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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CDYL |
Gene summary |
Gene information | Gene symbol | CDYL | Gene ID | 9425 |
Gene name | chromodomain Y like | |
Synonyms | CDYL1 | |
Cytomap | 6p25.1 | |
Type of gene | protein-coding | |
Description | chromodomain Y-like proteinCDY-like, autosomalchromodomain protein, Y-likecrotonyl-CoA hydratasetestis-specific chromodomain Y-like protein | |
Modification date | 20200313 | |
UniProtAcc | C9JQG7, Q9Y232, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
CDYL | GO:0120094 | negative regulation of peptidyl-lysine crotonylation | 28803779 |
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Gene structures and expression levels for CDYL |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
TC | UP | ENST00000472453.5 | CDYL-207:lncRNA:CDYL | 5.611193e+00 | 1.215409e+00 | 2.282377e-04 | 3.105080e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CDYL |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_113164 | chr6 | 4943546:4943756:4952266:4952409:4953898:4954373 | 4952266:4952409 |
exon_skip_139832 | chr6 | 4776736:4776807:4891713:4892379:4935515:4935771 | 4891713:4892379 |
exon_skip_272228 | chr6 | 4891713:4892379:4935515:4935771:4937565:4937737 | 4935515:4935771 |
exon_skip_87898 | chr6 | 4776442:4776807:4891713:4892379:4935515:4935771 | 4891713:4892379 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CDYL |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000328908 | 4935515 | 4935771 | Frame-shift |
ENST00000328908 | 4952266 | 4952409 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CDYL |
p-ENSG00000153046_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000328908 | 3436 | 598 | 4952266 | 4952409 | 1627 | 1769 | 498 | 546 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9Y232 | 498 | 546 | 521 | 524 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GTR |
Q9Y232 | 498 | 546 | 1 | 598 | Chain | ID=PRO_0000080221;Note=Chromodomain Y-like protein |
Q9Y232 | 498 | 546 | 496 | 505 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GTR |
Q9Y232 | 498 | 546 | 511 | 516 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GTR |
Q9Y232 | 498 | 546 | 526 | 528 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GTR |
Q9Y232 | 498 | 546 | 529 | 541 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GTR |
Q9Y232 | 498 | 546 | 545 | 556 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GTR |
Q9Y232 | 498 | 546 | 521 | 521 | Mutagenesis | Note=Abolishes CoA-binding and ability to inhibit histone crotonylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28803779;Dbxref=PMID:28803779 |
Q9Y232 | 498 | 546 | 362 | 594 | Region | Note=Acetyl-CoA-binding domain;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CDYL |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CDYL |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CDYL |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDYL |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
HCC | exon_skip_87898 | rs7743681 | chr6:4932800 | 7.162013e-04 | 4.501548e-02 |
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Correlation with RNA binding proteins (RBPs) for CDYL |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CDYL |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDYL |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |