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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NRXN3 |
 Gene summary |
| Gene information | Gene symbol | NRXN3 | Gene ID | 9369 |
| Gene name | neurexin 3 | |
| Synonyms | C14orf60 | |
| Cytomap | 14q24.3-q31.1 | |
| Type of gene | protein-coding | |
| Description | neurexin 3neurexin IIIneurexin-3-alpha | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 30902061(Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NRXN3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000021645
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | DOWN | ENST00000553363.5 | NRXN3-204:protein_coding:NRXN3 | 6.167372e+00 | -8.910204e-01 | 5.690416e-07 | 1.739360e-04 |
| PG | DOWN | ENST00000554719.5 | NRXN3-207:protein_coding:NRXN3 | 7.855314e+01 | -1.383195e+00 | 1.397091e-06 | 1.137262e-04 |
| PG | DOWN | ENST00000553363.5 | NRXN3-204:protein_coding:NRXN3 | 2.099029e+00 | -1.225191e+00 | 1.145873e-05 | 5.593396e-04 |
| PG | DOWN | ENST00000553631.1 | NRXN3-205:protein_coding:NRXN3 | 4.385543e+00 | -9.840691e-01 | 5.637094e-05 | 1.797496e-03 |
| PG | DOWN | ENST00000634266.1 | NRXN3-216:lncRNA:NRXN3 | 6.443591e+01 | -1.111503e+00 | 6.462691e-05 | 1.992166e-03 |
| CB | UP | ENST00000557594.5 | NRXN3-215:protein_coding:NRXN3 | 1.023746e+03 | 9.520929e-01 | 6.341309e-10 | 3.008107e-08 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NRXN3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_11777 | chr14 | 79805112:79805199:79853539:79854217:79861039:79861258 | 79853539:79854217 |
| exon_skip_138791 | chr14 | 78968173:78968346:78972883:78972909:78988022:78988141 | 78972883:78972909 |
| exon_skip_142917 | chr14 | 79663931:79663949:79692173:79692262:79697630:79697937 | 79692173:79692262 |
| exon_skip_143285 | chr14 | 78803620:78803823:78810318:78810344:78957242:78957361 | 78810318:78810344 |
| exon_skip_15147 | chr14 | 78297831:78297860:78300680:78300691:78645120:78645421 | 78300680:78300691 |
| exon_skip_157785 | chr14 | 78278645:78278662:78297831:78297860:78645120:78645421 | 78297831:78297860 |
| exon_skip_159387 | chr14 | 78714756:78715139:78803620:78803823:78957242:78957361 | 78803620:78803823 |
| exon_skip_16438 | chr14 | 79697630:79697937:79805112:79805190:79861663:79861959 | 79805112:79805190 |
| exon_skip_17305 | chr14 | 79697630:79697937:79805112:79805199:79853539:79854217 | 79805112:79805199 |
| exon_skip_179082 | chr14 | 79280502:79280538:79467221:79467402:79663778:79663892 | 79467221:79467402 |
| exon_skip_199926 | chr14 | 79697630:79697937:79805112:79805190:79861342:79862445 | 79805112:79805190 |
| exon_skip_226654 | chr14 | 79697630:79697937:79805112:79805199:79861039:79862033 | 79805112:79805199 |
| exon_skip_227212 | chr14 | 79805112:79805199:79853539:79854217:79861039:79862033 | 79853539:79854217 |
| exon_skip_228236 | chr14 | 78645120:78645421:78651165:78651326:78709217:78709507 | 78651165:78651326 |
| exon_skip_256406 | chr14 | 79467221:79467402:79663778:79663949:79697630:79697937 | 79663778:79663949 |
| exon_skip_294067 | chr14 | 79663778:79663949:79697630:79697937:79805112:79805190 | 79697630:79697937 |
| exon_skip_67488 | chr14 | 79697630:79697937:79805112:79805199:79861663:79861959 | 79805112:79805199 |
| exon_skip_71370 | chr14 | 78243602:78243802:78278645:78278662:78297831:78297860 | 78278645:78278662 |
| exon_skip_84202 | chr14 | 79697630:79697937:79805112:79805190:79861039:79862033 | 79805112:79805190 |
| exon_skip_84657 | chr14 | 79663778:79663949:79692173:79692262:79697630:79697937 | 79692173:79692262 |
| exon_skip_86681 | chr14 | 78243766:78243802:78278645:78278662:78297831:78297860 | 78278645:78278662 |
| exon_skip_92295 | chr14 | 78645120:78645421:78649268:78649291:78651165:78651311 | 78649268:78649291 |
| exon_skip_99780 | chr14 | 79467221:79467402:79663778:79663949:79692173:79692262 | 79663778:79663949 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NRXN3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000557594 | 79697630 | 79697937 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000557594 | 79697630 | 79697937 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000557594 | 79467221 | 79467402 | Frame-shift |
| ENST00000557594 | 79663778 | 79663949 | Frame-shift |
| ENST00000557594 | 79697630 | 79697937 | Frame-shift |
| ENST00000557594 | 79805112 | 79805190 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NRXN3 |
p-ENSG00000021645_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NRXN3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for NRXN3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NRXN3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_143285 | -4.856296e-01 | 8.799192e-03 | chr14 | + | 78803620 | 78803823 | 78810318 | 78810344 | 78957242 | 78957361 |
| CDR | MSBB | IFG | exon_skip_143285 | -6.176930e-01 | 4.614200e-04 | chr14 | + | 78803620 | 78803823 | 78810318 | 78810344 | 78957242 | 78957361 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NRXN3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_143285 | rs6574469 | chr14:78752094 | 1.002480e-04 | 9.147511e-03 |
| PCC | exon_skip_92295 | rs10483911 | chr14:78634788 | 1.819703e-04 | 2.782442e-02 |
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Correlation with RNA binding proteins (RBPs) for NRXN3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | DAZAP1 | exon_skip_84657 | -5.146883e-01 | 8.578311e-12 |
| CB | TARDBP | exon_skip_84657 | -5.127970e-01 | 1.052120e-11 |
| CB | CNOT4 | exon_skip_84657 | -5.398628e-01 | 5.005956e-13 |
| CB | PCBP4 | exon_skip_84657 | 5.716164e-01 | 9.754453e-15 |
| CB | TRA2A | exon_skip_84657 | -6.424141e-01 | 2.704906e-19 |
| CB | NUP42 | exon_skip_84657 | 4.007667e-01 | 2.599168e-07 |
| CB | RBM45 | exon_skip_197083 | 4.889816e-01 | 5.020569e-10 |
| CB | NUP42 | exon_skip_197083 | 4.460182e-01 | 2.112481e-08 |
| CB | ZNF638 | exon_skip_227212 | -4.350070e-01 | 4.959261e-07 |
| CB | RBM6 | exon_skip_227212 | -4.385054e-01 | 3.917192e-07 |
| CB | U2AF2 | exon_skip_227212 | -4.598763e-01 | 8.743111e-08 |
| CB | TIA1 | exon_skip_227212 | 4.377018e-01 | 4.136261e-07 |
| CB | TRA2A | exon_skip_227212 | -4.780531e-01 | 2.247025e-08 |
| CB | RBM45 | exon_skip_227212 | 6.409048e-01 | 1.414660e-15 |
| CB | NUP42 | exon_skip_227212 | 5.469022e-01 | 5.969512e-11 |
| CB | PTBP1 | exon_skip_227212 | -4.210520e-01 | 1.238288e-06 |
| CB | RBM4 | exon_skip_227212 | -4.775844e-01 | 2.329477e-08 |
| FL | G3BP2 | exon_skip_143285 | 4.244984e-01 | 1.269603e-09 |
| HCC | DAZAP1 | exon_skip_84657 | -4.747052e-01 | 9.773594e-16 |
| HCC | RBMS2 | exon_skip_84657 | -4.264766e-01 | 1.081189e-12 |
| HCC | KHDRBS3 | exon_skip_84657 | -5.072926e-01 | 4.409810e-18 |
| IFG | G3BP2 | exon_skip_143285 | 5.923200e-01 | 8.974935e-04 |
| PG | G3BP2 | exon_skip_143285 | 4.315521e-01 | 2.299028e-08 |
| STG | G3BP2 | exon_skip_143285 | 4.744751e-01 | 6.689493e-06 |
| STG | KHDRBS2 | exon_skip_143285 | 4.851424e-01 | 3.851067e-06 |
| TC | G3BP2 | exon_skip_143285 | 6.971119e-01 | 9.797451e-18 |
| TC | KHDRBS2 | exon_skip_143285 | 7.015962e-01 | 4.926197e-18 |
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RelatedDrugs for NRXN3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NRXN3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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