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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TP53I11 |
 Gene summary |
| Gene information | Gene symbol | TP53I11 | Gene ID | 9537 |
| Gene name | tumor protein p53 inducible protein 11 | |
| Synonyms | PIG11 | |
| Cytomap | 11p11.2 | |
| Type of gene | protein-coding | |
| Description | tumor protein p53-inducible protein 11p53-induced gene 11 protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TP53I11 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000175274
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000525680.5 | TP53I11-208:protein_coding:TP53I11 | 7.410680e+00 | 6.038797e+00 | 7.061914e-05 | 8.923494e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TP53I11 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_110172 | chr11 | 44938207:44938366:44939166:44939281:44941003:44941077 | 44939166:44939281 |
| exon_skip_11713 | chr11 | 44938207:44938366:44939114:44939190:44950677:44950752 | 44939114:44939190 |
| exon_skip_162626 | chr11 | 44938207:44938366:44941003:44941077:44950677:44950752 | 44941003:44941077 |
| exon_skip_170708 | chr11 | 44935620:44935662:44936803:44936899:44937304:44937352 | 44936803:44936899 |
| exon_skip_171224 | chr11 | 44935620:44935662:44936559:44936689:44936803:44936899 | 44936559:44936689 |
| exon_skip_174999 | chr11 | 44938207:44938366:44939166:44939281:44950877:44951042 | 44939166:44939281 |
| exon_skip_182203 | chr11 | 44938207:44938366:44939166:44939281:44949973:44950160 | 44939166:44939281 |
| exon_skip_19129 | chr11 | 44935578:44935662:44936880:44936899:44937304:44937352 | 44936880:44936899 |
| exon_skip_211245 | chr11 | 44934980:44935017:44935561:44935662:44936803:44936899 | 44935561:44935662 |
| exon_skip_25313 | chr11 | 44937304:44937352:44937555:44937613:44938207:44938335 | 44937555:44937613 |
| exon_skip_290031 | chr11 | 44938207:44938366:44939166:44939281:44950677:44950752 | 44939166:44939281 |
| exon_skip_291529 | chr11 | 44935620:44935662:44937304:44937352:44938207:44938335 | 44937304:44937352 |
| exon_skip_34225 | chr11 | 44937321:44937352:44937555:44937613:44938207:44938335 | 44937555:44937613 |
| exon_skip_80449 | chr11 | 44936559:44936689:44936803:44936899:44937304:44937352 | 44936803:44936899 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TP53I11 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308212 | 44939166 | 44939281 | 3UTR-3UTR |
| ENST00000395648 | 44941003 | 44941077 | 3UTR-3UTR |
| ENST00000308212 | 44936803 | 44936899 | Frame-shift |
| ENST00000395648 | 44936803 | 44936899 | Frame-shift |
| ENST00000525680 | 44936803 | 44936899 | Frame-shift |
| ENST00000533940 | 44936803 | 44936899 | Frame-shift |
| ENST00000616990 | 44936803 | 44936899 | Frame-shift |
| ENST00000308212 | 44937555 | 44937613 | Frame-shift |
| ENST00000395648 | 44937555 | 44937613 | Frame-shift |
| ENST00000525680 | 44937555 | 44937613 | Frame-shift |
| ENST00000533940 | 44937555 | 44937613 | Frame-shift |
| ENST00000616990 | 44937555 | 44937613 | Frame-shift |
| ENST00000308212 | 44935561 | 44935662 | In-frame |
| ENST00000395648 | 44935561 | 44935662 | In-frame |
| ENST00000525680 | 44935561 | 44935662 | In-frame |
| ENST00000533940 | 44935561 | 44935662 | In-frame |
| ENST00000616990 | 44935561 | 44935662 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308212 | 44936803 | 44936899 | Frame-shift |
| ENST00000395648 | 44936803 | 44936899 | Frame-shift |
| ENST00000525680 | 44936803 | 44936899 | Frame-shift |
| ENST00000533940 | 44936803 | 44936899 | Frame-shift |
| ENST00000616990 | 44936803 | 44936899 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308212 | 44939166 | 44939281 | 3UTR-3UTR |
| ENST00000395648 | 44941003 | 44941077 | 3UTR-3UTR |
| ENST00000308212 | 44936803 | 44936899 | Frame-shift |
| ENST00000395648 | 44936803 | 44936899 | Frame-shift |
| ENST00000525680 | 44936803 | 44936899 | Frame-shift |
| ENST00000533940 | 44936803 | 44936899 | Frame-shift |
| ENST00000616990 | 44936803 | 44936899 | Frame-shift |
| ENST00000308212 | 44937555 | 44937613 | Frame-shift |
| ENST00000395648 | 44937555 | 44937613 | Frame-shift |
| ENST00000525680 | 44937555 | 44937613 | Frame-shift |
| ENST00000533940 | 44937555 | 44937613 | Frame-shift |
| ENST00000616990 | 44937555 | 44937613 | Frame-shift |
| ENST00000308212 | 44935561 | 44935662 | In-frame |
| ENST00000395648 | 44935561 | 44935662 | In-frame |
| ENST00000525680 | 44935561 | 44935662 | In-frame |
| ENST00000533940 | 44935561 | 44935662 | In-frame |
| ENST00000616990 | 44935561 | 44935662 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TP53I11 |
p-ENSG00000175274_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000308212 | 3700 | 189 | 44935561 | 44935662 | 912 | 1012 | 111 | 145 |
| ENST00000395648 | 3398 | 189 | 44935561 | 44935662 | 610 | 710 | 111 | 145 |
| ENST00000525680 | 2664 | 189 | 44935561 | 44935662 | 564 | 664 | 111 | 145 |
| ENST00000533940 | 3720 | 189 | 44935561 | 44935662 | 940 | 1040 | 111 | 145 |
| ENST00000616990 | 3584 | 189 | 44935561 | 44935662 | 796 | 896 | 111 | 145 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000308212 | 3700 | 189 | 44935561 | 44935662 | 912 | 1012 | 111 | 145 |
| ENST00000395648 | 3398 | 189 | 44935561 | 44935662 | 610 | 710 | 111 | 145 |
| ENST00000525680 | 2664 | 189 | 44935561 | 44935662 | 564 | 664 | 111 | 145 |
| ENST00000533940 | 3720 | 189 | 44935561 | 44935662 | 940 | 1040 | 111 | 145 |
| ENST00000616990 | 3584 | 189 | 44935561 | 44935662 | 796 | 896 | 111 | 145 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 1 | 189 | Chain | ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 130 | 130 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 109 | 129 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14683 | 111 | 145 | 131 | 151 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TP53I11 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000395648 | 44941003 | 44941077 | hsa-miR-6716-5p | chr11:44941066-44941073 | 8mer-1a | chr11:44941054-44941073 | 149.00 | -19.63 |
| Mayo | ENST00000308212 | 44939166 | 44939281 | hsa-miR-626 | chr11:44939202-44939209 | 8mer-1a | chr11:44939202-44939226 | 152.00 | -25.21 |
| Mayo | ENST00000308212 | 44939166 | 44939281 | hsa-miR-3188 | chr11:44939229-44939236 | 8mer-1a | chr11:44939217-44939238 | 166.00 | -32.53 |
| Mayo | ENST00000395648 | 44941003 | 44941077 | hsa-miR-6501-3p | chr11:44941025-44941032 | 8mer-1a | chr11:44941025-44941046 | 176.00 | -29.83 |
| Mayo | ENST00000308212 | 44939166 | 44939281 | hsa-miR-4649-3p | chr11:44939231-44939238 | 8mer-1a | chr11:44939217-44939238 | 166.00 | -32.53 |
| Mayo | ENST00000308212 | 44939166 | 44939281 | hsa-miR-6876-3p | chr11:44939202-44939209 | 8mer-1a | chr11:44939202-44939226 | 152.00 | -25.21 |
| ROSMAP | ENST00000395648 | 44941003 | 44941077 | hsa-miR-6716-5p | chr11:44941066-44941073 | 8mer-1a | chr11:44941054-44941073 | 149.00 | -19.63 |
| ROSMAP | ENST00000308212 | 44939166 | 44939281 | hsa-miR-626 | chr11:44939202-44939209 | 8mer-1a | chr11:44939202-44939226 | 152.00 | -25.21 |
| ROSMAP | ENST00000308212 | 44939166 | 44939281 | hsa-miR-3188 | chr11:44939229-44939236 | 8mer-1a | chr11:44939217-44939238 | 166.00 | -32.53 |
| ROSMAP | ENST00000395648 | 44941003 | 44941077 | hsa-miR-6501-3p | chr11:44941025-44941032 | 8mer-1a | chr11:44941025-44941046 | 176.00 | -29.83 |
| ROSMAP | ENST00000308212 | 44939166 | 44939281 | hsa-miR-4649-3p | chr11:44939231-44939238 | 8mer-1a | chr11:44939217-44939238 | 166.00 | -32.53 |
| ROSMAP | ENST00000308212 | 44939166 | 44939281 | hsa-miR-6876-3p | chr11:44939202-44939209 | 8mer-1a | chr11:44939202-44939226 | 152.00 | -25.21 |
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SNVs in the skipped exons for TP53I11 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TP53I11 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TP53I11 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_170708 | rs7107225 | chr11:44985190 | 2.455438e-06 | 3.678597e-04 |
| HCC | exon_skip_25313 | rs12576326 | chr11:44958832 | 5.356628e-04 | 3.583669e-02 |
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Correlation with RNA binding proteins (RBPs) for TP53I11 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM45 | exon_skip_230269 | 4.336802e-01 | 2.658280e-08 |
| CB | RBM4 | exon_skip_230269 | -4.425066e-01 | 1.278570e-08 |
| CB | RBM6 | exon_skip_170708 | -4.309065e-01 | 1.588452e-08 |
| CB | PCBP4 | exon_skip_170708 | 5.178591e-01 | 3.212826e-12 |
| CB | PCBP4 | exon_skip_19129 | 4.188086e-01 | 1.063196e-07 |
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RelatedDrugs for TP53I11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TP53I11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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