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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for GAL3ST1 |
 Gene summary |
| Gene information | Gene symbol | GAL3ST1 | Gene ID | 9514 |
| Gene name | galactose-3-O-sulfotransferase 1 | |
| Synonyms | CST | |
| Cytomap | 22q12.2 | |
| Type of gene | protein-coding | |
| Description | galactosylceramide sulfotransferase3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferasecerebroside (3'-phosphoadenylylsulfate:galactosylceramide 3') sulfotransferase | |
| Modification date | 20200313 | |
| UniProtAcc | A0A024R1D7, C9J2M1, C9J2X7, C9J3S3, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for GAL3ST1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000128242
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000402321.5 | GAL3ST1-203:protein_coding:GAL3ST1 | 1.600648e+01 | 8.483094e-01 | 1.752644e-03 | 2.174298e-02 |
| PG | UP | ENST00000447224.5 | GAL3ST1-219:protein_coding:GAL3ST1 | 8.697982e-01 | 1.347475e+00 | 3.618455e-03 | 3.647303e-02 |
| CB | DOWN | ENST00000406955.5 | GAL3ST1-206:protein_coding:GAL3ST1 | 4.312003e+01 | -8.736237e-01 | 1.421930e-03 | 6.945268e-03 |
| TC | DOWN | ENST00000406955.5 | GAL3ST1-206:protein_coding:GAL3ST1 | 1.646543e+02 | -9.026462e-01 | 4.586283e-05 | 8.681573e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GAL3ST1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_195519 | chr22 | 30558279:30558388:30563230:30563278:30565077:30565172 | 30563230:30563278 |
| exon_skip_203685 | chr22 | 30557262:30557401:30558279:30558388:30574466:30574511 | 30558279:30558388 |
| exon_skip_228882 | chr22 | 30557262:30557401:30558260:30558388:30564825:30564889 | 30558260:30558388 |
| exon_skip_239043 | chr22 | 30557262:30557401:30558279:30558388:30564825:30564889 | 30558279:30558388 |
| exon_skip_267084 | chr22 | 30556010:30556093:30557262:30557401:30574466:30574511 | 30557262:30557401 |
| exon_skip_30128 | chr22 | 30558279:30558388:30563230:30563278:30564825:30564889 | 30563230:30563278 |
| exon_skip_74505 | chr22 | 30557262:30557401:30558279:30558388:30572687:30572830 | 30558279:30558388 |
| exon_skip_96616 | chr22 | 30558279:30558388:30563230:30563278:30564825:30564901 | 30563230:30563278 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for GAL3ST1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000401975 | 30558260 | 30558388 | 3UTR-3UTR |
| ENST00000406361 | 30558279 | 30558388 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000406361 | 30558279 | 30558388 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402369 | 30557262 | 30557401 | 3UTR-3CDS |
| ENST00000401975 | 30558260 | 30558388 | 3UTR-3UTR |
| ENST00000406361 | 30558279 | 30558388 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for GAL3ST1 |
p-ENSG00000128242_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in GAL3ST1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000401975 | 30558260 | 30558388 | hsa-miR-3155a | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| Mayo | ENST00000406361 | 30558279 | 30558388 | hsa-miR-3155a | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| Mayo | ENST00000401975 | 30558260 | 30558388 | hsa-miR-3155b | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| Mayo | ENST00000406361 | 30558279 | 30558388 | hsa-miR-3155b | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| Mayo | ENST00000401975 | 30558260 | 30558388 | hsa-miR-484 | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| Mayo | ENST00000406361 | 30558279 | 30558388 | hsa-miR-484 | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| Mayo | ENST00000401975 | 30558260 | 30558388 | hsa-miR-4759 | chr22:30558282-30558289 | 8mer-1a | chr22:30558268-30558290 | 157.00 | -22.21 |
| Mayo | ENST00000401975 | 30558260 | 30558388 | hsa-miR-4284 | chr22:30558337-30558344 | 8mer-1a | chr22:30558327-30558344 | 140.00 | -13.71 |
| Mayo | ENST00000406361 | 30558279 | 30558388 | hsa-miR-4284 | chr22:30558337-30558344 | 8mer-1a | chr22:30558327-30558344 | 140.00 | -13.71 |
| Mayo | ENST00000401975 | 30558260 | 30558388 | hsa-miR-504-3p | chr22:30558358-30558365 | 8mer-1a | chr22:30558344-30558365 | 170.00 | -30.53 |
| Mayo | ENST00000406361 | 30558279 | 30558388 | hsa-miR-504-3p | chr22:30558358-30558365 | 8mer-1a | chr22:30558344-30558365 | 170.00 | -30.53 |
| MSBB | ENST00000406361 | 30558279 | 30558388 | hsa-miR-3155a | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| MSBB | ENST00000406361 | 30558279 | 30558388 | hsa-miR-3155b | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| MSBB | ENST00000406361 | 30558279 | 30558388 | hsa-miR-484 | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| MSBB | ENST00000406361 | 30558279 | 30558388 | hsa-miR-4284 | chr22:30558337-30558344 | 8mer-1a | chr22:30558327-30558344 | 140.00 | -13.71 |
| MSBB | ENST00000406361 | 30558279 | 30558388 | hsa-miR-504-3p | chr22:30558358-30558365 | 8mer-1a | chr22:30558344-30558365 | 170.00 | -30.53 |
| ROSMAP | ENST00000401975 | 30558260 | 30558388 | hsa-miR-3155a | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| ROSMAP | ENST00000406361 | 30558279 | 30558388 | hsa-miR-3155a | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| ROSMAP | ENST00000401975 | 30558260 | 30558388 | hsa-miR-3155b | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| ROSMAP | ENST00000406361 | 30558279 | 30558388 | hsa-miR-3155b | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| ROSMAP | ENST00000401975 | 30558260 | 30558388 | hsa-miR-484 | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| ROSMAP | ENST00000406361 | 30558279 | 30558388 | hsa-miR-484 | chr22:30558323-30558330 | 8mer-1a | chr22:30558307-30558330 | 167.00 | -35.09 |
| ROSMAP | ENST00000401975 | 30558260 | 30558388 | hsa-miR-4759 | chr22:30558282-30558289 | 8mer-1a | chr22:30558268-30558290 | 157.00 | -22.21 |
| ROSMAP | ENST00000401975 | 30558260 | 30558388 | hsa-miR-4284 | chr22:30558337-30558344 | 8mer-1a | chr22:30558327-30558344 | 140.00 | -13.71 |
| ROSMAP | ENST00000406361 | 30558279 | 30558388 | hsa-miR-4284 | chr22:30558337-30558344 | 8mer-1a | chr22:30558327-30558344 | 140.00 | -13.71 |
| ROSMAP | ENST00000401975 | 30558260 | 30558388 | hsa-miR-504-3p | chr22:30558358-30558365 | 8mer-1a | chr22:30558344-30558365 | 170.00 | -30.53 |
| ROSMAP | ENST00000406361 | 30558279 | 30558388 | hsa-miR-504-3p | chr22:30558358-30558365 | 8mer-1a | chr22:30558344-30558365 | 170.00 | -30.53 |
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SNVs in the skipped exons for GAL3ST1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GAL3ST1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GAL3ST1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for GAL3ST1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for GAL3ST1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GAL3ST1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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