | 139865625 | Frame-shift |
| ENST00000361474 | 139871721 | 139871841 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361474 | 139865549 | 139865625 | Frame-shift |
| ENST00000361474 | 139871721 | 139871841 | Frame-shift |
| ENST00000361474 | 139880856 | 139880974 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for NRG2 |
p-ENSG00000158458_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in NRG2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for NRG2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for NRG2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NRG2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for NRG2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | NUP42 | exon_skip_20990 | 4.806238e-01 | 2.818371e-10 |
| CB | FXR2 | exon_skip_33277 | -4.519994e-01 | 3.995794e-09 |
| CB | SRSF4 | exon_skip_33277 | -5.561875e-01 | 6.964121e-14 |
| CB | RBM4B | exon_skip_33277 | -5.060068e-01 | 2.167422e-11 |
| CB | RBM4B | exon_skip_123607 | -4.199599e-01 | 6.517302e-08 |
| CB | NUP42 | exon_skip_95856 | 4.673106e-01 | 9.973139e-10 |
| CB | RBM4B | exon_skip_95856 | -4.019049e-01 | 2.386401e-07 |
Top |
RelatedDrugs for NRG2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NRG2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|