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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MAP4K4 |
 Gene summary |
| Gene information | Gene symbol | MAP4K4 | Gene ID | 9448 |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 4 | |
| Synonyms | FLH21957|HEL-S-31|HGK|MEKKK4|NIK | |
| Cytomap | 2q11.2 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase- | |
| Modification date | 20200315 | |
| UniProtAcc | A0A0D9SEY1, A0A0D9SG62, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAP4K4 | GO:0006468 | protein phosphorylation | 9890973 |
| MAP4K4 | GO:0035556 | intracellular signal transduction | 9890973 |
| MAP4K4 | GO:0046328 | regulation of JNK cascade | 14966141 |
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Gene structures and expression levels for MAP4K4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000071054
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| DLPFC | UP | ENST00000413150.6 | MAP4K4-206:protein_coding:MAP4K4 | 1.011438e+03 | 8.478586e-01 | 2.303846e-05 | 2.574464e-03 |
| DLPFC | UP | ENST00000456652.5 | MAP4K4-212:protein_coding:MAP4K4 | 2.307556e+01 | 1.066135e+00 | 2.765523e-04 | 1.409127e-02 |
| PCC | UP | ENST00000413150.6 | MAP4K4-206:protein_coding:MAP4K4 | 6.442008e+02 | 1.629620e+00 | 3.578143e-05 | 3.066887e-03 |
| STG | UP | ENST00000425019.5 | MAP4K4-210:protein_coding:MAP4K4 | 4.470767e+01 | 2.473934e+01 | 1.535603e-35 | 7.405670e-32 |
| STG | UP | ENST00000418101.1 | MAP4K4-208:protein_coding:MAP4K4 | 4.411864e+01 | 3.593034e+00 | 1.506740e-06 | 7.018756e-04 |
| STG | UP | ENST00000634702.1 | MAP4K4-221:protein_coding:MAP4K4 | 3.291736e+02 | 1.428448e+00 | 1.657975e-04 | 1.484454e-02 |
| PG | UP | ENST00000413150.6 | MAP4K4-206:protein_coding:MAP4K4 | 7.906019e+02 | 1.442397e+00 | 1.660711e-05 | 7.314878e-04 |
| CB | UP | ENST00000417294.5 | MAP4K4-207:protein_coding:MAP4K4 | 1.957162e+01 | 1.789310e+00 | 1.826197e-04 | 1.232205e-03 |
| CB | UP | ENST00000421882.5 | MAP4K4-209:protein_coding:MAP4K4 | 5.577823e+01 | 8.571867e-01 | 3.563771e-04 | 2.165004e-03 |
| CB | DOWN | ENST00000350198.8 | MAP4K4-204:protein_coding:MAP4K4 | 1.445753e+02 | -1.555238e+00 | 3.484707e-03 | 1.460179e-02 |
| TC | UP | ENST00000425019.5 | MAP4K4-210:protein_coding:MAP4K4 | 5.433303e+01 | 2.268610e+00 | 3.731800e-05 | 7.351160e-04 |
| TC | DOWN | ENST00000350198.8 | MAP4K4-204:protein_coding:MAP4K4 | 8.103325e+01 | -4.237209e+00 | 4.806084e-03 | 3.254861e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP4K4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_106117 | chr2 | 101698530:101698538:101790720:101790776:101823928:101824053 | 101790720:101790776 |
| exon_skip_107909 | chr2 | 101859736:101859864:101860825:101860986:101864930:101864959 | 101860825:101860986 |
| exon_skip_108964 | chr2 | 101870375:101870415:101871494:101871685:101873647:101873764 | 101871494:101871685 |
| exon_skip_117502 | chr2 | 101834409:101834463:101835900:101835978:101839819:101839932 | 101835900:101835978 |
| exon_skip_122906 | chr2 | 101855977:101856138:101858996:101859082:101859736:101859864 | 101858996:101859082 |
| exon_skip_123465 | chr2 | 101867212:101867309:101868029:101868037:101869622:101869797 | 101868029:101868037 |
| exon_skip_125756 | chr2 | 101887778:101887937:101888796:101888935:101891166:101891249 | 101888796:101888935 |
| exon_skip_143520 | chr2 | 101825402:101825429:101829504:101829594:101831721:101831816 | 101829504:101829594 |
| exon_skip_153474 | chr2 | 101859736:101859864:101860825:101860986:101864930:101865003 | 101860825:101860986 |
| exon_skip_158632 | chr2 | 101860825:101860986:101863821:101864051:101864930:101865003 | 101863821:101864051 |
| exon_skip_158738 | chr2 | 101856120:101856138:101858996:101859082:101859643:101859864 | 101858996:101859082 |
| exon_skip_160597 | chr2 | 101855985:101856138:101858996:101859082:101859643:101859864 | 101858996:101859082 |
| exon_skip_168374 | chr2 | 101873711:101873764:101874082:101874252:101877003:101877146 | 101874082:101874252 |
| exon_skip_226544 | chr2 | 101859736:101859864:101863821:101864051:101864930:101864959 | 101863821:101864051 |
| exon_skip_229740 | chr2 | 101855977:101856138:101858996:101859082:101859643:101859864 | 101858996:101859082 |
| exon_skip_229811 | chr2 | 101859736:101859864:101860825:101860986:101863821:101863889 | 101860825:101860986 |
| exon_skip_231591 | chr2 | 101870295:101870415:101871494:101871685:101873647:101873764 | 101871494:101871685 |
| exon_skip_232197 | chr2 | 101829504:101829594:101831721:101831851:101834409:101834463 | 101831721:101831851 |
| exon_skip_234613 | chr2 | 101867212:101867309:101868029:101868037:101869622:101869663 | 101868029:101868037 |
| exon_skip_248999 | chr2 | 101882559:101882685:101885187:101885287:101887088:101887237 | 101885187:101885287 |
| exon_skip_251551 | chr2 | 101835946:101835978:101839819:101839994:101842609:101842681 | 101839819:101839994 |
| exon_skip_266922 | chr2 | 101834409:101834463:101835900:101835978:101839819:101839914 | 101835900:101835978 |
| exon_skip_27224 | chr2 | 101882551:101882685:101885187:101885287:101887088:101887237 | 101885187:101885287 |
| exon_skip_279028 | chr2 | 101844101:101844311:101855977:101856138:101858996:101859082 | 101855977:101856138 |
| exon_skip_280689 | chr2 | 101860825:101860986:101863821:101864051:101864930:101864959 | 101863821:101864051 |
| exon_skip_287801 | chr2 | 101698530:101698538:101790720:101790776:101823928:101823972 | 101790720:101790776 |
| exon_skip_290212 | chr2 | 101855977:101856138:101858996:101859082:101859643:101859663 | 101858996:101859082 |
| exon_skip_292145 | chr2 | 101859736:101859864:101860825:101860986:101863821:101864051 | 101860825:101860986 |
| exon_skip_35111 | chr2 | 101698081:101698137:101698473:101698538:101790720:101790776 | 101698473:101698538 |
| exon_skip_39338 | chr2 | 101877003:101877146:101882551:101882685:101885187:101885287 | 101882551:101882685 |
| exon_skip_61000 | chr2 | 101859736:101859864:101863821:101864051:101864930:101865003 | 101863821:101864051 |
| exon_skip_83766 | chr2 | 101856122:101856138:101858996:101859082:101859736:101859864 | 101858996:101859082 |
| exon_skip_88955 | chr2 | 101835900:101835978:101839819:101839994:101842609:101842681 | 101839819:101839994 |
| exon_skip_93016 | chr2 | 101844228:101844311:101855977:101856138:101858996:101859082 | 101855977:101856138 |
| exon_skip_96987 | chr2 | 101873647:101873764:101874082:101874252:101877003:101877146 | 101874082:101874252 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_153474 | MSBB_PG | 2.597479e-01 | 3.604762e-01 | -1.007283e-01 | 3.331868e-04 |
| exon_skip_226544 | Mayo_TC | 5.500000e-01 | 6.617949e-01 | -1.117949e-01 | 6.206366e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for MAP4K4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000347699 | 101829504 | 101829594 | Frame-shift |
| ENST00000347699 | 101835900 | 101835978 | Frame-shift |
| ENST00000347699 | 101839819 | 101839994 | Frame-shift |
| ENST00000347699 | 101885187 | 101885287 | Frame-shift |
| ENST00000347699 | 101888796 | 101888935 | Frame-shift |
| ENST00000347699 | 101790720 | 101790776 | In-frame |
| ENST00000347699 | 101855977 | 101856138 | In-frame |
| ENST00000347699 | 101858996 | 101859082 | In-frame |
| ENST00000347699 | 101860825 | 101860986 | In-frame |
| ENST00000347699 | 101874082 | 101874252 | In-frame |
| ENST00000347699 | 101882551 | 101882685 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000347699 | 101829504 | 101829594 | Frame-shift |
| ENST00000347699 | 101831721 | 101831851 | Frame-shift |
| ENST00000347699 | 101835900 | 101835978 | Frame-shift |
| ENST00000347699 | 101839819 | 101839994 | Frame-shift |
| ENST00000347699 | 101790720 | 101790776 | In-frame |
| ENST00000347699 | 101855977 | 101856138 | In-frame |
| ENST00000347699 | 101858996 | 101859082 | In-frame |
| ENST00000347699 | 101860825 | 101860986 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000347699 | 101829504 | 101829594 | Frame-shift |
| ENST00000347699 | 101835900 | 101835978 | Frame-shift |
| ENST00000347699 | 101839819 | 101839994 | Frame-shift |
| ENST00000347699 | 101885187 | 101885287 | Frame-shift |
| ENST00000347699 | 101888796 | 101888935 | Frame-shift |
| ENST00000347699 | 101698473 | 101698538 | In-frame |
| ENST00000347699 | 101790720 | 101790776 | In-frame |
| ENST00000347699 | 101855977 | 101856138 | In-frame |
| ENST00000347699 | 101858996 | 101859082 | In-frame |
| ENST00000347699 | 101860825 | 101860986 | In-frame |
| ENST00000347699 | 101874082 | 101874252 | In-frame |
| ENST00000347699 | 101882551 | 101882685 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP4K4 |
p-ENSG00000071054_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000347699 | 3809 | 1239 | 101790720 | 101790776 | 125 | 180 | 41 | 60 |
| ENST00000347699 | 3809 | 1239 | 101855977 | 101856138 | 1235 | 1395 | 411 | 465 |
| ENST00000347699 | 3809 | 1239 | 101858996 | 101859082 | 1397 | 1482 | 465 | 494 |
| ENST00000347699 | 3809 | 1239 | 101860825 | 101860986 | 1706 | 1866 | 568 | 622 |
| ENST00000347699 | 3809 | 1239 | 101874082 | 101874252 | 2637 | 2806 | 879 | 935 |
| ENST00000347699 | 3809 | 1239 | 101882551 | 101882685 | 2952 | 3085 | 984 | 1028 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000347699 | 3809 | 1239 | 101790720 | 101790776 | 125 | 180 | 41 | 60 |
| ENST00000347699 | 3809 | 1239 | 101855977 | 101856138 | 1235 | 1395 | 411 | 465 |
| ENST00000347699 | 3809 | 1239 | 101858996 | 101859082 | 1397 | 1482 | 465 | 494 |
| ENST00000347699 | 3809 | 1239 | 101860825 | 101860986 | 1706 | 1866 | 568 | 622 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000347699 | 3809 | 1239 | 101698473 | 101698538 | 59 | 123 | 19 | 41 |
| ENST00000347699 | 3809 | 1239 | 101790720 | 101790776 | 125 | 180 | 41 | 60 |
| ENST00000347699 | 3809 | 1239 | 101855977 | 101856138 | 1235 | 1395 | 411 | 465 |
| ENST00000347699 | 3809 | 1239 | 101858996 | 101859082 | 1397 | 1482 | 465 | 494 |
| ENST00000347699 | 3809 | 1239 | 101860825 | 101860986 | 1706 | 1866 | 568 | 622 |
| ENST00000347699 | 3809 | 1239 | 101874082 | 101874252 | 2637 | 2806 | 879 | 935 |
| ENST00000347699 | 3809 | 1239 | 101882551 | 101882685 | 2952 | 3085 | 984 | 1028 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O95819 | 41 | 60 | 35 | 44 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 50 | 58 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 54 | 54 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O95819 | 41 | 60 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 41 | 60 | 25 | 289 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O95819 | 41 | 60 | 45 | 47 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 60 | 62 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZP5 |
| O95819 | 411 | 465 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 465 | 494 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 568 | 622 | 569 | 622 | Alternative sequence | ID=VSP_007055;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9890973;Dbxref=PMID:9890973 |
| O95819 | 568 | 622 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 879 | 935 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 879 | 935 | 926 | 1213 | Domain | Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795 |
| O95819 | 879 | 935 | 900 | 900 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195 |
| O95819 | 879 | 935 | 913 | 913 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| O95819 | 879 | 935 | 858 | 1212 | Region | Note=Mediates interaction with RAP2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14966141;Dbxref=PMID:14966141 |
| O95819 | 984 | 1028 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 984 | 1028 | 926 | 1213 | Domain | Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795 |
| O95819 | 984 | 1028 | 858 | 1212 | Region | Note=Mediates interaction with RAP2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14966141;Dbxref=PMID:14966141 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O95819 | 41 | 60 | 35 | 44 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 50 | 58 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 54 | 54 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O95819 | 41 | 60 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 41 | 60 | 25 | 289 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O95819 | 41 | 60 | 45 | 47 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 60 | 62 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZP5 |
| O95819 | 411 | 465 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 465 | 494 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 568 | 622 | 569 | 622 | Alternative sequence | ID=VSP_007055;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9890973;Dbxref=PMID:9890973 |
| O95819 | 568 | 622 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O95819 | 19 | 41 | 25 | 33 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 19 | 41 | 35 | 44 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 19 | 41 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 19 | 41 | 25 | 289 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O95819 | 19 | 41 | 31 | 39 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O95819 | 19 | 41 | 22 | 24 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 35 | 44 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 50 | 58 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 54 | 54 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O95819 | 41 | 60 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 41 | 60 | 25 | 289 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O95819 | 41 | 60 | 45 | 47 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y |
| O95819 | 41 | 60 | 60 | 62 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZP5 |
| O95819 | 411 | 465 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 465 | 494 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 568 | 622 | 569 | 622 | Alternative sequence | ID=VSP_007055;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9890973;Dbxref=PMID:9890973 |
| O95819 | 568 | 622 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 879 | 935 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 879 | 935 | 926 | 1213 | Domain | Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795 |
| O95819 | 879 | 935 | 900 | 900 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195 |
| O95819 | 879 | 935 | 913 | 913 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| O95819 | 879 | 935 | 858 | 1212 | Region | Note=Mediates interaction with RAP2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14966141;Dbxref=PMID:14966141 |
| O95819 | 984 | 1028 | 2 | 1239 | Chain | ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4 |
| O95819 | 984 | 1028 | 926 | 1213 | Domain | Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795 |
| O95819 | 984 | 1028 | 858 | 1212 | Region | Note=Mediates interaction with RAP2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14966141;Dbxref=PMID:14966141 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MAP4K4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MAP4K4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MAP4K4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | ROSMAP | PCC | exon_skip_123465 | -4.149833e-01 | 2.340000e-10 | chr2 | + | 101867212 | 101867309 | 101868029 | 101868037 | 101869622 | 101869797 |
| ADstage | ROSMAP | PCC | exon_skip_153474 | -3.146993e-01 | 2.510000e-06 | chr2 | + | 101859736 | 101859864 | 101860825 | 101860986 | 101864930 | 101865003 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP4K4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MAP4K4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SRSF11 | exon_skip_292145 | 4.667899e-01 | 1.046696e-09 |
| CB | CNOT4 | exon_skip_292145 | 4.066754e-01 | 1.662566e-07 |
| CB | TIA1 | exon_skip_292145 | 4.581278e-01 | 2.311546e-09 |
| CB | PCBP1 | exon_skip_292145 | 4.214296e-01 | 5.242887e-08 |
| CB | HNRNPK | exon_skip_292145 | 4.751324e-01 | 4.777877e-10 |
| CB | PCBP2 | exon_skip_292145 | 4.858269e-01 | 1.694417e-10 |
| CB | SF1 | exon_skip_292145 | 4.981181e-01 | 4.920627e-11 |
| CB | HNRNPAB | exon_skip_292145 | 4.270588e-01 | 3.325986e-08 |
| CB | RALYL | exon_skip_292145 | 4.671884e-01 | 1.008692e-09 |
| CB | PTBP3 | exon_skip_292145 | 4.400397e-01 | 1.127646e-08 |
| CB | CELF1 | exon_skip_292145 | 4.677863e-01 | 9.541613e-10 |
| CB | RBM23 | exon_skip_292145 | 5.514590e-01 | 1.246760e-13 |
| CB | EWSR1 | exon_skip_292145 | 4.687215e-01 | 8.745292e-10 |
| CB | SRSF9 | exon_skip_292145 | 4.408058e-01 | 1.056400e-08 |
| CB | EIF4B | exon_skip_292145 | 4.418294e-01 | 9.679391e-09 |
| CB | SRSF11 | exon_skip_153474 | 4.768553e-01 | 2.726625e-10 |
| CB | TIA1 | exon_skip_153474 | 5.566869e-01 | 3.716841e-14 |
| CB | HNRNPK | exon_skip_153474 | 5.065696e-01 | 1.296955e-11 |
| CB | PCBP2 | exon_skip_153474 | 4.589049e-01 | 1.497361e-09 |
| CB | SF1 | exon_skip_153474 | 4.294993e-01 | 1.987212e-08 |
| CB | RALYL | exon_skip_153474 | 5.998547e-01 | 1.026483e-16 |
| CB | PTBP3 | exon_skip_153474 | 4.591347e-01 | 1.465973e-09 |
| CB | CELF1 | exon_skip_153474 | 4.285073e-01 | 2.159211e-08 |
| CB | SRSF9 | exon_skip_153474 | 4.683299e-01 | 6.198413e-10 |
| CB | EIF4B | exon_skip_153474 | 5.294852e-01 | 1.004788e-12 |
| CB | FXR2 | exon_skip_61000 | -4.647252e-01 | 7.691074e-10 |
| CB | PCBP1 | exon_skip_61000 | -4.096341e-01 | 9.064291e-08 |
| CB | PCBP2 | exon_skip_61000 | -4.028939e-01 | 1.535516e-07 |
| CB | FUBP1 | exon_skip_61000 | -4.597218e-01 | 1.229410e-09 |
| CB | KHSRP | exon_skip_61000 | -4.691914e-01 | 5.027514e-10 |
| CB | FXR2 | exon_skip_156822 | -4.339734e-01 | 2.093262e-08 |
| CB | PCBP2 | exon_skip_156822 | -4.006829e-01 | 2.863561e-07 |
| CB | KHSRP | exon_skip_156822 | -4.335800e-01 | 2.162602e-08 |
| CB | NUP42 | exon_skip_231591 | 4.496910e-01 | 2.741217e-09 |
| DLPFC | RBMS2 | exon_skip_144049 | -4.022552e-01 | 9.847419e-15 |
| DLPFC | RBFOX2 | exon_skip_144049 | 4.434473e-01 | 6.579980e-18 |
| DLPFC | SRSF11 | exon_skip_153474 | -4.652715e-01 | 1.013996e-19 |
| DLPFC | KHDRBS2 | exon_skip_153474 | 5.033921e-01 | 2.624213e-23 |
| FL | RBM45 | exon_skip_231591 | -4.045837e-01 | 4.069408e-09 |
| HCC | PCBP4 | exon_skip_61000 | 4.472205e-01 | 7.881771e-15 |
| HCC | RBM6 | exon_skip_158632 | 4.077976e-01 | 4.854106e-12 |
| HCC | PCBP4 | exon_skip_158632 | 4.647538e-01 | 1.322547e-15 |
| HCC | TRA2A | exon_skip_158632 | 4.100351e-01 | 3.616958e-12 |
| IFG | QKI | exon_skip_292145 | 4.451436e-01 | 1.761078e-02 |
| IFG | PABPC1 | exon_skip_292145 | 4.302722e-01 | 2.228486e-02 |
| IFG | KHDRBS2 | exon_skip_153474 | 5.929584e-01 | 8.831892e-04 |
| IFG | ENOX1 | exon_skip_153474 | 4.083620e-01 | 3.097551e-02 |
| IFG | RALYL | exon_skip_153474 | 5.976166e-01 | 7.846846e-04 |
| IFG | SRSF9 | exon_skip_153474 | 5.225438e-01 | 4.335311e-03 |
| IFG | PCBP4 | exon_skip_156822 | 4.588786e-01 | 1.605903e-02 |
| IFG | PCBP4 | exon_skip_158632 | 4.000001e-01 | 4.289592e-02 |
| IFG | PCBP4 | exon_skip_231591 | 4.260817e-01 | 2.377104e-02 |
| PCC | RBM6 | exon_skip_153474 | -4.288877e-01 | 4.948698e-11 |
| PCC | QKI | exon_skip_153474 | -4.290644e-01 | 4.849846e-11 |
| PCC | RALYL | exon_skip_153474 | 4.340242e-01 | 2.739385e-11 |
| PCC | PTBP1 | exon_skip_153474 | -6.028324e-01 | 1.161094e-22 |
| PCC | PABPC1 | exon_skip_153474 | -4.108539e-01 | 3.653441e-10 |
| PCC | RBMS2 | exon_skip_144049 | -4.661150e-01 | 5.392975e-13 |
| PCC | RBFOX2 | exon_skip_144049 | 6.410063e-01 | 2.841313e-26 |
| PCC | ELAVL4 | exon_skip_144049 | 5.340422e-01 | 2.987618e-17 |
| PCC | RALYL | exon_skip_144049 | 4.107865e-01 | 3.680044e-10 |
| PCC | PTBP1 | exon_skip_144049 | -4.552161e-01 | 2.144220e-12 |
| PCC | CPEB1 | exon_skip_144049 | 4.765046e-01 | 1.381262e-13 |
| PCC | PCBP2 | exon_skip_231591 | -4.052024e-01 | 6.673281e-10 |
| PG | PCBP1 | exon_skip_153474 | 4.061208e-01 | 9.035869e-08 |
| PG | HNRNPK | exon_skip_153474 | 4.410700e-01 | 4.741253e-09 |
| PG | KHDRBS2 | exon_skip_153474 | 5.139941e-01 | 3.092134e-12 |
| PG | RALYL | exon_skip_153474 | 5.470960e-01 | 5.963506e-14 |
| PG | CELF1 | exon_skip_153474 | 4.416211e-01 | 4.513609e-09 |
| PG | RBM6 | exon_skip_231591 | -4.079863e-01 | 8.693773e-10 |
| PG | PCBP2 | exon_skip_231591 | -4.414562e-01 | 2.221847e-11 |
| PG | RBM45 | exon_skip_231591 | -4.079979e-01 | 8.683284e-10 |
| PG | SRSF9 | exon_skip_231591 | -4.399147e-01 | 2.654319e-11 |
| TC | RBM6 | exon_skip_266922 | -4.662263e-01 | 5.189676e-10 |
| TC | KHDRBS2 | exon_skip_107909 | 6.491944e-01 | 1.624162e-20 |
| TC | RALYL | exon_skip_107909 | 6.476951e-01 | 2.121882e-20 |
| TC | PTBP3 | exon_skip_107909 | 5.201357e-01 | 1.802338e-12 |
| TC | CELF1 | exon_skip_107909 | 5.719839e-01 | 2.778894e-15 |
| TC | ESRP1 | exon_skip_107909 | 5.947654e-01 | 1.108196e-16 |
| TC | PCBP4 | exon_skip_226544 | 4.389186e-01 | 6.408041e-09 |
| TC | PCBP2 | exon_skip_226544 | -4.179159e-01 | 3.829046e-08 |
| TC | PCBP2 | exon_skip_104533 | -4.084664e-01 | 8.231386e-08 |
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RelatedDrugs for MAP4K4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O95819 | approved|investigational | DB12010 | Fostamatinib | small molecule | O95819 |
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RelatedDiseases for MAP4K4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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