|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for CADPS2 |
 Gene summary |
| Gene information | Gene symbol | CADPS2 | Gene ID | 93664 |
| Gene name | calcium dependent secretion activator 2 | |
| Synonyms | CAPS2 | |
| Cytomap | 7q31.32 | |
| Type of gene | protein-coding | |
| Description | calcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A087X1P3, B7ZM57, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for CADPS2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000081803
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000476131.1 | CADPS2-207:lncRNA:CADPS2 | 2.812259e+00 | -1.022607e+00 | 8.114649e-04 | 1.253777e-02 |
| CB | UP | ENST00000412584.6 | CADPS2-204:protein_coding:CADPS2 | 1.621521e+03 | 9.157128e-01 | 1.405014e-05 | 1.403947e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CADPS2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_115869 | chr7 | 122360973:122361013:122379368:122379442:122387026:122387173 | 122379368:122379442 |
| exon_skip_117438 | chr7 | 122393441:122393582:122407540:122407696:122416061:122416164 | 122407540:122407696 |
| exon_skip_119008 | chr7 | 122407540:122407696:122414068:122414076:122416061:122416162 | 122414068:122414076 |
| exon_skip_127541 | chr7 | 122441512:122441575:122451374:122451475:122471375:122471562 | 122451374:122451475 |
| exon_skip_131747 | chr7 | 122388583:122388738:122393441:122393582:122407540:122407696 | 122393441:122393582 |
| exon_skip_154592 | chr7 | 122416061:122416164:122436360:122436380:122438341:122438376 | 122436360:122436380 |
| exon_skip_155181 | chr7 | 122554550:122554689:122581179:122581290:122615181:122615299 | 122581179:122581290 |
| exon_skip_169867 | chr7 | 122379368:122379442:122386295:122386309:122387026:122387167 | 122386295:122386309 |
| exon_skip_171016 | chr7 | 122513249:122513315:122554550:122554689:122581179:122581290 | 122554550:122554689 |
| exon_skip_176072 | chr7 | 122451374:122451475:122471375:122471562:122474381:122474517 | 122471375:122471562 |
| exon_skip_190231 | chr7 | 122387026:122387173:122388583:122388738:122393196:122393245 | 122388583:122388738 |
| exon_skip_201990 | chr7 | 122388583:122388738:122393196:122393315:122393441:122393582 | 122393196:122393315 |
| exon_skip_216967 | chr7 | 122360788:122360820:122360930:122361013:122379368:122379442 | 122360930:122361013 |
| exon_skip_219366 | chr7 | 122474381:122474517:122480852:122480860:122490081:122490281 | 122480852:122480860 |
| exon_skip_226763 | chr7 | 122387140:122387173:122388583:122388738:122393196:122393245 | 122388583:122388738 |
| exon_skip_237624 | chr7 | 122320037:122320338:122325477:122325581:122345574:122345681 | 122325477:122325581 |
| exon_skip_269854 | chr7 | 122387026:122387173:122388583:122388738:122393196:122393315 | 122388583:122388738 |
| exon_skip_274010 | chr7 | 122491418:122491420:122513249:122513315:122554550:122554689 | 122513249:122513315 |
| exon_skip_286331 | chr7 | 122345574:122345681:122360788:122360820:122360930:122361003 | 122360788:122360820 |
| exon_skip_2916 | chr7 | 122325477:122325581:122345574:122345681:122360788:122360813 | 122345574:122345681 |
| exon_skip_38039 | chr7 | 122621481:122621717:122629248:122629328:122663237:122663569 | 122629248:122629328 |
| exon_skip_43214 | chr7 | 122615181:122615299:122621481:122621717:122629248:122629328 | 122621481:122621717 |
| exon_skip_43873 | chr7 | 122379368:122379442:122386295:122386309:122387026:122387173 | 122386295:122386309 |
| exon_skip_4672 | chr7 | 122379368:122379442:122386295:122386309:122387026:122387127 | 122386295:122386309 |
| exon_skip_50011 | chr7 | 122360930:122361013:122379368:122379442:122386295:122386309 | 122379368:122379442 |
| exon_skip_56401 | chr7 | 122360930:122361013:122379368:122379442:122387026:122387127 | 122379368:122379442 |
| exon_skip_7014 | chr7 | 122360930:122361013:122379368:122379442:122387026:122387173 | 122379368:122379442 |
| exon_skip_71405 | chr7 | 122320296:122320338:122325477:122325581:122345574:122345681 | 122325477:122325581 |
| exon_skip_72166 | chr7 | 122388583:122388738:122393441:122393582:122407540:122407632 | 122393441:122393582 |
| exon_skip_76442 | chr7 | 122325477:122325581:122345574:122345681:122360788:122360820 | 122345574:122345681 |
| exon_skip_81195 | chr7 | 122407540:122407696:122414068:122414076:122416061:122416164 | 122414068:122414076 |
| exon_skip_9573 | chr7 | 122345574:122345681:122360788:122360820:122360930:122361013 | 122360788:122360820 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
 |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_219366 | MSBB_PG | 6.844828e-01 | 8.511765e-01 | -1.666937e-01 | 2.781287e-02 |
| exon_skip_119008 | Mayo_TC | 5.546341e-01 | 6.755385e-01 | -1.209043e-01 | 1.781686e-05 |
| exon_skip_219366 | Mayo_TC | 4.938272e-01 | 6.737288e-01 | -1.799017e-01 | 4.884252e-07 |
Top |
Open reading frame (ORF) annotation in the exon skipping event for CADPS2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000449022 | 122513249 | 122513315 | Frame-shift |
| ENST00000449022 | 122581179 | 122581290 | Frame-shift |
| ENST00000449022 | 122325477 | 122325581 | In-frame |
| ENST00000449022 | 122345574 | 122345681 | In-frame |
| ENST00000449022 | 122360788 | 122360820 | In-frame |
| ENST00000449022 | 122379368 | 122379442 | In-frame |
| ENST00000449022 | 122388583 | 122388738 | In-frame |
| ENST00000449022 | 122393196 | 122393315 | In-frame |
| ENST00000449022 | 122414068 | 122414076 | In-frame |
| ENST00000449022 | 122480852 | 122480860 | In-frame |
| ENST00000449022 | 122621481 | 122621717 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000449022 | 122513249 | 122513315 | Frame-shift |
| ENST00000449022 | 122581179 | 122581290 | Frame-shift |
| ENST00000449022 | 122325477 | 122325581 | In-frame |
| ENST00000449022 | 122379368 | 122379442 | In-frame |
| ENST00000449022 | 122388583 | 122388738 | In-frame |
| ENST00000449022 | 122393196 | 122393315 | In-frame |
| ENST00000449022 | 122414068 | 122414076 | In-frame |
| ENST00000449022 | 122480852 | 122480860 | In-frame |
| ENST00000449022 | 122621481 | 122621717 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000449022 | 122471375 | 122471562 | Frame-shift |
| ENST00000449022 | 122513249 | 122513315 | Frame-shift |
| ENST00000449022 | 122554550 | 122554689 | Frame-shift |
| ENST00000449022 | 122581179 | 122581290 | Frame-shift |
| ENST00000449022 | 122325477 | 122325581 | In-frame |
| ENST00000449022 | 122345574 | 122345681 | In-frame |
| ENST00000449022 | 122360788 | 122360820 | In-frame |
| ENST00000449022 | 122360930 | 122361013 | In-frame |
| ENST00000449022 | 122379368 | 122379442 | In-frame |
| ENST00000449022 | 122388583 | 122388738 | In-frame |
| ENST00000449022 | 122393196 | 122393315 | In-frame |
| ENST00000449022 | 122414068 | 122414076 | In-frame |
| ENST00000449022 | 122451374 | 122451475 | In-frame |
| ENST00000449022 | 122480852 | 122480860 | In-frame |
| ENST00000449022 | 122621481 | 122621717 | In-frame |
| ENST00000449022 | 122629248 | 122629328 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for CADPS2 |
p-ENSG00000081803_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000449022 | 4090 | 1296 | 122621481 | 122621717 | 888 | 1123 | 289 | 367 |
| ENST00000449022 | 4090 | 1296 | 122393196 | 122393315 | 2909 | 3027 | 963 | 1002 |
| ENST00000449022 | 4090 | 1296 | 122388583 | 122388738 | 3029 | 3183 | 1003 | 1054 |
| ENST00000449022 | 4090 | 1296 | 122379368 | 122379442 | 3333 | 3406 | 1104 | 1128 |
| ENST00000449022 | 4090 | 1296 | 122360788 | 122360820 | 3492 | 3523 | 1157 | 1167 |
| ENST00000449022 | 4090 | 1296 | 122345574 | 122345681 | 3525 | 3631 | 1168 | 1203 |
| ENST00000449022 | 4090 | 1296 | 122325477 | 122325581 | 3633 | 3736 | 1204 | 1238 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000449022 | 4090 | 1296 | 122621481 | 122621717 | 888 | 1123 | 289 | 367 |
| ENST00000449022 | 4090 | 1296 | 122393196 | 122393315 | 2909 | 3027 | 963 | 1002 |
| ENST00000449022 | 4090 | 1296 | 122388583 | 122388738 | 3029 | 3183 | 1003 | 1054 |
| ENST00000449022 | 4090 | 1296 | 122379368 | 122379442 | 3333 | 3406 | 1104 | 1128 |
| ENST00000449022 | 4090 | 1296 | 122325477 | 122325581 | 3633 | 3736 | 1204 | 1238 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000449022 | 4090 | 1296 | 122629248 | 122629328 | 807 | 886 | 262 | 288 |
| ENST00000449022 | 4090 | 1296 | 122621481 | 122621717 | 888 | 1123 | 289 | 367 |
| ENST00000449022 | 4090 | 1296 | 122451374 | 122451475 | 2207 | 2307 | 729 | 762 |
| ENST00000449022 | 4090 | 1296 | 122393196 | 122393315 | 2909 | 3027 | 963 | 1002 |
| ENST00000449022 | 4090 | 1296 | 122388583 | 122388738 | 3029 | 3183 | 1003 | 1054 |
| ENST00000449022 | 4090 | 1296 | 122379368 | 122379442 | 3333 | 3406 | 1104 | 1128 |
| ENST00000449022 | 4090 | 1296 | 122360930 | 122361013 | 3408 | 3490 | 1129 | 1156 |
| ENST00000449022 | 4090 | 1296 | 122360788 | 122360820 | 3492 | 3523 | 1157 | 1167 |
| ENST00000449022 | 4090 | 1296 | 122345574 | 122345681 | 3525 | 3631 | 1168 | 1203 |
| ENST00000449022 | 4090 | 1296 | 122325477 | 122325581 | 3633 | 3736 | 1204 | 1238 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86UW7 | 289 | 367 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 289 | 367 | 367 | 447 | Domain | Note=C2 |
| Q86UW7 | 289 | 367 | 298 | 298 | Natural variant | ID=VAR_024786;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12659812;Dbxref=dbSNP:rs17144625,PMID:12659812 |
| Q86UW7 | 289 | 367 | 360 | 360 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q86UW7 | 963 | 1002 | 963 | 1003 | Alternative sequence | ID=VSP_016817;Note=In isoform 2 and isoform 3. KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST->N;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:14702 |
| Q86UW7 | 963 | 1002 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 963 | 1002 | 885 | 1056 | Domain | Note=MHD1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00587 |
| Q86UW7 | 963 | 1002 | 755 | 1074 | Region | Note=Interaction with DRD2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15857609;Dbxref=PMID:15857609 |
| Q86UW7 | 1003 | 1054 | 963 | 1003 | Alternative sequence | ID=VSP_016817;Note=In isoform 2 and isoform 3. KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST->N;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:14702 |
| Q86UW7 | 1003 | 1054 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1003 | 1054 | 885 | 1056 | Domain | Note=MHD1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00587 |
| Q86UW7 | 1003 | 1054 | 755 | 1074 | Region | Note=Interaction with DRD2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15857609;Dbxref=PMID:15857609 |
| Q86UW7 | 1104 | 1128 | 1104 | 1104 | Alternative sequence | ID=VSP_016818;Note=In isoform 2. E->EFGSQW;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMe |
| Q86UW7 | 1104 | 1128 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1157 | 1167 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1168 | 1203 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1204 | 1238 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86UW7 | 289 | 367 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 289 | 367 | 367 | 447 | Domain | Note=C2 |
| Q86UW7 | 289 | 367 | 298 | 298 | Natural variant | ID=VAR_024786;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12659812;Dbxref=dbSNP:rs17144625,PMID:12659812 |
| Q86UW7 | 289 | 367 | 360 | 360 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q86UW7 | 963 | 1002 | 963 | 1003 | Alternative sequence | ID=VSP_016817;Note=In isoform 2 and isoform 3. KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST->N;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:14702 |
| Q86UW7 | 963 | 1002 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 963 | 1002 | 885 | 1056 | Domain | Note=MHD1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00587 |
| Q86UW7 | 963 | 1002 | 755 | 1074 | Region | Note=Interaction with DRD2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15857609;Dbxref=PMID:15857609 |
| Q86UW7 | 1003 | 1054 | 963 | 1003 | Alternative sequence | ID=VSP_016817;Note=In isoform 2 and isoform 3. KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST->N;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:14702 |
| Q86UW7 | 1003 | 1054 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1003 | 1054 | 885 | 1056 | Domain | Note=MHD1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00587 |
| Q86UW7 | 1003 | 1054 | 755 | 1074 | Region | Note=Interaction with DRD2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15857609;Dbxref=PMID:15857609 |
| Q86UW7 | 1104 | 1128 | 1104 | 1104 | Alternative sequence | ID=VSP_016818;Note=In isoform 2. E->EFGSQW;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMe |
| Q86UW7 | 1104 | 1128 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1204 | 1238 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86UW7 | 262 | 288 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 289 | 367 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 289 | 367 | 367 | 447 | Domain | Note=C2 |
| Q86UW7 | 289 | 367 | 298 | 298 | Natural variant | ID=VAR_024786;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12659812;Dbxref=dbSNP:rs17144625,PMID:12659812 |
| Q86UW7 | 289 | 367 | 360 | 360 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q86UW7 | 729 | 762 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 729 | 762 | 755 | 1074 | Region | Note=Interaction with DRD2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15857609;Dbxref=PMID:15857609 |
| Q86UW7 | 963 | 1002 | 963 | 1003 | Alternative sequence | ID=VSP_016817;Note=In isoform 2 and isoform 3. KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST->N;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:14702 |
| Q86UW7 | 963 | 1002 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 963 | 1002 | 885 | 1056 | Domain | Note=MHD1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00587 |
| Q86UW7 | 963 | 1002 | 755 | 1074 | Region | Note=Interaction with DRD2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15857609;Dbxref=PMID:15857609 |
| Q86UW7 | 1003 | 1054 | 963 | 1003 | Alternative sequence | ID=VSP_016817;Note=In isoform 2 and isoform 3. KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST->N;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:14702 |
| Q86UW7 | 1003 | 1054 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1003 | 1054 | 885 | 1056 | Domain | Note=MHD1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00587 |
| Q86UW7 | 1003 | 1054 | 755 | 1074 | Region | Note=Interaction with DRD2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15857609;Dbxref=PMID:15857609 |
| Q86UW7 | 1104 | 1128 | 1104 | 1104 | Alternative sequence | ID=VSP_016818;Note=In isoform 2. E->EFGSQW;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMe |
| Q86UW7 | 1104 | 1128 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1129 | 1156 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1157 | 1167 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1168 | 1203 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
| Q86UW7 | 1204 | 1238 | 1 | 1296 | Chain | ID=PRO_0000053868;Note=Calcium-dependent secretion activator 2 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in CADPS2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for CADPS2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for CADPS2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CADPS2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for CADPS2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP4 | exon_skip_201990 | 4.643349e-01 | 7.045895e-10 |
| CB | TRA2A | exon_skip_201990 | -4.556412e-01 | 1.590607e-09 |
| CB | CNOT4 | exon_skip_154592 | -4.070875e-01 | 1.335809e-07 |
| CB | TRA2A | exon_skip_154592 | -5.538643e-01 | 6.393765e-14 |
| CB | NUP42 | exon_skip_154592 | 5.960357e-01 | 2.238609e-16 |
| DLPFC | HNRNPF | exon_skip_81195 | -4.318050e-01 | 8.004605e-13 |
| DLPFC | RC3H1 | exon_skip_201990 | 4.322458e-01 | 9.186346e-14 |
| FL | RALYL | exon_skip_201990 | 4.194013e-01 | 8.553201e-10 |
| FL | SRSF9 | exon_skip_119008 | 4.092182e-01 | 2.151439e-09 |
| FL | SRSF2 | exon_skip_154592 | 4.033407e-01 | 5.023103e-09 |
| FL | PTBP1 | exon_skip_219366 | -4.073701e-01 | 7.898903e-09 |
| IFG | RBM5 | exon_skip_81195 | -4.135429e-01 | 2.870743e-02 |
| PCC | HNRNPF | exon_skip_119008 | -5.488403e-01 | 1.332761e-17 |
| PCC | PTBP1 | exon_skip_219366 | -7.173017e-01 | 2.249906e-33 |
| PG | HNRNPK | exon_skip_201990 | 4.623764e-01 | 1.293524e-11 |
| PG | RALYL | exon_skip_201990 | 5.294734e-01 | 2.437575e-15 |
| PG | NOVA1 | exon_skip_201990 | 4.603465e-01 | 1.630387e-11 |
| PG | PTBP1 | exon_skip_219366 | -4.917235e-01 | 1.498128e-11 |
| STG | TIA1 | exon_skip_201990 | 4.064633e-01 | 8.511962e-05 |
| STG | HNRNPK | exon_skip_201990 | 4.296137e-01 | 2.953976e-05 |
| STG | FUBP1 | exon_skip_201990 | 4.093528e-01 | 7.489974e-05 |
| STG | RALYL | exon_skip_201990 | 5.386202e-01 | 6.193949e-08 |
| STG | NOVA1 | exon_skip_201990 | 5.680704e-01 | 7.810633e-09 |
| STG | NUP42 | exon_skip_154592 | 4.636045e-01 | 6.120263e-06 |
| STG | SRSF9 | exon_skip_154592 | 4.152498e-01 | 6.352267e-05 |
| STG | PTBP1 | exon_skip_219366 | -4.826237e-01 | 5.796792e-06 |
| TC | HNRNPK | exon_skip_201990 | 4.762891e-01 | 6.353781e-10 |
| TC | RC3H1 | exon_skip_201990 | 4.175811e-01 | 9.583847e-08 |
| TC | RALYL | exon_skip_201990 | 8.194786e-01 | 7.535676e-38 |
| TC | PTBP3 | exon_skip_201990 | 4.752910e-01 | 6.976173e-10 |
| TC | SRSF5 | exon_skip_201990 | 5.373402e-01 | 1.132180e-12 |
| TC | NOVA1 | exon_skip_201990 | 7.866946e-01 | 5.075037e-33 |
| TC | EWSR1 | exon_skip_119008 | 4.244133e-01 | 8.449068e-08 |
| TC | SRSF9 | exon_skip_119008 | 4.177920e-01 | 1.401577e-07 |
| TC | SRSF2 | exon_skip_154592 | 6.349175e-01 | 3.453785e-18 |
| TC | CNOT4 | exon_skip_154592 | 4.031720e-01 | 3.433259e-07 |
| TC | NUP42 | exon_skip_154592 | 7.026359e-01 | 1.745937e-23 |
| TC | SRSF9 | exon_skip_154592 | 4.217200e-01 | 8.490535e-08 |
| TC | MBNL1 | exon_skip_219366 | 4.536975e-01 | 1.806336e-08 |
| TC | PTBP1 | exon_skip_219366 | -5.199204e-01 | 4.608063e-11 |
| TC | PTBP3 | exon_skip_219366 | 4.692925e-01 | 4.953112e-09 |
Top |
RelatedDrugs for CADPS2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CADPS2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|